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Q29013

- PO2F2_PIG

UniProt

Q29013 - PO2F2_PIG

Protein

POU domain, class 2, transcription factor 2

Gene

POU2F2

Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Transcription factor that specifically binds to the octamer motif (5'-ATTTGCAT-3'). Regulates transcription in a number of tissues in addition to activating immunoglobulin gene expression. Modulates transcription transactivation by NR3C1, AR and PGR By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi297 – 35660HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    POU domain, class 2, transcription factor 2
    Alternative name(s):
    Lymphoid-restricted immunoglobulin octamer-binding protein NF-A2
    Octamer-binding protein 2
    Short name:
    Oct-2
    Octamer-binding transcription factor 2
    Short name:
    OTF-2
    Gene namesi
    Name:POU2F2
    Synonyms:OCT2, OTF2
    OrganismiSus scrofa (Pig)
    Taxonomic identifieri9823 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
    ProteomesiUP000008227: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 478478POU domain, class 2, transcription factor 2PRO_0000100716Add
    BLAST

    Expressioni

    Tissue specificityi

    Predominantly expressed in B-cells.

    Interactioni

    Subunit structurei

    Interacts with NR3C1, AR and PGR.By similarity

    Protein-protein interaction databases

    STRINGi9823.ENSSSCP00000003274.

    Structurei

    3D structure databases

    ProteinModelPortaliQ29013.
    SMRiQ29013. Positions 199-359.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini195 – 26975POU-specificPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni389 – 41022Leucine-zipperAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi77 – 804Poly-Pro
    Compositional biasi417 – 4248Gly-rich
    Compositional biasi437 – 4404Poly-Pro

    Sequence similaritiesi

    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation
    Contains 1 POU-specific domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG267922.
    HOVERGENiHBG052783.
    KOiK09364.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    1.10.260.40. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR010982. Lambda_DNA-bd_dom.
    IPR013847. POU.
    IPR000327. POU_specific.
    IPR000972. TF_octamer.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    PF00157. Pou. 1 hit.
    [Graphical view]
    PRINTSiPR00029. OCTAMER.
    PR00028. POUDOMAIN.
    SMARTiSM00389. HOX. 1 hit.
    SM00352. POU. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    SSF47413. SSF47413. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    PS00035. POU_1. 1 hit.
    PS00465. POU_2. 1 hit.
    PS51179. POU_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q29013-1 [UniParc]FASTAAdd to Basket

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    MVHSSMGAPE IRMSKPLEAE KQGLDSPSEH TDTERNGPDT NHQNPQNKTS    50
    PFSVSPTGPS TKIKAEDPSG DSAPAGPPPP QAVQAHLSQV QLMLTGRQLA 100
    GDIQQILQLQ QLVLVPGHHL QPPAQFLLPQ AQQSQPGLLP TPNLFQLPQQ 150
    TQGALLTSQP RAGLPTQAVT RPTLSDPHLS HPQPPKCLEP PSHPEEASDL 200
    EELEQFARTF KQRRIKLGFT QGDVGLAMGK LYGNDFSQTT ISRFEALNLS 250
    FKNMCKLKPL LEKWLNDAET MSVDSSLPSP NQLSRPSLGF DGLPGRRRKK 300
    RTSIETNVRF ALEKSFLANQ KPTSEEILLI AEQLHMEKEV IRVWFCNRRQ 350
    KEKRINPCSA APMLPSPGKP ASYSPHLVTP QGGAGTLPLS QASSSLSTTV 400
    TTLSSAVGTL HPSRTAGGGA AGGGAAPPLN SIPSVTPPPP ATTNSTNPSP 450
    QGSHSAIGLS GLNPSTGPGL WNPAPYQP 478
    Length:478
    Mass (Da):51,099
    Last modified:November 1, 1996 - v1
    Checksum:iFD196758B603B718
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti212 – 2121Q → V in AAA74657. (PubMed:8270542)Curated
    Sequence conflicti215 – 2151I → M in AAA74657. (PubMed:8270542)Curated
    Sequence conflicti222 – 2221G → V in AAA74657. (PubMed:8270542)Curated
    Sequence conflicti233 – 2331G → A in AAA74657. (PubMed:8270542)Curated
    Sequence conflicti238 – 2381Q → K in AAA74657. (PubMed:8270542)Curated
    Sequence conflicti285 – 2851R → S in AAA74657. (PubMed:8270542)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00794 mRNA. Translation: AAA80148.1.
    L03842 Genomic DNA. Translation: AAA74657.1.
    PIRiI47154.
    RefSeqiNP_999205.1. NM_214040.1.
    UniGeneiSsc.145.

    Genome annotation databases

    GeneIDi397105.
    KEGGissc:397105.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00794 mRNA. Translation: AAA80148.1 .
    L03842 Genomic DNA. Translation: AAA74657.1 .
    PIRi I47154.
    RefSeqi NP_999205.1. NM_214040.1.
    UniGenei Ssc.145.

    3D structure databases

    ProteinModelPortali Q29013.
    SMRi Q29013. Positions 199-359.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9823.ENSSSCP00000003274.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 397105.
    KEGGi ssc:397105.

    Organism-specific databases

    CTDi 100304591.

    Phylogenomic databases

    eggNOGi NOG267922.
    HOVERGENi HBG052783.
    KOi K09364.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    1.10.260.40. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR010982. Lambda_DNA-bd_dom.
    IPR013847. POU.
    IPR000327. POU_specific.
    IPR000972. TF_octamer.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    PF00157. Pou. 1 hit.
    [Graphical view ]
    PRINTSi PR00029. OCTAMER.
    PR00028. POUDOMAIN.
    SMARTi SM00389. HOX. 1 hit.
    SM00352. POU. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    SSF47413. SSF47413. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    PS00035. POU_1. 1 hit.
    PS00465. POU_2. 1 hit.
    PS51179. POU_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning, sequencing and restriction fragment length polymorphism analysis of a porcine cDNA for OCT2."
      Tuggle C.K., Helm J., Rothschild M.F.
      Anim. Genet. 25:141-145(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Spleen.
    2. "Cloning and sequence analysis of the swine Oct-2 POU-domain genomic region."
      Tuggle C.K.
      J. Anim. Sci. 71:3172-3172(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 210-350.
      Strain: Duroc.

    Entry informationi

    Entry nameiPO2F2_PIG
    AccessioniPrimary (citable) accession number: Q29013
    Secondary accession number(s): Q29089
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3