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Q29076 (PO2F1_PIG) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
POU domain, class 2, transcription factor 1
Alternative name(s):
NF-A1
Octamer-binding protein 1
Short name=Oct-1
Octamer-binding transcription factor 1
Short name=OTF-1
Gene names
Name:POU2F1
Synonyms:OTF1
OrganismSus scrofa (Pig) [Reference proteome]
Taxonomic identifier9823 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus

Protein attributes

Sequence length745 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR By similarity.

Subunit structure

Interacts with NR3C1, AR, PGR and HCFC1 By similarity.

Subcellular location

Nucleus By similarity.

Post-translational modification

Phosphorylated by PRKDC By similarity.

Sequence similarities

Belongs to the POU transcription factor family. Class-2 subfamily.

Contains 1 homeobox DNA-binding domain.

Contains 1 POU-specific domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   DomainHomeobox
   LigandDNA-binding
   Molecular functionActivator
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processtranscription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionsequence-specific DNA binding

Inferred from electronic annotation. Source: InterPro

sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 745745POU domain, class 2, transcription factor 1
PRO_0000100710

Regions

Domain280 – 35475POU-specific
DNA binding381 – 44060Homeobox
Compositional bias574 – 5785Poly-Ala
Compositional bias592 – 5987Poly-Ala
Compositional bias697 – 7026Poly-Ala

Amino acid modifications

Modified residue2701Phosphothreonine By similarity
Modified residue2831Phosphoserine By similarity
Modified residue3871Phosphoserine By similarity
Modified residue4501Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q29076 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 83564E9CC03741BA

FASTA74576,596
        10         20         30         40         50         60 
MNNPSETSKP SMESGDSNTG TQTNGLDFQK QPVPVGGAIS TAQAQAFLGH LHQVQLAGTS 

        70         80         90        100        110        120 
LQAAAQSLNV QSKSNEESGD SQQPSQPSQQ PSVQAAIPQT QLMLAGGQIT GLTLTPAQQQ 

       130        140        150        160        170        180 
LLLQQAQAQA QLLAAAVQQH SASQQHSAAG ATISASAATP MTQIPLSQPI QIAQDLQQLQ 

       190        200        210        220        230        240 
QLQQQNLNLQ QFVLGHPTTN LQPAQFIISQ TPQGQQGLLQ AQNLLTQLPQ QSQANLLQSQ 

       250        260        270        280        290        300 
PSITLTSQPA TPTRTIAATP IQTLPQSQST PKRIDTPSLE EPSDLEELEQ FAKTFKQRRI 

       310        320        330        340        350        360 
KLGFTQGDVG LAMGKLYGND FSQTTISRFE ALNLSFKNMC KLKPLLEKWL NDAENLSSDS 

       370        380        390        400        410        420 
ALCSPSALNS PGLGVEGLNR RRKKRTSIET NIRVALEKSF LENQKPTSEE ITMIADQLNM 

       430        440        450        460        470        480 
EKEVIRVWFC NRRQKEKRIN PPSSGGTSSS PIKAIFPSPT SLVGTTPSLV TSSAATTLTV 

       490        500        510        520        530        540 
NPVLPLTSAA VTNLSVTGTT DTTSNNTATV ISTAPPASSA VTSPSLSPSP SASGSTSEVS 

       550        560        570        580        590        600 
SASETSTTQT TSTPLSSPLG TSQVMVTASG LQTAAAAALQ GAAQLPANAS LAAMAAAAGL 

       610        620        630        640        650        660 
NPGLMAPSQF AAGGALLSLN PGTLGGALSP ALMSNSTLAT IQALASGGSL PITSLDATGN 

       670        680        690        700        710        720 
LVFGNAGGAP NIVTAPLFLN PQNLSLLTSN PVSLVSAAAA SAGNSGPVAS LHATSTSAES 

       730        740 
IQNSLFTVAS ASGAASTTTT ASKAQ 

« Hide

References

[1]"Cloning and mapping of porcine OTF1 extends a synteny group conserved on SSC 4 and HSA 1."
Tuggle C.K., Schmitz C.B., Wang L., Rothschild M.F.
Mamm. Genome 6:673-676(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain and Spleen.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L38524 mRNA. Translation: AAA93523.1.
RefSeqNP_999429.1. NM_214264.1.
UniGeneSsc.16253.

3D structure databases

ProteinModelPortalQ29076.
SMRQ29076. Positions 281-441.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9823.ENSSSCP00000006729.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID397501.
KEGGssc:397501.

Organism-specific databases

CTD5451.

Phylogenomic databases

eggNOGNOG267922.
HOGENOMHOG000220842.
HOVERGENHBG057016.
KOK09364.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_specific.
IPR000972. TF_octamer.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view]
PRINTSPR00029. OCTAMER.
PR00028. POUDOMAIN.
SMARTSM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePO2F1_PIG
AccessionPrimary (citable) accession number: Q29076
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: February 19, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families