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Q29013 (PO2F2_PIG) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
POU domain, class 2, transcription factor 2
Alternative name(s):
Lymphoid-restricted immunoglobulin octamer-binding protein NF-A2
Octamer-binding protein 2
Short name=Oct-2
Octamer-binding transcription factor 2
Short name=OTF-2
Gene names
Name:POU2F2
Synonyms:OCT2, OTF2
OrganismSus scrofa (Pig) [Reference proteome]
Taxonomic identifier9823 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus

Protein attributes

Sequence length478 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Transcription factor that specifically binds to the octamer motif (5'-ATTTGCAT-3'). Regulates transcription in a number of tissues in addition to activating immunoglobulin gene expression. Modulates transcription transactivation by NR3C1, AR and PGR By similarity.

Subunit structure

Interacts with NR3C1, AR and PGR By similarity.

Subcellular location

Nucleus.

Tissue specificity

Predominantly expressed in B-cells.

Sequence similarities

Belongs to the POU transcription factor family. Class-2 subfamily.

Contains 1 homeobox DNA-binding domain.

Contains 1 POU-specific domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   DomainHomeobox
   LigandDNA-binding
   Molecular functionActivator
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processtranscription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionsequence-specific DNA binding

Inferred from electronic annotation. Source: InterPro

sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 478478POU domain, class 2, transcription factor 2
PRO_0000100716

Regions

Domain195 – 26975POU-specific
DNA binding297 – 35660Homeobox
Region389 – 41022Leucine-zipper
Compositional bias77 – 804Poly-Pro
Compositional bias417 – 4248Gly-rich
Compositional bias437 – 4404Poly-Pro

Experimental info

Sequence conflict2121Q → V in AAA74657. Ref.2
Sequence conflict2151I → M in AAA74657. Ref.2
Sequence conflict2221G → V in AAA74657. Ref.2
Sequence conflict2331G → A in AAA74657. Ref.2
Sequence conflict2381Q → K in AAA74657. Ref.2
Sequence conflict2851R → S in AAA74657. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q29013 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: FD196758B603B718

FASTA47851,099
        10         20         30         40         50         60 
MVHSSMGAPE IRMSKPLEAE KQGLDSPSEH TDTERNGPDT NHQNPQNKTS PFSVSPTGPS 

        70         80         90        100        110        120 
TKIKAEDPSG DSAPAGPPPP QAVQAHLSQV QLMLTGRQLA GDIQQILQLQ QLVLVPGHHL 

       130        140        150        160        170        180 
QPPAQFLLPQ AQQSQPGLLP TPNLFQLPQQ TQGALLTSQP RAGLPTQAVT RPTLSDPHLS 

       190        200        210        220        230        240 
HPQPPKCLEP PSHPEEASDL EELEQFARTF KQRRIKLGFT QGDVGLAMGK LYGNDFSQTT 

       250        260        270        280        290        300 
ISRFEALNLS FKNMCKLKPL LEKWLNDAET MSVDSSLPSP NQLSRPSLGF DGLPGRRRKK 

       310        320        330        340        350        360 
RTSIETNVRF ALEKSFLANQ KPTSEEILLI AEQLHMEKEV IRVWFCNRRQ KEKRINPCSA 

       370        380        390        400        410        420 
APMLPSPGKP ASYSPHLVTP QGGAGTLPLS QASSSLSTTV TTLSSAVGTL HPSRTAGGGA 

       430        440        450        460        470 
AGGGAAPPLN SIPSVTPPPP ATTNSTNPSP QGSHSAIGLS GLNPSTGPGL WNPAPYQP 

« Hide

References

[1]"Cloning, sequencing and restriction fragment length polymorphism analysis of a porcine cDNA for OCT2."
Tuggle C.K., Helm J., Rothschild M.F.
Anim. Genet. 25:141-145(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Spleen.
[2]"Cloning and sequence analysis of the swine Oct-2 POU-domain genomic region."
Tuggle C.K.
J. Anim. Sci. 71:3172-3172(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 210-350.
Strain: Duroc.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U00794 mRNA. Translation: AAA80148.1.
L03842 Genomic DNA. Translation: AAA74657.1.
PIRI47154.
RefSeqNP_999205.1. NM_214040.1.
UniGeneSsc.145.

3D structure databases

ProteinModelPortalQ29013.
SMRQ29013. Positions 199-359.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9823.ENSSSCP00000003274.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID397105.
KEGGssc:397105.

Organism-specific databases

CTD100304591.

Phylogenomic databases

eggNOGNOG267922.
HOVERGENHBG052783.
KOK09364.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_specific.
IPR000972. TF_octamer.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view]
PRINTSPR00029. OCTAMER.
PR00028. POUDOMAIN.
SMARTSM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePO2F2_PIG
AccessionPrimary (citable) accession number: Q29013
Secondary accession number(s): Q29089
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: March 19, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families