Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ficolin-1

Gene

FCN1

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Extracellular lectin functioning as a pattern-recognition receptor in innate immunity. Binds the sugar moieties of pathogen-associated molecular patterns (PAMPs) displayed on microbes and activates the lectin pathway of the complement system. May also activate monocytes through a G protein-coupled receptor, FFAR2, inducing the secretion of interleukin-8/IL-8. Binds preferentially to 9-O-acetylated 2-6-linked sialic acid derivatives and to various glycans containing sialic acid engaged in a 2-3 linkage (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi262CalciumBy similarity1
Metal bindingi264CalciumBy similarity1
Sitei300Mediates specificity for sialic acidsBy similarity1
Sitei312Mediates specificity for sialic acidsBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Immunity, Innate immunity

Keywords - Ligandi

Calcium, Lectin, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ficolin-1
Alternative name(s):
Ficolin-A
Ficolin-alpha
Gene namesi
Name:FCN1
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Unplaced

Subcellular locationi

  • Secreted By similarity
  • Cell membrane By similarity; Peripheral membrane protein By similarity; Extracellular side By similarity

  • Note: Found on the monocyte and granulocyte surface.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29By similarityAdd BLAST29
ChainiPRO_000026957030 – 326Ficolin-1Add BLAST297

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi111 ↔ 139PROSITE-ProRule annotation
Disulfide bondi118 ↔ 146PROSITE-ProRule annotation
Glycosylationi265N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi270 ↔ 283PROSITE-ProRule annotation
Glycosylationi313N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ29042.
PeptideAtlasiQ29042.
PRIDEiQ29042.

Expressioni

Tissue specificityi

Most abundantly expressed in placenta and lung.1 Publication

Interactioni

Subunit structurei

Homotrimer. Interacts with elastin/ELN. Interacts (via Fibrinogen C-terminal domain) with FFAR2. Interacts with CRP; may regulate monocyte activation by FCN1.By similarity

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000023182.

Structurei

3D structure databases

ProteinModelPortaliQ29042.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini55 – 93Collagen-likeAdd BLAST39
Domaini109 – 326Fibrinogen C-terminalPROSITE-ProRule annotationAdd BLAST218

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni115 – 154A domain; contributes to trimerizationBy similarityAdd BLAST40
Regioni155 – 243B domain; contributes to trimerizationBy similarityAdd BLAST89
Regioni282 – 284Carbohydrate-bindingBy similarity3
Regioni317 – 326P domainBy similarity10

Domaini

The fibrinogen C-terminal domain mediates calcium-dependent binding to carbohydrates and tethering to the cell surface in monocytes and granulocytes. The domain undergoes a conformational switch at pH under 6.2, and looses its carbohydrate-binding ability.By similarity

Sequence similaritiesi

Belongs to the ficolin lectin family.Curated
Contains 1 collagen-like domain.Curated
Contains 1 fibrinogen C-terminal domain.PROSITE-ProRule annotation

Keywords - Domaini

Collagen, Repeat, Signal

Phylogenomic databases

eggNOGiKOG2579. Eukaryota.
ENOG410ZYS4. LUCA.
HOVERGENiHBG001644.
InParanoidiQ29042.
KOiK10104.

Family and domain databases

CDDicd00087. FReD. 1 hit.
Gene3Di3.90.215.10. 1 hit.
4.10.530.10. 1 hit.
InterProiIPR008160. Collagen.
IPR014716. Fibrinogen_a/b/g_C_1.
IPR014715. Fibrinogen_a/b/g_C_2.
IPR002181. Fibrinogen_a/b/g_C_dom.
IPR020837. Fibrinogen_CS.
[Graphical view]
PfamiPF01391. Collagen. 1 hit.
PF00147. Fibrinogen_C. 1 hit.
[Graphical view]
SMARTiSM00186. FBG. 1 hit.
[Graphical view]
SUPFAMiSSF56496. SSF56496. 1 hit.
PROSITEiPS00514. FIBRINOGEN_C_1. 1 hit.
PS51406. FIBRINOGEN_C_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q29042-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELSRVAVAL GPTGQLLLFL SFQTLAAQAA DTCPEVKVVG LEGSDKLSIL
60 70 80 90 100
RGCPGLPGAA GPKGEAGANG PKGERGSPGV VGKAGPAGPK GDRGEKGARG
110 120 130 140 150
EKGEPGQLQS CATGPRTCKE LLTRGHFLSG WHTIYLPDCQ PLTVLCDMDT
160 170 180 190 200
DGGGWTVFQR RSDGSVDFYR DWAAYKRGFG SQLGEFWLGN DHIHALTAQG
210 220 230 240 250
TSELRVDLVD FEGNHQFAKY RSFQVAGEAE KYKLVLGGFL EGNAGDSLSS
260 270 280 290 300
HRDQFFSTKD QDNDNHSGNC AEQYHGAWWY NACHSSNLNG RYLRGLHTSY
310 320
ANGVNWRSGR GYNYSYQVSE MKVRLT
Length:326
Mass (Da):35,246
Last modified:November 1, 1996 - v1
Checksum:i170A5E9EA1E8F310
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L12345 mRNA. Translation: AAC69641.1.
PIRiB47172.
RefSeqiNP_999325.1. NM_214160.2.
UniGeneiSsc.16008.

Genome annotation databases

GeneIDi397316.
KEGGissc:397316.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L12345 mRNA. Translation: AAC69641.1.
PIRiB47172.
RefSeqiNP_999325.1. NM_214160.2.
UniGeneiSsc.16008.

3D structure databases

ProteinModelPortaliQ29042.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000023182.

Proteomic databases

PaxDbiQ29042.
PeptideAtlasiQ29042.
PRIDEiQ29042.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi397316.
KEGGissc:397316.

Organism-specific databases

CTDi2219.

Phylogenomic databases

eggNOGiKOG2579. Eukaryota.
ENOG410ZYS4. LUCA.
HOVERGENiHBG001644.
InParanoidiQ29042.
KOiK10104.

Family and domain databases

CDDicd00087. FReD. 1 hit.
Gene3Di3.90.215.10. 1 hit.
4.10.530.10. 1 hit.
InterProiIPR008160. Collagen.
IPR014716. Fibrinogen_a/b/g_C_1.
IPR014715. Fibrinogen_a/b/g_C_2.
IPR002181. Fibrinogen_a/b/g_C_dom.
IPR020837. Fibrinogen_CS.
[Graphical view]
PfamiPF01391. Collagen. 1 hit.
PF00147. Fibrinogen_C. 1 hit.
[Graphical view]
SMARTiSM00186. FBG. 1 hit.
[Graphical view]
SUPFAMiSSF56496. SSF56496. 1 hit.
PROSITEiPS00514. FIBRINOGEN_C_1. 1 hit.
PS51406. FIBRINOGEN_C_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFCN1_PIG
AccessioniPrimary (citable) accession number: Q29042
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: November 1, 1996
Last modified: November 30, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.