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Protein

Keratin, type II cytoskeletal 3

Gene

KRT3

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type II cytoskeletal 3
Alternative name(s):
Cytokeratin-3
Short name:
CK-3
Keratin-3
Short name:
K3
Type-II keratin Kb3
Gene namesi
Name:KRT3
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Intermediate filament, Keratin

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000637171 – 629Keratin, type II cytoskeletal 3Add BLAST629

Proteomic databases

PRIDEiQ29426.

Expressioni

Tissue specificityi

Cornea specific. Expressed in the basal cells of corneal epithelium and stroma. Also expressed in esophageal epithelium.2 Publications

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins. Keratin-3 associates with keratin-12.

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000008551.

Structurei

3D structure databases

ProteinModelPortaliQ29426.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 182HeadAdd BLAST182
Regioni183 – 494RodAdd BLAST312
Regioni183 – 218Coil 1AAdd BLAST36
Regioni219 – 239Linker 1Add BLAST21
Regioni240 – 331Coil 1BAdd BLAST92
Regioni332 – 355Linker 12Add BLAST24
Regioni356 – 494Coil 2Add BLAST139
Regioni495 – 629TailAdd BLAST135

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi10 – 154Gly-richAdd BLAST145
Compositional biasi522 – 615Gly-richAdd BLAST94

Sequence similaritiesi

Belongs to the intermediate filament family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IKBD. Eukaryota.
ENOG4111UGN. LUCA.
HOGENOMiHOG000230976.
HOVERGENiHBG013015.
InParanoidiQ29426.
KOiK07605.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR032444. Keratin_2_head.
IPR003054. Keratin_II.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 2 hits.
PfamiPF00038. Filament. 1 hit.
PF16208. Keratin_2_head. 1 hit.
[Graphical view]
PRINTSiPR01276. TYPE2KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
PROSITEiPS00226. IF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q29426-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNRQVCKTSG GGSLSFSGRS AVVSGSGGGG SSSRMSCVAR SVAAGGGASG
60 70 80 90 100
FRGGAGGFGS RSLYNLGGHK SISMSVAAGG SRAGGFGGGR SICGSGFGGG
110 120 130 140 150
LGGGLGGGLG SGFGGGFGGG FGGAGAFGGA GGFGGAGGFG GPGGFGGPGG
160 170 180 190 200
FPGGIQEVTV NQSLLQPLNV EIDPQIGQVR AQEREQIKTL NNKFASFIDK
210 220 230 240 250
VRFLEQQNKV LETKWELLQR QGPNSVTGTN NLEPLFENRI NYLRSYLDSI
260 270 280 290 300
VGERGRLDSE LRSMQDLVED FKKKYEDEIN KRTAAENEFV TLKKDVDAAY
310 320 330 340 350
MNKVELQAKV DSLMDEINFL RTLYDAELSQ MQSHVSDMSV VLSMDNNRSL
360 370 380 390 400
DLDSIIAEVR AQYEDIAQRS RAEAEAWYQT KLGELQTTAG RHGDDLRSTK
410 420 430 440 450
NEIAEINRMI QRLRNEIENV KKQNASLQTA IAEAEQRGEL ALKDANAKLQ
460 470 480 490 500
ELQAALQQAK DDLARLLRDY QELMNVKLAL DVEIATYRKL LEGEESRMSG
510 520 530 540 550
ECQSAVSISV VNSSSTTSAA AGGYGGGYGG GYGGGFGVGG GAGSGFGRGG
560 570 580 590 600
GSGFGGGSGL GGGSGFGGGS GLGGGSGLGG GSIGFSVGSS GFGSGSGGRI
610 620
GVSGGGFSSG SSSRGSSVKF SQSSQRYSR
Length:629
Mass (Da):64,341
Last modified:November 1, 1996 - v1
Checksum:iA4F456D366AC1A72
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S65740 Genomic DNA. Translation: AAB28323.1.
X74371 Genomic DNA. Translation: CAA52409.1.
PIRiS42629.
RefSeqiXP_002711051.1. XM_002711005.2.

Genome annotation databases

GeneIDi100353668.
KEGGiocu:100353668.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S65740 Genomic DNA. Translation: AAB28323.1.
X74371 Genomic DNA. Translation: CAA52409.1.
PIRiS42629.
RefSeqiXP_002711051.1. XM_002711005.2.

3D structure databases

ProteinModelPortaliQ29426.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000008551.

Proteomic databases

PRIDEiQ29426.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100353668.
KEGGiocu:100353668.

Organism-specific databases

CTDi3850.

Phylogenomic databases

eggNOGiENOG410IKBD. Eukaryota.
ENOG4111UGN. LUCA.
HOGENOMiHOG000230976.
HOVERGENiHBG013015.
InParanoidiQ29426.
KOiK07605.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR032444. Keratin_2_head.
IPR003054. Keratin_II.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 2 hits.
PfamiPF00038. Filament. 1 hit.
PF16208. Keratin_2_head. 1 hit.
[Graphical view]
PRINTSiPR01276. TYPE2KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
PROSITEiPS00226. IF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiK2C3_RABIT
AccessioniPrimary (citable) accession number: Q29426
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.