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Protein
Submitted name:

Interferon beta

Gene

interferon-beta-1

Organism
Sus scrofa (Pig)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  1. adaptive immune response Source: Ensembl
  2. B cell activation involved in immune response Source: Ensembl
  3. cellular response to dsRNA Source: Ensembl
  4. cellular response to interferon-beta Source: Ensembl
  5. defense response to bacterium Source: Ensembl
  6. defense response to virus Source: UniProtKB-KW
  7. humoral immune response Source: Ensembl
  8. negative regulation of T cell differentiation Source: Ensembl
  9. negative regulation of T-helper 2 cell cytokine production Source: Ensembl
  10. negative regulation of viral genome replication Source: Ensembl
  11. positive regulation of apoptotic signaling pathway Source: Ensembl
  12. positive regulation of peptidyl-serine phosphorylation of STAT protein Source: Ensembl
  13. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  14. response to exogenous dsRNA Source: Ensembl
  15. type I interferon signaling pathway Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

CytokineUniRule annotationSAAS annotation

Keywords - Biological processi

Antiviral defenseUniRule annotationSAAS annotation

Enzyme and pathway databases

ReactomeiREACT_272079. Factors involved in megakaryocyte development and platelet production.
REACT_275628. Regulation of IFNA signaling.
REACT_287353. TRAF6 mediated IRF7 activation.
REACT_339207. Interferon alpha/beta signaling.
REACT_343929. TRAF3-dependent IRF activation pathway.

Names & Taxonomyi

Protein namesi
Submitted name:
Interferon betaImported
Submitted name:
Interferon-betaImported
Submitted name:
Interferon-beta-1Imported
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:interferon-beta-1Imported
Synonyms:IFN-betaImported, IFNBImported, INTERFERON-BETA-1Imported, interferon-beta/ poIFN-betaImported
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
ProteomesiUP000008227 Componenti: Chromosome 1

Subcellular locationi

Secreted SAAS annotation

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

SecretedSAAS annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121 PotentialImportedAdd
BLAST
Chaini22 – 186165interferon-beta-1ImportedPRO_5000143646Add
BLAST

Keywords - PTMi

Disulfide bondSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliQ29412.
SMRiQ29412. Positions 22-186.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alpha/beta interferon family.UniRule annotation

Keywords - Domaini

SignalImported

Phylogenomic databases

GeneTreeiENSGT00760000119150.
HOVERGENiHBG052086.
InParanoidiQ29412.
OMAiNGRLEYC.
OrthoDBiEOG7J9VRD.
TreeFamiTF336177.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000471. Interferon_alpha/beta/delta.
IPR015588. Interferon_beta.
[Graphical view]
PANTHERiPTHR11691. PTHR11691. 1 hit.
PTHR11691:SF7. PTHR11691:SF7. 1 hit.
PfamiPF00143. Interferon. 1 hit.
[Graphical view]
PRINTSiPR00266. INTERFERONAB.
SMARTiSM00076. IFabd. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00252. INTERFERON_A_B_D. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q29412-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANKCILQIA LLMCFSTTAL SMSYDVLRYQ QRSSNLACQK LLGQLPGTPQ
60 70 80 90 100
YCLEDRMNFE VPEEIMQPPQ FQKEDAVLII HEMLQQIFGI LRRNFSSTGW
110 120 130 140 150
NETVIKTILV ELDGQMDDLE TILEEIMEEE NFPRGDMTIL HLKKYYLSIL
160 170 180
QYLKSKEYRS CAWTVVQVEI LRNFSFLNRL TDYLRN
Length:186
Mass (Da):21,878
Last modified:November 1, 1996 - v1
Checksum:i5F16B8B3C3AE603D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FP102266 Genomic DNA. No translation available.
M86762 Genomic DNA. Translation: AAA31056.1.
S41178 Genomic DNA. Translation: AAB22723.1.
GQ415073 mRNA. Translation: ACV42408.1.
JN391525 Genomic DNA. Translation: AEO19707.1.
UniGeneiSsc.42778.

Genome annotation databases

EnsembliENSSSCT00000005691; ENSSSCP00000005550; ENSSSCG00000005163.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FP102266 Genomic DNA. No translation available.
M86762 Genomic DNA. Translation: AAA31056.1.
S41178 Genomic DNA. Translation: AAB22723.1.
GQ415073 mRNA. Translation: ACV42408.1.
JN391525 Genomic DNA. Translation: AEO19707.1.
UniGeneiSsc.42778.

3D structure databases

ProteinModelPortaliQ29412.
SMRiQ29412. Positions 22-186.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSSSCT00000005691; ENSSSCP00000005550; ENSSSCG00000005163.

Phylogenomic databases

GeneTreeiENSGT00760000119150.
HOVERGENiHBG052086.
InParanoidiQ29412.
OMAiNGRLEYC.
OrthoDBiEOG7J9VRD.
TreeFamiTF336177.

Enzyme and pathway databases

ReactomeiREACT_272079. Factors involved in megakaryocyte development and platelet production.
REACT_275628. Regulation of IFNA signaling.
REACT_287353. TRAF6 mediated IRF7 activation.
REACT_339207. Interferon alpha/beta signaling.
REACT_343929. TRAF3-dependent IRF activation pathway.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000471. Interferon_alpha/beta/delta.
IPR015588. Interferon_beta.
[Graphical view]
PANTHERiPTHR11691. PTHR11691. 1 hit.
PTHR11691:SF7. PTHR11691:SF7. 1 hit.
PfamiPF00143. Interferon. 1 hit.
[Graphical view]
PRINTSiPR00266. INTERFERONAB.
SMARTiSM00076. IFabd. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00252. INTERFERON_A_B_D. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of a gene encoding porcine interferon-beta."
    Artursson K., Gobl A., Lindersson M., Johansson M., Alm G.
    J. Interferon Res. 12:153-160(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "Molecular cloning of a gene encoding porcine interferon-beta."
    Artursson K., Gobl A., Lindersson M., Johansson M., Alm G.
    J. Interferon Res. 0:0-0(1991)
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: BloodImported.
  3. Porcine genome sequencing project
    Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Swine Genome Sequencing Consortium
    Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "Differential expression and activity of the porcine type I interferon family."
    Sang Y., Rowland R.R., Hesse R.A., Blecha F.
    Physiol. Genomics 42:248-258(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  6. "Sequence and characterisation of the interferon beta genes and promoters from wild African suids."
    Netherton C.L., Oura C.A., Taylor G.
    Submitted (JUN-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  7. Ensembl
    Submitted (JUN-2011) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiQ29412_PIG
AccessioniPrimary (citable) accession number: Q29412
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: April 1, 2015
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.