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Protein
Submitted name:

Interleukin 1-beta

Gene

interleukin 1-beta

Organism
Sus scrofa (Pig)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production.UniRule annotation

Miscellaneous

IL1B production occurs in 2 steps, each being controlled by different stimuli. First, inflammatory signals, such as LPS, stimulate the synthesis and promote the accumulation of cytosolic stores of pro-IL1B (priming). Then additional signals are required for inflammasome assembly, leading to CASP1 activation, pro-IL1B processing and eventually secretion of the active cytokine. IL1B processing and secretion are temporarily associated.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokineUniRule annotationSAAS annotation, MitogenUniRule annotation, PyrogenUniRule annotation
Biological processInflammatory response

Names & Taxonomyi

Protein namesi
Submitted name:
Interleukin 1-betaImported
Gene namesi
Name:interleukin 1-betaImported
Synonyms:IL1BUniRule annotation
OrganismiSus scrofa (Pig)Imported
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

CytoplasmUniRule annotation, Cytoplasmic vesicleUniRule annotation, LysosomeUniRule annotation, SecretedUniRule annotationSAAS annotation

Expressioni

Gene expression databases

GenevisibleiQ29082 SS

Interactioni

Subunit structurei

Monomer. Interacts with MEFV.UniRule annotation

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ29082
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 101IL1_propepInterPro annotationAdd BLAST101

Sequence similaritiesi

Belongs to the IL-1 family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG410IGSZ Eukaryota
ENOG410XU2E LUCA
HOVERGENiHBG007328

Family and domain databases

InterProiView protein in InterPro
IPR003296 IL-1_beta
IPR020877 IL-1_CS
IPR000975 IL-1_fam
IPR003502 IL-1_propep
IPR008996 IL1/FGF
PANTHERiPTHR44849 PTHR44849, 1 hit
PfamiView protein in Pfam
PF00340 IL1, 1 hit
PF02394 IL1_propep, 1 hit
PRINTSiPR00264 INTERLEUKIN1
SUPFAMiSSF50353 SSF50353, 1 hit
PROSITEiView protein in PROSITE
PS00253 INTERLEUKIN_1, 1 hit

Sequencei

Sequence statusi: Complete.

Q29082-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATVPEPAKE VMANNGDNNN DLLFEADGPK EMKCRTQNLD LSPLGDGSIQ
60 70 80 90 100
LQISHQLCNE SSRPMVSVIV AKEEPMNPSS QVVCDDDPKS IFSSVFEEEP
110 120 130 140 150
IVLEKHANGF LCDATPVQSV DCKLQDKDEK ALVLAGPHEL KALHLLKGDL
160 170 180 190 200
KREVVFCMSF VQGDDSDDKI PVTLGIKGKN LYLSCVMKDD TPTLQLEDVD
210 220 230 240 250
PKSYPKRDME KRFVFYKTEI KNRVEFESAL YPNWYISTSQ AEQKPVFLGN
260
SKGRQDITDF TMEVLSP
Length:267
Mass (Da):29,893
Last modified:November 1, 1996 - v1
Checksum:i4830645DA5FF9967
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X74568 Genomic DNA Translation: CAA52660.1
PIRiS38373
RefSeqiNP_001005149.1, NM_001005149.1
UniGeneiSsc.28829
Ssc.95937

Genome annotation databases

GeneIDi396565

Similar proteinsi

Entry informationi

Entry nameiQ29082_PIG
AccessioniPrimary (citable) accession number: Q29082
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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