Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Tenascin

Gene

TNC

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Tenascin
Short name:
TN
Alternative name(s):
Cytotactin
GMEM
GP 150-225
Glioma-associated-extracellular matrix antigen
Hexabrachion
JI
Myotendinous antigen
Neuronectin
P230
Tenascin-C
Short name:
TN-C
Gene namesi
Name:TNC
Synonyms:HXB
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000000774223 – 1746TenascinAdd BLAST1724

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi38N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi64InterchainPROSITE-ProRule annotation
Modified residuei65PhosphoserineBy similarity1
Modified residuei70PhosphoserineBy similarity1
Modified residuei72PhosphoserineBy similarity1
Glycosylationi166N-linked (GlcNAc...)Sequence analysis1
Glycosylationi184N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi190 ↔ 200By similarity
Disulfide bondi194 ↔ 205By similarity
Disulfide bondi207 ↔ 216By similarity
Disulfide bondi221 ↔ 231By similarity
Disulfide bondi225 ↔ 236By similarity
Disulfide bondi238 ↔ 247By similarity
Disulfide bondi252 ↔ 263By similarity
Disulfide bondi256 ↔ 268By similarity
Disulfide bondi270 ↔ 279By similarity
Disulfide bondi284 ↔ 294By similarity
Disulfide bondi288 ↔ 299By similarity
Disulfide bondi301 ↔ 310By similarity
Disulfide bondi315 ↔ 325By similarity
Disulfide bondi319 ↔ 330By similarity
Glycosylationi327N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi332 ↔ 341By similarity
Disulfide bondi346 ↔ 356By similarity
Disulfide bondi350 ↔ 361By similarity
Disulfide bondi363 ↔ 372By similarity
Disulfide bondi377 ↔ 387By similarity
Disulfide bondi381 ↔ 392By similarity
Disulfide bondi394 ↔ 403By similarity
Disulfide bondi408 ↔ 418By similarity
Disulfide bondi412 ↔ 423By similarity
Disulfide bondi425 ↔ 434By similarity
Disulfide bondi439 ↔ 449By similarity
Disulfide bondi443 ↔ 454By similarity
Disulfide bondi456 ↔ 465By similarity
Disulfide bondi470 ↔ 480By similarity
Disulfide bondi474 ↔ 485By similarity
Disulfide bondi487 ↔ 496By similarity
Disulfide bondi501 ↔ 511By similarity
Disulfide bondi505 ↔ 516By similarity
Disulfide bondi518 ↔ 527By similarity
Disulfide bondi532 ↔ 542By similarity
Disulfide bondi536 ↔ 547By similarity
Disulfide bondi549 ↔ 558By similarity
Disulfide bondi563 ↔ 573By similarity
Disulfide bondi567 ↔ 578By similarity
Disulfide bondi580 ↔ 589By similarity
Disulfide bondi594 ↔ 604By similarity
Disulfide bondi598 ↔ 609By similarity
Disulfide bondi611 ↔ 620By similarity
Glycosylationi788N-linked (GlcNAc...)Sequence analysis1
Modified residuei905PhosphothreonineBy similarity1
Glycosylationi1034N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1079N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1121N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1354N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ29116.
PeptideAtlasiQ29116.
PRIDEiQ29116.

Expressioni

Tissue specificityi

Submaxillary glands and brain.

Developmental stagei

Predominantly expressed in the embryonic and early postnatal stages. Little or no detection in adult brain.

Inductioni

By TGF-beta.

Interactioni

Subunit structurei

Homohexamer; disulfide-linked. A homotrimer may be formed in the triple coiled-coil region and may be stabilized by disulfide rings at both ends. Two of such half-hexabrachions may be disulfide linked within the central globule. Interacts with CSPG4 (By similarity).By similarity

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000005891.

Structurei

3D structure databases

ProteinModelPortaliQ29116.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini174 – 186EGF-like 1; incompletePROSITE-ProRule annotationAdd BLAST13
Domaini187 – 217EGF-like 2PROSITE-ProRule annotationAdd BLAST31
Domaini218 – 249EGF-like 3PROSITE-ProRule annotationAdd BLAST32
Domaini250 – 280EGF-like 4PROSITE-ProRule annotationAdd BLAST31
Domaini281 – 311EGF-like 5PROSITE-ProRule annotationAdd BLAST31
Domaini312 – 342EGF-like 6PROSITE-ProRule annotationAdd BLAST31
Domaini343 – 373EGF-like 7PROSITE-ProRule annotationAdd BLAST31
Domaini374 – 404EGF-like 8PROSITE-ProRule annotationAdd BLAST31
Domaini405 – 435EGF-like 9PROSITE-ProRule annotationAdd BLAST31
Domaini436 – 466EGF-like 10PROSITE-ProRule annotationAdd BLAST31
Domaini467 – 497EGF-like 11PROSITE-ProRule annotationAdd BLAST31
Domaini498 – 528EGF-like 12PROSITE-ProRule annotationAdd BLAST31
Domaini529 – 559EGF-like 13PROSITE-ProRule annotationAdd BLAST31
Domaini560 – 589EGF-like 14PROSITE-ProRule annotationAdd BLAST30
Domaini590 – 620EGF-like 15PROSITE-ProRule annotationAdd BLAST31
Domaini625 – 717Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST93
Domaini718 – 801Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST84
Domaini805 – 894Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST90
Domaini895 – 988Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST94
Domaini989 – 1075Fibronectin type-III 5PROSITE-ProRule annotationAdd BLAST87
Domaini1076 – 1166Fibronectin type-III 6PROSITE-ProRule annotationAdd BLAST91
Domaini1167 – 1256Fibronectin type-III 7PROSITE-ProRule annotationAdd BLAST90
Domaini1257 – 1346Fibronectin type-III 8PROSITE-ProRule annotationAdd BLAST90
Domaini1347 – 1433Fibronectin type-III 9PROSITE-ProRule annotationAdd BLAST87
Domaini1434 – 1522Fibronectin type-III 10PROSITE-ProRule annotationAdd BLAST89
Domaini1520 – 1735Fibrinogen C-terminalPROSITE-ProRule annotationAdd BLAST216

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni23 – 185Involved in hexamer formationAdd BLAST163

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili118 – 145Sequence analysisAdd BLAST28

Sequence similaritiesi

Belongs to the tenascin family.Curated
Contains 15 EGF-like domains.PROSITE-ProRule annotation
Contains 1 fibrinogen C-terminal domain.PROSITE-ProRule annotation
Contains 10 fibronectin type-III domains.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiKOG2579. Eukaryota.
ENOG410ZYS4. LUCA.
HOGENOMiHOG000234355.
HOVERGENiHBG008949.
InParanoidiQ29116.
KOiK06252.

