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Protein

CD44 antigen

Gene

CD44

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. In cancer cells, may play an important role in invadopodia formation. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Receptor for LGALS9; the interaction enhances binding of SMAD3 to the FOXP3 promoter, leading to up-regulation of FOXP3 expression and increased induced regulatory T (iTreg) cell stability and suppressive function.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei41 – 411HyaluronanBy similarity
Binding sitei78 – 781HyaluronanBy similarity
Binding sitei79 – 791HyaluronanBy similarity
Binding sitei105 – 1051HyaluronanBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
CD44 antigen
Alternative name(s):
Extracellular matrix receptor III
Short name:
ECMR-III
GP90 lymphocyte homing/adhesion receptor
HUTCH-I
Hermes antigen
Hyaluronate receptor
Phagocytic glycoprotein 1
Short name:
PGP-1
Phagocytic glycoprotein I
Short name:
PGP-I
CD_antigen: CD44
Gene namesi
Name:CD44
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

  • Cell membrane By similarity; Single-pass type I membrane protein By similarity

  • Note: Colocalizes with actin in membrane protrusions at wounding edges.By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini21 – 273253ExtracellularSequence analysisAdd
BLAST
Transmembranei274 – 29421HelicalSequence analysisAdd
BLAST
Topological domaini295 – 36672CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence analysisAdd
BLAST
Chaini21 – 366346CD44 antigenPRO_0000026683Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi25 – 251N-linked (GlcNAc...)Sequence analysis
Disulfide bondi28 ↔ 129PROSITE-ProRule annotation
Disulfide bondi53 ↔ 118PROSITE-ProRule annotation
Glycosylationi57 – 571N-linked (GlcNAc...)Sequence analysis
Disulfide bondi77 ↔ 97PROSITE-ProRule annotation
Glycosylationi100 – 1001N-linked (GlcNAc...)Sequence analysis
Glycosylationi110 – 1101N-linked (GlcNAc...)Sequence analysis
Glycosylationi120 – 1201N-linked (GlcNAc...)Sequence analysis
Glycosylationi222 – 2221N-linked (GlcNAc...)Sequence analysis
Glycosylationi260 – 2601N-linked (GlcNAc...)Sequence analysis
Modified residuei296 – 2961Phosphoserine; by PKCBy similarity
Modified residuei314 – 3141PhosphothreonineBy similarity
Modified residuei321 – 3211PhosphoserineBy similarity
Modified residuei330 – 3301PhosphoserineBy similarity

Post-translational modificationi

N- and O-glycosylated; contains glycosaminoglycan chondroitin sulfate.By similarity
Phosphorylated on serine residues.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Proteoglycan

Proteomic databases

PaxDbiQ29423.
PRIDEiQ29423.

Expressioni

Tissue specificityi

Mesenteric lymph node and liver, not in heart.

Interactioni

Subunit structurei

Interacts with HA, as well as other glycosaminoglycans, collagen, laminin, and fibronectin via its N-terminal segment. Interacts with ANK, the ERM proteins (VIL2, RDX and MSN), and NF2 via its C-terminal segment. Interacts with PKN2. Interacts with TIAM1 and TIAM2. Interacts with UNC119.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000048925.

Structurei

3D structure databases

ProteinModelPortaliQ29423.
SMRiQ29423. Positions 20-183.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini32 – 12089LinkPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni229 – 27345StemAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi150 – 1589Arg/Lys-rich (basic)

Domaini

The lectin-like LINK domain is responsible for hyaluronan binding.By similarity

Sequence similaritiesi

Contains 1 Link domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IZCP. Eukaryota.
ENOG4111S6T. LUCA.
HOGENOMiHOG000231746.
HOVERGENiHBG003850.
InParanoidiQ29423.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
IPR001231. CD44_antigen.
IPR000538. Link_dom.
[Graphical view]
PfamiPF00193. Xlink. 1 hit.
[Graphical view]
PRINTSiPR00658. CD44.
PR01265. LINKMODULE.
SMARTiSM00445. LINK. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS01241. LINK_1. 1 hit.
PS50963. LINK_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q29423-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTFWWRAAW GLCLVQLSLA QIDLNITCRY AGVFHVEKNG RYSISKTEAA
60 70 80 90 100
DLCKAFNSTL PTMAQMEAAR NIGFETCRYG FIEGHVVIPR IHPNSICAAN
110 120 130 140 150
NTGVYILTSN TSQYDTICFN ASAPPGEDCT SVTDLPNAFE GPITITIVNR
160 170 180 190 200
DGTRYTKKGE YRTNPEDINP SVVSPSSPPD DEMSSGSPSE RSTSGGYSIF
210 220 230 240 250
HTHLPTVHPS RPRRPWSQRA ENTSDTRDYG SSHDPSGRSY TTHASESAGH
260 270 280 290 300
SSGSEEHGAN TTSGPMRKPQ IPEWLIILAS LLALALILAV CIAVNSRRRC
310 320 330 340 350
GQKKKLVINN GNGTMEERKP SGLNGEASKS QEMVHLVNKG SSETPDQFMT
360
ADETRNLQNV DMKIGV
Length:366
Mass (Da):40,002
Last modified:November 1, 1997 - v1
Checksum:i438A5A1E631E02B4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X62881 mRNA. Translation: CAA44675.1.
S63418 mRNA. Translation: AAB20016.1.
PIRiA53286.
UniGeneiBt.5494.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X62881 mRNA. Translation: CAA44675.1.
S63418 mRNA. Translation: AAB20016.1.
PIRiA53286.
UniGeneiBt.5494.

3D structure databases

ProteinModelPortaliQ29423.
SMRiQ29423. Positions 20-183.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000048925.

Proteomic databases

PaxDbiQ29423.
PRIDEiQ29423.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG410IZCP. Eukaryota.
ENOG4111S6T. LUCA.
HOGENOMiHOG000231746.
HOVERGENiHBG003850.
InParanoidiQ29423.

Miscellaneous databases

NextBioi20805141.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
IPR001231. CD44_antigen.
IPR000538. Link_dom.
[Graphical view]
PfamiPF00193. Xlink. 1 hit.
[Graphical view]
PRINTSiPR00658. CD44.
PR01265. LINKMODULE.
SMARTiSM00445. LINK. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS01241. LINK_1. 1 hit.
PS50963. LINK_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Sequence of the bovine CD44 cDNA: comparison with human and mouse sequences."
    Bosworth B.T., St John T., Gallatin W.M., Harp J.A.
    Mol. Immunol. 28:1131-1135(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiCD44_BOVIN
AccessioniPrimary (citable) accession number: Q29423
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 11, 2015
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.