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Q29041 (FCN2_PIG) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ficolin-2
Alternative name(s):
Collagen/fibrinogen domain-containing protein 2
Ficolin-B
Ficolin-beta
L-ficolin
Gene names
Name:FCN2
OrganismSus scrofa (Pig) [Reference proteome]
Taxonomic identifier9823 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus

Protein attributes

Sequence length323 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc-binding lectin By similarity.

Subunit structure

Homopolymer; disulfide-linked. Interacts with elastin. Interacts with MASP1 and MASP2 By similarity. Ref.1

Subcellular location

Secreted By similarity.

Tissue specificity

Mainly expressed in skeletal muscle. Ref.1

Sequence similarities

Belongs to the ficolin lectin family.

Contains 1 collagen-like domain.

Contains 1 fibrinogen C-terminal domain.

Ontologies

Keywords
   Biological processComplement activation lectin pathway
Immunity
Innate immunity
   Cellular componentSecreted
   DomainCollagen
Repeat
Signal
   LigandLectin
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcomplement activation, lectin pathway

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcollagen trimer

Inferred from electronic annotation. Source: UniProtKB-KW

extracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2626 Potential
Chain27 – 323297Ficolin-2
PRO_0000269571

Regions

Domain52 – 10251Collagen-like
Domain106 – 323218Fibrinogen C-terminal

Amino acid modifications

Glycosylation2491N-linked (GlcNAc...) Potential
Glycosylation3021N-linked (GlcNAc...) Potential
Glycosylation3101N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q29041 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 849BF031D77E16B7

FASTA32334,682
        10         20         30         40         50         60 
MDTRGVAAAM RPLVLLVAFL CTAAPALDTC PEVKVVGLEG SDKLSILRGC PGLPGAAGPK 

        70         80         90        100        110        120 
GEAGASGPKG GQGPPGAPGE PGPPGPKGDR GEKGEPGPKG ESWETEQCLT GPRTCKELLT 

       130        140        150        160        170        180 
RGHILSGWHT IYLPDCQPLT VLCDMDTDGG GWTVFQRRSD GSVDFYRDWA AYKRGFGSQL 

       190        200        210        220        230        240 
GEFWLGNDHI HALTAQGTNE LRVDLVDFEG NHQFAKYRSF QVADEAEKYM LVLGAFVEGN 

       250        260        270        280        290        300 
AGDSLTSHNN SLFTTKDQDN DQYASNCAVL YQGAWWYNSC HVSNLNGRYL GGSHGSFANG 

       310        320 
VNWSSGKGYN YSYKVSEMKF RAT 

« Hide

References

[1]"Molecular cloning and characterization of ficolin, a multimeric protein with fibrinogen- and collagen-like domains."
Ichijo H., Hellman U., Wernstedt C., Gonez L.J., Claesson-Welsh L., Heldin C.H., Miyazono K.
J. Biol. Chem. 268:14505-14513(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBUNIT, TISSUE SPECIFICITY.
Tissue: Uterus.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L12344 mRNA. Translation: AAA92455.1.
PIRA47172.
RefSeqNP_999033.1. NM_213868.1.
UniGeneSsc.137.

3D structure databases

ProteinModelPortalQ29041.
SMRQ29041. Positions 108-321.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID396881.
KEGGssc:396881.

Organism-specific databases

CTD2220.

Phylogenomic databases

HOVERGENHBG001644.
KOK10104.

Family and domain databases

Gene3D3.90.215.10. 1 hit.
4.10.530.10. 1 hit.
InterProIPR008160. Collagen.
IPR014716. Fibrinogen_a/b/g_C_1.
IPR014715. Fibrinogen_a/b/g_C_2.
IPR002181. Fibrinogen_a/b/g_C_dom.
IPR020837. Fibrinogen_CS.
[Graphical view]
PfamPF01391. Collagen. 1 hit.
PF00147. Fibrinogen_C. 1 hit.
[Graphical view]
SMARTSM00186. FBG. 1 hit.
[Graphical view]
SUPFAMSSF56496. SSF56496. 1 hit.
PROSITEPS00514. FIBRINOGEN_C_1. 1 hit.
PS51406. FIBRINOGEN_C_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFCN2_PIG
AccessionPrimary (citable) accession number: Q29041
Entry history
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families