Family and domain databases

CDDicd00063. FN3. 10 hits.
cd00087. FReD. 1 hit.
Gene3Di2.60.40.10. 10 hits.
3.90.215.10. 1 hit.
4.10.530.10. 1 hit.
InterProiIPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR013111. EGF_extracell.
IPR014716. Fibrinogen_a/b/g_C_1.
IPR014715. Fibrinogen_a/b/g_C_2.
IPR002181. Fibrinogen_a/b/g_C_dom.
IPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR033078. TNC.
[Graphical view]
PANTHERiPTHR19143:SF38. PTHR19143:SF38. 2 hits.
PfamiPF07974. EGF_2. 3 hits.
PF00147. Fibrinogen_C. 1 hit.
PF00041. fn3. 10 hits.
[Graphical view]
SMARTiSM00181. EGF. 14 hits.
SM00186. FBG. 1 hit.
SM00060. FN3. 10 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 7 hits.
SSF56496. SSF56496. 1 hit.
PROSITEiPS00022. EGF_1. 15 hits.
PS01186. EGF_2. 14 hits.
PS50026. EGF_3. 5 hits.
PS51406. FIBRINOGEN_C_2. 1 hit.
PS50853. FN3. 9 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Isoforms are produced in a tissue- and time-specific manner during development.
Isoform Minor-2 (identifier: Q29116-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGVVTRLLVG TFLASLALPA QGGVLKKVIR HKRQTGVNVT LPEESQPVVF
60 70 80 90 100
NHVYNIKLPV GSQCSVDLES ASGDKDLAAP SEPSESVQEH TVDGENQIVF
110 120 130 140 150
THRINIPRRA CGCAAAPDVK ELLSRLEELE NLVSSLREQC TSGAGCCLQP
160 170 180 190 200
AEGRLDTRPF CSGRGNFSTE GCGCVCEPGW KGPNCSEPEC PSNCHLRGQC
210 220 230 240 250
VDGQCVCNEG FTGEDCSQLA CPSDCNDQGK CVNGVCVCFE GYSGVDCSRE
260 270 280 290 300
TCPVPCSEEH GRCVDGRCVC QEGFAGEDCN EPLCLHNCHG RGRCVENECV
310 320 330 340 350
CDEGFTGEDC GELICPKDCF DRGRCINGTC YCDEGFEGED CGRLACPHGC
360 370 380 390 400
RGRGRCEEGQ CVCDEGFAGA DCSERRCPSD CHNRGRCLDG RCECDDGFEG
410 420 430 440 450
EDCGELRCPG GCSGHGRCVN GQCVCDEGRT GEDCSQLRCP NDCHGRGRCV
460 470 480 490 500
QGRCECEHGF QGYDCSEMSC PHDCHQHGRC VNGMCVCDDG YTGEDCRELR
510 520 530 540 550
CPGDCSQRGR CVDGRCVCEH GFAGPDCADL ACPSDCHGRG RCVNGQCVCH
560 570 580 590 600
EGFTGKDCGQ RRCPGDCHGQ GRCVDGQCVC HEGFTGLDCG QRSCPNDCSN
610 620 630 640 650
WGQCVSGRCI CNEGYSGEDC SQVSPPKDLI VTEVTEETVN LAWDNEMRVT
660 670 680 690 700
EYLIVYTPTH EDGLEMQFRV PGDQTSTTIR ELEPGVEYFI RVFAILENKK
710 720 730 740 750
SIPVSARVAT YLPTPEGLKF KSIKETSVEV EWDPLDIAFE TWEIIFRNMN
760 770 780 790 800
KEDEGEITKS LRRPETTYRQ TGLAPGQEYE ISLHIVKNNT RGPGLKRVTT
810 820 830 840 850
TRLDAPSQIE AKDVTDTTAL ITWFKPLAEI DGIELTYGIK DVPGDRTTID
860 870 880 890 900
LTHEENQYSI GNLKPDTEYE VSLISRRADM SSNPAKETFT TGLDAPRNLR
910 920 930 940 950
RISQTDNSIT LEWRNGKAAA DTYRIKYAPI SGGDHAEVEV PRSPQTTTKA
960 970 980 990 1000
TLTGLRPGTE YGIGVSAVKG DKESDPATIN AATDLDPPKD FRVSELKESS
1010 1020 1030 1040 1050
LTLLWRTPLA KFDRYRLNYG LPSGQPVEVQ LPRNATSYIL RGLEPGQEYT
1060 1070 1080 1090 1100
ILLTAEKGRH KSKPARVKAS TAGEPEIGNL SVSDITPESF SLSWTATEGA
1110 1120 1130 1140 1150
FETFTIEIID SNRFLETMEY NISGAERTAH ISGLRPGNDF IVYLSGLAPG
1160 1170 1180 1190 1200
IQTKPISATA TTEAEPEVDN LLVSDATPDG FRLSWTADEG VFDSFVLKIR
1210 1220 1230 1240 1250
DTKKQSEPLE ITLLASERTR DITGLREATE YEIELYGISS GKRSQPVSAI
1260 1270 1280 1290 1300
ATTAMGSPKE ITFSDITENS ATVSWMVPTA QVESFRITYV PITGGAPSVV
1310 1320 1330 1340 1350
TVDGTKTQTR LLRLLPGVEY LVSVIAVKGF EESEPVSGTL TTALDGPSGL
1360 1370 1380 1390 1400
VTANITDSEA LAMWQPAIAP VDHYVISYTG DRVPEITRTV SGNTVEYALT
1410 1420 1430 1440 1450
NLEPATEYTL RIFAEKGPQK SSTITTKFTT DLDSPRDLTA TEVQSETALL
1460 1470 1480 1490 1500
TWRPPRASVT GYLLVYESVD GTLKEVVVGP ETTSYSLSGL SPSTHYTARI
1510 1520 1530 1540 1550
QALNGPLRSK MSQTVFTTIG LLYPFPRDCS QAMLNGDTTS GLYTIYVNND
1560 1570 1580 1590 1600
KAQKLEVFCD MTSDSGGWIV FLRRKNGRED FYRNWKAYAA GFGDLKEEFW
1610 1620 1630 1640 1650
LGLDALSKIT AQGQYELRVD LRDHGETAYA VYDRFSVGDA RTRYKLKVEG
1660 1670 1680 1690 1700
YSGTAGDSMA YHNGRSFSTF DKDTDSAITN CALSYKGAFW YKNCHRVNLM
1710 1720 1730 1740
GRYGDNSHSQ GVNWFHWKGH EYSIQFAEMK LRPSNFRNLE GRRKRA
Length:1,746
Mass (Da):191,400
Last modified:November 1, 1996 - v1
Checksum:i56549B1CFE5E5C88
GO
Isoform Major (identifier: Q29116-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1072-1162: Missing.

