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Q29412

- Q29412_PIG

UniProt

Q29412 - Q29412_PIG

Protein
Submitted name:

Interferon beta

Gene

interferon-beta-1

Organism
Sus scrofa (Pig)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. transcription corepressor activity Source: Ensembl

    GO - Biological processi

    1. adaptive immune response Source: Ensembl
    2. cellular response to exogenous dsRNA Source: Ensembl
    3. defense response to bacterium Source: Ensembl
    4. defense response to virus Source: UniProtKB-KW
    5. execution phase of apoptosis Source: Ensembl
    6. humoral immune response Source: Ensembl
    7. negative regulation of T cell differentiation Source: Ensembl
    8. negative regulation of T-helper 2 cell cytokine production Source: Ensembl
    9. negative regulation of viral genome replication Source: Ensembl
    10. negative regulation of viral transcription Source: Ensembl
    11. positive regulation of peptidyl-serine phosphorylation of STAT protein Source: Ensembl
    12. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl

    Keywords - Molecular functioni

    CytokineUniRule annotationSAAS annotation

    Keywords - Biological processi

    Antiviral defenseUniRule annotationSAAS annotation

    Enzyme and pathway databases

    ReactomeiREACT_208274. Factors involved in megakaryocyte development and platelet production.
    REACT_211800. TRAF6 mediated IRF7 activation.
    REACT_212375. TRAF3-dependent IRF activation pathway.
    REACT_216640. Regulation of IFNA signaling.
    REACT_217851. Interferon alpha/beta signaling.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Interferon betaImported
    Submitted name:
    Interferon-betaImported
    Submitted name:
    Interferon-beta-1Imported
    Submitted name:
    Uncharacterized proteinImported
    Gene namesi
    Name:interferon-beta-1Imported
    Synonyms:IFN-betaImported, IFNBImported, INTERFERON-BETA-1Imported, interferon-beta/ poIFN-betaImported
    OrganismiSus scrofa (Pig)Imported
    Taxonomic identifieri9823 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
    ProteomesiUP000008227: Chromosome 1

    Subcellular locationi

    Secreted SAAS annotation

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-KW

    Keywords - Cellular componenti

    SecretedSAAS annotation

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121 PotentialImportedAdd
    BLAST
    Chaini22 – 186165interferon-beta-1ImportedPRO_5000143646Add
    BLAST

    Keywords - PTMi

    Disulfide bondSAAS annotation

    Structurei

    3D structure databases

    ProteinModelPortaliQ29412.
    SMRiQ29412. Positions 22-186.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the alpha/beta interferon family.UniRule annotation

    Keywords - Domaini

    SignalImported

    Phylogenomic databases

    GeneTreeiENSGT00640000091444.
    HOVERGENiHBG052086.
    OMAiNGRLEYC.
    OrthoDBiEOG7J9VRD.
    TreeFamiTF336177.

    Family and domain databases

    Gene3Di1.20.1250.10. 1 hit.
    InterProiIPR009079. 4_helix_cytokine-like_core.
    IPR012351. 4_helix_cytokine_core.
    IPR000471. Interferon_alpha/beta/delta.
    IPR015588. Interferon_beta.
    [Graphical view]
    PANTHERiPTHR11691. PTHR11691. 1 hit.
    PTHR11691:SF7. PTHR11691:SF7. 1 hit.
    PfamiPF00143. Interferon. 1 hit.
    [Graphical view]
    PRINTSiPR00266. INTERFERONAB.
    SMARTiSM00076. IFabd. 1 hit.
    [Graphical view]
    SUPFAMiSSF47266. SSF47266. 1 hit.
    PROSITEiPS00252. INTERFERON_A_B_D. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q29412-1 [UniParc]FASTAAdd to Basket

