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Q29041

- FCN2_PIG

UniProt

Q29041 - FCN2_PIG

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Protein
Ficolin-2
Gene
FCN2
Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc-binding lectin By similarity.

GO - Biological processi

  1. complement activation, lectin pathway Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Complement activation lectin pathway, Immunity, Innate immunity

Keywords - Ligandi

Lectin

Names & Taxonomyi

Protein namesi
Recommended name:
Ficolin-2
Alternative name(s):
Collagen/fibrinogen domain-containing protein 2
Ficolin-B
Ficolin-beta
L-ficolin
Gene namesi
Name:FCN2
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
ProteomesiUP000008227: Unplaced

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. collagen trimer Source: UniProtKB-KW
  2. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626 Reviewed prediction
Add
BLAST
Chaini27 – 323297Ficolin-2
PRO_0000269571Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi249 – 2491N-linked (GlcNAc...) Reviewed prediction
Glycosylationi302 – 3021N-linked (GlcNAc...) Reviewed prediction
Glycosylationi310 – 3101N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Expressioni

Tissue specificityi

Mainly expressed in skeletal muscle.1 Publication

Interactioni

Subunit structurei

Homopolymer; disulfide-linked. Interacts with elastin. Interacts with MASP1 and MASP2 By similarity.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ29041.
SMRiQ29041. Positions 108-321.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini52 – 10251Collagen-like
Add
BLAST
Domaini106 – 323218Fibrinogen C-terminal
Add
BLAST

Sequence similaritiesi

Belongs to the ficolin lectin family.

Keywords - Domaini

Collagen, Repeat, Signal

Phylogenomic databases

HOVERGENiHBG001644.
KOiK10104.

Family and domain databases

Gene3Di3.90.215.10. 1 hit.
4.10.530.10. 1 hit.
InterProiIPR008160. Collagen.
IPR014716. Fibrinogen_a/b/g_C_1.
IPR014715. Fibrinogen_a/b/g_C_2.
IPR002181. Fibrinogen_a/b/g_C_dom.
IPR020837. Fibrinogen_CS.
[Graphical view]
PfamiPF01391. Collagen. 1 hit.
PF00147. Fibrinogen_C. 1 hit.
[Graphical view]
SMARTiSM00186. FBG. 1 hit.
[Graphical view]
SUPFAMiSSF56496. SSF56496. 1 hit.
PROSITEiPS00514. FIBRINOGEN_C_1. 1 hit.
PS51406. FIBRINOGEN_C_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q29041-1 [UniParc]FASTAAdd to Basket

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MDTRGVAAAM RPLVLLVAFL CTAAPALDTC PEVKVVGLEG SDKLSILRGC    50
PGLPGAAGPK GEAGASGPKG GQGPPGAPGE PGPPGPKGDR GEKGEPGPKG 100
ESWETEQCLT GPRTCKELLT RGHILSGWHT IYLPDCQPLT VLCDMDTDGG 150
GWTVFQRRSD GSVDFYRDWA AYKRGFGSQL GEFWLGNDHI HALTAQGTNE 200
LRVDLVDFEG NHQFAKYRSF QVADEAEKYM LVLGAFVEGN AGDSLTSHNN 250
SLFTTKDQDN DQYASNCAVL YQGAWWYNSC HVSNLNGRYL GGSHGSFANG 300
VNWSSGKGYN YSYKVSEMKF RAT 323
Length:323
Mass (Da):34,682
Last modified:November 1, 1996 - v1
Checksum:i849BF031D77E16B7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L12344 mRNA. Translation: AAA92455.1.
PIRiA47172.
RefSeqiNP_999033.1. NM_213868.1.
UniGeneiSsc.137.

Genome annotation databases

GeneIDi396881.
KEGGissc:396881.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L12344 mRNA. Translation: AAA92455.1 .
PIRi A47172.
RefSeqi NP_999033.1. NM_213868.1.
UniGenei Ssc.137.

3D structure databases

ProteinModelPortali Q29041.
SMRi Q29041. Positions 108-321.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 396881.
KEGGi ssc:396881.

Organism-specific databases

CTDi 2220.

Phylogenomic databases

HOVERGENi HBG001644.
KOi K10104.

Family and domain databases

Gene3Di 3.90.215.10. 1 hit.
4.10.530.10. 1 hit.
InterProi IPR008160. Collagen.
IPR014716. Fibrinogen_a/b/g_C_1.
IPR014715. Fibrinogen_a/b/g_C_2.
IPR002181. Fibrinogen_a/b/g_C_dom.
IPR020837. Fibrinogen_CS.
[Graphical view ]
Pfami PF01391. Collagen. 1 hit.
PF00147. Fibrinogen_C. 1 hit.
[Graphical view ]
SMARTi SM00186. FBG. 1 hit.
[Graphical view ]
SUPFAMi SSF56496. SSF56496. 1 hit.
PROSITEi PS00514. FIBRINOGEN_C_1. 1 hit.
PS51406. FIBRINOGEN_C_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning and characterization of ficolin, a multimeric protein with fibrinogen- and collagen-like domains."
    Ichijo H., Hellman U., Wernstedt C., Gonez L.J., Claesson-Welsh L., Heldin C.H., Miyazono K.
    J. Biol. Chem. 268:14505-14513(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBUNIT, TISSUE SPECIFICITY.
    Tissue: Uterus.

Entry informationi

Entry nameiFCN2_PIG
AccessioniPrimary (citable) accession number: Q29041
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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