ID   DHSO_PIG                Reviewed;          97 AA.
AC   Q29318;
DT   13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   16-JUN-2009, entry version 50.
DE   RecName: Full=Sorbitol dehydrogenase;
DE            EC=1.1.1.14;
DE   AltName: Full=L-iditol 2-dehydrogenase;
DE   Flags: Fragment;
GN   Name=SORD;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae;
OC   Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Small intestine;
RX   MEDLINE=96327607; PubMed=8672129; DOI=10.1007/s003359900153;
RA   Winteroe A.K., Fredholm M., Davies W.;
RT   "Evaluation and characterization of a porcine small intestine cDNA
RT   library: analysis of 839 clones.";
RL   Mamm. Genome 7:509-517(1996).
CC   -!- CATALYTIC ACTIVITY: L-iditol + NAD(+) = L-sorbose + NADH.
CC   -!- COFACTOR: Binds 1 zinc ion per subunit (By similarity).
CC   -!- SUBUNIT: Homotetramer (By similarity).
CC   -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC       family.
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DR   EMBL; F14714; CAA23205.1; -; mRNA.
DR   HOVERGEN; Q29318; -.
DR   BRENDA; 1.1.1.14; 249.
DR   GO; GO:0003939; F:L-iditol 2-dehydrogenase activity; IEA:EC.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR013154; ADH_GroES-like.
DR   InterPro; IPR002085; ADH_SF_Zn.
DR   InterPro; IPR002328; ADH_Zn_CS.
DR   PANTHER; PTHR11695; ADH_Sf_Zn; 1.
DR   Pfam; PF08240; ADH_N; 1.
DR   PROSITE; PS00059; ADH_ZINC; 1.
PE   3: Inferred from homology;
KW   Acetylation; Metal-binding; NAD; Oxidoreductase; Zinc.
FT   INIT_MET      1      1       Removed (By similarity).
FT   CHAIN         2    >97       Sorbitol dehydrogenase.
FT                                /FTId=PRO_0000160818.
FT   METAL        44     44       Zinc; catalytic (By similarity).
FT   METAL        69     69       Zinc; catalytic (By similarity).
FT   METAL        70     70       Zinc; catalytic (By similarity).
FT   MOD_RES       2      2       N-acetylalanine (By similarity).
FT   NON_TER      97     97
SQ   SEQUENCE   97 AA;  10327 MW;  B681170DD30868CB CRC64;
     MAAAKPENLS LVVHGPGDLR LENYPIPEPG PNXVLLKMHS VGICGSDVHY WQHGRIGNFV
     VKKPMVLGHE ASGTXVKVGS LVTHLKPGDR XAXEPGA
//