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Protein

Pregnancy-associated glycoprotein 1

Gene
N/A
Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Appears to be proteolytically inactive.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei89PROSITE-ProRule annotation1
Active sitei270PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAspartyl protease, Hydrolase, Protease

Protein family/group databases

MEROPSiA01.089.

Names & Taxonomyi

Protein namesi
Recommended name:
Pregnancy-associated glycoprotein 1 (EC:3.4.23.-)
Short name:
PAG 1
Alternative name(s):
Pregnancy-specific protein B
Short name:
PSP-B
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 29

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 15Sequence analysisAdd BLAST15
PropeptideiPRO_000002609916 – 53Activation peptide1 PublicationAdd BLAST38
ChainiPRO_000002610054 – 380Pregnancy-associated glycoprotein 1Add BLAST327

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi57N-linked (GalNAc...) asparagineSequence analysis2 Publications1
Glycosylationi74N-linked (GalNAc...) asparagineSequence analysis2 Publications1
Disulfide bondi102 ↔ 107By similarity
Glycosylationi125N-linked (GalNAc...) asparagineSequence analysis2 Publications1
Glycosylationi182N-linked (GalNAc...) asparagineSequence analysis2 Publications1
Disulfide bondi261 ↔ 265By similarity
Disulfide bondi303 ↔ 337By similarity

Post-translational modificationi

N-Glycosylated; glycans consist of N-acetyl-galactosamine (GalNAc) and N-acetyllactosamine (PubMed:17071780, PubMed:15822115). Terminal GalNAc on Asn-linked glycans is greatly reduced prior to parturition while lactosamine-type N-glycans remain unaltered (PubMed:17071780).2 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PaxDbiQ29432.
PRIDEiQ29432.

PTM databases

iPTMnetiQ29432.

Expressioni

Tissue specificityi

Trophoblast and placental tissue. Produced specifically in the invasive binucleate cells of the placenta. Becomes detectable in maternal serum soon after implantation.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000025593.

Structurei

3D structure databases

ProteinModelPortaliQ29432.
SMRiQ29432.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini71 – 377Peptidase A1PROSITE-ProRule annotationAdd BLAST307

Sequence similaritiesi

Belongs to the peptidase A1 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1339. Eukaryota.
ENOG410XNV7. LUCA.
GeneTreeiENSGT00760000118929.
HOGENOMiHOG000197681.
HOVERGENiHBG000482.
InParanoidiQ29432.
KOiK06002.
OMAiFNTEGSK.
OrthoDBiEOG091G0JP7.
TreeFamiTF314990.

Family and domain databases

Gene3Di2.40.70.10. 2 hits.
InterProiView protein in InterPro
IPR001461. Aspartic_peptidase_A1.
IPR001969. Aspartic_peptidase_AS.
IPR012848. Aspartic_peptidase_N.
IPR033121. PEPTIDASE_A1.
IPR021109. Peptidase_aspartic_dom_sf.
PANTHERiPTHR13683. PTHR13683. 1 hit.
PfamiView protein in Pfam
PF07966. A1_Propeptide. 1 hit.
PF00026. Asp. 1 hit.
PRINTSiPR00792. PEPSIN.
SUPFAMiSSF50630. SSF50630. 1 hit.
PROSITEiView protein in PROSITE
PS00141. ASP_PROTEASE. 1 hit.
PS51767. PEPTIDASE_A1. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q29432-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKWLVLLGLV AFSECIVKIP LRRLKTMRNV VSGKNMLNNF LKEHAYSLSQ
60 70 80 90 100
ISFRGSNLTT HPLRNIKDLV YMGNITIGTP PQEFQVVFDT ASSDLWVPSD
110 120 130 140 150
FCTSPACSTH VRFRHLQSST FRLTNKTFRI TYGSGRMKGV VVHDTVRIGN
160 170 180 190 200
LVSTDQPFGL SIEEYGFEGR IYDGVLGLNY PNISFSGAIP IFDKLKNQRA
210 220 230 240 250
ISEPVFAFYL SKDEREGSVV MFGGVDHRYY EGELNWVPLI QAGDWSVHMD
260 270 280 290 300
RISIERKIIA CSDGCKALVD TGTSDIVGPR RLVNNIHRLI GAIPRGSEHY
310 320 330 340 350
VPCSEVNTLP SIVFTINGIN YPVPGRAYIL KDDRGRCYTT FQENRVSSST
360 370 380
ETWYLGDVFL RLYFSVFDRG NDRIGLARAV
Length:380
Mass (Da):42,847
Last modified:November 1, 1997 - v1
Checksum:i77D6FFED68C445B6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti56S → H AA sequence (PubMed:1946444).Curated1
Sequence conflicti60 – 61TH → PG AA sequence (PubMed:1946444).Curated2
Sequence conflicti66I → F AA sequence (PubMed:1946444).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M73962 mRNA. Translation: AAB53145.1.
L27832, L27833, L27834 Genomic DNA. Translation: AAA96331.1.
BC134743 mRNA. Translation: AAI34744.1.
PIRiB41545.
RefSeqiNP_776836.1. NM_174411.2.
UniGeneiBt.15401.

Genome annotation databases

EnsembliENSBTAT00000025593; ENSBTAP00000025593; ENSBTAG00000037908.
GeneIDi281964.
KEGGibta:281964.

Similar proteinsi

Entry informationi

Entry nameiPAG1_BOVIN
AccessioniPrimary (citable) accession number: Q29432
Secondary accession number(s): A7YWR8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 22, 2017
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families