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Protein

Pregnancy-associated glycoprotein 1

Gene
N/A
Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Appears to be proteolytically inactive.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei94PROSITE-ProRule annotation1
Active sitei277PROSITE-ProRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionAspartyl protease, Hydrolase, Protease

Protein family/group databases

MEROPSiA01.971.

Names & Taxonomyi

Protein namesi
Recommended name:
Pregnancy-associated glycoprotein 1 (EC:3.4.23.-)
Short name:
PAG 1
Short name:
PAG1
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000026106? – 389Pregnancy-associated glycoprotein 1
Signal peptidei1 – 15Sequence analysisAdd BLAST15
PropeptideiPRO_000002610516 – ?Activation peptideSequence analysis

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi79N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi107 ↔ 112By similarity
Glycosylationi130N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi268 ↔ 272By similarity
Disulfide bondi311 ↔ 345By similarity
Glycosylationi348N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PaxDbiQ29078.
PRIDEiQ29078.

Expressioni

Tissue specificityi

Expressed throughout the chorion, with the signal localized exclusively over the trophectoderm.

Developmental stagei

Expression was detected at day 15, coinciding with the beginning of implantation, and continued throughout gestation.

Interactioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000013930.

Structurei

3D structure databases

ProteinModelPortaliQ29078.
SMRiQ29078.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini76 – 386Peptidase A1PROSITE-ProRule annotationAdd BLAST311

Sequence similaritiesi

Belongs to the peptidase A1 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1339. Eukaryota.
ENOG410XNV7. LUCA.
HOGENOMiHOG000197681.
HOVERGENiHBG000482.

Family and domain databases

Gene3Di2.40.70.10. 2 hits.
InterProiView protein in InterPro
IPR001461. Aspartic_peptidase_A1.
IPR001969. Aspartic_peptidase_AS.
IPR012848. Aspartic_peptidase_N.
IPR033121. PEPTIDASE_A1.
IPR021109. Peptidase_aspartic_dom.
PANTHERiPTHR13683. PTHR13683. 1 hit.
PfamiView protein in Pfam
PF07966. A1_Propeptide. 1 hit.
PF00026. Asp. 1 hit.
PRINTSiPR00792. PEPSIN.
SUPFAMiSSF50630. SSF50630. 1 hit.
PROSITEiView protein in PROSITE
PS00141. ASP_PROTEASE. 1 hit.
PS51767. PEPTIDASE_A1. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q29078-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKWLVILGLV ALSECLVIIP LTKVKSIREN LREKDLLLNF LKEHPYNMIQ
60 70 80 90 100
KFGLKGSLCS PKISCLRLWN YLDMVYVGNI TIGTPPQLFS VIFDTASSDL
110 120 130 140 150
WVPSNQCHSR ACVTHRSFNP TLSSTFQSSN RTVKLAPHSG LVSGLLGYDT
160 170 180 190 200
VQIGRFKSEN QAFGLSQSEP VKELENAFFD GVLGLGYPSL AIQGTTPVFD
210 220 230 240 250
NLRKQGQIPE PVFALYLSTN TKKGSVLMIG GVDNNFFTGN LKWVPLSARN
260 270 280 290 300
YWQITLDRIT WRGVVVGCTR GCQAILDSGS AFLLGPSRQI SSIQKIIQAR
310 320 330 340 350
FIENEYQVRC CARTTLADFI FTINNVQYPV PARAYIRKGS TPRRCYSNFS
360 370 380
GGTESLGKEE TWILGEVFLR LYFTVFDRGQ NRIGLRIAV
Length:389
Mass (Da):43,533
Last modified:November 1, 1997 - v1
Checksum:i764A1D2C17A3F416
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L34360 Genomic DNA. Translation: AAA81530.1.
PIRiI46616.
UniGeneiSsc.15906.

Similar proteinsi

Entry informationi

Entry nameiPAG1_PIG
AccessioniPrimary (citable) accession number: Q29078
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: May 10, 2017
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families