Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q29076

- PO2F1_PIG

UniProt

Q29076 - PO2F1_PIG

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

POU domain, class 2, transcription factor 1

Gene

POU2F1

Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi381 – 44060HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro
  2. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
POU domain, class 2, transcription factor 1
Alternative name(s):
NF-A1
Octamer-binding protein 1
Short name:
Oct-1
Octamer-binding transcription factor 1
Short name:
OTF-1
Gene namesi
Name:POU2F1
Synonyms:OTF1
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
ProteomesiUP000008227: Unplaced

Subcellular locationi

Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 745745POU domain, class 2, transcription factor 1PRO_0000100710Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei270 – 2701PhosphothreonineBy similarity
Modified residuei283 – 2831PhosphoserineBy similarity
Modified residuei387 – 3871PhosphoserineBy similarity
Modified residuei450 – 4501PhosphoserineBy similarity

Post-translational modificationi

Phosphorylated by PRKDC.By similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Interacts with NR3C1, AR, PGR and HCFC1.By similarity

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000006729.

Structurei

3D structure databases

ProteinModelPortaliQ29076.
SMRiQ29076. Positions 281-441.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini280 – 35475POU-specificPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi574 – 5785Poly-Ala
Compositional biasi592 – 5987Poly-Ala
Compositional biasi697 – 7026Poly-Ala

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation
Contains 1 POU-specific domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG267922.
HOGENOMiHOG000220842.
HOVERGENiHBG057016.
InParanoidiQ29076.
KOiK09364.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_specific.
IPR000972. TF_octamer.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view]
PRINTSiPR00029. OCTAMER.
PR00028. POUDOMAIN.
SMARTiSM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q29076-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNNPSETSKP SMESGDSNTG TQTNGLDFQK QPVPVGGAIS TAQAQAFLGH
60 70 80 90 100
LHQVQLAGTS LQAAAQSLNV QSKSNEESGD SQQPSQPSQQ PSVQAAIPQT
110 120 130 140 150
QLMLAGGQIT GLTLTPAQQQ LLLQQAQAQA QLLAAAVQQH SASQQHSAAG
160 170 180 190 200
ATISASAATP MTQIPLSQPI QIAQDLQQLQ QLQQQNLNLQ QFVLGHPTTN
210 220 230 240 250
LQPAQFIISQ TPQGQQGLLQ AQNLLTQLPQ QSQANLLQSQ PSITLTSQPA
260 270 280 290 300
TPTRTIAATP IQTLPQSQST PKRIDTPSLE EPSDLEELEQ FAKTFKQRRI
310 320 330 340 350
KLGFTQGDVG LAMGKLYGND FSQTTISRFE ALNLSFKNMC KLKPLLEKWL
360 370 380 390 400
NDAENLSSDS ALCSPSALNS PGLGVEGLNR RRKKRTSIET NIRVALEKSF
410 420 430 440 450
LENQKPTSEE ITMIADQLNM EKEVIRVWFC NRRQKEKRIN PPSSGGTSSS
460 470 480 490 500
PIKAIFPSPT SLVGTTPSLV TSSAATTLTV NPVLPLTSAA VTNLSVTGTT
510 520 530 540 550
DTTSNNTATV ISTAPPASSA VTSPSLSPSP SASGSTSEVS SASETSTTQT
560 570 580 590 600
TSTPLSSPLG TSQVMVTASG LQTAAAAALQ GAAQLPANAS LAAMAAAAGL
610 620 630 640 650
NPGLMAPSQF AAGGALLSLN PGTLGGALSP ALMSNSTLAT IQALASGGSL
660 670 680 690 700
PITSLDATGN LVFGNAGGAP NIVTAPLFLN PQNLSLLTSN PVSLVSAAAA
710 720 730 740
SAGNSGPVAS LHATSTSAES IQNSLFTVAS ASGAASTTTT ASKAQ
Length:745
Mass (Da):76,596
Last modified:November 1, 1996 - v1
Checksum:i83564E9CC03741BA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L38524 mRNA. Translation: AAA93523.1.
RefSeqiNP_999429.1. NM_214264.1.
UniGeneiSsc.16253.

Genome annotation databases

GeneIDi397501.
KEGGissc:397501.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L38524 mRNA. Translation: AAA93523.1 .
RefSeqi NP_999429.1. NM_214264.1.
UniGenei Ssc.16253.

3D structure databases

ProteinModelPortali Q29076.
SMRi Q29076. Positions 281-441.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9823.ENSSSCP00000006729.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 397501.
KEGGi ssc:397501.

Organism-specific databases

CTDi 5451.

Phylogenomic databases

eggNOGi NOG267922.
HOGENOMi HOG000220842.
HOVERGENi HBG057016.
InParanoidi Q29076.
KOi K09364.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProi IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_specific.
IPR000972. TF_octamer.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view ]
PRINTSi PR00029. OCTAMER.
PR00028. POUDOMAIN.
SMARTi SM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEi PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and mapping of porcine OTF1 extends a synteny group conserved on SSC 4 and HSA 1."
    Tuggle C.K., Schmitz C.B., Wang L., Rothschild M.F.
    Mamm. Genome 6:673-676(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain and Spleen.

Entry informationi

Entry nameiPO2F1_PIG
AccessioniPrimary (citable) accession number: Q29076
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3