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Protein
Submitted name:

Ryanodine receptor

Gene

RYR1

Organism
Sus scrofa (Pig)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

ReceptorImported

Names & Taxonomyi

Protein namesi
Submitted name:
Ryanodine receptorImported
Gene namesi
Name:RYR1Imported
OrganismiSus scrofa (Pig)Imported
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei4319 – 433618HelicalSequence analysisAdd
BLAST
Transmembranei4558 – 457821HelicalSequence analysisAdd
BLAST
Transmembranei4646 – 466924HelicalSequence analysisAdd
BLAST
Transmembranei4835 – 485723HelicalSequence analysisAdd
BLAST
Transmembranei4916 – 493924HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiQ29105.

Expressioni

Gene expression databases

GenevisibleiQ29105. SS.

Interactioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000003203.

Structurei

3D structure databases

ProteinModelPortaliQ29105.
SMRiQ29105. Positions 3610-3636.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini98 – 15356MIRInterPro annotationAdd
BLAST
Domaini160 – 20546MIRInterPro annotationAdd
BLAST
Domaini211 – 26555MIRInterPro annotationAdd
BLAST
Domaini271 – 33464MIRInterPro annotationAdd
BLAST
Domaini336 – 39358MIRInterPro annotationAdd
BLAST
Domaini582 – 798217B30.2/SPRYInterPro annotationAdd
BLAST
Domaini1014 – 1209196B30.2/SPRYInterPro annotationAdd
BLAST
Domaini1358 – 1571214B30.2/SPRYInterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1870 – 192556Sequence analysisAdd
BLAST

