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Protein

Interleukin-12 subunit alpha

Gene

IL12A

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine, Growth factor

Enzyme and pathway databases

ReactomeiR-SSC-447115. Interleukin-12 family signaling.
R-SSC-8984722. Interleukin-35 Signalling.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-12 subunit alpha
Short name:
IL-12A
Alternative name(s):
Cytotoxic lymphocyte maturation factor 35 kDa subunit
Short name:
CLMF p35
IL-12 subunit p35
Gene namesi
Name:IL12A
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 13

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000001561026 – 222Interleukin-12 subunit alphaAdd BLAST197

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi42N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi67 ↔ 199By similarity
Disulfide bondi88 ↔ 126By similarity
Glycosylationi96N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi99Interchain (with C-195 in IL12B)By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ29053.
PRIDEiQ29053.

Expressioni

Gene expression databases

BgeeiENSSSCG00000011730.
GenevisibleiQ29053. SS.

Interactioni

Subunit structurei

Heterodimer with IL12B; disulfide-linked. The heterodimer is known as interleukin IL-12 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000012501.

Structurei

3D structure databases

ProteinModelPortaliQ29053.
SMRiQ29053.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-6 superfamily.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IVIR. Eukaryota.
ENOG410ZGHJ. LUCA.
GeneTreeiENSGT00390000016906.
HOGENOMiHOG000113026.
HOVERGENiHBG063691.
InParanoidiQ29053.
KOiK05406.
TreeFamiTF330814.

Family and domain databases

InterProiView protein in InterPro
IPR009079. 4_helix_cytokine-like_core.
IPR004281. IL-12_alpha.
PANTHERiPTHR45311. PTHR45311. 1 hit.
PfamiView protein in Pfam
PF03039. IL12. 1 hit.
SUPFAMiSSF47266. SSF47266. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q29053-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCPLRNLLLV ATLVLLNHLD HLSLGRSLPA TTAGPGMFKC LNHSQNLLKA
60 70 80 90 100
VSNTLQKAKQ TLEFYSCTSE EIDHEDITKD KTSTVEACLP LELATNESCL
110 120 130 140 150
AARETSLITN GNCLTSGKTS FMTTLCLSSI YEDLKMYHVE FQAMNAKLLM
160 170 180 190 200
DPKRQIFLDQ NMLTAITELM QALNFNSETV PQKPSLEELD FYKTKIKLCI
210 220
LLHAFRIRAV TIDRMMSYLN SS
Length:222
Mass (Da):24,945
Last modified:July 15, 1998 - v2
Checksum:i027D04411333AC94
GO

Sequence cautioni

The sequence AAA73897 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L35765 mRNA. Translation: AAA73897.1. Different initiation.
RefSeqiNP_999158.1. NM_213993.1.
UniGeneiSsc.13.

Genome annotation databases

EnsembliENSSSCT00000012840; ENSSSCP00000012500; ENSSSCG00000011730.
GeneIDi397053.
KEGGissc:397053.

Similar proteinsi

Entry informationi

Entry nameiIL12A_PIG
AccessioniPrimary (citable) accession number: Q29053
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: November 22, 2017
This is version 110 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families