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Q29412 (Q29412_PIG) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names

Interferon-beta EMBL AAB22723.1

Interferon-beta-1 EMBL AAA31056.1

Uncharacterized protein Ensembl ENSSSCP00000005550
Gene names
Name:interferon-beta-1 EMBL AAA31056.1
Synonyms:IFN-beta EMBL ACV42408.1, IFNB EMBL AEO19707.1, INTERFERON-BETA-1 Ensembl ENSSSCP00000005550, interferon-beta/ poIFN-beta EMBL AAB22723.1
OrganismSus scrofa (Pig) [Reference proteome]
Taxonomic identifier9823 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus

Protein attributes

Sequence length186 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Secreted By similarity SAAS SAAS000471.

Sequence similarities

Belongs to the alpha/beta interferon family. RuleBase RU000436

Ontologies

Keywords
   Biological processAntiviral defense SAAS SAAS000471 RuleBase RU000436
   Cellular componentSecreted SAAS SAAS000471
   DomainSignal EMBL AAA31056.1
   Molecular functionCytokine SAAS SAAS000471 RuleBase RU000436
   PTMDisulfide bond SAAS SAAS000471
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processadaptive immune response

Inferred from electronic annotation. Source: Ensembl

cellular response to exogenous dsRNA

Inferred from electronic annotation. Source: Ensembl

defense response to bacterium

Inferred from electronic annotation. Source: Ensembl

defense response to virus

Inferred from electronic annotation. Source: UniProtKB-KW

execution phase of apoptosis

Inferred from electronic annotation. Source: Ensembl

humoral immune response

Inferred from electronic annotation. Source: Ensembl

negative regulation of T cell differentiation

Inferred from electronic annotation. Source: Ensembl

negative regulation of T-helper 2 cell cytokine production

Inferred from electronic annotation. Source: Ensembl

negative regulation of viral genome replication

Inferred from electronic annotation. Source: Ensembl

negative regulation of viral transcription

Inferred from electronic annotation. Source: Ensembl

positive regulation of peptidyl-serine phosphorylation of STAT protein

Inferred from electronic annotation. Source: Ensembl

positive regulation of transcription from RNA polymerase II promoter

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentextracellular space

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functiontranscription corepressor activity

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential EMBL AAA31056.1
Chain22 – 186165interferon-beta-1 EMBL AAA31056.1
PRO_5000143646

Sequences

Sequence LengthMass (Da)Tools
Q29412 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 5F16B8B3C3AE603D

FASTA18621,878
        10         20         30         40         50         60 
MANKCILQIA LLMCFSTTAL SMSYDVLRYQ QRSSNLACQK LLGQLPGTPQ YCLEDRMNFE 

        70         80         90        100        110        120 
VPEEIMQPPQ FQKEDAVLII HEMLQQIFGI LRRNFSSTGW NETVIKTILV ELDGQMDDLE 

       130        140        150        160        170        180 
TILEEIMEEE NFPRGDMTIL HLKKYYLSIL QYLKSKEYRS CAWTVVQVEI LRNFSFLNRL 


TDYLRN 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning of a gene encoding porcine interferon-beta."
Artursson K., Gobl A., Lindersson M., Johansson M., Alm G.
J. Interferon Res. 12:153-160(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
[2]"Molecular cloning of a gene encoding porcine interferon-beta."
Artursson K., Gobl A., Lindersson M., Johansson M., Alm G.
J. Interferon Res. 0:0-0(1992)
Cited for: NUCLEOTIDE SEQUENCE.
Tissue: Blood EMBL AAA31056.1.
[3]Swine Genome Sequencing Consortium
Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Porcine genome sequencing project
Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"Differential expression and activity of the porcine type I interferon family."
Sang Y., Rowland R.R., Hesse R.A., Blecha F.
Physiol. Genomics 42:248-258(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
[6]"Sequence and characterisation of the interferon beta genes and promoters from wild African suids."
Netherton C.L., Oura C.A., Taylor G.
Submitted (JUL-2011) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
[7]Ensembl
Submitted (JUL-2011) to UniProtKB
Cited for: IDENTIFICATION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
FP102266 Genomic DNA. No translation available.
M86762 Genomic DNA. Translation: AAA31056.1.
S41178 Genomic DNA. Translation: AAB22723.1.
GQ415073 mRNA. Translation: ACV42408.1.
JN391525 Genomic DNA. Translation: AEO19707.1.
UniGeneSsc.42778.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSSSCT00000005691; ENSSSCP00000005550; ENSSSCG00000005163.

Phylogenomic databases

GeneTreeENSGT00640000091444.
HOVERGENHBG052086.
OMANGRLEYC.
OrthoDBEOG7J9VRD.
TreeFamTF336177.

Family and domain databases

Gene3D1.20.1250.10. 1 hit.
InterProIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000471. Interferon_alpha/beta/delta.
IPR015588. Interferon_beta.
[Graphical view]
PANTHERPTHR11691. PTHR11691. 1 hit.
PTHR11691:SF7. PTHR11691:SF7. 1 hit.
PfamPF00143. Interferon. 1 hit.
[Graphical view]
PRINTSPR00266. INTERFERONAB.
SMARTSM00076. IFabd. 1 hit.
[Graphical view]
SUPFAMSSF47266. SSF47266. 1 hit.
PROSITEPS00252. INTERFERON_A_B_D. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ29412_PIG
AccessionPrimary (citable) accession number: Q29412
Entry history
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: April 16, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)