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Protein

Keratin, type II cytoskeletal 3

Gene

KRT3

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type II cytoskeletal 3
Alternative name(s):
Cytokeratin-3
Short name:
CK-3
Keratin-3
Short name:
K3
Type-II keratin Kb3
Gene namesi
Name:KRT3
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Intermediate filament, Keratin

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000637171 – 629Keratin, type II cytoskeletal 3Add BLAST629

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei17PhosphoserineBy similarity1
Modified residuei20PhosphoserineBy similarity1
Modified residuei62PhosphoserineBy similarity1
Modified residuei281N6,N6-dimethyllysineBy similarity1
Modified residuei349PhosphoserineBy similarity1
Modified residuei599Omega-N-methylarginineBy similarity1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

PRIDEiQ29426.

Expressioni

Tissue specificityi

Cornea specific. Expressed in the basal cells of corneal epithelium and stroma. Also expressed in esophageal epithelium.2 Publications

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins. Keratin-3 associates with keratin-12.

Structurei

3D structure databases

ProteinModelPortaliQ29426.
SMRiQ29426.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 182HeadAdd BLAST182
Regioni183 – 494RodAdd BLAST312
Regioni183 – 218Coil 1AAdd BLAST36
Regioni219 – 239Linker 1Add BLAST21
Regioni240 – 331Coil 1BAdd BLAST92
Regioni332 – 355Linker 12Add BLAST24
Regioni356 – 494Coil 2Add BLAST139
Regioni495 – 629TailAdd BLAST135

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi10 – 154Gly-richAdd BLAST145
Compositional biasi522 – 615Gly-richAdd BLAST94

Sequence similaritiesi

Belongs to the intermediate filament family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IKBD. Eukaryota.
ENOG4111UGN. LUCA.
HOGENOMiHOG000230976.
HOVERGENiHBG013015.
InParanoidiQ29426.
KOiK07605.

Family and domain databases

InterProiView protein in InterPro
IPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR032444. Keratin_2_head.
IPR003054. Keratin_II.
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiView protein in Pfam
PF00038. Filament. 1 hit.
PF16208. Keratin_2_head. 1 hit.
PRINTSiPR01276. TYPE2KERATIN.
SMARTiView protein in SMART
SM01391. Filament. 1 hit.
PROSITEiView protein in PROSITE
PS00226. IF. 1 hit.

Sequencei

Sequence statusi: Complete.

Q29426-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNRQVCKTSG GGSLSFSGRS AVVSGSGGGG SSSRMSCVAR SVAAGGGASG
60 70 80 90 100
FRGGAGGFGS RSLYNLGGHK SISMSVAAGG SRAGGFGGGR SICGSGFGGG
110 120 130 140 150
LGGGLGGGLG SGFGGGFGGG FGGAGAFGGA GGFGGAGGFG GPGGFGGPGG
160 170 180 190 200
FPGGIQEVTV NQSLLQPLNV EIDPQIGQVR AQEREQIKTL NNKFASFIDK
210 220 230 240 250
VRFLEQQNKV LETKWELLQR QGPNSVTGTN NLEPLFENRI NYLRSYLDSI
260 270 280 290 300
VGERGRLDSE LRSMQDLVED FKKKYEDEIN KRTAAENEFV TLKKDVDAAY
310 320 330 340 350
MNKVELQAKV DSLMDEINFL RTLYDAELSQ MQSHVSDMSV VLSMDNNRSL
360 370 380 390 400
DLDSIIAEVR AQYEDIAQRS RAEAEAWYQT KLGELQTTAG RHGDDLRSTK
410 420 430 440 450
NEIAEINRMI QRLRNEIENV KKQNASLQTA IAEAEQRGEL ALKDANAKLQ
460 470 480 490 500
ELQAALQQAK DDLARLLRDY QELMNVKLAL DVEIATYRKL LEGEESRMSG
510 520 530 540 550
ECQSAVSISV VNSSSTTSAA AGGYGGGYGG GYGGGFGVGG GAGSGFGRGG
560 570 580 590 600
GSGFGGGSGL GGGSGFGGGS GLGGGSGLGG GSIGFSVGSS GFGSGSGGRI
610 620
GVSGGGFSSG SSSRGSSVKF SQSSQRYSR
Length:629
Mass (Da):64,341
Last modified:November 1, 1996 - v1
Checksum:iA4F456D366AC1A72
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S65740 Genomic DNA. Translation: AAB28323.1.
X74371 Genomic DNA. Translation: CAA52409.1.
PIRiS42629.
RefSeqiXP_002711051.1. XM_002711005.2.

Genome annotation databases

GeneIDi100353668.
KEGGiocu:100353668.

Similar proteinsi

Entry informationi

Entry nameiK2C3_RABIT
AccessioniPrimary (citable) accession number: Q29426
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: November 1, 1996
Last modified: August 30, 2017
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families