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Q29397 (SV2A_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Synaptic vesicle glycoprotein 2A
Alternative name(s):
p87
Gene names
Name:SV2A
OrganismBos taurus (Bovine)
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length742 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles By similarity.

Subunit structure

Interacts with SYT1/synaptotagmin-1 in a calcium-dependent manner. Binds the adapter protein complex AP-2 By similarity.

Subcellular location

Cytoplasmic vesicle › secretory vesicle › synaptic vesicle membrane; Multi-pass membrane protein By similarity. Note: Enriched in chromaffin granules, not present in adrenal microsomes. Associated with both insulin granules and synaptic-like microvesicles in insulin-secreting cells of the pancreas By similarity.

Post-translational modification

Phosphorylation by CK1 of the N-terminal cytoplasmic domain regulates interaction with SYT1 By similarity.

N-glycosylated By similarity.

Sequence similarities

Belongs to the major facilitator superfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 742742Synaptic vesicle glycoprotein 2A
PRO_0000239763

Regions

Topological domain1 – 169169Cytoplasmic Potential
Transmembrane170 – 19021Helical; Potential
Topological domain191 – 20515Extracellular Potential
Transmembrane206 – 22621Helical; Potential
Topological domain227 – 2337Cytoplasmic Potential
Transmembrane234 – 25421Helical; Potential
Topological domain255 – 2628Extracellular Potential
Transmembrane263 – 28321Helical; Potential
Topological domain284 – 29411Cytoplasmic Potential
Transmembrane295 – 31521Helical; Potential
Topological domain316 – 33419Extracellular Potential
Transmembrane335 – 35521Helical; Potential
Topological domain356 – 44792Cytoplasmic Potential
Transmembrane448 – 46821Helical; Potential
Topological domain469 – 598130Extracellular Potential
Transmembrane599 – 61921Helical; Potential
Topological domain620 – 6267Cytoplasmic Potential
Transmembrane627 – 64721Helical; Potential
Topological domain648 – 6514Extracellular Potential
Transmembrane652 – 67221Helical; Potential
Topological domain673 – 68513Cytoplasmic Potential
Transmembrane686 – 70823Helical; Potential
Topological domain709 – 7124Extracellular Potential
Transmembrane713 – 73119Helical; Potential
Topological domain732 – 74211Cytoplasmic Potential
Region1 – 5757Interaction with SYT1 By similarity

Amino acid modifications

Modified residue651Phosphotyrosine By similarity
Modified residue661Phosphotyrosine By similarity
Modified residue801Phosphoserine By similarity
Modified residue811Phosphoserine By similarity
Modified residue841Phosphothreonine By similarity
Modified residue4801Phosphotyrosine By similarity
Glycosylation4981N-linked (GlcNAc...) Potential
Glycosylation5481N-linked (GlcNAc...) Potential
Glycosylation5731N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q29397 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 58AE0C9BB224DEB8

FASTA74282,589
        10         20         30         40         50         60 
MEEGFRDRAA FIRGAKDIAK EVKKHATKKV VKGLDRVQDE YSRRSYSRFE EEDDDDDFPA 

        70         80         90        100        110        120 
PADGYYRGEG AQDEEEGGAS SDATEGHDED DEIYEGEYQG IPRAESGGKG ERMADGAPLA 

       130        140        150        160        170        180 
GVRGGLGDGE GPPGGRGEAQ RRKEREELAQ QYEAILRECG HGRFQWTLYF VLGLALMADG 

       190        200        210        220        230        240 
VEVFVVGFVL PSAEKDMCLS DSNKGMLGLI VYLGMMVGAF LWGGLADRLG RRQCLLISLS 

       250        260        270        280        290        300 
VNSVFAFFSS FVQGYGTFLF CRLLSGVGIG GSIPIVFSYF SEFLAQEKRG EHLSWLCMFW 

       310        320        330        340        350        360 
MIGGVYAAAM AWAIIPHYGW SFQMGSAYQF HSWRVFVLVC AFPSVFAIGA LTTQPESPRF 

       370        380        390        400        410        420 
FLENGKHDEA WMVLKQVHDT NMRAKGHPER VFSVTHIKTI HQEDELIEIQ SDTGAWYQRW 

       430        440        450        460        470        480 
GVRALSLGGQ VWGNFLSCFG PEYRRITLMM MGVWFTMSFS YYGLTVWFPD MIRHLQAVDY 

       490        500        510        520        530        540 
AARTKVFPGE RVEHVTFNFT LENQIHRGGQ YFNDKFIGLR LKSVSFEDSL FEECYFEDVT 

       550        560        570        580        590        600 
SSNTFFRNCT FINTVFYNTD LFEYKFVNSR LVNSTFLHNK EGCPLDVTGT GEGAYMVYFV 

       610        620        630        640        650        660 
SFLGTLAVLP GNIVSALLMD KIGRLRMLAG SSVMSCVSCF FLSFGNSESA MIALLCLFGG 

       670        680        690        700        710        720 
VSIASWNALD VLTVELYPSD KRTTAFGFLN ALCKLAAVLG ISIFTSFVGI TKAAPILFAS 

       730        740 
AALALGSSLA LKLPETRGQV LQ

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References

[1]"Identification, characterization, and molecular cloning of a novel transporter-like protein localized to the central nervous system."
Gingrich J.A., Andersen P.H., Tiberi M., el Mestikawy S., Jorgensen P.N., Fremeau R.T. Jr., Caron M.G.
FEBS Lett. 312:115-122(1992) [PubMed: 1426240] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		S47919 mRNA. Translation: AAB24028.1.
IPIIPI00708267.
PIRS27263.
RefSeqNP_776387.1. NM_173962.2.
UniGeneBt.22009.

3D structure databases

ProteinModelPortalQ29397.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ29397.

Proteomic databases

PRIDEQ29397.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000002101; ENSBTAP00000002101; ENSBTAG00000001599.
GeneID280936.
KEGGbta:280936.

Organism-specific databases

CTD9900.

Phylogenomic databases

eggNOGmaNOG15956.
GeneTreeENSGT00550000074384.
HOVERGENHBG053967.
InParanoidQ29397.
OMAHATKKVV.
OrthoDBEOG4K0QMZ.
PhylomeDBQ29397.

Family and domain databases

InterProIPR011701. MFS.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR005828. Sub_transporter.
IPR005829. Sugar_transporter_CS.
IPR022308. SV2_chordata.
[Graphical view]
KOK06258.
PfamPF07690. MFS_1. 1 hit.
PF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMSSF103473. MFS_gen_substrate_transporter. 1 hit.
TIGRFAMsTIGR01299. Synapt_SV2. 1 hit.
PROSITEPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSV2A_BOVIN
AccessionPrimary (citable) accession number: Q29397
Entry history
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: November 1, 1996
Last modified: November 16, 2011
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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