Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q29041

- FCN2_PIG

UniProt

Q29041 - FCN2_PIG

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Ficolin-2

Gene

FCN2

Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc-binding lectin (By similarity).By similarity

GO - Molecular functioni

  1. carbohydrate binding Source: UniProtKB-KW

GO - Biological processi

  1. complement activation, lectin pathway Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Complement activation lectin pathway, Immunity, Innate immunity

Keywords - Ligandi

Lectin

Names & Taxonomyi

Protein namesi
Recommended name:
Ficolin-2
Alternative name(s):
Collagen/fibrinogen domain-containing protein 2
Ficolin-B
Ficolin-beta
L-ficolin
Gene namesi
Name:FCN2
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
ProteomesiUP000008227: Unplaced

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. collagen trimer Source: UniProtKB-KW
  2. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence AnalysisAdd
BLAST
Chaini27 – 323297Ficolin-2PRO_0000269571Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi249 – 2491N-linked (GlcNAc...)Sequence Analysis
Glycosylationi302 – 3021N-linked (GlcNAc...)Sequence Analysis
Glycosylationi310 – 3101N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Expressioni

Tissue specificityi

Mainly expressed in skeletal muscle.1 Publication

Interactioni

Subunit structurei

Homopolymer; disulfide-linked. Interacts with elastin. Interacts with MASP1 and MASP2 (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ29041.
SMRiQ29041. Positions 108-321.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini52 – 10251Collagen-likeAdd
BLAST
Domaini106 – 323218Fibrinogen C-terminalPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ficolin lectin family.Curated
Contains 1 collagen-like domain.Curated
Contains 1 fibrinogen C-terminal domain.PROSITE-ProRule annotation

Keywords - Domaini

Collagen, Repeat, Signal

Phylogenomic databases

HOVERGENiHBG001644.
InParanoidiQ29041.
KOiK10104.

Family and domain databases

Gene3Di3.90.215.10. 1 hit.
4.10.530.10. 1 hit.
InterProiIPR008160. Collagen.
IPR014716. Fibrinogen_a/b/g_C_1.
IPR014715. Fibrinogen_a/b/g_C_2.
IPR002181. Fibrinogen_a/b/g_C_dom.
IPR020837. Fibrinogen_CS.
[Graphical view]
PfamiPF01391. Collagen. 1 hit.
PF00147. Fibrinogen_C. 1 hit.
[Graphical view]
SMARTiSM00186. FBG. 1 hit.
[Graphical view]
SUPFAMiSSF56496. SSF56496. 1 hit.
PROSITEiPS00514. FIBRINOGEN_C_1. 1 hit.
PS51406. FIBRINOGEN_C_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q29041-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDTRGVAAAM RPLVLLVAFL CTAAPALDTC PEVKVVGLEG SDKLSILRGC
60 70 80 90 100
PGLPGAAGPK GEAGASGPKG GQGPPGAPGE PGPPGPKGDR GEKGEPGPKG
110 120 130 140 150
ESWETEQCLT GPRTCKELLT RGHILSGWHT IYLPDCQPLT VLCDMDTDGG
160 170 180 190 200
GWTVFQRRSD GSVDFYRDWA AYKRGFGSQL GEFWLGNDHI HALTAQGTNE
210 220 230 240 250
LRVDLVDFEG NHQFAKYRSF QVADEAEKYM LVLGAFVEGN AGDSLTSHNN
260 270 280 290 300
SLFTTKDQDN DQYASNCAVL YQGAWWYNSC HVSNLNGRYL GGSHGSFANG
310 320
VNWSSGKGYN YSYKVSEMKF RAT
Length:323
Mass (Da):34,682
Last modified:November 1, 1996 - v1
Checksum:i849BF031D77E16B7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L12344 mRNA. Translation: AAA92455.1.
PIRiA47172.
RefSeqiNP_999033.1. NM_213868.1.
UniGeneiSsc.137.

Genome annotation databases

GeneIDi396881.
KEGGissc:396881.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L12344 mRNA. Translation: AAA92455.1 .
PIRi A47172.
RefSeqi NP_999033.1. NM_213868.1.
UniGenei Ssc.137.

3D structure databases

ProteinModelPortali Q29041.
SMRi Q29041. Positions 108-321.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 396881.
KEGGi ssc:396881.

Organism-specific databases

CTDi 2220.

Phylogenomic databases

HOVERGENi HBG001644.
InParanoidi Q29041.
KOi K10104.

Family and domain databases

Gene3Di 3.90.215.10. 1 hit.
4.10.530.10. 1 hit.
InterProi IPR008160. Collagen.
IPR014716. Fibrinogen_a/b/g_C_1.
IPR014715. Fibrinogen_a/b/g_C_2.
IPR002181. Fibrinogen_a/b/g_C_dom.
IPR020837. Fibrinogen_CS.
[Graphical view ]
Pfami PF01391. Collagen. 1 hit.
PF00147. Fibrinogen_C. 1 hit.
[Graphical view ]
SMARTi SM00186. FBG. 1 hit.
[Graphical view ]
SUPFAMi SSF56496. SSF56496. 1 hit.
PROSITEi PS00514. FIBRINOGEN_C_1. 1 hit.
PS51406. FIBRINOGEN_C_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning and characterization of ficolin, a multimeric protein with fibrinogen- and collagen-like domains."
    Ichijo H., Hellman U., Wernstedt C., Gonez L.J., Claesson-Welsh L., Heldin C.H., Miyazono K.
    J. Biol. Chem. 268:14505-14513(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBUNIT, TISSUE SPECIFICITY.
    Tissue: Uterus.

Entry informationi

Entry nameiFCN2_PIG
AccessioniPrimary (citable) accession number: Q29041
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3