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Protein

Interleukin-2

Gene

IL2

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Growth factor

Keywords - Biological processi

Adaptive immunity, Immunity

Enzyme and pathway databases

ReactomeiR-CFA-114604. GPVI-mediated activation cascade.
R-CFA-392451. G beta:gamma signalling through PI3Kgamma.
R-CFA-451927. Interleukin-2 signaling.
R-CFA-5673001. RAF/MAP kinase cascade.
R-CFA-912526. Interleukin receptor SHC signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-2
Short name:
IL-2
Alternative name(s):
T-cell growth factor
Short name:
TCGF
Gene namesi
Name:IL2
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Chromosome 19

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020By similarityAdd
BLAST
Chaini21 – 155135Interleukin-2PRO_0000015476Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi24 – 241O-linked (GalNAc...)By similarity
Disulfide bondi79 ↔ 127By similarity
Glycosylationi112 – 1121N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ29416.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000005941.

Structurei

3D structure databases

ProteinModelPortaliQ29416.
SMRiQ29416. Positions 24-155.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-2 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J049. Eukaryota.
ENOG41119SF. LUCA.
GeneTreeiENSGT00390000003555.
HOGENOMiHOG000048727.
HOVERGENiHBG007496.
InParanoidiQ29416.
KOiK05429.
OMAiLMSNINV.
OrthoDBiEOG091G0VTZ.
TreeFamiTF338200.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000779. IL-2.
IPR030477. IL-2_CS.
[Graphical view]
PANTHERiPTHR11443. PTHR11443. 1 hit.
PfamiPF00715. IL2. 1 hit.
[Graphical view]
PRINTSiPR00265. INTERLEUKIN2.
ProDomiPD003649. Interleukin-2. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00189. IL2. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00424. INTERLEUKIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q29416-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYKMQLLSCI ALTLVLVANS APITSSSTKE TEQQMEQLLL DLQLLLNGVN
60 70 80 90 100
NYENPQLSRM LTFKFYTPKK ATEFTHLQCL AEELKNLEEV LGLPQSKNVH
110 120 130 140 150
LTDTKELISN MNVTLLKLKG SETSYNCEYD DETATITEFL NKWITFCQSI

FSTLT
Length:155
Mass (Da):17,668
Last modified:November 1, 1996 - v1
Checksum:iD123E486B7F4AC1D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti4 – 41M → I in AAA75360 (PubMed:8571541).Curated
Sequence conflicti37 – 371Q → R in AAA75360 (PubMed:8571541).Curated
Sequence conflicti151 – 1511F → Y in AAA75360 (PubMed:8571541).Curated
Sequence conflicti154 – 1541L → M in AAA75360 (PubMed:8571541).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D30710 mRNA. Translation: BAA06378.1.
U11689 mRNA. Translation: AAA75360.1.
U28141 mRNA. Translation: AAA68969.1.
RefSeqiNP_001003305.1. NM_001003305.1.
UniGeneiCfa.7.

Genome annotation databases

EnsembliENSCAFT00000006417; ENSCAFP00000005941; ENSCAFG00000004008.
GeneIDi403989.
KEGGicfa:403989.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D30710 mRNA. Translation: BAA06378.1.
U11689 mRNA. Translation: AAA75360.1.
U28141 mRNA. Translation: AAA68969.1.
RefSeqiNP_001003305.1. NM_001003305.1.
UniGeneiCfa.7.

3D structure databases

ProteinModelPortaliQ29416.
SMRiQ29416. Positions 24-155.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000005941.

Proteomic databases

PaxDbiQ29416.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSCAFT00000006417; ENSCAFP00000005941; ENSCAFG00000004008.
GeneIDi403989.
KEGGicfa:403989.

Organism-specific databases

CTDi3558.

Phylogenomic databases

eggNOGiENOG410J049. Eukaryota.
ENOG41119SF. LUCA.
GeneTreeiENSGT00390000003555.
HOGENOMiHOG000048727.
HOVERGENiHBG007496.
InParanoidiQ29416.
KOiK05429.
OMAiLMSNINV.
OrthoDBiEOG091G0VTZ.
TreeFamiTF338200.

Enzyme and pathway databases

ReactomeiR-CFA-114604. GPVI-mediated activation cascade.
R-CFA-392451. G beta:gamma signalling through PI3Kgamma.
R-CFA-451927. Interleukin-2 signaling.
R-CFA-5673001. RAF/MAP kinase cascade.
R-CFA-912526. Interleukin receptor SHC signaling.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000779. IL-2.
IPR030477. IL-2_CS.
[Graphical view]
PANTHERiPTHR11443. PTHR11443. 1 hit.
PfamiPF00715. IL2. 1 hit.
[Graphical view]
PRINTSiPR00265. INTERLEUKIN2.
ProDomiPD003649. Interleukin-2. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00189. IL2. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00424. INTERLEUKIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIL2_CANLF
AccessioniPrimary (citable) accession number: Q29416
Secondary accession number(s): Q28249
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: September 7, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.