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Protein

Ficolin-1

Gene

FCN1

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Complement-activating lectin and pattern recognition receptor. Binds GlcNAc. Binds preferentially to 9-O-acetylated 2-6-linked sialic acid derivatives and to various glycans containing sialic acid engaged in a 2-3 linkage (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi262 – 2621CalciumBy similarity
Metal bindingi264 – 2641CalciumBy similarity
Sitei300 – 3001Mediates specificity for sialic acidsBy similarity
Sitei312 – 3121Mediates specificity for sialic acidsBy similarity

GO - Molecular functioni

  1. carbohydrate binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. innate immune response Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Immunity, Innate immunity

Keywords - Ligandi

Calcium, Lectin, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ficolin-1
Alternative name(s):
Ficolin-A
Ficolin-alpha
Gene namesi
Name:FCN1
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
ProteomesiUP000008227 Componenti: Unplaced

Subcellular locationi

  1. Secreted

  2. Note: Found on the monocyte and granulocyte surface.By similarity

GO - Cellular componenti

  1. collagen trimer Source: UniProtKB-KW
  2. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929By similarityAdd
BLAST
Chaini30 – 326297Ficolin-1PRO_0000269570Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi111 ↔ 139PROSITE-ProRule annotation
Disulfide bondi118 ↔ 146PROSITE-ProRule annotation
Glycosylationi265 – 2651N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi270 ↔ 283PROSITE-ProRule annotation
Glycosylationi313 – 3131N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Expressioni

Tissue specificityi

Most abundantly expressed in placenta and lung.1 Publication

Interactioni

Subunit structurei

Homotrimer (By similarity). Interacts with elastin.By similarity1 Publication

Structurei

3D structure databases

SMRiQ29042. Positions 111-324.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini55 – 9339Collagen-likeAdd
BLAST
Domaini109 – 326218Fibrinogen C-terminalPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni115 – 15440A domain; contributes to trimerizationBy similarityAdd
BLAST
Regioni155 – 24389B domain; contributes to trimerizationBy similarityAdd
BLAST
Regioni282 – 2843Carbohydrate-bindingBy similarity
Regioni317 – 32610P domainBy similarity

Domaini

The Fibrinogen C-terminal domain mediates calcium-dependent binding to carbohydrates and tethering to the cell surface in monocytes and granulocytes. The domain undergoes a conformational switch at pH under 6.2, and looses its carbohydrate-binding ability (By similarity).By similarity

Sequence similaritiesi

Belongs to the ficolin lectin family.Curated
Contains 1 collagen-like domain.Curated
Contains 1 fibrinogen C-terminal domain.PROSITE-ProRule annotation

Keywords - Domaini

Collagen, Repeat, Signal

Phylogenomic databases

HOVERGENiHBG001644.
InParanoidiQ29042.
KOiK10104.

Family and domain databases

Gene3Di3.90.215.10. 1 hit.
4.10.530.10. 1 hit.
InterProiIPR008160. Collagen.
IPR014716. Fibrinogen_a/b/g_C_1.
IPR014715. Fibrinogen_a/b/g_C_2.
IPR002181. Fibrinogen_a/b/g_C_dom.
IPR020837. Fibrinogen_CS.
[Graphical view]
PfamiPF01391. Collagen. 1 hit.
PF00147. Fibrinogen_C. 1 hit.
[Graphical view]
SMARTiSM00186. FBG. 1 hit.
[Graphical view]
SUPFAMiSSF56496. SSF56496. 1 hit.
PROSITEiPS00514. FIBRINOGEN_C_1. 1 hit.
PS51406. FIBRINOGEN_C_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q29042-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELSRVAVAL GPTGQLLLFL SFQTLAAQAA DTCPEVKVVG LEGSDKLSIL
60 70 80 90 100
RGCPGLPGAA GPKGEAGANG PKGERGSPGV VGKAGPAGPK GDRGEKGARG
110 120 130 140 150
EKGEPGQLQS CATGPRTCKE LLTRGHFLSG WHTIYLPDCQ PLTVLCDMDT
160 170 180 190 200
DGGGWTVFQR RSDGSVDFYR DWAAYKRGFG SQLGEFWLGN DHIHALTAQG
210 220 230 240 250
TSELRVDLVD FEGNHQFAKY RSFQVAGEAE KYKLVLGGFL EGNAGDSLSS
260 270 280 290 300
HRDQFFSTKD QDNDNHSGNC AEQYHGAWWY NACHSSNLNG RYLRGLHTSY
310 320
ANGVNWRSGR GYNYSYQVSE MKVRLT
Length:326
Mass (Da):35,246
Last modified:November 1, 1996 - v1
Checksum:i170A5E9EA1E8F310
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L12345 mRNA. Translation: AAC69641.1.
PIRiB47172.
RefSeqiNP_999325.1. NM_214160.2.
UniGeneiSsc.16008.

Genome annotation databases

GeneIDi397316.
KEGGissc:397316.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L12345 mRNA. Translation: AAC69641.1.
PIRiB47172.
RefSeqiNP_999325.1. NM_214160.2.
UniGeneiSsc.16008.

3D structure databases

SMRiQ29042. Positions 111-324.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi397316.
KEGGissc:397316.

Organism-specific databases

CTDi2219.

Phylogenomic databases

HOVERGENiHBG001644.
InParanoidiQ29042.
KOiK10104.

Family and domain databases

Gene3Di3.90.215.10. 1 hit.
4.10.530.10. 1 hit.
InterProiIPR008160. Collagen.
IPR014716. Fibrinogen_a/b/g_C_1.
IPR014715. Fibrinogen_a/b/g_C_2.
IPR002181. Fibrinogen_a/b/g_C_dom.
IPR020837. Fibrinogen_CS.
[Graphical view]
PfamiPF01391. Collagen. 1 hit.
PF00147. Fibrinogen_C. 1 hit.
[Graphical view]
SMARTiSM00186. FBG. 1 hit.
[Graphical view]
SUPFAMiSSF56496. SSF56496. 1 hit.
PROSITEiPS00514. FIBRINOGEN_C_1. 1 hit.
PS51406. FIBRINOGEN_C_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning and characterization of ficolin, a multimeric protein with fibrinogen- and collagen-like domains."
    Ichijo H., Hellman U., Wernstedt C., Gonez L.J., Claesson-Welsh L., Heldin C.H., Miyazono K.
    J. Biol. Chem. 268:14505-14513(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBUNIT, TISSUE SPECIFICITY.
    Tissue: Uterus.

Entry informationi

Entry nameiFCN1_PIG
AccessioniPrimary (citable) accession number: Q29042
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: November 1, 1996
Last modified: April 1, 2015
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.