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Q291H4

- MTAP_DROPS

UniProt

Q291H4 - MTAP_DROPS

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Protein

S-methyl-5'-thioadenosine phosphorylase

Gene
GA18442
Organism
Drosophila pseudoobscura pseudoobscura (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates By similarity.UniRule annotation

Catalytic activityi

S-methyl-5'-thioadenosine + phosphate = adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei24 – 241Phosphate By similarity
Sitei184 – 1841Important for substrate specificity By similarity
Binding sitei202 – 2021Substrate; via amide nitrogen By similarity
Binding sitei203 – 2031Phosphate By similarity
Sitei239 – 2391Important for substrate specificity By similarity

GO - Molecular functioni

  1. phosphorylase activity Source: InterPro
  2. S-methyl-5-thioadenosine phosphorylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. L-methionine salvage from methylthioadenosine Source: UniProtKB-HAMAP
  2. purine ribonucleoside salvage Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Purine salvage

Enzyme and pathway databases

UniPathwayiUPA00904; UER00873.

Names & Taxonomyi

Protein namesi
Recommended name:
S-methyl-5'-thioadenosine phosphorylase (EC:2.4.2.28)
Alternative name(s):
5'-methylthioadenosine phosphorylase
Short name:
MTA phosphorylase
Short name:
MTAP
Short name:
MTAPase
Gene namesi
ORF Names:GA18442
OrganismiDrosophila pseudoobscura pseudoobscura (Fruit fly)
Taxonomic identifieri46245 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000001819: Chromosome 3, UP000001819: Partially assembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0078444. Dpse\GA18442.

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 289289S-methyl-5'-thioadenosine phosphorylaseUniRule annotationPRO_0000415120Add
BLAST

Interactioni

Subunit structurei

Homotrimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi7237.FBpp0277616.

Structurei

3D structure databases

ProteinModelPortaliQ291H4.
SMRiQ291H4. Positions 16-277.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni66 – 672Phosphate binding By similarity
Regioni99 – 1002Phosphate binding By similarity
Regioni226 – 2283Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

InParanoidiQ291H4.
KOiK00772.
OMAiCEAQLCY.
OrthoDBiEOG771270.
PhylomeDBiQ291H4.

Family and domain databases

Gene3Di3.40.50.1580. 1 hit.
HAMAPiMF_01963. MTAP.
InterProiIPR010044. MTAP.
IPR000845. Nucleoside_phosphorylase_d.
IPR001369. PNP/MTAP.
IPR018099. Purine_phosphorylase-2_CS.
[Graphical view]
PANTHERiPTHR11904. PTHR11904. 1 hit.
PfamiPF01048. PNP_UDP_1. 1 hit.
[Graphical view]
SUPFAMiSSF53167. SSF53167. 1 hit.
TIGRFAMsiTIGR01694. MTAP. 1 hit.
PROSITEiPS01240. PNP_MTAP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q291H4-1 [UniParc]FASTAAdd to Basket

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MLHIKCKDTD LDPIPVKIGI IGGSGLDDPD ILENRQEKVI STPYGEPSDA    50
LIQGEIGGVQ CVLLARHGRK HDIMPSNVNY RANIWALRDV GCTHLIVSTA 100
CGSLREQIKP GNLVMPHDFI DRTTKRSQTF YDGSATSPRG VCHLPMYPAF 150
SERTRNILIE AAKELEIPAH EKATIVTIEG PRFSSRSESL MFREWGGDLI 200
NMTTCPEVVL AKEAGLLYGS VAIATDYDCW RMGCEGVNVQ DVLKTFAENV 250
IKVKKILVNA VGRIAKEDWS EDILNAKQCV CNNTMSGAM 289
Length:289
Mass (Da):31,844
Last modified:April 4, 2006 - v1
Checksum:i2109F54933516F64
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CM000071 Genomic DNA. Translation: EAL25138.1.
RefSeqiXP_001360563.1. XM_001360526.2.

Genome annotation databases

EnsemblMetazoaiFBtr0279178; FBpp0277616; FBgn0078444.
GeneIDi4803922.
KEGGidpo:Dpse_GA18442.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CM000071 Genomic DNA. Translation: EAL25138.1 .
RefSeqi XP_001360563.1. XM_001360526.2.

3D structure databases

ProteinModelPortali Q291H4.
SMRi Q291H4. Positions 16-277.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7237.FBpp0277616.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0279178 ; FBpp0277616 ; FBgn0078444 .
GeneIDi 4803922.
KEGGi dpo:Dpse_GA18442.

Organism-specific databases

FlyBasei FBgn0078444. Dpse\GA18442.

Phylogenomic databases

InParanoidi Q291H4.
KOi K00772.
OMAi CEAQLCY.
OrthoDBi EOG771270.
PhylomeDBi Q291H4.

Enzyme and pathway databases

UniPathwayi UPA00904 ; UER00873 .

Family and domain databases

Gene3Di 3.40.50.1580. 1 hit.
HAMAPi MF_01963. MTAP.
InterProi IPR010044. MTAP.
IPR000845. Nucleoside_phosphorylase_d.
IPR001369. PNP/MTAP.
IPR018099. Purine_phosphorylase-2_CS.
[Graphical view ]
PANTHERi PTHR11904. PTHR11904. 1 hit.
Pfami PF01048. PNP_UDP_1. 1 hit.
[Graphical view ]
SUPFAMi SSF53167. SSF53167. 1 hit.
TIGRFAMsi TIGR01694. MTAP. 1 hit.
PROSITEi PS01240. PNP_MTAP_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal, gene, and cis-element evolution."
    Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S., Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O., Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F., Howells S.L.
    , Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A., Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M., Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J., Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y., Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F., Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M., Weinstock G.M., Gibbs R.A.
    Genome Res. 15:1-18(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MV2-25 / Tucson 14011-0121.94.

Entry informationi

Entry nameiMTAP_DROPS
AccessioniPrimary (citable) accession number: Q291H4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 25, 2012
Last sequence update: April 4, 2006
Last modified: July 9, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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