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Protein

Cyclic nucleotide-gated cation channel alpha-3

Gene

CNGA3

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of cone photoreceptors. Essential for the generation of light-evoked electrical responses in the red-, green- and blue sensitive cones Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficacy of the channel when coexpressed with CNGB3 (By similarity). Could be responsible for cGMP-induced calcium entry in cells other than sensory cells. Might be involved in chemotaxis of sperm.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei568cGMPSequence analysis1
Binding sitei583cGMPSequence analysis1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi501 – 624cGMPAdd BLAST124

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Ligand-gated ion channel

Keywords - Biological processi

Ion transport, Sensory transduction, Transport, Vision

Keywords - Ligandi

cGMP, cGMP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclic nucleotide-gated cation channel alpha-3
Alternative name(s):
Cone photoreceptor cGMP-gated channel subunit alpha
Cyclic nucleotide-gated channel alpha-3
Short name:
CNG channel alpha-3
Short name:
CNG-3
Short name:
CNG3
Gene namesi
Name:CNGA3
Synonyms:CNCG3
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 11

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei186 – 206HelicalSequence analysisAdd BLAST21
Transmembranei322 – 342HelicalSequence analysisAdd BLAST21
Transmembranei398 – 418HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002193161 – 706Cyclic nucleotide-gated cation channel alpha-3Add BLAST706

Proteomic databases

PaxDbiQ29441.
PRIDEiQ29441.

Expressioni

Tissue specificityi

Testis, kidney, retinal cone and heart.

Gene expression databases

BgeeiENSBTAG00000009834.

Interactioni

Subunit structurei

Tetramer formed of three CNGA3 and one CNGB3 modulatory subunits (By similarity). Forms functional heterooligomeric channels with CNG4 in vitro.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000052464.

Structurei

3D structure databases

ProteinModelPortaliQ29441.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili645 – 688By similarityAdd BLAST44

Domaini

The C-terminal coiled-coil domain mediates homotrimerization of CNGA subunits.By similarity

Sequence similaritiesi

Contains 1 cyclic nucleotide-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0500. Eukaryota.
ENOG410YWWI. LUCA.
GeneTreeiENSGT00760000118772.
HOGENOMiHOG000007898.
HOVERGENiHBG000281.
InParanoidiQ29441.
KOiK04950.
OMAiYLWANRK.
OrthoDBiEOG091G03EW.
TreeFamiTF319048.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
InterProiIPR032406. CLZ_dom.
IPR018490. cNMP-bd-like.
IPR018488. cNMP-bd_CS.
IPR000595. cNMP-bd_dom.
IPR005821. Ion_trans_dom.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF16526. CLZ. 1 hit.
PF00027. cNMP_binding. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 1 hit.
PROSITEiPS00888. CNMP_BINDING_1. 1 hit.
PS00889. CNMP_BINDING_2. 1 hit.
PS50042. CNMP_BINDING_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q29441-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKISTQYSH PTRTHPSVRT MDRDLDCIEN GLSRTHLPCE ETSSELQEGI
60 70 80 90 100
AMETRGLAES RQSSFTSQGP TRLSRLIISL RAWSARHLHQ EDQRPDSFLE
110 120 130 140 150
RFRGAELQEV SSRESHVQFN VGSQEPPDRG RSAWPLARNN TNTCNNSEKD
160 170 180 190 200
DKAKKEEKEK KEEKKENPKK EEKKKDSVVM DPSSNMYYHW LTVIAVPVFY
210 220 230 240 250
NWCLLVCRAC FDELQSEHLM LWLVLDYSAD ILYGMDMLVR ARTGFLEQGL
260 270 280 290 300
MVMDASRLWK HYTQTLHFKL DVLSLVPTDL AYFKLGMNYP ELRFNRLLKL
310 320 330 340 350
ARLFEFFDRT ETRTNYPNMF RIGNLVLYIL IIIHWNACIY FAISKFIGFG
360 370 380 390 400
TDSWVYPNVS NPEYGRLSRK YIYSLYWSTL TLTTIGETPP PVKDEEYLFV
410 420 430 440 450
VIDFLVGVLI FATIVGNVGS MISNMNASRA EFQAKIDSIK QYMQFRKVTK
460 470 480 490 500
DLETRVIRWF DYLWANKKTV DEKEVLKSLP DKLKAEIAIN VHLDTLRKVR
510 520 530 540 550
IFQDCEAGLL VELVLKLRPA VFSPGDYICK KGDIGREMYI IKEGKLAVVA
560 570 580 590 600
EDGITQFVVL GDGSYFGEIS ILNIKGSKSG NRRTANIRSI GYSDLFCLSK
610 620 630 640 650
DDLMEALTEY PEAKKALEEK GRQILMKDNL IDEELAKAGA DPKDIEEKVE
660 670 680 690 700
HLETSLDSLQ TRFARLLAEY NATQMKVKQR LSQLESQVKM GLPPDGDAPQ

TEASQP
Length:706
Mass (Da):81,132
Last modified:November 1, 1997 - v1
Checksum:iF4990DCD29B56239
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X89600 mRNA. Translation: CAA61759.1.
X76485 mRNA. Translation: CAA54023.1.
PIRiA55251.
RefSeqiNP_776704.1. NM_174279.2.
UniGeneiBt.109785.

Genome annotation databases

EnsembliENSBTAT00000056449; ENSBTAP00000052464; ENSBTAG00000009834.
GeneIDi281701.
KEGGibta:281701.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X89600 mRNA. Translation: CAA61759.1.
X76485 mRNA. Translation: CAA54023.1.
PIRiA55251.
RefSeqiNP_776704.1. NM_174279.2.
UniGeneiBt.109785.

3D structure databases

ProteinModelPortaliQ29441.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000052464.

Proteomic databases

PaxDbiQ29441.
PRIDEiQ29441.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000056449; ENSBTAP00000052464; ENSBTAG00000009834.
GeneIDi281701.
KEGGibta:281701.

Organism-specific databases

CTDi1261.

Phylogenomic databases

eggNOGiKOG0500. Eukaryota.
ENOG410YWWI. LUCA.
GeneTreeiENSGT00760000118772.
HOGENOMiHOG000007898.
HOVERGENiHBG000281.
InParanoidiQ29441.
KOiK04950.
OMAiYLWANRK.
OrthoDBiEOG091G03EW.
TreeFamiTF319048.

Gene expression databases

BgeeiENSBTAG00000009834.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
InterProiIPR032406. CLZ_dom.
IPR018490. cNMP-bd-like.
IPR018488. cNMP-bd_CS.
IPR000595. cNMP-bd_dom.
IPR005821. Ion_trans_dom.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF16526. CLZ. 1 hit.
PF00027. cNMP_binding. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 1 hit.
PROSITEiPS00888. CNMP_BINDING_1. 1 hit.
PS00889. CNMP_BINDING_2. 1 hit.
PS50042. CNMP_BINDING_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCNGA3_BOVIN
AccessioniPrimary (citable) accession number: Q29441
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: September 7, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.