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Reviewed, UniProtKB/Swiss-Prot Q29228 (AL9A1_PIG)

Last modified June 16, 2009. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    4-trimethylaminobutyraldehyde dehydrogenase
      Short name=TMABADH
    EC=1.2.1.47
Alternative name(s):
    Aldehyde dehydrogenase family 9 member A1
    EC=1.2.1.3
Gene names
Name: ALDH9A1
Synonyms: ALDH9
OrganismSus scrofa (Pig)
Taxonomic identifier9823 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus

Protein attributes

Sequence length69 AA.
Sequence statusFragment.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Function

Converts gamma-trimethylaminobutyraldehyde into gamma-butyrobetaine By similarity.

Catalytic activity

4-trimethylammoniobutanal + NAD+ + H2O = 4-trimethylammoniobutanoate + NADH.

An aldehyde + NAD+ + H2O = an acid + NADH.

Pathway

Amine and polyamine biosynthesis; carnitine biosynthesis.

Subunit structure

Homotetramer By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandNAD
   Molecular functionOxidoreductase
Gene Ontology (GO)
   Biological processoxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular function4-trimethylammoniobutyraldehyde dehydrogenase activity

Inferred from electronic annotation. Source: EC

aldehyde dehydrogenase (NAD) activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – ›69›694-trimethylaminobutyraldehyde dehydrogenase
PRO_0000056487

Experimental info

Non-terminal residue11
Non-terminal residue691

Sequences

Sequence LengthMass (Da)Tools
Q29228-1 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: D30F604E1BD039D1

FASTA697,674
        10         20         30         40         50         60 
EPATGRVIAT LTCSGEKEVN LAVQDAKAAF KIWSQKSGME RCRILLEAAR XIRERKEEIA 


TMETINNGK 

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References

[1]"Evaluation and characterization of a porcine small intestine cDNA library: analysis of 839 clones."
Winteroe A.K., Fredholm M., Davies W.
Mamm. Genome 7:509-517(1996) [PubMed: 8672129] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Small intestine.

Cross-references

Sequence databases

F14819 mRNA. Translation: CAA23277.1.

3D structure databases

HSSPHSSP built from PDB template 1A4S based on UniProtKB P56533.
ModBaseSearch...

Phylogenomic databases

HOVERGENQ29228.

Enzyme and pathway databases

BRENDA1.2.1.3. 249.
1.2.1.47. 249.

Family and domain databases

InterProIPR016160. Ald_DH_CS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH.
[Graphical view]
Gene3DG3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHERPTHR11699. Aldehyde_dehyd. 1 hit.
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
PROSITEPS00070. ALDEHYDE_DEHYDR_CYS. Partial match.
PS00687. ALDEHYDE_DEHYDR_GLU. Partial match.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameAL9A1_PIG
AccessionPrimary (citable) accession number: Q29228
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: June 16, 2009
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents