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Q29228

- AL9A1_PIG

UniProt

Q29228 - AL9A1_PIG

Protein

4-trimethylaminobutyraldehyde dehydrogenase

Gene

ALDH9A1

Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Converts gamma-trimethylaminobutyraldehyde into gamma-butyrobetaine.By similarity

    Catalytic activityi

    4-trimethylammoniobutanal + NAD+ + H2O = 4-trimethylammoniobutanoate + NADH.
    An aldehyde + NAD+ + H2O = a carboxylate + NADH.

    Pathwayi

    GO - Molecular functioni

    1. 4-trimethylammoniobutyraldehyde dehydrogenase activity Source: UniProtKB-EC
    2. aldehyde dehydrogenase (NAD) activity Source: UniProtKB-EC

    GO - Biological processi

    1. carnitine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    UniPathwayiUPA00118.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    4-trimethylaminobutyraldehyde dehydrogenase (EC:1.2.1.47)
    Short name:
    TMABADH
    Alternative name(s):
    Aldehyde dehydrogenase family 9 member A1 (EC:1.2.1.3)
    Gene namesi
    Name:ALDH9A1
    Synonyms:ALDH9
    OrganismiSus scrofa (Pig)
    Taxonomic identifieri9823 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
    ProteomesiUP000008227: Unplaced

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini‹1 – ›69›694-trimethylaminobutyraldehyde dehydrogenasePRO_0000056487Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei27 – 271N6-succinyllysineBy similarity

    Proteomic databases

    PaxDbiQ29228.
    PRIDEiQ29228.

    Interactioni

    Subunit structurei

    Homotetramer.By similarity

    Protein-protein interaction databases

    STRINGi9823.ENSSSCP00000006743.

    Structurei

    3D structure databases

    ProteinModelPortaliQ29228.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the aldehyde dehydrogenase family.Curated

    Phylogenomic databases

    eggNOGiCOG1012.
    HOGENOMiHOG000271505.

    Family and domain databases

    Gene3Di3.40.605.10. 1 hit.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    [Graphical view]
    PfamiPF00171. Aldedh. 1 hit.
    [Graphical view]
    SUPFAMiSSF53720. SSF53720. 1 hit.

    Sequencei

    Sequence statusi: Fragment.

    Q29228-1 [UniParc]FASTAAdd to Basket

    « Hide

    EPATGRVIAT LTCSGEKEVN LAVQDAKAAF KIWSQKSGME RCRILLEAAR   50
    XIRERKEEIA TMETINNGK 69
    Length:69
    Mass (Da):7,674
    Last modified:November 1, 1996 - v1
    Checksum:iD30F604E1BD039D1
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11
    Non-terminal residuei69 – 691

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    F14819 mRNA. Translation: CAA23277.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    F14819 mRNA. Translation: CAA23277.1 .

    3D structure databases

    ProteinModelPortali Q29228.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9823.ENSSSCP00000006743.

    Proteomic databases

    PaxDbi Q29228.
    PRIDEi Q29228.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    eggNOGi COG1012.
    HOGENOMi HOG000271505.

    Enzyme and pathway databases

    UniPathwayi UPA00118 .

    Family and domain databases

    Gene3Di 3.40.605.10. 1 hit.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    [Graphical view ]
    Pfami PF00171. Aldedh. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53720. SSF53720. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Evaluation and characterization of a porcine small intestine cDNA library: analysis of 839 clones."
      Winteroe A.K., Fredholm M., Davies W.
      Mamm. Genome 7:509-517(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Small intestine.

    Entry informationi

    Entry nameiAL9A1_PIG
    AccessioniPrimary (citable) accession number: Q29228
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3