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Protein

POU domain, class 2, transcription factor 2

Gene

POU2F2

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Transcription factor that specifically binds to the octamer motif (5'-ATTTGCAT-3'). Regulates transcription in a number of tissues in addition to activating immunoglobulin gene expression. Modulates transcription transactivation by NR3C1, AR and PGR (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi297 – 356HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
POU domain, class 2, transcription factor 2
Alternative name(s):
Lymphoid-restricted immunoglobulin octamer-binding protein NF-A2
Octamer-binding protein 2
Short name:
Oct-2
Octamer-binding transcription factor 2
Short name:
OTF-2
Gene namesi
Name:POU2F2
Synonyms:OCT2, OTF2
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001007161 – 478POU domain, class 2, transcription factor 2Add BLAST478

Proteomic databases

PRIDEiQ29013.

Expressioni

Tissue specificityi

Predominantly expressed in B-cells.

Interactioni

Subunit structurei

Interacts with NR3C1, AR and PGR.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ29013.
SMRiQ29013.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini195 – 269POU-specificPROSITE-ProRule annotationAdd BLAST75

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni389 – 410Leucine-zipperAdd BLAST22

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi77 – 80Poly-Pro4
Compositional biasi417 – 424Gly-rich8
Compositional biasi437 – 440Poly-Pro4

Sequence similaritiesi

Keywords - Domaini

Homeobox

Phylogenomic databases

HOVERGENiHBG052783.
InParanoidiQ29013.
KOiK09364.

Family and domain databases

CDDicd00086. homeodomain. 1 hit.
InterProiView protein in InterPro
IPR009057. Homeobox-like.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_dom.
IPR000972. TF_octamer.
PfamiView protein in Pfam
PF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
PRINTSiPR00029. OCTAMER.
PR00028. POUDOMAIN.
SMARTiView protein in SMART
SM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEiView protein in PROSITE
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.

Sequencei

Sequence statusi: Complete.

Q29013-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVHSSMGAPE IRMSKPLEAE KQGLDSPSEH TDTERNGPDT NHQNPQNKTS
60 70 80 90 100
PFSVSPTGPS TKIKAEDPSG DSAPAGPPPP QAVQAHLSQV QLMLTGRQLA
110 120 130 140 150
GDIQQILQLQ QLVLVPGHHL QPPAQFLLPQ AQQSQPGLLP TPNLFQLPQQ
160 170 180 190 200
TQGALLTSQP RAGLPTQAVT RPTLSDPHLS HPQPPKCLEP PSHPEEASDL
210 220 230 240 250
EELEQFARTF KQRRIKLGFT QGDVGLAMGK LYGNDFSQTT ISRFEALNLS
260 270 280 290 300
FKNMCKLKPL LEKWLNDAET MSVDSSLPSP NQLSRPSLGF DGLPGRRRKK
310 320 330 340 350
RTSIETNVRF ALEKSFLANQ KPTSEEILLI AEQLHMEKEV IRVWFCNRRQ
360 370 380 390 400
KEKRINPCSA APMLPSPGKP ASYSPHLVTP QGGAGTLPLS QASSSLSTTV
410 420 430 440 450
TTLSSAVGTL HPSRTAGGGA AGGGAAPPLN SIPSVTPPPP ATTNSTNPSP
460 470
QGSHSAIGLS GLNPSTGPGL WNPAPYQP
Length:478
Mass (Da):51,099
Last modified:November 1, 1996 - v1
Checksum:iFD196758B603B718
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti212Q → V in AAA74657 (PubMed:8270542).Curated1
Sequence conflicti215I → M in AAA74657 (PubMed:8270542).Curated1
Sequence conflicti222G → V in AAA74657 (PubMed:8270542).Curated1
Sequence conflicti233G → A in AAA74657 (PubMed:8270542).Curated1
Sequence conflicti238Q → K in AAA74657 (PubMed:8270542).Curated1
Sequence conflicti285R → S in AAA74657 (PubMed:8270542).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00794 mRNA. Translation: AAA80148.1.
L03842 Genomic DNA. Translation: AAA74657.1.
PIRiI47154.
RefSeqiNP_999205.1. NM_214040.1.
UniGeneiSsc.145.

Genome annotation databases

GeneIDi397105.
KEGGissc:397105.

Similar proteinsi

Entry informationi

Entry nameiPO2F2_PIG
AccessioniPrimary (citable) accession number: Q29013
Secondary accession number(s): Q29089
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: September 27, 2017
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families