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Protein

Cyclic nucleotide-gated cation channel alpha-3

Gene

CNGA3

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of cone photoreceptors. Essential for the generation of light-evoked electrical responses in the red-, green- and blue sensitive cones Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficacy of the channel when coexpressed with CNGB3 (By similarity). Could be responsible for cGMP-induced calcium entry in cells other than sensory cells. Might be involved in chemotaxis of sperm.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei568cGMPSequence analysis1
Binding sitei583cGMPSequence analysis1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi501 – 624cGMPAdd BLAST124

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel, Ligand-gated ion channel
Biological processIon transport, Sensory transduction, Transport, Vision
LigandcGMP, cGMP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclic nucleotide-gated cation channel alpha-3
Alternative name(s):
Cone photoreceptor cGMP-gated channel subunit alpha
Cyclic nucleotide-gated channel alpha-3
Short name:
CNG channel alpha-3
Short name:
CNG-3
Short name:
CNG3
Gene namesi
Name:CNGA3
Synonyms:CNCG3
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 11

Organism-specific databases

VGNCiVGNC:27499 CNGA3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei186 – 206HelicalSequence analysisAdd BLAST21
Transmembranei322 – 342HelicalSequence analysisAdd BLAST21
Transmembranei398 – 418HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002193161 – 706Cyclic nucleotide-gated cation channel alpha-3Add BLAST706

Proteomic databases

PaxDbiQ29441
PRIDEiQ29441

Expressioni

Tissue specificityi

Testis, kidney, retinal cone and heart.

Gene expression databases

BgeeiENSBTAG00000009834

Interactioni

Subunit structurei

Tetramer formed of three CNGA3 and one CNGB3 modulatory subunits (By similarity). Forms functional heterooligomeric channels with CNG4 in vitro.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000052464

Structurei

3D structure databases

ProteinModelPortaliQ29441
SMRiQ29441
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili645 – 688By similarityAdd BLAST44

Domaini

The C-terminal coiled-coil domain mediates homotrimerization of CNGA subunits.By similarity

Sequence similaritiesi

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0500 Eukaryota
ENOG410YWWI LUCA
GeneTreeiENSGT00900000140801
HOGENOMiHOG000007898
HOVERGENiHBG000281
InParanoidiQ29441
KOiK04950
OMAiYLWANRK
OrthoDBiEOG091G03EW
TreeFamiTF319048

Family and domain databases

CDDicd00038 CAP_ED, 1 hit
Gene3Di2.60.120.10, 1 hit
InterProiView protein in InterPro
IPR032406 CLZ_dom
IPR018490 cNMP-bd-like
IPR018488 cNMP-bd_CS
IPR000595 cNMP-bd_dom
IPR005821 Ion_trans_dom
IPR014710 RmlC-like_jellyroll
PfamiView protein in Pfam
PF16526 CLZ, 1 hit
PF00027 cNMP_binding, 1 hit
PF00520 Ion_trans, 1 hit
SMARTiView protein in SMART
SM00100 cNMP, 1 hit
SUPFAMiSSF51206 SSF51206, 1 hit
PROSITEiView protein in PROSITE
PS00888 CNMP_BINDING_1, 1 hit
PS00889 CNMP_BINDING_2, 1 hit
PS50042 CNMP_BINDING_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q29441-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKISTQYSH PTRTHPSVRT MDRDLDCIEN GLSRTHLPCE ETSSELQEGI
60 70 80 90 100
AMETRGLAES RQSSFTSQGP TRLSRLIISL RAWSARHLHQ EDQRPDSFLE
110 120 130 140 150
RFRGAELQEV SSRESHVQFN VGSQEPPDRG RSAWPLARNN TNTCNNSEKD
160 170 180 190 200
DKAKKEEKEK KEEKKENPKK EEKKKDSVVM DPSSNMYYHW LTVIAVPVFY
210 220 230 240 250
NWCLLVCRAC FDELQSEHLM LWLVLDYSAD ILYGMDMLVR ARTGFLEQGL
260 270 280 290 300
MVMDASRLWK HYTQTLHFKL DVLSLVPTDL AYFKLGMNYP ELRFNRLLKL
310 320 330 340 350
ARLFEFFDRT ETRTNYPNMF RIGNLVLYIL IIIHWNACIY FAISKFIGFG
360 370 380 390 400
TDSWVYPNVS NPEYGRLSRK YIYSLYWSTL TLTTIGETPP PVKDEEYLFV
410 420 430 440 450
VIDFLVGVLI FATIVGNVGS MISNMNASRA EFQAKIDSIK QYMQFRKVTK
460 470 480 490 500
DLETRVIRWF DYLWANKKTV DEKEVLKSLP DKLKAEIAIN VHLDTLRKVR
510 520 530 540 550
IFQDCEAGLL VELVLKLRPA VFSPGDYICK KGDIGREMYI IKEGKLAVVA
560 570 580 590 600
EDGITQFVVL GDGSYFGEIS ILNIKGSKSG NRRTANIRSI GYSDLFCLSK
610 620 630 640 650
DDLMEALTEY PEAKKALEEK GRQILMKDNL IDEELAKAGA DPKDIEEKVE
660 670 680 690 700
HLETSLDSLQ TRFARLLAEY NATQMKVKQR LSQLESQVKM GLPPDGDAPQ

TEASQP
Length:706
Mass (Da):81,132
Last modified:November 1, 1997 - v1
Checksum:iF4990DCD29B56239
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X89600 mRNA Translation: CAA61759.1
X76485 mRNA Translation: CAA54023.1
PIRiA55251
RefSeqiNP_776704.1, NM_174279.2
UniGeneiBt.109785

Genome annotation databases

EnsembliENSBTAT00000056449; ENSBTAP00000052464; ENSBTAG00000009834
GeneIDi281701
KEGGibta:281701

Similar proteinsi

Entry informationi

Entry nameiCNGA3_BOVIN
AccessioniPrimary (citable) accession number: Q29441
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: March 28, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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