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Protein

Decorin

Gene

DCN

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

May affect the rate of fibrils formation.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-CFA-1474228. Degradation of the extracellular matrix.
R-CFA-1971475. A tetrasaccharide linker sequence is required for GAG synthesis.
R-CFA-2022870. Chondroitin sulfate biosynthesis.
R-CFA-2022923. Dermatan sulfate biosynthesis.
R-CFA-2024101. CS/DS degradation.
R-CFA-3000178. ECM proteoglycans.

Names & Taxonomyi

Protein namesi
Recommended name:
Decorin
Alternative name(s):
Bone proteoglycan II
PG-S2
Gene namesi
Name:DCN
Synonyms:DCN1C
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Chromosome 15

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16By similarityAdd BLAST16
PropeptideiPRO_000003270517 – 30By similarityAdd BLAST14
ChainiPRO_000003270631 – 360DecorinAdd BLAST330

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi34O-linked (Xyl...) (glycosaminoglycan)By similarity1
Disulfide bondi55 ↔ 61By similarity
Disulfide bondi59 ↔ 68By similarity
Glycosylationi212N-linked (GlcNAc...)Sequence analysis1
Glycosylationi263N-linked (GlcNAc...)Sequence analysis1
Glycosylationi304N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi314 ↔ 347By similarity

Post-translational modificationi

The attached glycosaminoglycan chain can be either chondroitin sulfate or dermatan sulfate depending upon the tissue of origin.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Proteoglycan

Proteomic databases

PaxDbiQ29393.
PRIDEiQ29393.

Interactioni

Subunit structurei

Binds to type I and type II collagen, fibronectin and TGF-beta. Forms a ternary complex with MFAP2 and ELN. Interacts with DPT (By similarity).By similarity

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000009230.

Structurei

3D structure databases

ProteinModelPortaliQ29393.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati74 – 94LRR 1Add BLAST21
Repeati95 – 118LRR 2Add BLAST24
Repeati119 – 142LRR 3Add BLAST24
Repeati143 – 163LRR 4Add BLAST21
Repeati164 – 187LRR 5Add BLAST24
Repeati188 – 213LRR 6Add BLAST26
Repeati214 – 234LRR 7Add BLAST21
Repeati235 – 258LRR 8Add BLAST24
Repeati259 – 282LRR 9Add BLAST24
Repeati283 – 305LRR 10Add BLAST23
Repeati306 – 335LRR 11Add BLAST30
Repeati336 – 360LRR 12Add BLAST25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi55 – 68Cys-richAdd BLAST14

Sequence similaritiesi

Contains 12 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000118969.
HOGENOMiHOG000261690.
HOVERGENiHBG016052.
InParanoidiQ29393.
KOiK04660.
OMAiPLGPVCP.
OrthoDBiEOG091G044B.
TreeFamiTF334562.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR028549. Decorin.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRRNT.
IPR016352. SLRP_I_decor/aspor/byglycan.
[Graphical view]
PANTHERiPTHR24369:SF5. PTHR24369:SF5. 1 hit.
PfamiPF13855. LRR_8. 3 hits.
PF01462. LRRNT. 1 hit.
[Graphical view]
PIRSFiPIRSF002490. SLRP_I. 1 hit.
SMARTiSM00369. LRR_TYP. 6 hits.
SM00013. LRRNT. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 7 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q29393-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKATIIFLLL AQVSWAGPFQ QRGLFDFMLE DEASGIGPED RAPDMPDLEL
60 70 80 90 100
LGPVCPFRCQ CHLRVVQCSD LGLDKVPKDL PPDTTLLDLQ NNKITEIKDG
110 120 130 140 150
DFKNLKNLHT LILVNNKISK ISPGAFTPLL KLERLYLSKN HLKELPEKMP
160 170 180 190 200
KTLQELRAHE NEITKVRKAV FNGLNQMIVV ELGTNPLKSS GIENGAFQGM
210 220 230 240 250
KKLSYIRIAD TNITTIPQGL PPSLTELHLE GNKITKVDAS SLKGLNNLAK
260 270 280 290 300
LGLSFNSISA VDNGTLANTP HLRELHLDNN KLIRVPGGLA EHKYIQVVYL
310 320 330 340 350
HNNNISAVGS NDFCPPGYNT KKASYSGVSL FSNPVQYWEI QPSTFRCVYV
360
RSAIQLGNYK
Length:360
Mass (Da):39,980
Last modified:January 1, 1998 - v2
Checksum:i99BEE11A9C812906
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U83141 mRNA. Translation: AAB51245.1.
L77684 Genomic DNA. Translation: AAA98062.1.
RefSeqiNP_001003228.1. NM_001003228.1.
XP_005628882.1. XM_005628825.2.
XP_005628883.1. XM_005628826.2.
XP_005628885.1. XM_005628828.1.
UniGeneiCfa.3762.

Genome annotation databases

EnsembliENSCAFT00000009945; ENSCAFP00000009230; ENSCAFG00000006142.
GeneIDi403904.
KEGGicfa:403904.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U83141 mRNA. Translation: AAB51245.1.
L77684 Genomic DNA. Translation: AAA98062.1.
RefSeqiNP_001003228.1. NM_001003228.1.
XP_005628882.1. XM_005628825.2.
XP_005628883.1. XM_005628826.2.
XP_005628885.1. XM_005628828.1.
UniGeneiCfa.3762.

3D structure databases

ProteinModelPortaliQ29393.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000009230.

Proteomic databases

PaxDbiQ29393.
PRIDEiQ29393.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSCAFT00000009945; ENSCAFP00000009230; ENSCAFG00000006142.
GeneIDi403904.
KEGGicfa:403904.

Organism-specific databases

CTDi1634.

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000118969.
HOGENOMiHOG000261690.
HOVERGENiHBG016052.
InParanoidiQ29393.
KOiK04660.
OMAiPLGPVCP.
OrthoDBiEOG091G044B.
TreeFamiTF334562.

Enzyme and pathway databases

ReactomeiR-CFA-1474228. Degradation of the extracellular matrix.
R-CFA-1971475. A tetrasaccharide linker sequence is required for GAG synthesis.
R-CFA-2022870. Chondroitin sulfate biosynthesis.
R-CFA-2022923. Dermatan sulfate biosynthesis.
R-CFA-2024101. CS/DS degradation.
R-CFA-3000178. ECM proteoglycans.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR028549. Decorin.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRRNT.
IPR016352. SLRP_I_decor/aspor/byglycan.
[Graphical view]
PANTHERiPTHR24369:SF5. PTHR24369:SF5. 1 hit.
PfamiPF13855. LRR_8. 3 hits.
PF01462. LRRNT. 1 hit.
[Graphical view]
PIRSFiPIRSF002490. SLRP_I. 1 hit.
SMARTiSM00369. LRR_TYP. 6 hits.
SM00013. LRRNT. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 7 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPGS2_CANLF
AccessioniPrimary (citable) accession number: Q29393
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: November 2, 2016
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.