Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Decorin

Gene

DCN

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May affect the rate of fibrils formation.By similarity

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-CFA-1474228 Degradation of the extracellular matrix
R-CFA-1971475 A tetrasaccharide linker sequence is required for GAG synthesis
R-CFA-2022870 Chondroitin sulfate biosynthesis
R-CFA-2022923 Dermatan sulfate biosynthesis
R-CFA-2024101 CS/DS degradation
R-CFA-3000178 ECM proteoglycans

Names & Taxonomyi

Protein namesi
Recommended name:
Decorin
Alternative name(s):
Bone proteoglycan II
PG-S2
Gene namesi
Name:DCN
Synonyms:DCN1C
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Chromosome 15

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16By similarityAdd BLAST16
PropeptideiPRO_000003270517 – 30By similarityAdd BLAST14
ChainiPRO_000003270631 – 360DecorinAdd BLAST330

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi34O-linked (Xyl...) (glycosaminoglycan) serineBy similarity1
Disulfide bondi55 ↔ 61By similarity
Disulfide bondi59 ↔ 68By similarity
Glycosylationi212N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi263N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi304N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi314 ↔ 347By similarity

Post-translational modificationi

The attached glycosaminoglycan chain can be either chondroitin sulfate or dermatan sulfate depending upon the tissue of origin.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Proteoglycan

Proteomic databases

PaxDbiQ29393
PRIDEiQ29393

Expressioni

Gene expression databases

BgeeiENSCAFG00000006142

Interactioni

Subunit structurei

Binds to type I and type II collagen, fibronectin and TGF-beta. Forms a ternary complex with MFAP2 and ELN. Interacts with DPT (By similarity).By similarity

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000009230

Structurei

3D structure databases

ProteinModelPortaliQ29393
SMRiQ29393
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati74 – 94LRR 1Add BLAST21
Repeati95 – 118LRR 2Add BLAST24
Repeati119 – 142LRR 3Add BLAST24
Repeati143 – 163LRR 4Add BLAST21
Repeati164 – 187LRR 5Add BLAST24
Repeati188 – 213LRR 6Add BLAST26
Repeati214 – 234LRR 7Add BLAST21
Repeati235 – 258LRR 8Add BLAST24
Repeati259 – 282LRR 9Add BLAST24
Repeati283 – 305LRR 10Add BLAST23
Repeati306 – 335LRR 11Add BLAST30
Repeati336 – 360LRR 12Add BLAST25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi55 – 68Cys-richAdd BLAST14

Sequence similaritiesi

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00760000118969
HOGENOMiHOG000261690
HOVERGENiHBG016052
InParanoidiQ29393
KOiK04660
OMAiPLGPVCP
OrthoDBiEOG091G044B
TreeFamiTF334562

Family and domain databases

Gene3Di3.80.10.101 hit
InterProiView protein in InterPro
IPR028549 Decorin
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR000372 LRRNT
IPR016352 SLRP_I_decor/aspor/byglycan
PANTHERiPTHR44053:SF2 PTHR44053:SF2, 1 hit
PfamiView protein in Pfam
PF13855 LRR_8, 3 hits
PF01462 LRRNT, 1 hit
PIRSFiPIRSF002490 SLRP_I, 1 hit
SMARTiView protein in SMART
SM00369 LRR_TYP, 6 hits
SM00013 LRRNT, 1 hit
PROSITEiView protein in PROSITE
PS51450 LRR, 7 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q29393-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKATIIFLLL AQVSWAGPFQ QRGLFDFMLE DEASGIGPED RAPDMPDLEL
60 70 80 90 100
LGPVCPFRCQ CHLRVVQCSD LGLDKVPKDL PPDTTLLDLQ NNKITEIKDG
110 120 130 140 150
DFKNLKNLHT LILVNNKISK ISPGAFTPLL KLERLYLSKN HLKELPEKMP
160 170 180 190 200
KTLQELRAHE NEITKVRKAV FNGLNQMIVV ELGTNPLKSS GIENGAFQGM
210 220 230 240 250
KKLSYIRIAD TNITTIPQGL PPSLTELHLE GNKITKVDAS SLKGLNNLAK
260 270 280 290 300
LGLSFNSISA VDNGTLANTP HLRELHLDNN KLIRVPGGLA EHKYIQVVYL
310 320 330 340 350
HNNNISAVGS NDFCPPGYNT KKASYSGVSL FSNPVQYWEI QPSTFRCVYV
360
RSAIQLGNYK
Length:360
Mass (Da):39,980
Last modified:January 1, 1998 - v2
Checksum:i99BEE11A9C812906
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U83141 mRNA Translation: AAB51245.1
L77684 Genomic DNA Translation: AAA98062.1
RefSeqiNP_001003228.1, NM_001003228.1
XP_005628882.1, XM_005628825.2
XP_005628883.1, XM_005628826.2
XP_005628885.1, XM_005628828.1
UniGeneiCfa.3762

Genome annotation databases

EnsembliENSCAFT00000009945; ENSCAFP00000009230; ENSCAFG00000006142
GeneIDi403904
KEGGicfa:403904

Similar proteinsi

Entry informationi

Entry nameiPGS2_CANLF
AccessioniPrimary (citable) accession number: Q29393
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: March 28, 2018
This is version 121 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome