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Q29042

- FCN1_PIG

UniProt

Q29042 - FCN1_PIG

Protein

Ficolin-1

Gene

FCN1

Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 68 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Complement-activating lectin and pattern recognition receptor. Binds GlcNAc. Binds preferentially to 9-O-acetylated 2-6-linked sialic acid derivatives and to various glycans containing sialic acid engaged in a 2-3 linkage By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi262 – 2621CalciumBy similarity
    Metal bindingi264 – 2641CalciumBy similarity
    Sitei300 – 3001Mediates specificity for sialic acidsBy similarity
    Sitei312 – 3121Mediates specificity for sialic acidsBy similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. innate immune response Source: UniProtKB-KW

    Keywords - Biological processi

    Immunity, Innate immunity

    Keywords - Ligandi

    Calcium, Lectin, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ficolin-1
    Alternative name(s):
    Ficolin-A
    Ficolin-alpha
    Gene namesi
    Name:FCN1
    OrganismiSus scrofa (Pig)
    Taxonomic identifieri9823 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
    ProteomesiUP000008227: Unplaced

    Subcellular locationi

    Secreted
    Note: Found on the monocyte and granulocyte surface.By similarity

    GO - Cellular componenti

    1. collagen trimer Source: UniProtKB-KW
    2. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2929By similarityAdd
    BLAST
    Chaini30 – 326297Ficolin-1PRO_0000269570Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi111 ↔ 139PROSITE-ProRule annotation
    Disulfide bondi118 ↔ 146PROSITE-ProRule annotation
    Glycosylationi265 – 2651N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi270 ↔ 283PROSITE-ProRule annotation
    Glycosylationi313 – 3131N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Expressioni

    Tissue specificityi

    Most abundantly expressed in placenta and lung.1 Publication

    Interactioni

    Subunit structurei

    Homotrimer By similarity. Interacts with elastin.By similarity1 Publication

    Structurei

    3D structure databases

    ProteinModelPortaliQ29042.
    SMRiQ29042. Positions 111-324.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini55 – 9339Collagen-likeAdd
    BLAST
    Domaini109 – 326218Fibrinogen C-terminalPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni115 – 15440A domain; contributes to trimerizationBy similarityAdd
    BLAST
    Regioni155 – 24389B domain; contributes to trimerizationBy similarityAdd
    BLAST
    Regioni282 – 2843Carbohydrate-bindingBy similarity
    Regioni317 – 32610P domainBy similarity

    Domaini

    The Fibrinogen C-terminal domain mediates calcium-dependent binding to carbohydrates and tethering to the cell surface in monocytes and granulocytes. The domain undergoes a conformational switch at pH under 6.2, and looses its carbohydrate-binding ability By similarity.By similarity

    Sequence similaritiesi

    Belongs to the ficolin lectin family.Curated
    Contains 1 collagen-like domain.Curated
    Contains 1 fibrinogen C-terminal domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Collagen, Repeat, Signal

    Phylogenomic databases

    HOVERGENiHBG001644.
    KOiK10104.

    Family and domain databases

    Gene3Di3.90.215.10. 1 hit.
    4.10.530.10. 1 hit.
    InterProiIPR008160. Collagen.
    IPR014716. Fibrinogen_a/b/g_C_1.
    IPR014715. Fibrinogen_a/b/g_C_2.
    IPR002181. Fibrinogen_a/b/g_C_dom.
    IPR020837. Fibrinogen_CS.
    [Graphical view]
    PfamiPF01391. Collagen. 1 hit.
    PF00147. Fibrinogen_C. 1 hit.
    [Graphical view]
    SMARTiSM00186. FBG. 1 hit.
    [Graphical view]
    SUPFAMiSSF56496. SSF56496. 1 hit.
    PROSITEiPS00514. FIBRINOGEN_C_1. 1 hit.
    PS51406. FIBRINOGEN_C_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q29042-1 [UniParc]FASTAAdd to Basket

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    MELSRVAVAL GPTGQLLLFL SFQTLAAQAA DTCPEVKVVG LEGSDKLSIL    50
    RGCPGLPGAA GPKGEAGANG PKGERGSPGV VGKAGPAGPK GDRGEKGARG 100
    EKGEPGQLQS CATGPRTCKE LLTRGHFLSG WHTIYLPDCQ PLTVLCDMDT 150
    DGGGWTVFQR RSDGSVDFYR DWAAYKRGFG SQLGEFWLGN DHIHALTAQG 200
    TSELRVDLVD FEGNHQFAKY RSFQVAGEAE KYKLVLGGFL EGNAGDSLSS 250
    HRDQFFSTKD QDNDNHSGNC AEQYHGAWWY NACHSSNLNG RYLRGLHTSY 300
    ANGVNWRSGR GYNYSYQVSE MKVRLT 326
    Length:326
    Mass (Da):35,246
    Last modified:November 1, 1996 - v1
    Checksum:i170A5E9EA1E8F310
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L12345 mRNA. Translation: AAC69641.1.
    PIRiB47172.
    RefSeqiNP_999325.1. NM_214160.2.
    UniGeneiSsc.16008.

    Genome annotation databases

    GeneIDi397316.
    KEGGissc:397316.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L12345 mRNA. Translation: AAC69641.1 .
    PIRi B47172.
    RefSeqi NP_999325.1. NM_214160.2.
    UniGenei Ssc.16008.

    3D structure databases

    ProteinModelPortali Q29042.
    SMRi Q29042. Positions 111-324.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 397316.
    KEGGi ssc:397316.

    Organism-specific databases

    CTDi 2219.

    Phylogenomic databases

    HOVERGENi HBG001644.
    KOi K10104.

    Family and domain databases

    Gene3Di 3.90.215.10. 1 hit.
    4.10.530.10. 1 hit.
    InterProi IPR008160. Collagen.
    IPR014716. Fibrinogen_a/b/g_C_1.
    IPR014715. Fibrinogen_a/b/g_C_2.
    IPR002181. Fibrinogen_a/b/g_C_dom.
    IPR020837. Fibrinogen_CS.
    [Graphical view ]
    Pfami PF01391. Collagen. 1 hit.
    PF00147. Fibrinogen_C. 1 hit.
    [Graphical view ]
    SMARTi SM00186. FBG. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56496. SSF56496. 1 hit.
    PROSITEi PS00514. FIBRINOGEN_C_1. 1 hit.
    PS51406. FIBRINOGEN_C_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and characterization of ficolin, a multimeric protein with fibrinogen- and collagen-like domains."
      Ichijo H., Hellman U., Wernstedt C., Gonez L.J., Claesson-Welsh L., Heldin C.H., Miyazono K.
      J. Biol. Chem. 268:14505-14513(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBUNIT, TISSUE SPECIFICITY.
      Tissue: Uterus.

    Entry informationi

    Entry nameiFCN1_PIG
    AccessioniPrimary (citable) accession number: Q29042
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 12, 2006
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 68 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3