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG2243. Eukaryota.
ENOG410YCNW. LUCA.
HOVERGENiHBG006699.
KOiK04961.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
1.25.10.30. 1 hit.
InterProiIPR001870. B30.2/SPRY.
IPR013320. ConA-like_dom.
IPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
IPR014821. Ins145_P3_rcpt.
IPR005821. Ion_trans_dom.
IPR016093. MIR_motif.
IPR013662. RIH_assoc-dom.
IPR000699. RIH_dom.
IPR013333. Ryan_recept.
IPR003032. Ryanodine_rcpt.
IPR015925. Ryanodine_recept-rel.
IPR009460. Ryanrecept_TM4-6.
IPR033215. RyR1.
IPR003877. SPRY_dom.
[Graphical view]
PANTHERiPTHR13715. PTHR13715. 6 hits.
PTHR13715:SF15. PTHR13715:SF15. 6 hits.
PfamiPF13833. EF-hand_8. 1 hit.
PF08709. Ins145_P3_rec. 1 hit.
PF00520. Ion_trans. 1 hit.
PF02815. MIR. 1 hit.
PF08454. RIH_assoc. 1 hit.
PF06459. RR_TM4-6. 1 hit.
PF01365. RYDR_ITPR. 2 hits.
PF02026. RyR. 4 hits.
PF00622. SPRY. 3 hits.
[Graphical view]
PRINTSiPR00795. RYANODINER.
SMARTiSM00472. MIR. 4 hits.
SM00449. SPRY. 3 hits.
[Graphical view]
SUPFAMiSSF100909. SSF100909. 2 hits.
SSF47473. SSF47473. 1 hit.
SSF49899. SSF49899. 3 hits.
SSF82109. SSF82109. 2 hits.
PROSITEiPS50188. B302_SPRY. 3 hits.
PS50919. MIR. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q29105-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDGGEGEDE VQFLRTDDEV VLQCNATVLK EQLKLCLAAE GFGNRLCFLE
60 70 80 90 100
PTSNAQNVPP DLAICCFVLE QSLSVRALQE MLANTVEAGV ESSQGGGHRT
110 120 130 140 150
LLYGHAILLR HAHSGMYLSC LTTSRSMTDK LAFDVGLQED ATGEACWWTT
160 170 180 190 200
HPASKQRSEG EKVRVGDDLI LVSVSSERYL HLSTASGELQ VDASFMQTLW
210 220 230 240 250
NMNPICSGCE EGYVTGGHVL RLFHGHMDEC LTISPADSDD QRRLVYYEGG
260 270 280 290 300
SVCTHARSLW RLEPLRISWS GSHLRWGQPL RIRHVTTGRY LALIEDQGLV
310 320 330 340 350
VVDASKAHTK ATSFCFRISK EKLDTAPKRD VEGMGPPEIK YGESLCFVQH
360 370 380 390 400
VASGLWLTYA APDPKALRLG VLKKKAILHQ EGHMDDALSL TRCQQEESQA
410 420 430 440 450
ARMIYSTAGL YNHFIKGLDS FSGKPRGSGA PAGTALPLEG VILSLQDLIG
460 470 480 490 500
YFEPPSEELQ HEEKQSKLRS LRNRQSLFQE EGMLSLVLNC IDRLNVYTTA
510 520 530 540 550
AHFAEFAGEE AAESWKEIVN LLYEILASLI RGNRANCALF SNNLDWLVSK
560 570 580 590 600
LDRLEASSGI LEVLYCVLIE SPEVLNIIQE NHIKSIISLL DKHGRNHKVL
610 620 630 640 650
DVLCSLCVCN GVAVRSNQDL ITENLLPGRE LLLQTNLINY VTSIRPNIFV
660 670 680 690 700
GRAEGTTQYS KWYFEVMVDE VVPFLTAQAT HLRVGWALTE GYSPYPGGGE
710 720 730 740 750
GWGGNGVGDD LYSYGFDGLH LWTGHVPRLV TSPGQHLLAP EDVVSCCLDL
760 770 780 790 800
SVPSISFRIN GCPVQGVFEA FNLNGLFFPV VSFSAGVKVR FLLGGRHGEF
810 820 830 840 850
KFLPPPGYAP CHEAVLPRER LRLEPIKEYR REGPRGPHLV GPSRCLSHTD
860 870 880 890 900
FVPCPVDTVQ IVLPPHLERI REKLAENIHE LWALTRIEQG WTYGPVRDDN
910 920 930 940 950
KRLHPCLVDF HSLPEPERNY NLQMSGETLK TLLALGCHVG MADEKAEDNL
960 970 980 990 1000
RKTKLPKTYM MSNGYKPAPL DLSHVRLTPA QTTLVDRLAE NGHNVWARDR
1010 1020 1030 1040 1050
VAQGWSYSAV QDIPARRNPR LVPYRLLDEA TKRSNRDSLC QAVRTLLGYG
1060 1070 1080 1090 1100
YNIEPPDQEP SQVESQSRWD RVRIFRAEKS YAVQSGRWYF EFEAVTTGEM
1110 1120 1130 1140 1150
RVGWARPELR PDVELGADEL AYVFNGHRGQ RWHLGSELFG RPWQSGDVVG
1160 1170 1180 1190 1200
CMIDLTENTI IFTLNGEVLM SDSGSETAFR DIEVGDGFLP VCSLGPGQVG
1210 1220 1230 1240 1250
HLNLGQDVSS LRFFAICGLQ EGFEPFAINM QRPVTTWFSK SLPQFEAVPL
