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Q29076

- PO2F1_PIG

UniProt

Q29076 - PO2F1_PIG

Protein

POU domain, class 2, transcription factor 1

Gene

POU2F1

Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi381 – 44060HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    POU domain, class 2, transcription factor 1
    Alternative name(s):
    NF-A1
    Octamer-binding protein 1
    Short name:
    Oct-1
    Octamer-binding transcription factor 1
    Short name:
    OTF-1
    Gene namesi
    Name:POU2F1
    Synonyms:OTF1
    OrganismiSus scrofa (Pig)
    Taxonomic identifieri9823 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
    ProteomesiUP000008227: Unplaced

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 745745POU domain, class 2, transcription factor 1PRO_0000100710Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei270 – 2701PhosphothreonineBy similarity
    Modified residuei283 – 2831PhosphoserineBy similarity
    Modified residuei387 – 3871PhosphoserineBy similarity
    Modified residuei450 – 4501PhosphoserineBy similarity

    Post-translational modificationi

    Phosphorylated by PRKDC.By similarity

    Keywords - PTMi

    Phosphoprotein

    Interactioni

    Subunit structurei

    Interacts with NR3C1, AR, PGR and HCFC1.By similarity

    Protein-protein interaction databases

    STRINGi9823.ENSSSCP00000006729.

    Structurei

    3D structure databases

    ProteinModelPortaliQ29076.
    SMRiQ29076. Positions 281-441.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini280 – 35475POU-specificPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi574 – 5785Poly-Ala
    Compositional biasi592 – 5987Poly-Ala
    Compositional biasi697 – 7026Poly-Ala

    Sequence similaritiesi

    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation
    Contains 1 POU-specific domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG267922.
    HOGENOMiHOG000220842.
    HOVERGENiHBG057016.
    KOiK09364.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    1.10.260.40. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR010982. Lambda_DNA-bd_dom.
    IPR013847. POU.
    IPR000327. POU_specific.
    IPR000972. TF_octamer.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    PF00157. Pou. 1 hit.
    [Graphical view]
    PRINTSiPR00029. OCTAMER.
    PR00028. POUDOMAIN.
    SMARTiSM00389. HOX. 1 hit.
    SM00352. POU. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    SSF47413. SSF47413. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    PS00035. POU_1. 1 hit.
    PS00465. POU_2. 1 hit.
    PS51179. POU_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q29076-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNNPSETSKP SMESGDSNTG TQTNGLDFQK QPVPVGGAIS TAQAQAFLGH    50
    LHQVQLAGTS LQAAAQSLNV QSKSNEESGD SQQPSQPSQQ PSVQAAIPQT 100
    QLMLAGGQIT GLTLTPAQQQ LLLQQAQAQA QLLAAAVQQH SASQQHSAAG 150
    ATISASAATP MTQIPLSQPI QIAQDLQQLQ QLQQQNLNLQ QFVLGHPTTN 200
    LQPAQFIISQ TPQGQQGLLQ AQNLLTQLPQ QSQANLLQSQ PSITLTSQPA 250
    TPTRTIAATP IQTLPQSQST PKRIDTPSLE EPSDLEELEQ FAKTFKQRRI 300
    KLGFTQGDVG LAMGKLYGND FSQTTISRFE ALNLSFKNMC KLKPLLEKWL 350
    NDAENLSSDS ALCSPSALNS PGLGVEGLNR RRKKRTSIET NIRVALEKSF 400
    LENQKPTSEE ITMIADQLNM EKEVIRVWFC NRRQKEKRIN PPSSGGTSSS 450
    PIKAIFPSPT SLVGTTPSLV TSSAATTLTV NPVLPLTSAA VTNLSVTGTT 500
    DTTSNNTATV ISTAPPASSA VTSPSLSPSP SASGSTSEVS SASETSTTQT 550
    TSTPLSSPLG TSQVMVTASG LQTAAAAALQ GAAQLPANAS LAAMAAAAGL 600
    NPGLMAPSQF AAGGALLSLN PGTLGGALSP ALMSNSTLAT IQALASGGSL 650
    PITSLDATGN LVFGNAGGAP NIVTAPLFLN PQNLSLLTSN PVSLVSAAAA 700
    SAGNSGPVAS LHATSTSAES IQNSLFTVAS ASGAASTTTT ASKAQ 745
    Length:745
    Mass (Da):76,596
    Last modified:November 1, 1996 - v1
    Checksum:i83564E9CC03741BA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L38524 mRNA. Translation: AAA93523.1.
    RefSeqiNP_999429.1. NM_214264.1.
    UniGeneiSsc.16253.

    Genome annotation databases

    GeneIDi397501.
    KEGGissc:397501.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L38524 mRNA. Translation: AAA93523.1 .
    RefSeqi NP_999429.1. NM_214264.1.
    UniGenei Ssc.16253.

    3D structure databases

    ProteinModelPortali Q29076.
    SMRi Q29076. Positions 281-441.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9823.ENSSSCP00000006729.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 397501.
    KEGGi ssc:397501.

    Organism-specific databases

    CTDi 5451.

    Phylogenomic databases

    eggNOGi NOG267922.
    HOGENOMi HOG000220842.
    HOVERGENi HBG057016.
    KOi K09364.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    1.10.260.40. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR010982. Lambda_DNA-bd_dom.
    IPR013847. POU.
    IPR000327. POU_specific.
    IPR000972. TF_octamer.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    PF00157. Pou. 1 hit.
    [Graphical view ]
    PRINTSi PR00029. OCTAMER.
    PR00028. POUDOMAIN.
    SMARTi SM00389. HOX. 1 hit.
    SM00352. POU. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    SSF47413. SSF47413. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    PS00035. POU_1. 1 hit.
    PS00465. POU_2. 1 hit.
    PS51179. POU_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and mapping of porcine OTF1 extends a synteny group conserved on SSC 4 and HSA 1."
      Tuggle C.K., Schmitz C.B., Wang L., Rothschild M.F.
      Mamm. Genome 6:673-676(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain and Spleen.

    Entry informationi

    Entry nameiPO2F1_PIG
    AccessioniPrimary (citable) accession number: Q29076
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 99 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3