Reviewed, UniProtKB/Swiss-Prot Q29228 (AL9A1_PIG)

Names and origin

Protein names

Recommended name:
    4-trimethylaminobutyraldehyde dehydrogenase
      Short name=TMABADH
    EC=1.2.1.47
Alternative name(s):
    Aldehyde dehydrogenase family 9 member A1
    EC=1.2.1.3

Gene names

Name:	ALDH9A1
Synonyms:	ALDH9

Organism

Sus scrofa (Pig)

Taxonomic identifier

9823 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Suina › Suidae › Sus

Protein attributes

Sequence length	69 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Converts gamma-trimethylaminobutyraldehyde into gamma-butyrobetaine By similarity.
Catalytic activity	4-trimethylammoniobutanal + NAD+ + H2O = 4-trimethylammoniobutanoate + NADH. An aldehyde + NAD+ + H2O = an acid + NADH.
Pathway	Amine and polyamine biosynthesis; carnitine biosynthesis.
Subunit structure	Homotetramer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	NAD
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	4-trimethylammoniobutyraldehyde dehydrogenase activity Inferred from electronic annotation. Source: EC aldehyde dehydrogenase (NAD) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – ›69	›69	4-trimethylaminobutyraldehyde dehydrogenase		PRO_0000056487
Experimental info
	Non-terminal residue	1	1
	Non-terminal residue	69	1

Sequences

	Sequence		Length	Mass (Da)
	Q29228-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: D30F604E1BD039D1	FASTA	69	7,674
	10 20 30 40 50 60 EPATGRVIAT LTCSGEKEVN LAVQDAKAAF KIWSQKSGME RCRILLEAAR XIRERKEEIA TMETINNGK

References

[1]	"Evaluation and characterization of a porcine small intestine cDNA library: analysis of 839 clones." Winteroe A.K., Fredholm M., Davies W. Mamm. Genome 7:509-517(1996) [PubMed: 8672129] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Small intestine.

Cross-references

Sequence databases
EMBLGenBankDDBJ	F14819 mRNA. Translation: CAA23277.1.
3D structure databases
HSSP	HSSP built from PDB template 1A4S based on UniProtKB P56533.
ModBase	Search...
Phylogenomic databases
HOVERGEN	Q29228.
Enzyme and pathway databases
BRENDA	1.2.1.3. 249. 1.2.1.47. 249.
Family and domain databases
InterPro	IPR016160. Ald_DH_CS. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH. [Graphical view]
Gene3D	G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHER	PTHR11699. Aldehyde_dehyd. 1 hit.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. Partial match. PS00687. ALDEHYDE_DEHYDR_GLU. Partial match. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AL9A1_PIG

Accession

Primary (citable) accession number: Q29228

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1996
Last modified:	June 16, 2009
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)