ID   Q29412_PIG              Unreviewed;       186 AA.
AC   Q29412;
DT   01-NOV-1996, integrated into UniProtKB/TrEMBL.
DT   01-NOV-1996, sequence version 1.
DT   27-MAR-2024, entry version 157.
DE   SubName: Full=Interferon beta {ECO:0000313|EMBL:AAB22723.1, ECO:0000313|EMBL:AEO19707.1};
DE   SubName: Full=Interferon-beta-1 {ECO:0000313|EMBL:AAA31056.1, ECO:0000313|Ensembl:ENSSSCP00000005550.1};
GN   Name=IFNB1 {ECO:0000313|Ensembl:ENSSSCP00000005550.1,
GN   ECO:0000313|VGNC:VGNC:89038};
GN   Synonyms=IFN-beta {ECO:0000313|EMBL:ACV42408.1}, IFNB
GN   {ECO:0000313|EMBL:AEO19707.1}, interferon-beta-1
GN   {ECO:0000313|EMBL:AAA31056.1}, interferon-beta/ poIFN-beta
GN   {ECO:0000313|EMBL:AAB22723.1};
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823 {ECO:0000313|EMBL:AAA31056.1};
RN   [1] {ECO:0000313|EMBL:AAB22723.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=1640116;
RA   Artursson K., Gobl A., Lindersson M., Johansson M., Alm G.;
RT   "Molecular cloning of a gene encoding porcine interferon-beta.";
RL   J. Interferon Res. 12:153-160(1992).
RN   [2] {ECO:0000313|EMBL:AAA31056.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Blood {ECO:0000313|EMBL:AAA31056.1};
RA   Artursson K., Gobl A., Lindersson M., Johansson M., Alm G.;
RT   "Molecular cloning of a gene encoding porcine interferon-beta.";
RL   J. Interferon Res. 0:0-0(1992).
RN   [3] {ECO:0000313|Ensembl:ENSSSCP00000005550.1, ECO:0000313|Proteomes:UP000008227}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000005550.1,
RC   ECO:0000313|Proteomes:UP000008227};
RG   Porcine genome sequencing project;
RL   Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000313|EMBL:ACV42408.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=20406849; DOI=10.1152/physiolgenomics.00198.2009;
RA   Sang Y., Rowland R.R., Hesse R.A., Blecha F.;
RT   "Differential expression and activity of the porcine type I interferon
RT   family.";
RL   Physiol. Genomics 42:248-258(2010).
RN   [5] {ECO:0000313|EMBL:AEO19707.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Netherton C.L., Oura C.A., Taylor G.;
RT   "Sequence and characterisation of the interferon beta genes and promoters
RT   from wild African suids.";
RL   Submitted (JUL-2011) to the EMBL/GenBank/DDBJ databases.
RN   [6] {ECO:0000313|Ensembl:ENSSSCP00000005550.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBUNIT: Monomer. {ECO:0000256|ARBA:ARBA00011245}.
CC   -!- SIMILARITY: Belongs to the alpha/beta interferon family.
CC       {ECO:0000256|RuleBase:RU000436}.
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DR   EMBL; M86762; AAA31056.1; -; Genomic_DNA.
DR   EMBL; S41178; AAB22723.1; -; Genomic_DNA.
DR   EMBL; GQ415073; ACV42408.1; -; mRNA.
DR   EMBL; JN391525; AEO19707.1; -; Genomic_DNA.
DR   STRING; 9823.ENSSSCP00000005550; -.
DR   PaxDb; 9823-ENSSSCP00000005550; -.
DR   Ensembl; ENSSSCT00000005691.2; ENSSSCP00000005550.1; ENSSSCG00000005163.2.
DR   VGNC; VGNC:89038; IFNB1.
DR   eggNOG; ENOG502SQGR; Eukaryota.
DR   GeneTree; ENSGT01000000214430; -.
DR   HOGENOM; CLU_109427_1_0_1; -.
DR   OMA; HWQKEHL; -.
DR   TreeFam; TF336177; -.
DR   Reactome; R-SSC-909733; Interferon alpha/beta signaling.
DR   Reactome; R-SSC-912694; Regulation of IFNA/IFNB signaling.
DR   Proteomes; UP000008227; Chromosome 1.
DR   Bgee; ENSSSCG00000005163; Expressed in lung.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0008811; F:chloramphenicol O-acetyltransferase activity; IEA:Ensembl.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0005132; F:type I interferon receptor binding; IBA:GO_Central.
DR   GO; GO:0002250; P:adaptive immune response; IBA:GO_Central.
DR   GO; GO:0002312; P:B cell activation involved in immune response; IEA:Ensembl.
DR   GO; GO:0030183; P:B cell differentiation; IBA:GO_Central.
DR   GO; GO:0042100; P:B cell proliferation; IBA:GO_Central.
DR   GO; GO:0035458; P:cellular response to interferon-beta; IEA:Ensembl.
DR   GO; GO:0098586; P:cellular response to virus; IEA:Ensembl.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR   GO; GO:0006959; P:humoral immune response; IBA:GO_Central.
DR   GO; GO:0002323; P:natural killer cell activation involved in immune response; IBA:GO_Central.
DR   GO; GO:0045581; P:negative regulation of T cell differentiation; IEA:Ensembl.
DR   GO; GO:2000552; P:negative regulation of T-helper 2 cell cytokine production; IEA:Ensembl.
DR   GO; GO:0045071; P:negative regulation of viral genome replication; IEA:Ensembl.
DR   GO; GO:2001235; P:positive regulation of apoptotic signaling pathway; IEA:Ensembl.
DR   GO; GO:0033141; P:positive regulation of peptidyl-serine phosphorylation of STAT protein; IBA:GO_Central.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR   GO; GO:0007259; P:receptor signaling pathway via JAK-STAT; IEA:Ensembl.
DR   GO; GO:0043330; P:response to exogenous dsRNA; IBA:GO_Central.
DR   GO; GO:0002286; P:T cell activation involved in immune response; IBA:GO_Central.
DR   GO; GO:0060337; P:type I interferon-mediated signaling pathway; IEA:Ensembl.
DR   CDD; cd00095; IFab; 1.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR000471; Interferon_alpha/beta/delta.
DR   PANTHER; PTHR11691:SF72; INTERFERON BETA; 1.
DR   PANTHER; PTHR11691; TYPE I INTERFERON; 1.
DR   Pfam; PF00143; Interferon; 1.
DR   PRINTS; PR00266; INTERFERONAB.
DR   SMART; SM00076; IFabd; 1.
DR   SUPFAM; SSF47266; 4-helical cytokines; 1.
DR   PROSITE; PS00252; INTERFERON_A_B_D; 1.
PE   2: Evidence at transcript level;
KW   Antiviral defense {ECO:0000256|ARBA:ARBA00023118,
KW   ECO:0000256|RuleBase:RU000436}; Cytokine {ECO:0000256|RuleBase:RU000436};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           22..186
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5015097256"
SQ   SEQUENCE   186 AA;  21878 MW;  5F16B8B3C3AE603D CRC64;
     MANKCILQIA LLMCFSTTAL SMSYDVLRYQ QRSSNLACQK LLGQLPGTPQ YCLEDRMNFE
     VPEEIMQPPQ FQKEDAVLII HEMLQQIFGI LRRNFSSTGW NETVIKTILV ELDGQMDDLE
     TILEEIMEEE NFPRGDMTIL HLKKYYLSIL QYLKSKEYRS CAWTVVQVEI LRNFSFLNRL
     TDYLRN
//