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Protein

Ficolin-2

Gene

FCN2

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc-binding lectin (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi259CalciumBy similarity1
Metal bindingi261CalciumBy similarity1
Metal bindingi265Calcium; via carbonyl oxygenBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Complement activation lectin pathway, Immunity, Innate immunity

Keywords - Ligandi

Calcium, Lectin, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ficolin-2
Alternative name(s):
Collagen/fibrinogen domain-containing protein 2
Ficolin-B
Ficolin-beta
L-ficolin
Gene namesi
Name:FCN2
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000026957127 – 323Ficolin-2Add BLAST297

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi108 ↔ 136By similarity
Disulfide bondi115 ↔ 143By similarity
Glycosylationi249N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi267 ↔ 280By similarity
Glycosylationi302N-linked (GlcNAc...)Sequence analysis1
Glycosylationi310N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ29041.
PeptideAtlasiQ29041.
PRIDEiQ29041.

Expressioni

Tissue specificityi

Mainly expressed in skeletal muscle.1 Publication

Interactioni

Subunit structurei

Homotrimer. Interacts with elastin. Interacts with MASP1 and MASP2.By similarity

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000019414.

Structurei

3D structure databases

ProteinModelPortaliQ29041.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini52 – 102Collagen-likeAdd BLAST51
Domaini106 – 323Fibrinogen C-terminalPROSITE-ProRule annotationAdd BLAST218

Domaini

The fibrinogen-like domain (FBG) contains calcium-binding sites that may be involved in carbohydrate binding.By similarity

Sequence similaritiesi

Belongs to the ficolin lectin family.Curated
Contains 1 collagen-like domain.Curated
Contains 1 fibrinogen C-terminal domain.PROSITE-ProRule annotation

Keywords - Domaini

Collagen, Repeat, Signal

Phylogenomic databases

eggNOGiKOG2579. Eukaryota.
ENOG410ZYS4. LUCA.
HOVERGENiHBG001644.
InParanoidiQ29041.
KOiK10104.

Family and domain databases

CDDicd00087. FReD. 1 hit.
Gene3Di3.90.215.10. 1 hit.
4.10.530.10. 1 hit.
InterProiIPR008160. Collagen.
IPR014716. Fibrinogen_a/b/g_C_1.
IPR014715. Fibrinogen_a/b/g_C_2.
IPR002181. Fibrinogen_a/b/g_C_dom.
IPR020837. Fibrinogen_CS.
[Graphical view]
PfamiPF01391. Collagen. 1 hit.
PF00147. Fibrinogen_C. 1 hit.
[Graphical view]
SMARTiSM00186. FBG. 1 hit.
[Graphical view]
SUPFAMiSSF56496. SSF56496. 1 hit.
PROSITEiPS00514. FIBRINOGEN_C_1. 1 hit.
PS51406. FIBRINOGEN_C_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q29041-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTRGVAAAM RPLVLLVAFL CTAAPALDTC PEVKVVGLEG SDKLSILRGC
60 70 80 90 100
PGLPGAAGPK GEAGASGPKG GQGPPGAPGE PGPPGPKGDR GEKGEPGPKG
110 120 130 140 150
ESWETEQCLT GPRTCKELLT RGHILSGWHT IYLPDCQPLT VLCDMDTDGG
160 170 180 190 200
GWTVFQRRSD GSVDFYRDWA AYKRGFGSQL GEFWLGNDHI HALTAQGTNE
210 220 230 240 250
LRVDLVDFEG NHQFAKYRSF QVADEAEKYM LVLGAFVEGN AGDSLTSHNN
260 270 280 290 300
SLFTTKDQDN DQYASNCAVL YQGAWWYNSC HVSNLNGRYL GGSHGSFANG
310 320
VNWSSGKGYN YSYKVSEMKF RAT
Length:323
Mass (Da):34,682
Last modified:November 1, 1996 - v1
Checksum:i849BF031D77E16B7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L12344 mRNA. Translation: AAA92455.1.
PIRiA47172.
RefSeqiNP_999033.1. NM_213868.1.
UniGeneiSsc.137.
Ssc.97239.

Genome annotation databases

GeneIDi396881.
KEGGissc:396881.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L12344 mRNA. Translation: AAA92455.1.
PIRiA47172.
RefSeqiNP_999033.1. NM_213868.1.
UniGeneiSsc.137.
Ssc.97239.

3D structure databases

ProteinModelPortaliQ29041.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000019414.

Proteomic databases

PaxDbiQ29041.
PeptideAtlasiQ29041.
PRIDEiQ29041.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi396881.
KEGGissc:396881.

Organism-specific databases

CTDi2220.

Phylogenomic databases

eggNOGiKOG2579. Eukaryota.
ENOG410ZYS4. LUCA.
HOVERGENiHBG001644.
InParanoidiQ29041.
KOiK10104.

Family and domain databases

CDDicd00087. FReD. 1 hit.
Gene3Di3.90.215.10. 1 hit.
4.10.530.10. 1 hit.
InterProiIPR008160. Collagen.
IPR014716. Fibrinogen_a/b/g_C_1.
IPR014715. Fibrinogen_a/b/g_C_2.
IPR002181. Fibrinogen_a/b/g_C_dom.
IPR020837. Fibrinogen_CS.
[Graphical view]
PfamiPF01391. Collagen. 1 hit.
PF00147. Fibrinogen_C. 1 hit.
[Graphical view]
SMARTiSM00186. FBG. 1 hit.
[Graphical view]
SUPFAMiSSF56496. SSF56496. 1 hit.
PROSITEiPS00514. FIBRINOGEN_C_1. 1 hit.
PS51406. FIBRINOGEN_C_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFCN2_PIG
AccessioniPrimary (citable) accession number: Q29041
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: November 1, 1996
Last modified: November 30, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.