EDNRA

Functionⁱ

Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3 (By similarity).By similarity

GO - Molecular functionⁱ

endothelin receptor activity Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

enteric nervous system development Source: InterPro
glucose transmembrane transport Source: UniProtKB
regulation of blood pressure Source: InterPro
vasoconstriction Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	G-protein coupled receptor, Receptor, Transducer

Molecular function

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Endothelin-1 receptorCurated Alternative name(s): Endothelin receptor type ABy similarity Short name: ET-A Short name: ET-AR
Gene namesⁱ	Name:EDNRABy similarity
Organismⁱ	Sus scrofa (Pig)
Taxonomic identifierⁱ	9823 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Laurasiatheria › Cetartiodactyla › Suina › Suidae › Sus
Proteomesⁱ	UP000008227 Componentⁱ: Unplaced

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	21 – 80	ExtracellularSequence analysisAdd BLAST	60
Transmembraneⁱ	81 – 102	Helical; Name=1Sequence analysisAdd BLAST	22
Topological domainⁱ	103 – 112	CytoplasmicSequence analysis	10
Transmembraneⁱ	113 – 132	Helical; Name=2Sequence analysisAdd BLAST	20
Topological domainⁱ	133 – 159	ExtracellularSequence analysisAdd BLAST	27
Transmembraneⁱ	160 – 181	Helical; Name=3Sequence analysisAdd BLAST	22
Topological domainⁱ	182 – 205	CytoplasmicSequence analysisAdd BLAST	24
Transmembraneⁱ	206 – 229	Helical; Name=4Sequence analysisAdd BLAST	24
Topological domainⁱ	230 – 256	ExtracellularSequence analysisAdd BLAST	27
Transmembraneⁱ	257 – 278	Helical; Name=5Sequence analysisAdd BLAST	22
Topological domainⁱ	279 – 306	CytoplasmicSequence analysisAdd BLAST	28
Transmembraneⁱ	307 – 328	Helical; Name=6Sequence analysisAdd BLAST	22
Topological domainⁱ	329 – 347	ExtracellularSequence analysisAdd BLAST	19
Transmembraneⁱ	348 – 372	Helical; Name=7Sequence analysisAdd BLAST	25
Topological domainⁱ	373 – 427	CytoplasmicSequence analysisAdd BLAST	55

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Chemistry databases

ChEMBLⁱ	CHEMBL4130

ChEMBLⁱ

CHEMBL4130

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 20	Sequence analysisAdd BLAST		20
ChainⁱPRO_0000012723	21 – 427	Endothelin-1 receptorAdd BLAST		407

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	29	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	62	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	158 ↔ 239	PROSITE-ProRule annotation
Modified residueⁱ	425	PhosphoserineBy similarity	1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbⁱ	Q29010
PRIDEⁱ	Q29010

Interactionⁱ

Subunit structureⁱ

Interacts with HDAC7 and KAT5.By similarity

Protein-protein interaction databases

STRINGⁱ	9823.ENSSSCP00000009635

STRINGⁱ

9823.ENSSSCP00000009635

Chemistry databases

BindingDBⁱ

Q29010

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q29010
SMRⁱ	Q29010
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRA sub-subfamily.PROSITE-ProRule annotation

Keywords - Domainⁱ

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG3656 Eukaryota ENOG410XRW9 LUCA
HOGENOMⁱ	HOG000272623
HOVERGENⁱ	HBG051443
InParanoidⁱ	Q29010
KEGG Orthology (KO) More...KOⁱ	K04197

Family and domain databases

InterProⁱ	View protein in InterPro IPR000499 Endthln_rcpt IPR002175 ETA_rcpt IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00001 7tm_1, 1 hit
PRINTSⁱ	PR00570 ENDOTHELINAR PR00366 ENDOTHELINR PR00237 GPCRRHODOPSN
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

