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Q29228 (AL9A1_PIG) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
4-trimethylaminobutyraldehyde dehydrogenase

Short name=TMABADH
EC=1.2.1.47
Alternative name(s):
Aldehyde dehydrogenase family 9 member A1
EC=1.2.1.3
Gene names
Name:ALDH9A1
Synonyms:ALDH9
OrganismSus scrofa (Pig) [Reference proteome]
Taxonomic identifier9823 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus

Protein attributes

Sequence length69 AA.
Sequence statusFragment.
Protein existenceInferred from homology

General annotation (Comments)

Function

Converts gamma-trimethylaminobutyraldehyde into gamma-butyrobetaine By similarity.

Catalytic activity

4-trimethylammoniobutanal + NAD+ + H2O = 4-trimethylammoniobutanoate + NADH.

An aldehyde + NAD+ + H2O = a carboxylate + NADH.

Pathway

Amine and polyamine biosynthesis; carnitine biosynthesis.

Subunit structure

Homotetramer By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcarnitine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_function4-trimethylammoniobutyraldehyde dehydrogenase activity

Inferred from electronic annotation. Source: UniProtKB-EC

aldehyde dehydrogenase (NAD) activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – ›69›694-trimethylaminobutyraldehyde dehydrogenase
PRO_0000056487

Amino acid modifications

Modified residue271N6-succinyllysine By similarity

Experimental info

Non-terminal residue11
Non-terminal residue691

Sequences

Sequence LengthMass (Da)Tools
Q29228 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: D30F604E1BD039D1

FASTA697,674
        10         20         30         40         50         60 
EPATGRVIAT LTCSGEKEVN LAVQDAKAAF KIWSQKSGME RCRILLEAAR XIRERKEEIA 


TMETINNGK 

« Hide

References

[1]"Evaluation and characterization of a porcine small intestine cDNA library: analysis of 839 clones."
Winteroe A.K., Fredholm M., Davies W.
Mamm. Genome 7:509-517(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Small intestine.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
F14819 mRNA. Translation: CAA23277.1.

3D structure databases

ProteinModelPortalQ29228.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9823.ENSSSCP00000006743.

Proteomic databases

PaxDbQ29228.
PRIDEQ29228.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

eggNOGCOG1012.
HOGENOMHOG000271505.

Enzyme and pathway databases

UniPathwayUPA00118.

Family and domain databases

Gene3D3.40.605.10. 1 hit.
InterProIPR016161. Ald_DH/histidinol_DH.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMSSF53720. SSF53720. 1 hit.
ProtoNetSearch...

Entry information

Entry nameAL9A1_PIG
AccessionPrimary (citable) accession number: Q29228
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: March 19, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways