UniProtKB - Q29010 (EDNRA_PIG)
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Protein
Endothelin-1 receptor
Gene
EDNRA
Organism
Sus scrofa (Pig)
Status
Functioni
Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3 (By similarity).By similarity
GO - Molecular functioni
- endothelin receptor activity Source: InterPro
GO - Biological processi
- enteric nervous system development Source: InterPro
- glucose transmembrane transport Source: UniProtKB
- regulation of blood pressure Source: InterPro
- vasoconstriction Source: InterPro
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Names & Taxonomyi
Protein namesi | Recommended name: Endothelin-1 receptorCuratedAlternative name(s): Endothelin receptor type ABy similarity Short name: ET-A Short name: ET-AR |
Gene namesi | Name:EDNRABy similarity |
Organismi | Sus scrofa (Pig) |
Taxonomic identifieri | 9823 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Suina › Suidae › Sus |
Proteomesi |
|
Subcellular locationi
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 21 – 80 | ExtracellularSequence analysisAdd BLAST | 60 | |
Transmembranei | 81 – 102 | Helical; Name=1Sequence analysisAdd BLAST | 22 | |
Topological domaini | 103 – 112 | CytoplasmicSequence analysis | 10 | |
Transmembranei | 113 – 132 | Helical; Name=2Sequence analysisAdd BLAST | 20 | |
Topological domaini | 133 – 159 | ExtracellularSequence analysisAdd BLAST | 27 | |
Transmembranei | 160 – 181 | Helical; Name=3Sequence analysisAdd BLAST | 22 | |
Topological domaini | 182 – 205 | CytoplasmicSequence analysisAdd BLAST | 24 | |
Transmembranei | 206 – 229 | Helical; Name=4Sequence analysisAdd BLAST | 24 | |
Topological domaini | 230 – 256 | ExtracellularSequence analysisAdd BLAST | 27 | |
Transmembranei | 257 – 278 | Helical; Name=5Sequence analysisAdd BLAST | 22 | |
Topological domaini | 279 – 306 | CytoplasmicSequence analysisAdd BLAST | 28 | |
Transmembranei | 307 – 328 | Helical; Name=6Sequence analysisAdd BLAST | 22 | |
Topological domaini | 329 – 347 | ExtracellularSequence analysisAdd BLAST | 19 | |
Transmembranei | 348 – 372 | Helical; Name=7Sequence analysisAdd BLAST | 25 | |
Topological domaini | 373 – 427 | CytoplasmicSequence analysisAdd BLAST | 55 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 20 | Sequence analysisAdd BLAST | 20 | |
ChainiPRO_0000012723 | 21 – 427 | Endothelin-1 receptorAdd BLAST | 407 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 29 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 62 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 158 ↔ 239 | PROSITE-ProRule annotation | ||
Modified residuei | 425 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
PaxDbi | Q29010 |
PRIDEi | Q29010 |
Interactioni
Subunit structurei
Interacts with HDAC7 and KAT5.By similarity
Protein-protein interaction databases
STRINGi | 9823.ENSSSCP00000009635 |
Chemistry databases
BindingDBi | Q29010 |
Structurei
3D structure databases
ProteinModelPortali | Q29010 |
SMRi | Q29010 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRA sub-subfamily.PROSITE-ProRule annotation
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3656 Eukaryota ENOG410XRW9 LUCA |
HOGENOMi | HOG000272623 |
HOVERGENi | HBG051443 |
InParanoidi | Q29010 |
KOi | K04197 |
Family and domain databases
InterProi | View protein in InterPro IPR000499 Endthln_rcpt IPR002175 ETA_rcpt IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001 7tm_1, 1 hit |
PRINTSi | PR00570 ENDOTHELINAR PR00366 ENDOTHELINR PR00237 GPCRRHODOPSN |
PROSITEi | View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q29010-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
METFCFRVSF WVALLGCVIS DNPESHSTNL STHVDDFTTF RGTEFSLVVT
60 70 80 90 100
THRPTNLALP SNGSMHNYCP QQTKITSAFK YINTVISCTI FIVGMVGNAT
110 120 130 140 150
LLRIIYQNKC MRNGPNALIA SLALGDLIYV VIDLPINVFK LLAGRWPFEN
160 170 180 190 200
HDFGVFLCKL FPFLQKSSVG ITVLNLCALS VDRYRAVASW SRVQGIGIPL
210 220 230 240 250
VTAIEIVSIW ILSFILAIPE AIGFVMVPFE YKGEEHKTCM LNATSKFMEF
260 270 280 290 300
YQDVKDWWLF GFYFCMPLVC TAIFYTLMTC EMLNRRNGSL RIALSEHLKQ
310 320 330 340 350
RREVAKTVFC LVVIFALCWF PLHLSRILKK TVYDEMDKNR CELLSFLLLM
360 370 380 390 400
DYIGINLATM NSCINPIALY FVSKKFKNCF QSCLCCCCYQ SKSLMTSVPM
410 420
NGTSIQWKNH EQNNHNTERS SHKDSIN
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | S80652 mRNA Translation: AAB36014.1 |
RefSeqi | NP_999394.1, NM_214229.1 |
UniGenei | Ssc.16189 |
Genome annotation databases
GeneIDi | 397457 |
KEGGi | ssc:397457 |
Similar proteinsi
Entry informationi
Entry namei | EDNRA_PIG | |
Accessioni | Q29010Primary (citable) accession number: Q29010 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1998 |
Last sequence update: | November 1, 1996 | |
Last modified: | April 25, 2018 | |
This is version 100 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |