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Protein

Decorin

Gene

DCN

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May affect the rate of fibrils formation.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-CFA-1474228. Degradation of the extracellular matrix.
R-CFA-1971475. A tetrasaccharide linker sequence is required for GAG synthesis.
R-CFA-2022870. Chondroitin sulfate biosynthesis.
R-CFA-2022923. Dermatan sulfate biosynthesis.
R-CFA-2024101. CS/DS degradation.
R-CFA-3000178. ECM proteoglycans.

Names & Taxonomyi

Protein namesi
Recommended name:
Decorin
Alternative name(s):
Bone proteoglycan II
PG-S2
Gene namesi
Name:DCN
Synonyms:DCN1C
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Chromosome 15

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616By similarityAdd
BLAST
Propeptidei17 – 3014By similarityPRO_0000032705Add
BLAST
Chaini31 – 360330DecorinPRO_0000032706Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi34 – 341O-linked (Xyl...) (glycosaminoglycan)By similarity
Disulfide bondi55 ↔ 61By similarity
Disulfide bondi59 ↔ 68By similarity
Glycosylationi212 – 2121N-linked (GlcNAc...)Sequence analysis
Glycosylationi263 – 2631N-linked (GlcNAc...)Sequence analysis
Glycosylationi304 – 3041N-linked (GlcNAc...)Sequence analysis
Disulfide bondi314 ↔ 347By similarity

Post-translational modificationi

The attached glycosaminoglycan chain can be either chondroitin sulfate or dermatan sulfate depending upon the tissue of origin.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Proteoglycan

Proteomic databases

PaxDbiQ29393.
PRIDEiQ29393.

Interactioni

Subunit structurei

Binds to type I and type II collagen, fibronectin and TGF-beta. Forms a ternary complex with MFAP2 and ELN. Interacts with DPT (By similarity).By similarity

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000009230.

Structurei

3D structure databases

ProteinModelPortaliQ29393.
SMRiQ29393. Positions 52-356.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati74 – 9421LRR 1Add
BLAST
Repeati95 – 11824LRR 2Add
BLAST
Repeati119 – 14224LRR 3Add
BLAST
Repeati143 – 16321LRR 4Add
BLAST
Repeati164 – 18724LRR 5Add
BLAST
Repeati188 – 21326LRR 6Add
BLAST
Repeati214 – 23421LRR 7Add
BLAST
Repeati235 – 25824LRR 8Add
BLAST
Repeati259 – 28224LRR 9Add
BLAST
Repeati283 – 30523LRR 10Add
BLAST
Repeati306 – 33530LRR 11Add
BLAST
Repeati336 – 36025LRR 12Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi55 – 6814Cys-richAdd
BLAST

Sequence similaritiesi

Contains 12 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000118969.
HOGENOMiHOG000261690.
HOVERGENiHBG016052.
InParanoidiQ29393.
KOiK04660.
OMAiPLGPVCP.
OrthoDBiEOG76739V.
TreeFamiTF334562.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR028549. Decorin.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRRNT.
IPR016352. SLRP_I_decor/aspor/byglycan.
[Graphical view]
PANTHERiPTHR24369:SF5. PTHR24369:SF5. 1 hit.
PfamiPF13855. LRR_8. 3 hits.
PF01462. LRRNT. 1 hit.
[Graphical view]
PIRSFiPIRSF002490. SLRP_I. 1 hit.
SMARTiSM00369. LRR_TYP. 6 hits.
SM00013. LRRNT. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 7 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q29393-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKATIIFLLL AQVSWAGPFQ QRGLFDFMLE DEASGIGPED RAPDMPDLEL
60 70 80 90 100
LGPVCPFRCQ CHLRVVQCSD LGLDKVPKDL PPDTTLLDLQ NNKITEIKDG
110 120 130 140 150
DFKNLKNLHT LILVNNKISK ISPGAFTPLL KLERLYLSKN HLKELPEKMP
160 170 180 190 200
KTLQELRAHE NEITKVRKAV FNGLNQMIVV ELGTNPLKSS GIENGAFQGM
210 220 230 240 250
KKLSYIRIAD TNITTIPQGL PPSLTELHLE GNKITKVDAS SLKGLNNLAK
260 270 280 290 300
LGLSFNSISA VDNGTLANTP HLRELHLDNN KLIRVPGGLA EHKYIQVVYL
310 320 330 340 350
HNNNISAVGS NDFCPPGYNT KKASYSGVSL FSNPVQYWEI QPSTFRCVYV
360
RSAIQLGNYK
Length:360
Mass (Da):39,980
Last modified:January 1, 1998 - v2
Checksum:i99BEE11A9C812906
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U83141 mRNA. Translation: AAB51245.1.
L77684 Genomic DNA. Translation: AAA98062.1.
RefSeqiNP_001003228.1. NM_001003228.1.
XP_005628882.1. XM_005628825.2.
XP_005628883.1. XM_005628826.2.
XP_005628885.1. XM_005628828.1.
UniGeneiCfa.3762.

Genome annotation databases

EnsembliENSCAFT00000009945; ENSCAFP00000009230; ENSCAFG00000006142.
GeneIDi403904.
KEGGicfa:403904.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U83141 mRNA. Translation: AAB51245.1.
L77684 Genomic DNA. Translation: AAA98062.1.
RefSeqiNP_001003228.1. NM_001003228.1.
XP_005628882.1. XM_005628825.2.
XP_005628883.1. XM_005628826.2.
XP_005628885.1. XM_005628828.1.
UniGeneiCfa.3762.

3D structure databases

ProteinModelPortaliQ29393.
SMRiQ29393. Positions 52-356.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000009230.

Proteomic databases

PaxDbiQ29393.
PRIDEiQ29393.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSCAFT00000009945; ENSCAFP00000009230; ENSCAFG00000006142.
GeneIDi403904.
KEGGicfa:403904.

Organism-specific databases

CTDi1634.

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000118969.
HOGENOMiHOG000261690.
HOVERGENiHBG016052.
InParanoidiQ29393.
KOiK04660.
OMAiPLGPVCP.
OrthoDBiEOG76739V.
TreeFamiTF334562.

Enzyme and pathway databases

ReactomeiR-CFA-1474228. Degradation of the extracellular matrix.
R-CFA-1971475. A tetrasaccharide linker sequence is required for GAG synthesis.
R-CFA-2022870. Chondroitin sulfate biosynthesis.
R-CFA-2022923. Dermatan sulfate biosynthesis.
R-CFA-2024101. CS/DS degradation.
R-CFA-3000178. ECM proteoglycans.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR028549. Decorin.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRRNT.
IPR016352. SLRP_I_decor/aspor/byglycan.
[Graphical view]
PANTHERiPTHR24369:SF5. PTHR24369:SF5. 1 hit.
PfamiPF13855. LRR_8. 3 hits.
PF01462. LRRNT. 1 hit.
[Graphical view]
PIRSFiPIRSF002490. SLRP_I. 1 hit.
SMARTiSM00369. LRR_TYP. 6 hits.
SM00013. LRRNT. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 7 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete coding sequence and genomic structure of canine decorin."
    Glant T.T.
    Submitted (DEC-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Gene-specific universal mammalian sequence-tagged sites: application to the canine genome."
    Venta P.J., Brouillette J.A., Yuzbasiyan-Gurkan V., Brewer G.J.
    Biochem. Genet. 34:321-341(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 244-259.

Entry informationi

Entry nameiPGS2_CANLF
AccessioniPrimary (citable) accession number: Q29393
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: June 8, 2016
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.