Q29467 (I5P1_CANFA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Type I inositol-1,4,5-trisphosphate 5-phosphatase
Short name=5PTase
EC=3.1.3.56

Gene names

Name:

INPP5A

Organism

Canis familiaris (Dog) (Canis lupus familiaris)

Taxonomic identifier

9615 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Carnivora › Caniformia › Canidae › Canis

Protein attributes

Sequence length	412 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Major isoenzyme hydrolyzing the calcium-mobilizing second messenger Ins(1,4,5)P3, this is a signal-terminating reaction.
Catalytic activity	D-myo-inositol 1,4,5-trisphosphate + H2O = myo-inositol 1,4-bisphosphate + phosphate. 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate.
Subcellular location	Membrane; Lipid-anchor.
Sequence similarities	Belongs to the inositol-1,4,5-trisphosphate 5-phosphatase type I family.

Ontologies

Keywords
Cellular component	Membrane
Molecular function	Hydrolase
PTM	Lipoprotein Methylation Palmitate Prenylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity Inferred from electronic annotation. Source: EC inositol-1,4,5-trisphosphate 5-phosphatase activity Inferred from electronic annotation. Source: EC inositol-polyphosphate 5-phosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 409	409	Type I inositol-1,4,5-trisphosphate 5-phosphatase		PRO_0000209718
	Propeptide	410 – 412	3	Removed in mature form Potential		PRO_0000396779
Amino acid modifications
	Modified residue	409	1	Cysteine methyl ester Potential
	Lipidation	408	1	S-palmitoyl cysteine Potential
	Lipidation	409	1	S-farnesyl cysteine Potential

Sequences

	Sequence		Length	Mass (Da)
	Q29467 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 5FC100C4E135D545	FASTA	412	47,683
	10 20 30 40 50 60 MAGKAAAPGT AVLLVTANVG SLFDDPENLQ KNWLREFYQV VHTHKPHFMA LHCQEFGGKN 70 80 90 100 110 120 YEASMSHVDK FVKELLSSDA MKEYNRARVY LDENFKSQEH FTALGSFYFL HESLKNIYQF 130 140 150 160 170 180 DFKAKKYKKV TGKEIYSDTL ESTPMLEKEK FPQDYFPECK WSRKGFVRTR WCVADCAFDL 190 200 210 220 230 240 VNIHLFHDAS NLVAWETSPS VYSGIRHKAL GYVLDRIIDQ RFEKVSYFVF GDFNFRLDSK 250 260 270 280 290 300 SVVETLCTKA TMQTVRAADT NEVVKLIFRE SDNDRKVMLQ LEKKLFHYFN QEVFRDNNGT 310 320 330 340 350 360 ALLEFDKELS VFKDRLYELD ISFPPSYPYS EDSGQGRQYM NTRCPAWCDR VLMSPSAREL 370 380 390 400 410 ILKSESEEKV VTYDHIGPNV CMGDHKPVFL AFRIAPGAGK PHAHVHKCCV VQ

References

[1]

"Cloning and expression in Escherichia coli of a dog thyroid cDNA encoding a novel inositol 1,4,5-trisphosphate 5-phosphatase." Verjans B., de Smedt F., Lecocq R., Vanweyenberg V., Moreau C., Erneux C. Biochem. J. 300:85-90(1994) [PubMed: 8198557] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Thyroid.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X75094 mRNA. Translation: CAA52985.1.
PIR	S44357.
RefSeq	NP_001003257.1. NM_001003257.1.
UniGene	Cfa.3798.
3D structure databases
ProteinModelPortal	Q29467.
ModBase	Search...
Protein-protein interaction databases
STRING	Q29467.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	403937.
KEGG	cfa:403937.
Organism-specific databases
CTD	3632.
Phylogenomic databases
eggNOG	maNOG08766.
GeneTree	ENSGT00390000015226.
HOVERGEN	HBG006102.
InParanoid	Q29467.
OrthoDB	EOG49P9ZD.
Enzyme and pathway databases
BRENDA	3.1.3.56. 1154.
Family and domain databases
InterPro	IPR005135. Endo/exonuclease/phosphatase. IPR000300. IPPc. [Graphical view]
KO	K01106.
Pfam	PF03372. Exo_endo_phos. 1 hit. [Graphical view]
SMART	SM00128. IPPc. 1 hit. [Graphical view]
SUPFAM	SSF56219. Exo_endo_phos. 1 hit.
ProtoNet	Search...

Entry information

Entry name

I5P1_CANFA

Accession

Primary (citable) accession number: Q29467

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	November 1, 1996
Last modified:	November 16, 2011
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program