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Protein

Ficolin-2

Gene

FCN2

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc-binding lectin (By similarity).By similarity

GO - Molecular functioni

  1. carbohydrate binding Source: UniProtKB-KW

GO - Biological processi

  1. complement activation, lectin pathway Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Complement activation lectin pathway, Immunity, Innate immunity

Keywords - Ligandi

Lectin

Names & Taxonomyi

Protein namesi
Recommended name:
Ficolin-2
Alternative name(s):
Collagen/fibrinogen domain-containing protein 2
Ficolin-B
Ficolin-beta
L-ficolin
Gene namesi
Name:FCN2
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
ProteomesiUP000008227: Unplaced

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. collagen trimer Source: UniProtKB-KW
  2. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence AnalysisAdd
BLAST
Chaini27 – 323297Ficolin-2PRO_0000269571Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi249 – 2491N-linked (GlcNAc...)Sequence Analysis
Glycosylationi302 – 3021N-linked (GlcNAc...)Sequence Analysis
Glycosylationi310 – 3101N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Expressioni

Tissue specificityi

Mainly expressed in skeletal muscle.1 Publication

Interactioni

Subunit structurei

Homopolymer; disulfide-linked. Interacts with elastin. Interacts with MASP1 and MASP2 (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ29041.
SMRiQ29041. Positions 108-321.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini52 – 10251Collagen-likeAdd
BLAST
Domaini106 – 323218Fibrinogen C-terminalPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ficolin lectin family.Curated
Contains 1 collagen-like domain.Curated
Contains 1 fibrinogen C-terminal domain.PROSITE-ProRule annotation

Keywords - Domaini

Collagen, Repeat, Signal

Phylogenomic databases

HOVERGENiHBG001644.
InParanoidiQ29041.
KOiK10104.

Family and domain databases

Gene3Di3.90.215.10. 1 hit.
4.10.530.10. 1 hit.
InterProiIPR008160. Collagen.
IPR014716. Fibrinogen_a/b/g_C_1.
IPR014715. Fibrinogen_a/b/g_C_2.
IPR002181. Fibrinogen_a/b/g_C_dom.
IPR020837. Fibrinogen_CS.
[Graphical view]
PfamiPF01391. Collagen. 1 hit.
PF00147. Fibrinogen_C. 1 hit.
[Graphical view]
SMARTiSM00186. FBG. 1 hit.
[Graphical view]
SUPFAMiSSF56496. SSF56496. 1 hit.
PROSITEiPS00514. FIBRINOGEN_C_1. 1 hit.
PS51406. FIBRINOGEN_C_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q29041-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTRGVAAAM RPLVLLVAFL CTAAPALDTC PEVKVVGLEG SDKLSILRGC
60 70 80 90 100
PGLPGAAGPK GEAGASGPKG GQGPPGAPGE PGPPGPKGDR GEKGEPGPKG
110 120 130 140 150
ESWETEQCLT GPRTCKELLT RGHILSGWHT IYLPDCQPLT VLCDMDTDGG
160 170 180 190 200
GWTVFQRRSD GSVDFYRDWA AYKRGFGSQL GEFWLGNDHI HALTAQGTNE
210 220 230 240 250
LRVDLVDFEG NHQFAKYRSF QVADEAEKYM LVLGAFVEGN AGDSLTSHNN
260 270 280 290 300
SLFTTKDQDN DQYASNCAVL YQGAWWYNSC HVSNLNGRYL GGSHGSFANG
310 320
VNWSSGKGYN YSYKVSEMKF RAT
Length:323
Mass (Da):34,682
Last modified:November 1, 1996 - v1
Checksum:i849BF031D77E16B7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L12344 mRNA. Translation: AAA92455.1.
PIRiA47172.
RefSeqiNP_999033.1. NM_213868.1.
UniGeneiSsc.137.

Genome annotation databases

GeneIDi396881.
KEGGissc:396881.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L12344 mRNA. Translation: AAA92455.1.
PIRiA47172.
RefSeqiNP_999033.1. NM_213868.1.
UniGeneiSsc.137.

3D structure databases

ProteinModelPortaliQ29041.
SMRiQ29041. Positions 108-321.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi396881.
KEGGissc:396881.

Organism-specific databases

CTDi2220.

Phylogenomic databases

HOVERGENiHBG001644.
InParanoidiQ29041.
KOiK10104.

Family and domain databases

Gene3Di3.90.215.10. 1 hit.
4.10.530.10. 1 hit.
InterProiIPR008160. Collagen.
IPR014716. Fibrinogen_a/b/g_C_1.
IPR014715. Fibrinogen_a/b/g_C_2.
IPR002181. Fibrinogen_a/b/g_C_dom.
IPR020837. Fibrinogen_CS.
[Graphical view]
PfamiPF01391. Collagen. 1 hit.
PF00147. Fibrinogen_C. 1 hit.
[Graphical view]
SMARTiSM00186. FBG. 1 hit.
[Graphical view]
SUPFAMiSSF56496. SSF56496. 1 hit.
PROSITEiPS00514. FIBRINOGEN_C_1. 1 hit.
PS51406. FIBRINOGEN_C_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning and characterization of ficolin, a multimeric protein with fibrinogen- and collagen-like domains."
    Ichijo H., Hellman U., Wernstedt C., Gonez L.J., Claesson-Welsh L., Heldin C.H., Miyazono K.
    J. Biol. Chem. 268:14505-14513(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBUNIT, TISSUE SPECIFICITY.
    Tissue: Uterus.

Entry informationi

Entry nameiFCN2_PIG
AccessioniPrimary (citable) accession number: Q29041
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: November 1, 1996
Last modified: January 7, 2015
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.