1260 1270 1280 1290 1300
EHPHYEVSRV DGTVDTPPCL RLTHRTWGSQ NSLVEMLFLR LSLPVQFHQH
1310 1320 1330 1340 1350
FRCTAGATPL APPGLQPPAE DEARAAEPDP DYENLRRSAG RWGEAEGGKE
1360 1370 1380 1390 1400
GTAKEGAPGG TAQAGVEAQP PRAENEKDAT TEKNKKRGFL FKAKKAAMMT
1410 1420 1430 1440 1450
QPPATPTLPR LPHEVVPADD RDDPDIILNT TTYYYSVRVF AGQEPSCVWV
1460 1470 1480 1490 1500
GWVTPDYHQH DMNFDLTKVR AVTVTMGDEQ GNIHSSLKCS NCYMVWGGDF
1510 1520 1530 1540 1550
VSPGQQGRIS HTDLVIGCLV DLATGLMTFT ANGKESNTFF QVEPNTKLFP
1560 1570 1580 1590 1600
AVFVLPTHQN VIQFELGKQK NIMPLSAAMF LSERKNPAPQ CPPRLEMQML
1610 1620 1630 1640 1650
MPVSWSRMPN HFLRVETRRA GERLGWAVQC QEPLTMMALH IPEENRCMDI
1660 1670 1680 1690 1700
LELSERLDLQ QFHSHTLRLY RAVCALGNNR VAHALCSHVD QAQLLHALED
1710 1720 1730 1740 1750
AHLPGPLRAG YYDLLISIHL ESACRSRRSM LSEYIVPLTP ETRAITLFPP
1760 1770 1780 1790 1800
GKRTENGPRR HGLPGVGVTT SLRPPHHFSA PCFVAALPAV GAAEAPARLS
1810 1820 1830 1840 1850
PSIPLEALRD KALRMLGEAV RDGGQHARDP VGGSVEFQFV PVLKLVSTLL
1860 1870 1880 1890 1900
VMGIFGDEDV KQILKMIEPE VFTEEEEEEE EEEEEEEEDE EEKEEDEEEE
1910 1920 1930 1940 1950
AREKEDEEKE EEETAEGEKE EYLEEGLLQM KLPESVKLQM CNLLEYFCDQ
1960 1970 1980 1990 2000
ELQHRVESLA AFAERYVDKL QANQRDRYGI LMKAFTMTAA ETARRTREFR
2010 2020 2030 2040 2050
SPPQEQINML LHFKDGEDEE DCPLPDEIRQ DLLEFHQDLL THCGIQLEGE
2060 2070 2080 2090 2100
EEEPEEEATL GSRLMSLLEK VRLVKKKEEK SEEEPPAEES KPQSLQELVS
2110 2120 2130 2140 2150
HTVVRWAQED FVQSPELVRA MFSLLHRQYD GLGELLRALP RAYTISPSSV
2160 2170 2180 2190 2200
EDTMSLLECL GQIRSLLIVQ MGPQEENLMI QSIGNIMNNK VFYQHPNLMR
2210 2220 2230 2240 2250
ALGMHETVME VMVNVLGGGE SKEIRFPKMV TSCCRFLCYF CRISRQNQRS
2260 2270 2280 2290 2300
MFDHLSYLLE NSGIGLGMQG STPLDVAAAS VIDNNELALA LQEQDLEKVV
2310 2320 2330 2340 2350
SYLAGCGLQS CPMLLAKGYP DIGWNPCGGE RYLDFLRFAV FVNGESVEEN
2360 2370 2380 2390 2400
ANVVVRLLIR KPECFGPALR GEGGSGLLAT IEEAIRISED PARDGPGVRR
2410 2420 2430 2440 2450
DRRREHFGEE PPEENRVHLG HAIMSFYAAL IDLLGRCAPE MHLIQAGKGE
2460 2470 2480 2490 2500
ALRIRAILRS LVPLDDLVGI ISLPLQIPTL GKDGALVQPK MSASFVPDHK
2510 2520 2530 2540 2550
ASMVLFLDRV YGIENQDFLL HVLDVGFLPD MRAAASLDTA TFSTTEMALA
2560 2570 2580 2590 2600
LNRYLCLAVL PLITKCAPLF AGTEHRAIMV DSMLHTVYRL SRGRSLTKAQ
2610 2620 2630 2640 2650
RDVIEECLMA LCRYIRPSML QHLLRRLVFD VPILNEFAKM PLKLLTNHYE
2660 2670 2680 2690 2700
RCWKYYCLPT GWANFGVTSE EELHLTRKLF WGIFDSLAHK KYDPELYRMA
2710 2720 2730 2740 2750
MPCLCAIAGA LPPDYVDASY SSKAEKKATV DAEGNFDPRP VETLNVIIPE
2760 2770 2780 2790 2800
KLDSFINKFA EYTHEKWAFD KIQNNWSYGE NIDEELKTHP MLRPYKTFSE
2810 2820 2830 2840 2850
KDKEIYRWPI KESLKAMIAW EWTIEKAREG EEEKTEKKKT RKISQSAQTY
2860 2870 2880 2890 2900
DAREGYNPQP PDLSGVTLSR ELQAMAEQLA ENYHNTWGRK KKQELEAKGG
2910 2920 2930 2940 2950
GTHPLLVPYD TLTAKEKARD REKAQELLKF LQMNGYAVTR GLKDMELDTS
2960 2970 2980 2990 3000
SIEKRFAFGF LQQLLRWMDI SQEFIAHLEA VVSSGRVEKS PHEQEIKFFA
3010 3020 3030 3040 3050
KILLPLINQY FTNHCLYFLS TPAKVLGSGG HASNKEKEMI TSLFCKLAAL
3060 3070 3080 3090 3100
VRHRVSLFGT DAPAVVNCLH ILARSLDART VMKSGPEIVK AGLRSFFESA
3110 3120 3130 3140 3150
SEDIEKMVEN LRLGKVSQAR TQVKGVGQNL TYTTVALLPV LTTLFQHIAQ
3160 3170 3180 3190 3200
HQFGDDVILD DVQVSCYRTL CSIYSLGTTR NPYVEKLRPA LGECLARLAA
3210 3220 3230 3240 3250
AMPVAFLEPQ LNEYNACSVY TTKSPRERAI LGLPNSVEEM CPDIPVLERL
3260 3270 3280 3290 3300
MADIGGLAES GARYTEMPHV IEITLPMLCS YLPRWWERGP EAPPPALPAG
3310 3320 3330 3340 3350
APPPCTAVTS DHLNSLLGNI LRIIVNNLGI DEASWMKRLA VFAQPIVSRA
3360 3370 3380 3390 3400
RPELLHSHFI PTIGRLRKRA GKVVAEEEQL RLEAKAEAEE GELLVRDEFS
3410 3420 3430 3440 3450
VLCRDLYALY PLLIRYVDNN RAHWLTEPNP SAEELFRMVG EIFIYWSKSH
3460 3470 3480 3490 3500
NFKREEQNFV VQNEINNMSF LTADNKSKMA KSGGSDQERT KKKRRGDRYS
3510 3520 3530 3540 3550
VQTSLIVATL KKMLPIGLNM CAPTDQELIT LAKTRYALKD TDEEVREFLQ
3560 3570 3580 3590 3600
NNLHLQGKVE GSPSLRWQMA LYRGLPGREE DADDPEKIVR RVQEVSAVLY
3610 3620 3630 3640 3650
HLEQMEHPYK SKKAVWHKLL SKQRRRAVVA CFRMTPLYNL PTHRACNMFL
3660 3670 3680 3690 3700
ESYKAAWILT EDHSFEDRMI DDLSKAGEQE EEEEEVEEKK PDPLHQLVLH
3710 3720 3730 3740 3750
FSRTALTEKS KLDEDYLYMA YADIMAKSCH LEEGGENGEA QEEVEVSFEE
3760 3770 3780 3790 3800
KEMEKQRLLY QQARLHNRGA AEMVLQMISA CKGETGAMVS STLKLGISIL
3810 3820 3830 3840 3850
NGGNADVQQK MLDYLKDKKE VGFFQSIQAL MQTCSVLDLN AFERQNKAEG
3860 3870 3880 3890 3900
LGMVNEDGTV INRQNGEKVM ADDEFTQDLF RFLQLLCEGH NNDFQNYLRT
3910 3920 3930 3940 3950
QTGNTTTINI IICTVDYLLR LQESISDFYW YYSGKDVIEE QGKRNFSKAM
3960 3970 3980 3990 4000
SVAKQVFNSL TEYIQGPCTG NQQSLAHSRL WDAVVGFLHV FAHMMMKLAQ
4010 4020 4030 4040 4050
DSSQIELLKE LLDLQKDMVV MLLSLLEGNV VNGMIARQMV DMLVESSSNV
4060 4070 4080 4090 4100
EMILKFFDMF LKLKDIVGSE AFQDYVTDPR GLISKKDFQK AMDSQKQFTG
4110 4120 4130 4140 4150
PEIQFLLSCS EADENEMIDC EEFANRFQEP ARDIGFNVAV LLTNLSEHVP
4160 4170 4180 4190 4200
HDPRLRNFLE LAENILEYFR PYLGRIEIMG ASGRIERIYF EISETNRAQW
4210 4220 4230 4240 4250
EMPQVKESKR QFIFDVVNEG GESEKMELFV SFCEDTIFEM QIAAQISEPE
4260 4270 4280 4290 4300
GEPEEDEDEG AGLAEAGAEG AEEGAVGPEG AAGTAAAGLT ARLAAATSRA
4310 4320 4330 4340 4350
LRGLSYRSLR RRVRRLRRLT AREAATALAA LLWAALAHAG AAGAGAAAGA
4360 4370 4380 4390 4400
LRLLWGSLFG GGLVEGAKKV TVTELLAGMP DPTGDEVHGE QPAGPGGEAD
4410 4420 4430 4440 4450
GEGAGEGAGE ALEGAGDEEV AVQEAGPGGA DGAVAVAEGG PFRPEGAGGL
4460 4470 4480 4490 4500
GDMGDTTPAE PPTPEGSPII KRKLGVDGEE EELPPEPEPE PEPEPEKADA
4510 4520 4530 4540 4550
ENGEKEEVPK PPPEPPKKTA PPPPPPKKEE GGSGGLEFWG ELEVQRVKFL
4560 4570 4580 4590 4600
NYLSRNFYTL RFLALFLAFA INFILLFYKV SDSPPGEDDM EGSAAGDLSG
4610 4620 4630 4640 4650
AGSGGGSGWG SGAGEEVEGD EDENMVYYFL EESTGYMEPA LRCLSLLHTL
4660 4670 4680 4690 4700
VAFLCIIGYN CLKVPLVIFK REKELARKLE FDGLYITEQP EDDDVKGQWD
4710 4720 4730 4740 4750
RLVLNTPSFP SNYWDKFVKR KVLDKHGDIY GRERIAELLG MDLATLEITA
4760 4770 4780 4790 4800
HNERKPEPPP GLLTWLMSID VKYQIWKFGV IFTDNSFLYL GWYMVMSLLG
4810 4820 4830 4840 4850
HYNNFFFAAH LLDIAMGVKT LRTILSSVTH NGKQLVMTVG LLAVVVYLYT
4860 4870 4880 4890 4900
VVAFNFFRKF YNKSEDEDEP DMKCDDMMTC YLFHMYVGVR AGGGIGDEIE
4910 4920 4930 4940 4950
DPAGDEYELY RVVFDITFFF FVIVILLAII QGLIIDAFGE LRDQQEQVRE
4960 4970 4980 4990 5000
DMETKCFICG IGSDYFDTTP HGFETHTLEE HNLANYMFFL MYLINKDETE
5010 5020 5030
HTGQESYVWK MYQERCWDFF PAGDCFRKQY EDQLS
Length:5,035
Mass (Da):565,157
Last modified:November 1, 1996 - v1
Checksum:iDE32C45B5D093A88
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M91452 mRNA. Translation: AAA31119.1.
PIRiI46646.
RefSeqiNP_001001534.1. NM_001001534.1.
UniGeneiSsc.8.

Genome annotation databases

GeneIDi396718.
KEGGissc:396718.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M91452 mRNA. Translation: AAA31119.1.
PIRiI46646.
RefSeqiNP_001001534.1. NM_001001534.1.
UniGeneiSsc.8.

3D structure databases

ProteinModelPortaliQ29105.
SMRiQ29105. Positions 3610-3636.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000003203.

Proteomic databases

PaxDbiQ29105.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi396718.
KEGGissc:396718.

Organism-specific databases

CTDi6261.

Phylogenomic databases

eggNOGiKOG2243. Eukaryota.
ENOG410YCNW. LUCA.
HOVERGENiHBG006699.
KOiK04961.

Gene expression databases

GenevisibleiQ29105. SS.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
1.25.10.30. 1 hit.
InterProiIPR001870. B30.2/SPRY.
IPR013320. ConA-like_dom.
IPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
IPR014821. Ins145_P3_rcpt.
IPR005821. Ion_trans_dom.
IPR016093. MIR_motif.
IPR013662. RIH_assoc-dom.
IPR000699. RIH_dom.
IPR013333. Ryan_recept.
IPR003032. Ryanodine_rcpt.
IPR015925. Ryanodine_recept-rel.
IPR009460. Ryanrecept_TM4-6.
IPR033215. RyR1.
IPR003877. SPRY_dom.
[Graphical view]
PANTHERiPTHR13715. PTHR13715. 6 hits.
PTHR13715:SF15. PTHR13715:SF15. 6 hits.
PfamiPF13833. EF-hand_8. 1 hit.
PF08709. Ins145_P3_rec. 1 hit.
PF00520. Ion_trans. 1 hit.
PF02815. MIR. 1 hit.
PF08454. RIH_assoc. 1 hit.
PF06459. RR_TM4-6. 1 hit.
PF01365. RYDR_ITPR. 2 hits.
PF02026. RyR. 4 hits.
PF00622. SPRY. 3 hits.
[Graphical view]
PRINTSiPR00795. RYANODINER.
SMARTiSM00472. MIR. 4 hits.
SM00449. SPRY. 3 hits.
[Graphical view]
SUPFAMiSSF100909. SSF100909. 2 hits.
SSF47473. SSF47473. 1 hit.
SSF49899. SSF49899. 3 hits.
SSF82109. SSF82109. 2 hits.
PROSITEiPS50188. B302_SPRY. 3 hits.
PS50919. MIR. 5 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ29105_PIG
AccessioniPrimary (citable) accession number: Q29105
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: September 7, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.