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Protein

Interleukin-10

Gene

IL10

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine

Enzyme and pathway databases

ReactomeiR-SSC-6783783 Interleukin-10 signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-10
Short name:
IL-10
Alternative name(s):
Cytokine synthesis inhibitory factor
Short name:
CSIF
Gene namesi
Name:IL10
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000001537019 – 175Interleukin-10Add BLAST157

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi26 ↔ 122By similarity
Disulfide bondi76 ↔ 128By similarity
Glycosylationi130N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ29055
PRIDEiQ29055

Expressioni

Gene expression databases

BgeeiENSSSCG00000015652
ExpressionAtlasiQ29055 baseline and differential
GenevisibleiQ29055 SS

Interactioni

Subunit structurei

Homodimer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000016594

Structurei

3D structure databases

ProteinModelPortaliQ29055
SMRiQ29055
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-10 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IYFW Eukaryota
ENOG4111PXC LUCA
GeneTreeiENSGT00510000048535
HOGENOMiHOG000072692
HOVERGENiHBG004110
InParanoidiQ29055
KOiK05443
OMAiPHMLREL
OrthoDBiEOG091G0Y3M
TreeFamiTF333253

Family and domain databases

InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR000098 IL-10
IPR020443 IL-10/19/20/22/24/26_fam
IPR020423 IL-10_CS
PfamiView protein in Pfam
PF00726 IL10, 1 hit
PRINTSiPR01294 INTRLEUKIN10
SMARTiView protein in SMART
SM00188 IL10, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit
PROSITEiView protein in PROSITE
PS00520 INTERLEUKIN_10, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q29055-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSSALLYCL IFLAGVAASI KSENSCIHFP TSLPHMLREL RAAFGPVKSF
60 70 80 90 100
FQTKDQMGDL LLTGSLLEDF KGYLGCQALS EMIQFYLEDV MPKAESDGED
110 120 130 140 150
IKEHVNSLGE KLKTLRLRLR RCHQFLPCEN KSKAVEEVKS AFSKLQERGV
160 170
YKAMGEFDIF INYIEAYMTM KMRKN
Length:175
Mass (Da):19,934
Last modified:November 1, 1996 - v1
Checksum:iDB85B9984C1570BF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L20001 mRNA Translation: AAA74410.1
PIRiI46591
RefSeqiNP_999206.1, NM_214041.1
UniGeneiSsc.148

Genome annotation databases

EnsembliENSSSCT00000017049; ENSSSCP00000016594; ENSSSCG00000015652
GeneIDi397106
KEGGissc:397106

Similar proteinsi

Entry informationi

Entry nameiIL10_PIG
AccessioniPrimary (citable) accession number: Q29055
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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