Show »
Length:1,655
Mass (Da):181,692
Checksum:i5120853B14467398
GO
Isoform Minor-1 (identifier: Q29116-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1072-1253: Missing.

Show »
Length:1,564
Mass (Da):171,634
Checksum:i7333CCF143243FFA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1007T → M AA sequence (PubMed:9498558).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0014171072 – 1253Missing in isoform Minor-1. 1 PublicationAdd BLAST182
Alternative sequenceiVSP_0014161072 – 1162Missing in isoform Major. 1 PublicationAdd BLAST91

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X61599 mRNA. Translation: CAA43796.1.
PIRiS19694.
RefSeqiNP_999395.1. NM_214230.1. [Q29116-1]
UniGeneiSsc.16209.

Genome annotation databases

GeneIDi397460.
KEGGissc:397460.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X61599 mRNA. Translation: CAA43796.1.
PIRiS19694.
RefSeqiNP_999395.1. NM_214230.1. [Q29116-1]
UniGeneiSsc.16209.

3D structure databases

ProteinModelPortaliQ29116.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000005891.

Proteomic databases

PaxDbiQ29116.
PeptideAtlasiQ29116.
PRIDEiQ29116.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi397460.
KEGGissc:397460.

Organism-specific databases

CTDi3371.

Phylogenomic databases

eggNOGiKOG2579. Eukaryota.
ENOG410ZYS4. LUCA.
HOGENOMiHOG000234355.
HOVERGENiHBG008949.
InParanoidiQ29116.
KOiK06252.

Family and domain databases

CDDicd00063. FN3. 10 hits.
cd00087. FReD. 1 hit.
Gene3Di2.60.40.10. 10 hits.
3.90.215.10. 1 hit.
4.10.530.10. 1 hit.
InterProiIPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR013111. EGF_extracell.
IPR014716. Fibrinogen_a/b/g_C_1.
IPR014715. Fibrinogen_a/b/g_C_2.
IPR002181. Fibrinogen_a/b/g_C_dom.
IPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR033078. TNC.
[Graphical view]
PANTHERiPTHR19143:SF38. PTHR19143:SF38. 2 hits.
PfamiPF07974. EGF_2. 3 hits.
PF00147. Fibrinogen_C. 1 hit.
PF00041. fn3. 10 hits.
[Graphical view]
SMARTiSM00181. EGF. 14 hits.
SM00186. FBG. 1 hit.
SM00060. FN3. 10 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 7 hits.
SSF56496. SSF56496. 1 hit.
PROSITEiPS00022. EGF_1. 15 hits.
PS01186. EGF_2. 14 hits.
PS50026. EGF_3. 5 hits.
PS51406. FIBRINOGEN_C_2. 1 hit.
PS50853. FN3. 9 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTENA_PIG
AccessioniPrimary (citable) accession number: Q29116
Secondary accession number(s): P98142
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1996
Last modified: November 30, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.