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Protein

CD44 antigen

Gene

CD44

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. In cancer cells, may play an important role in invadopodia formation. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Receptor for LGALS9; the interaction enhances binding of SMAD3 to the FOXP3 promoter, leading to up-regulation of FOXP3 expression and increased induced regulatory T (iTreg) cell stability and suppressive function.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei41HyaluronanBy similarity1
Binding sitei78HyaluronanBy similarity1
Binding sitei79HyaluronanBy similarity1
Binding sitei105HyaluronanBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptor
Biological processCell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
CD44 antigen
Alternative name(s):
Extracellular matrix receptor III
Short name:
ECMR-III
GP90 lymphocyte homing/adhesion receptor
HUTCH-I
Hermes antigen
Hyaluronate receptor
Phagocytic glycoprotein 1
Short name:
PGP-1
Phagocytic glycoprotein I
Short name:
PGP-I
CD_antigen: CD44
Gene namesi
Name:CD44
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini21 – 273ExtracellularSequence analysisAdd BLAST253
Transmembranei274 – 294HelicalSequence analysisAdd BLAST21
Topological domaini295 – 366CytoplasmicSequence analysisAdd BLAST72

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000002668321 – 366CD44 antigenAdd BLAST346

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi25N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi28 ↔ 129PROSITE-ProRule annotation
Disulfide bondi53 ↔ 118PROSITE-ProRule annotation
Glycosylationi57N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi77 ↔ 97PROSITE-ProRule annotation
Glycosylationi100N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi110N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi120N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi222N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi260N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei296Phosphoserine; by PKCBy similarity1
Modified residuei314PhosphothreonineBy similarity1
Modified residuei321PhosphoserineBy similarity1
Modified residuei330PhosphoserineBy similarity1

Post-translational modificationi

N- and O-glycosylated; contains glycosaminoglycan chondroitin sulfate.By similarity
Phosphorylated on serine residues.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Proteoglycan

Proteomic databases

PaxDbiQ29423.
PeptideAtlasiQ29423.
PRIDEiQ29423.

Expressioni

Tissue specificityi

Mesenteric lymph node and liver, not in heart.

Interactioni

Subunit structurei

Interacts with HA, as well as other glycosaminoglycans, collagen, laminin, and fibronectin via its N-terminal segment. Interacts with ANK, the ERM proteins (VIL2, RDX and MSN), and NF2 via its C-terminal segment. Interacts with PKN2. Interacts with TIAM1 and TIAM2. Interacts with UNC119. Interacts with PDPN (via extracellular domain); this interaction is required for PDPN-mediated directional migration and regulation of lamellipodia extension/stabilization during cell spreading and migration (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000048925.

Structurei

3D structure databases

ProteinModelPortaliQ29423.
SMRiQ29423.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 120LinkPROSITE-ProRule annotationAdd BLAST89

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni229 – 273StemAdd BLAST45

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi150 – 158Arg/Lys-rich (basic)9

Domaini

The lectin-like LINK domain is responsible for hyaluronan binding.By similarity

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IZCP. Eukaryota.
ENOG4111S6T. LUCA.
HOGENOMiHOG000231746.
HOVERGENiHBG003850.
InParanoidiQ29423.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiView protein in InterPro
IPR016186. C-type_lectin-like/link_sf.
IPR001231. CD44_antigen.
IPR016187. CTDL_fold.
IPR000538. Link_dom.
PANTHERiPTHR10225:SF6. PTHR10225:SF6. 2 hits.
PfamiView protein in Pfam
PF00193. Xlink. 1 hit.
PRINTSiPR00658. CD44.
PR01265. LINKMODULE.
SMARTiView protein in SMART
SM00445. LINK. 1 hit.
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiView protein in PROSITE
PS01241. LINK_1. 1 hit.
PS50963. LINK_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q29423-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTFWWRAAW GLCLVQLSLA QIDLNITCRY AGVFHVEKNG RYSISKTEAA
60 70 80 90 100
DLCKAFNSTL PTMAQMEAAR NIGFETCRYG FIEGHVVIPR IHPNSICAAN
110 120 130 140 150
NTGVYILTSN TSQYDTICFN ASAPPGEDCT SVTDLPNAFE GPITITIVNR
160 170 180 190 200
DGTRYTKKGE YRTNPEDINP SVVSPSSPPD DEMSSGSPSE RSTSGGYSIF
210 220 230 240 250
HTHLPTVHPS RPRRPWSQRA ENTSDTRDYG SSHDPSGRSY TTHASESAGH
260 270 280 290 300
SSGSEEHGAN TTSGPMRKPQ IPEWLIILAS LLALALILAV CIAVNSRRRC
310 320 330 340 350
GQKKKLVINN GNGTMEERKP SGLNGEASKS QEMVHLVNKG SSETPDQFMT
360
ADETRNLQNV DMKIGV
Length:366
Mass (Da):40,002
Last modified:November 1, 1997 - v1
Checksum:i438A5A1E631E02B4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X62881 mRNA. Translation: CAA44675.1.
S63418 mRNA. Translation: AAB20016.1.
PIRiA53286.
UniGeneiBt.5494.

Similar proteinsi

Entry informationi

Entry nameiCD44_BOVIN
AccessioniPrimary (citable) accession number: Q29423
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 22, 2017
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome