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Protein
Submitted name:

Interleukin 1-beta

Gene

interleukin 1-beta

Organism
Sus scrofa (Pig)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production.UniRule annotation

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

CytokineUniRule annotationSAAS annotation, MitogenUniRule annotation, PyrogenUniRule annotation

Keywords - Biological processi

Inflammatory response

Names & Taxonomyi

Protein namesi
Submitted name:
Interleukin 1-betaImported
Gene namesi
Name:interleukin 1-betaImported
OrganismiSus scrofa (Pig)Imported
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus

Subcellular locationi

  • Secreted SAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

SecretedSAAS annotation

PTM / Processingi

Proteomic databases

PaxDbiQ29082.

Expressioni

Gene expression databases

GenevisibleiQ29082. SS.

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000008635.

Structurei

3D structure databases

ProteinModelPortaliQ29082.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 101IL1_propepInterPro annotationAdd BLAST101

Sequence similaritiesi

Belongs to the IL-1 family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG410IGSZ. Eukaryota.
ENOG410XU2E. LUCA.
HOVERGENiHBG007328.

Family and domain databases

InterProiIPR008996. Cytokine_IL1-like.
IPR003294. IL-1_alpha/beta.
IPR003296. IL-1_beta.
IPR020877. IL-1_CS.
IPR000975. IL-1_fam.
IPR028142. IL-1_fam/FGF_fam.
IPR003502. IL-1_propep.
[Graphical view]
PANTHERiPTHR10078:SF20. PTHR10078:SF20. 1 hit.
PfamiPF00340. IL1. 1 hit.
PF02394. IL1_propep. 1 hit.
[Graphical view]
PRINTSiPR00262. IL1HBGF.
PR00264. INTERLEUKIN1.
PR01357. INTRLEUKN1AB.
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiPS00253. INTERLEUKIN_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q29082-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATVPEPAKE VMANNGDNNN DLLFEADGPK EMKCRTQNLD LSPLGDGSIQ
60 70 80 90 100
LQISHQLCNE SSRPMVSVIV AKEEPMNPSS QVVCDDDPKS IFSSVFEEEP
110 120 130 140 150
IVLEKHANGF LCDATPVQSV DCKLQDKDEK ALVLAGPHEL KALHLLKGDL
160 170 180 190 200
KREVVFCMSF VQGDDSDDKI PVTLGIKGKN LYLSCVMKDD TPTLQLEDVD
210 220 230 240 250
PKSYPKRDME KRFVFYKTEI KNRVEFESAL YPNWYISTSQ AEQKPVFLGN
260
SKGRQDITDF TMEVLSP
Length:267
Mass (Da):29,893
Last modified:November 1, 1996 - v1
Checksum:i4830645DA5FF9967
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X74568 Genomic DNA. Translation: CAA52660.1.
PIRiS38373.
RefSeqiNP_001005149.1. NM_001005149.1.
UniGeneiSsc.28829.
Ssc.95937.

Genome annotation databases

GeneIDi396565.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X74568 Genomic DNA. Translation: CAA52660.1.
PIRiS38373.
RefSeqiNP_001005149.1. NM_001005149.1.
UniGeneiSsc.28829.
Ssc.95937.

3D structure databases

ProteinModelPortaliQ29082.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000008635.

Proteomic databases

PaxDbiQ29082.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi396565.

Organism-specific databases

CTDi396565.

Phylogenomic databases

eggNOGiENOG410IGSZ. Eukaryota.
ENOG410XU2E. LUCA.
HOVERGENiHBG007328.

Gene expression databases

GenevisibleiQ29082. SS.

Family and domain databases

InterProiIPR008996. Cytokine_IL1-like.
IPR003294. IL-1_alpha/beta.
IPR003296. IL-1_beta.
IPR020877. IL-1_CS.
IPR000975. IL-1_fam.
IPR028142. IL-1_fam/FGF_fam.
IPR003502. IL-1_propep.
[Graphical view]
PANTHERiPTHR10078:SF20. PTHR10078:SF20. 1 hit.
PfamiPF00340. IL1. 1 hit.
PF02394. IL1_propep. 1 hit.
[Graphical view]
PRINTSiPR00262. IL1HBGF.
PR00264. INTERLEUKIN1.
PR01357. INTRLEUKN1AB.
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiPS00253. INTERLEUKIN_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ29082_PIG
AccessioniPrimary (citable) accession number: Q29082
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: October 5, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.