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Q29412

- Q29412_PIG

UniProt

Q29412 - Q29412_PIG

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Protein
Submitted name:

Interferon beta

Gene
interferon-beta-1, IFN-beta, IFNB, INTERFERON-BETA-1, interferon-beta/ poIFN-beta
Organism
Sus scrofa (Pig)
Status
Unreviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. transcription corepressor activity Source: Ensembl

GO - Biological processi

  1. adaptive immune response Source: Ensembl
  2. cellular response to exogenous dsRNA Source: Ensembl
  3. defense response to bacterium Source: Ensembl
  4. defense response to virus Source: UniProtKB-KW
  5. execution phase of apoptosis Source: Ensembl
  6. humoral immune response Source: Ensembl
  7. negative regulation of T cell differentiation Source: Ensembl
  8. negative regulation of T-helper 2 cell cytokine production Source: Ensembl
  9. negative regulation of viral genome replication Source: Ensembl
  10. negative regulation of viral transcription Source: Ensembl
  11. positive regulation of peptidyl-serine phosphorylation of STAT protein Source: Ensembl
  12. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

CytokineUniRule annotationSAAS annotations

Keywords - Biological processi

Antiviral defenseUniRule annotationSAAS annotations

Enzyme and pathway databases

ReactomeiREACT_208274. Factors involved in megakaryocyte development and platelet production.
REACT_211800. TRAF6 mediated IRF7 activation.
REACT_212375. TRAF3-dependent IRF activation pathway.
REACT_216640. Regulation of IFNA signaling.
REACT_217851. Interferon alpha/beta signaling.

Names & Taxonomyi

Protein namesi
Submitted name:
Interferon betaImported
Submitted name:
Interferon-betaImported
Submitted name:
Interferon-beta-1Imported
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:interferon-beta-1Imported
Synonyms:IFN-betaImported, IFNBImported, INTERFERON-BETA-1Imported, interferon-beta/ poIFN-betaImported
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
ProteomesiUP000008227: Chromosome 1

Subcellular locationi

Secreted By similarity SAAS annotations

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

SecretedSAAS annotations

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121 PredictedImportedAdd
BLAST
Chaini22 – 186165interferon-beta-1ImportedPRO_5000143646Add
BLAST

Keywords - PTMi

Disulfide bondSAAS annotations

Structurei

3D structure databases

ProteinModelPortaliQ29412.
SMRiQ29412. Positions 22-186.

Family & Domainsi

Sequence similaritiesi

Belongs to the alpha/beta interferon family.UniRule annotation

Keywords - Domaini

SignalImported

Phylogenomic databases

GeneTreeiENSGT00640000091444.
HOVERGENiHBG052086.
OMAiNGRLEYC.
OrthoDBiEOG7J9VRD.
TreeFamiTF336177.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000471. Interferon_alpha/beta/delta.
IPR015588. Interferon_beta.
[Graphical view]
PANTHERiPTHR11691. PTHR11691. 1 hit.
PTHR11691:SF7. PTHR11691:SF7. 1 hit.
PfamiPF00143. Interferon. 1 hit.
[Graphical view]
PRINTSiPR00266. INTERFERONAB.
SMARTiSM00076. IFabd. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00252. INTERFERON_A_B_D. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q29412-1 [UniParc]FASTAAdd to Basket

« Hide

MANKCILQIA LLMCFSTTAL SMSYDVLRYQ QRSSNLACQK LLGQLPGTPQ    50
YCLEDRMNFE VPEEIMQPPQ FQKEDAVLII HEMLQQIFGI LRRNFSSTGW 100
NETVIKTILV ELDGQMDDLE TILEEIMEEE NFPRGDMTIL HLKKYYLSIL 150
QYLKSKEYRS CAWTVVQVEI LRNFSFLNRL TDYLRN 186
Length:186
Mass (Da):21,878
Last modified:November 1, 1996 - v1
Checksum:i5F16B8B3C3AE603D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FP102266 Genomic DNA. No translation available.
M86762 Genomic DNA. Translation: AAA31056.1.
S41178 Genomic DNA. Translation: AAB22723.1.
GQ415073 mRNA. Translation: ACV42408.1.
JN391525 Genomic DNA. Translation: AEO19707.1.
UniGeneiSsc.42778.

Genome annotation databases

EnsembliENSSSCT00000005691; ENSSSCP00000005550; ENSSSCG00000005163.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FP102266 Genomic DNA. No translation available.
M86762 Genomic DNA. Translation: AAA31056.1 .
S41178 Genomic DNA. Translation: AAB22723.1 .
GQ415073 mRNA. Translation: ACV42408.1 .
JN391525 Genomic DNA. Translation: AEO19707.1 .
UniGenei Ssc.42778.

3D structure databases

ProteinModelPortali Q29412.
SMRi Q29412. Positions 22-186.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSSSCT00000005691 ; ENSSSCP00000005550 ; ENSSSCG00000005163 .

Phylogenomic databases

GeneTreei ENSGT00640000091444.
HOVERGENi HBG052086.
OMAi NGRLEYC.
OrthoDBi EOG7J9VRD.
TreeFami TF336177.

Enzyme and pathway databases

Reactomei REACT_208274. Factors involved in megakaryocyte development and platelet production.
REACT_211800. TRAF6 mediated IRF7 activation.
REACT_212375. TRAF3-dependent IRF activation pathway.
REACT_216640. Regulation of IFNA signaling.
REACT_217851. Interferon alpha/beta signaling.

Family and domain databases

Gene3Di 1.20.1250.10. 1 hit.
InterProi IPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000471. Interferon_alpha/beta/delta.
IPR015588. Interferon_beta.
[Graphical view ]
PANTHERi PTHR11691. PTHR11691. 1 hit.
PTHR11691:SF7. PTHR11691:SF7. 1 hit.
Pfami PF00143. Interferon. 1 hit.
[Graphical view ]
PRINTSi PR00266. INTERFERONAB.
SMARTi SM00076. IFabd. 1 hit.
[Graphical view ]
SUPFAMi SSF47266. SSF47266. 1 hit.
PROSITEi PS00252. INTERFERON_A_B_D. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of a gene encoding porcine interferon-beta."
    Artursson K., Gobl A., Lindersson M., Johansson M., Alm G.
    J. Interferon Res. 12:153-160(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "Molecular cloning of a gene encoding porcine interferon-beta."
    Artursson K., Gobl A., Lindersson M., Johansson M., Alm G.
    J. Interferon Res. 0:0-0(1992)
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: BloodImported.
  3. Swine Genome Sequencing Consortium
    Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Porcine genome sequencing project
    Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "Differential expression and activity of the porcine type I interferon family."
    Sang Y., Rowland R.R., Hesse R.A., Blecha F.
    Physiol. Genomics 42:248-258(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  6. "Sequence and characterisation of the interferon beta genes and promoters from wild African suids."
    Netherton C.L., Oura C.A., Taylor G.
    Submitted (JUL-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  7. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiQ29412_PIG
AccessioniPrimary (citable) accession number: Q29412
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: September 3, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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