    « Hide

    MANKCILQIA LLMCFSTTAL SMSYDVLRYQ QRSSNLACQK LLGQLPGTPQ    50
    YCLEDRMNFE VPEEIMQPPQ FQKEDAVLII HEMLQQIFGI LRRNFSSTGW 100
    NETVIKTILV ELDGQMDDLE TILEEIMEEE NFPRGDMTIL HLKKYYLSIL 150
    QYLKSKEYRS CAWTVVQVEI LRNFSFLNRL TDYLRN 186
    Length:186
    Mass (Da):21,878
    Last modified:November 1, 1996 - v1
    Checksum:i5F16B8B3C3AE603D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FP102266 Genomic DNA. No translation available.
    M86762 Genomic DNA. Translation: AAA31056.1.
    S41178 Genomic DNA. Translation: AAB22723.1.
    GQ415073 mRNA. Translation: ACV42408.1.
    JN391525 Genomic DNA. Translation: AEO19707.1.
    UniGeneiSsc.42778.

    Genome annotation databases

    EnsembliENSSSCT00000005691; ENSSSCP00000005550; ENSSSCG00000005163.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FP102266 Genomic DNA. No translation available.
    M86762 Genomic DNA. Translation: AAA31056.1 .
    S41178 Genomic DNA. Translation: AAB22723.1 .
    GQ415073 mRNA. Translation: ACV42408.1 .
    JN391525 Genomic DNA. Translation: AEO19707.1 .
    UniGenei Ssc.42778.

    3D structure databases

    ProteinModelPortali Q29412.
    SMRi Q29412. Positions 22-186.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSSSCT00000005691 ; ENSSSCP00000005550 ; ENSSSCG00000005163 .

    Phylogenomic databases

    GeneTreei ENSGT00640000091444.
    HOVERGENi HBG052086.
    OMAi NGRLEYC.
    OrthoDBi EOG7J9VRD.
    TreeFami TF336177.

    Enzyme and pathway databases

    Reactomei REACT_208274. Factors involved in megakaryocyte development and platelet production.
    REACT_211800. TRAF6 mediated IRF7 activation.
    REACT_212375. TRAF3-dependent IRF activation pathway.
    REACT_216640. Regulation of IFNA signaling.
    REACT_217851. Interferon alpha/beta signaling.

    Family and domain databases

    Gene3Di 1.20.1250.10. 1 hit.
    InterProi IPR009079. 4_helix_cytokine-like_core.
    IPR012351. 4_helix_cytokine_core.
    IPR000471. Interferon_alpha/beta/delta.
    IPR015588. Interferon_beta.
    [Graphical view ]
    PANTHERi PTHR11691. PTHR11691. 1 hit.
    PTHR11691:SF7. PTHR11691:SF7. 1 hit.
    Pfami PF00143. Interferon. 1 hit.
    [Graphical view ]
    PRINTSi PR00266. INTERFERONAB.
    SMARTi SM00076. IFabd. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47266. SSF47266. 1 hit.
    PROSITEi PS00252. INTERFERON_A_B_D. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of a gene encoding porcine interferon-beta."
      Artursson K., Gobl A., Lindersson M., Johansson M., Alm G.
      J. Interferon Res. 12:153-160(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    2. "Molecular cloning of a gene encoding porcine interferon-beta."
      Artursson K., Gobl A., Lindersson M., Johansson M., Alm G.
      J. Interferon Res. 0:0-0(1992)
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: BloodImported.
    3. Swine Genome Sequencing Consortium
      Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Porcine genome sequencing project
      Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "Differential expression and activity of the porcine type I interferon family."
      Sang Y., Rowland R.R., Hesse R.A., Blecha F.
      Physiol. Genomics 42:248-258(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    6. "Sequence and characterisation of the interferon beta genes and promoters from wild African suids."
      Netherton C.L., Oura C.A., Taylor G.
      Submitted (JUL-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    7. Ensembl
      Submitted (JUL-2011) to UniProtKB
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiQ29412_PIG
    AccessioniPrimary (citable) accession number: Q29412
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 1, 1996
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3