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Protein

POU domain, class 2, transcription factor 1

Gene

POU2F1

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi381 – 440HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

  • DNA binding transcription factor activity Source: InterPro
  • sequence-specific DNA binding Source: AgBase

GO - Biological processi

  • negative regulation of transcription, DNA-templated Source: AgBase
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
POU domain, class 2, transcription factor 1
Alternative name(s):
NF-A1
Octamer-binding protein 1
Short name:
Oct-1
Octamer-binding transcription factor 1
Short name:
OTF-1
Gene namesi
Name:POU2F1
Synonyms:OTF1
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001007101 – 745POU domain, class 2, transcription factor 1Add BLAST745

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei270PhosphothreonineBy similarity1
Modified residuei276PhosphothreonineBy similarity1
Modified residuei283PhosphoserineBy similarity1
Modified residuei387PhosphoserineBy similarity1
Modified residuei450PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated by PRKDC.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ29076
PRIDEiQ29076

Interactioni

Subunit structurei

Interacts with NR3C1, AR, PGR and HCFC1.By similarity

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000006729

Structurei

3D structure databases

ProteinModelPortaliQ29076
SMRiQ29076
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini280 – 354POU-specificPROSITE-ProRule annotationAdd BLAST75

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi574 – 578Poly-Ala5
Compositional biasi592 – 598Poly-Ala7
Compositional biasi697 – 702Poly-Ala6

Sequence similaritiesi

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG3802 Eukaryota
ENOG410XQ7X LUCA
HOGENOMiHOG000220842
HOVERGENiHBG057016
InParanoidiQ29076
KOiK09364

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR010982 Lambda_DNA-bd_dom_sf
IPR013847 POU
IPR000327 POU_dom
IPR000972 TF_octamer
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PF00157 Pou, 1 hit
PRINTSiPR00029 OCTAMER
PR00028 POUDOMAIN
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SM00352 POU, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
SSF47413 SSF47413, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
PS00035 POU_1, 1 hit
PS00465 POU_2, 1 hit
PS51179 POU_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q29076-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNNPSETSKP SMESGDSNTG TQTNGLDFQK QPVPVGGAIS TAQAQAFLGH
60 70 80 90 100
LHQVQLAGTS LQAAAQSLNV QSKSNEESGD SQQPSQPSQQ PSVQAAIPQT
110 120 130 140 150
QLMLAGGQIT GLTLTPAQQQ LLLQQAQAQA QLLAAAVQQH SASQQHSAAG
160 170 180 190 200
ATISASAATP MTQIPLSQPI QIAQDLQQLQ QLQQQNLNLQ QFVLGHPTTN
210 220 230 240 250
LQPAQFIISQ TPQGQQGLLQ AQNLLTQLPQ QSQANLLQSQ PSITLTSQPA
260 270 280 290 300
TPTRTIAATP IQTLPQSQST PKRIDTPSLE EPSDLEELEQ FAKTFKQRRI
310 320 330 340 350
KLGFTQGDVG LAMGKLYGND FSQTTISRFE ALNLSFKNMC KLKPLLEKWL
360 370 380 390 400
NDAENLSSDS ALCSPSALNS PGLGVEGLNR RRKKRTSIET NIRVALEKSF
410 420 430 440 450
LENQKPTSEE ITMIADQLNM EKEVIRVWFC NRRQKEKRIN PPSSGGTSSS
460 470 480 490 500
PIKAIFPSPT SLVGTTPSLV TSSAATTLTV NPVLPLTSAA VTNLSVTGTT
510 520 530 540 550
DTTSNNTATV ISTAPPASSA VTSPSLSPSP SASGSTSEVS SASETSTTQT
560 570 580 590 600
TSTPLSSPLG TSQVMVTASG LQTAAAAALQ GAAQLPANAS LAAMAAAAGL
610 620 630 640 650
NPGLMAPSQF AAGGALLSLN PGTLGGALSP ALMSNSTLAT IQALASGGSL
660 670 680 690 700
PITSLDATGN LVFGNAGGAP NIVTAPLFLN PQNLSLLTSN PVSLVSAAAA
710 720 730 740
SAGNSGPVAS LHATSTSAES IQNSLFTVAS ASGAASTTTT ASKAQ
Length:745
Mass (Da):76,596
Last modified:November 1, 1996 - v1
Checksum:i83564E9CC03741BA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L38524 mRNA Translation: AAA93523.1
RefSeqiNP_999429.1, NM_214264.1
UniGeneiSsc.16253

Genome annotation databases

GeneIDi397501
KEGGissc:397501

Similar proteinsi

Entry informationi

Entry nameiPO2F1_PIG
AccessioniPrimary (citable) accession number: Q29076
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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