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Protein

Hyaluronidase

Gene
N/A
Organism
Vulpes vulpes (Red fox)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

GlycosidaseUniRule annotation, Hydrolase

Protein family/group databases

CAZyiGH56. Glycoside Hydrolase Family 56.

Names & Taxonomyi

Protein namesi
Recommended name:
HyaluronidaseUniRule annotation (EC:3.2.1.35UniRule annotation)
Alternative name(s):
HyaluronoglucosaminidaseUniRule annotation
OrganismiVulpes vulpes (Red fox)Imported
Taxonomic identifieri9627 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeVulpes

Structurei

3D structure databases

ProteinModelPortaliQ29152.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 56 family.UniRule annotation

Phylogenomic databases

HOVERGENiHBG052053.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR017853. Glycoside_hydrolase_SF.
IPR018155. Hyaluronidase.
IPR001439. Hyaluronidase_PH20.
[Graphical view]
PANTHERiPTHR11769. PTHR11769. 1 hit.
PfamiPF01630. Glyco_hydro_56. 1 hit.
[Graphical view]
PIRSFiPIRSF038193. Hyaluronidase. 1 hit.
PIRSF500773. Hyaluronidase_PH20_Hyal5. 1 hit.
PRINTSiPR00846. GLHYDRLASE56.
SUPFAMiSSF51445. SSF51445. 1 hit.

Sequencei

Sequence statusi: Complete.

Q29152-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGVLRFQNIF FRSFLGSSGT TQAVFIFLLI PRCLTQEFRA PPFIPNVSFL
60 70 80 90 100
WGWNAPTELC AKRFNVQLDL NLFSLIGSPL KTVVGQGIAI FYADRLGYYP
110 120 130 140 150
HINKTTGKHV NGGIPQLGSL KKHLDKAKKD ISHYIETDSM GLAVIDWDSW
160 170 180 190 200
RPNWARNWRP KHIYKEQSID LAQQQHIHLN LTEVTQIAQA DFEKAARCFM
210 220 230 240 250
QETLKLGKFL RPNYLWGFYL YPDCYNYNYK NPNYNGSCYD IEERRNDEID
260 270 280 290 300
WLWKESTALF PSIYLKSKLK SSPFTALYVR NRVLEAIRVS KVKDIKHPLP
310 320 330 340 350
IFVYARPVFT DVLLTYLTED DLVNTIGESV SLGVSGIVMW GSLNLTENVQ
360 370 380 390 400
ICTELDTYIK NKLNPYIINV TLAAKMCSQV LCQDEGVCIR KHWNSNDYLH
410 420 430 440 450
LNPVNFAIQL ERSGRYTVQG KPTLEDLQQF SKKFYCACYA NTHCRERVDM
460 470 480 490 500
TDIHTIKVCV GEDVCIDVYL NLVPSGHLPV WKGKYVTSSN IFSVMPPATG
510 520 530 540
PPCVPGRDLN RCLKARFIVE DNSKTTQTGY QSIYIKNKKQ
Length:540
Mass (Da):62,034
Last modified:January 1, 1998 - v2
Checksum:i1A4E202F40951390
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U41412 mRNA. Translation: AAB86588.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U41412 mRNA. Translation: AAB86588.1.

3D structure databases

ProteinModelPortaliQ29152.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

CAZyiGH56. Glycoside Hydrolase Family 56.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG052053.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR017853. Glycoside_hydrolase_SF.
IPR018155. Hyaluronidase.
IPR001439. Hyaluronidase_PH20.
[Graphical view]
PANTHERiPTHR11769. PTHR11769. 1 hit.
PfamiPF01630. Glyco_hydro_56. 1 hit.
[Graphical view]
PIRSFiPIRSF038193. Hyaluronidase. 1 hit.
PIRSF500773. Hyaluronidase_PH20_Hyal5. 1 hit.
PRINTSiPR00846. GLHYDRLASE56.
SUPFAMiSSF51445. SSF51445. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. ten Have J.
    Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: TestisImported.
  2. "Cloning and characterization of the cDNA encoding the PH20 protein in the European red fox Vulpes vulpes."
    ten Have J., Beaton S., Bradley M.P.
    Reprod. Fertil. Dev. 10:165-172(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: TestisImported.

Entry informationi

Entry nameiQ29152_VULVU
AccessioniPrimary (citable) accession number: Q29152
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: January 1, 1998
Last modified: October 1, 2014
This is version 57 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.