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Q29076

- PO2F1_PIG

UniProt

Q29076 - PO2F1_PIG

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Protein
POU domain, class 2, transcription factor 1
Gene
POU2F1, OTF1
Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi381 – 44060Homeobox
Add
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro
  2. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
POU domain, class 2, transcription factor 1
Alternative name(s):
NF-A1
Octamer-binding protein 1
Short name:
Oct-1
Octamer-binding transcription factor 1
Short name:
OTF-1
Gene namesi
Name:POU2F1
Synonyms:OTF1
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
ProteomesiUP000008227: Unplaced

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 745745POU domain, class 2, transcription factor 1
PRO_0000100710Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei270 – 2701Phosphothreonine By similarity
Modified residuei283 – 2831Phosphoserine By similarity
Modified residuei387 – 3871Phosphoserine By similarity
Modified residuei450 – 4501Phosphoserine By similarity

Post-translational modificationi

Phosphorylated by PRKDC By similarity.

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Interacts with NR3C1, AR, PGR and HCFC1 By similarity.

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000006729.

Structurei

3D structure databases

ProteinModelPortaliQ29076.
SMRiQ29076. Positions 281-441.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini280 – 35475POU-specific
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi574 – 5785Poly-Ala
Compositional biasi592 – 5987Poly-Ala
Compositional biasi697 – 7026Poly-Ala

Sequence similaritiesi

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG267922.
HOGENOMiHOG000220842.
HOVERGENiHBG057016.
KOiK09364.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_specific.
IPR000972. TF_octamer.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view]
PRINTSiPR00029. OCTAMER.
PR00028. POUDOMAIN.
SMARTiSM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q29076-1 [UniParc]FASTAAdd to Basket

« Hide

MNNPSETSKP SMESGDSNTG TQTNGLDFQK QPVPVGGAIS TAQAQAFLGH    50
LHQVQLAGTS LQAAAQSLNV QSKSNEESGD SQQPSQPSQQ PSVQAAIPQT 100
QLMLAGGQIT GLTLTPAQQQ LLLQQAQAQA QLLAAAVQQH SASQQHSAAG 150
ATISASAATP MTQIPLSQPI QIAQDLQQLQ QLQQQNLNLQ QFVLGHPTTN 200
LQPAQFIISQ TPQGQQGLLQ AQNLLTQLPQ QSQANLLQSQ PSITLTSQPA 250
TPTRTIAATP IQTLPQSQST PKRIDTPSLE EPSDLEELEQ FAKTFKQRRI 300
KLGFTQGDVG LAMGKLYGND FSQTTISRFE ALNLSFKNMC KLKPLLEKWL 350
NDAENLSSDS ALCSPSALNS PGLGVEGLNR RRKKRTSIET NIRVALEKSF 400
LENQKPTSEE ITMIADQLNM EKEVIRVWFC NRRQKEKRIN PPSSGGTSSS 450
PIKAIFPSPT SLVGTTPSLV TSSAATTLTV NPVLPLTSAA VTNLSVTGTT 500
DTTSNNTATV ISTAPPASSA VTSPSLSPSP SASGSTSEVS SASETSTTQT 550
TSTPLSSPLG TSQVMVTASG LQTAAAAALQ GAAQLPANAS LAAMAAAAGL 600
NPGLMAPSQF AAGGALLSLN PGTLGGALSP ALMSNSTLAT IQALASGGSL 650
PITSLDATGN LVFGNAGGAP NIVTAPLFLN PQNLSLLTSN PVSLVSAAAA 700
SAGNSGPVAS LHATSTSAES IQNSLFTVAS ASGAASTTTT ASKAQ 745
Length:745
Mass (Da):76,596
Last modified:November 1, 1996 - v1
Checksum:i83564E9CC03741BA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L38524 mRNA. Translation: AAA93523.1.
RefSeqiNP_999429.1. NM_214264.1.
UniGeneiSsc.16253.

Genome annotation databases

GeneIDi397501.
KEGGissc:397501.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L38524 mRNA. Translation: AAA93523.1 .
RefSeqi NP_999429.1. NM_214264.1.
UniGenei Ssc.16253.

3D structure databases

ProteinModelPortali Q29076.
SMRi Q29076. Positions 281-441.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9823.ENSSSCP00000006729.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 397501.
KEGGi ssc:397501.

Organism-specific databases

CTDi 5451.

Phylogenomic databases

eggNOGi NOG267922.
HOGENOMi HOG000220842.
HOVERGENi HBG057016.
KOi K09364.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProi IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_specific.
IPR000972. TF_octamer.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view ]
PRINTSi PR00029. OCTAMER.
PR00028. POUDOMAIN.
SMARTi SM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEi PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and mapping of porcine OTF1 extends a synteny group conserved on SSC 4 and HSA 1."
    Tuggle C.K., Schmitz C.B., Wang L., Rothschild M.F.
    Mamm. Genome 6:673-676(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain and Spleen.

Entry informationi

Entry nameiPO2F1_PIG
AccessioniPrimary (citable) accession number: Q29076
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: February 19, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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