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Protein

POU domain, class 2, transcription factor 2

Gene

POU2F2

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Transcription factor that specifically binds to the octamer motif (5'-ATTTGCAT-3'). Regulates transcription in a number of tissues in addition to activating immunoglobulin gene expression. Modulates transcription transactivation by NR3C1, AR and PGR (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi297 – 35660HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
POU domain, class 2, transcription factor 2
Alternative name(s):
Lymphoid-restricted immunoglobulin octamer-binding protein NF-A2
Octamer-binding protein 2
Short name:
Oct-2
Octamer-binding transcription factor 2
Short name:
OTF-2
Gene namesi
Name:POU2F2
Synonyms:OCT2, OTF2
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
ProteomesiUP000008227 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 478478POU domain, class 2, transcription factor 2PRO_0000100716Add
BLAST

Expressioni

Tissue specificityi

Predominantly expressed in B-cells.

Gene expression databases

GenevisibleiQ29013. SS.

Interactioni

Subunit structurei

Interacts with NR3C1, AR and PGR.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ29013.
SMRiQ29013. Positions 199-359.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini195 – 26975POU-specificPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni389 – 41022Leucine-zipperAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi77 – 804Poly-Pro
Compositional biasi417 – 4248Gly-rich
Compositional biasi437 – 4404Poly-Pro

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation
Contains 1 POU-specific domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG267922.
HOVERGENiHBG052783.
InParanoidiQ29013.
KOiK09364.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_specific.
IPR000972. TF_octamer.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view]
PRINTSiPR00029. OCTAMER.
PR00028. POUDOMAIN.
SMARTiSM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q29013-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVHSSMGAPE IRMSKPLEAE KQGLDSPSEH TDTERNGPDT NHQNPQNKTS
60 70 80 90 100
PFSVSPTGPS TKIKAEDPSG DSAPAGPPPP QAVQAHLSQV QLMLTGRQLA
110 120 130 140 150
GDIQQILQLQ QLVLVPGHHL QPPAQFLLPQ AQQSQPGLLP TPNLFQLPQQ
160 170 180 190 200
TQGALLTSQP RAGLPTQAVT RPTLSDPHLS HPQPPKCLEP PSHPEEASDL
210 220 230 240 250
EELEQFARTF KQRRIKLGFT QGDVGLAMGK LYGNDFSQTT ISRFEALNLS
260 270 280 290 300
FKNMCKLKPL LEKWLNDAET MSVDSSLPSP NQLSRPSLGF DGLPGRRRKK
310 320 330 340 350
RTSIETNVRF ALEKSFLANQ KPTSEEILLI AEQLHMEKEV IRVWFCNRRQ
360 370 380 390 400
KEKRINPCSA APMLPSPGKP ASYSPHLVTP QGGAGTLPLS QASSSLSTTV
410 420 430 440 450
TTLSSAVGTL HPSRTAGGGA AGGGAAPPLN SIPSVTPPPP ATTNSTNPSP
460 470
QGSHSAIGLS GLNPSTGPGL WNPAPYQP
Length:478
Mass (Da):51,099
Last modified:November 1, 1996 - v1
Checksum:iFD196758B603B718
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti212 – 2121Q → V in AAA74657 (PubMed:8270542).Curated
Sequence conflicti215 – 2151I → M in AAA74657 (PubMed:8270542).Curated
Sequence conflicti222 – 2221G → V in AAA74657 (PubMed:8270542).Curated
Sequence conflicti233 – 2331G → A in AAA74657 (PubMed:8270542).Curated
Sequence conflicti238 – 2381Q → K in AAA74657 (PubMed:8270542).Curated
Sequence conflicti285 – 2851R → S in AAA74657 (PubMed:8270542).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00794 mRNA. Translation: AAA80148.1.
L03842 Genomic DNA. Translation: AAA74657.1.
PIRiI47154.
RefSeqiNP_999205.1. NM_214040.1.
UniGeneiSsc.145.

Genome annotation databases

GeneIDi397105.
KEGGissc:397105.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00794 mRNA. Translation: AAA80148.1.
L03842 Genomic DNA. Translation: AAA74657.1.
PIRiI47154.
RefSeqiNP_999205.1. NM_214040.1.
UniGeneiSsc.145.

3D structure databases

ProteinModelPortaliQ29013.
SMRiQ29013. Positions 199-359.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi397105.
KEGGissc:397105.

Organism-specific databases

CTDi100304591.

Phylogenomic databases

eggNOGiNOG267922.
HOVERGENiHBG052783.
InParanoidiQ29013.
KOiK09364.

Gene expression databases

GenevisibleiQ29013. SS.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_specific.
IPR000972. TF_octamer.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view]
PRINTSiPR00029. OCTAMER.
PR00028. POUDOMAIN.
SMARTiSM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning, sequencing and restriction fragment length polymorphism analysis of a porcine cDNA for OCT2."
    Tuggle C.K., Helm J., Rothschild M.F.
    Anim. Genet. 25:141-145(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Spleen.
  2. "Cloning and sequence analysis of the swine Oct-2 POU-domain genomic region."
    Tuggle C.K.
    J. Anim. Sci. 71:3172-3172(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 210-350.
    Strain: Duroc.

Entry informationi

Entry nameiPO2F2_PIG
AccessioniPrimary (citable) accession number: Q29013
Secondary accession number(s): Q29089
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: June 24, 2015
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.