Q29010-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
METFCFRVSF WVALLGCVIS DNPESHSTNL STHVDDFTTF RGTEFSLVVT 
        60         70         80         90        100
THRPTNLALP SNGSMHNYCP QQTKITSAFK YINTVISCTI FIVGMVGNAT 
       110        120        130        140        150
LLRIIYQNKC MRNGPNALIA SLALGDLIYV VIDLPINVFK LLAGRWPFEN 
       160        170        180        190        200
HDFGVFLCKL FPFLQKSSVG ITVLNLCALS VDRYRAVASW SRVQGIGIPL 
       210        220        230        240        250
VTAIEIVSIW ILSFILAIPE AIGFVMVPFE YKGEEHKTCM LNATSKFMEF 
       260        270        280        290        300
YQDVKDWWLF GFYFCMPLVC TAIFYTLMTC EMLNRRNGSL RIALSEHLKQ 
       310        320        330        340        350
RREVAKTVFC LVVIFALCWF PLHLSRILKK TVYDEMDKNR CELLSFLLLM 
       360        370        380        390        400
DYIGINLATM NSCINPIALY FVSKKFKNCF QSCLCCCCYQ SKSLMTSVPM 
       410        420 
NGTSIQWKNH EQNNHNTERS SHKDSIN

Length:427

Mass (Da):48,694

Last modified:November 1, 1996 - v1

Checksum:ⁱF09366051552D06D

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	S80652 mRNA Translation: AAB36014.1
NCBI Reference Sequences More...RefSeqⁱ	NP_999394.1, NM_214229.1
UniGeneⁱ	Ssc.16189

Genome annotation databases

GeneIDⁱ	397457
KEGGⁱ	ssc:397457

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q29010	P25101 H2QQ94 A0A2J8XNP6 A0A2J8MUE4 Q28467 A0A2J8XNP1 A0A2J8MUE2 P25101-5 UPI000328FC0D UPI0003C898A0 +125	Homo sapiens (Human) Pan troglodytes (Chimpanzee) Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) Dasypus novemcinctus (Nine-banded armadillo) Vicugna pacos (Alpaca) (Lama pacos) Galeopterus variegatus (Malayan flying lemur) (Cynocephalus variegatus) Orycteropus afer afer Erinaceus europaeus (Western European hedgehog) Ailuropoda melanoleuca (Giant panda) And more	427	UniRef90_P25101	Cluster: Endothelin-1 receptor	136

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q29010	P25101 H2QQ94 A0A2J8XNP6 A0A2J8MUE4 Q28467 A0A2J8XNP1 A0A2J8MUE2 P25101-5 UPI000328FC0D UPI0003C898A0 +619	Homo sapiens (Human) Pan troglodytes (Chimpanzee) Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) Dasypus novemcinctus (Nine-banded armadillo) Vicugna pacos (Alpaca) (Lama pacos) Galeopterus variegatus (Malayan flying lemur) (Cynocephalus variegatus) Orycteropus afer afer Ailuropoda melanoleuca (Giant panda) Sorex araneus (Eurasian common shrew) (European shrew) And more	427	UniRef50_P25101	Cluster: Endothelin-1 receptor	630

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	S80652 mRNA Translation: AAB36014.1
NCBI Reference Sequences More...RefSeqⁱ	NP_999394.1, NM_214229.1
UniGeneⁱ	Ssc.16189

3D structure databases

ProteinModelPortalⁱ	Q29010
SMRⁱ	Q29010
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	9823.ENSSSCP00000009635

STRINGⁱ

9823.ENSSSCP00000009635

Chemistry databases

BindingDBⁱ	Q29010
ChEMBLⁱ	CHEMBL4130

Protein family/group databases

GPCRDBⁱ	Search...

GPCRDBⁱ

Search...

Proteomic databases

PaxDbⁱ	Q29010
PRIDEⁱ	Q29010

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

GeneIDⁱ	397457
KEGGⁱ	ssc:397457

Organism-specific databases

CTDⁱ	1909

CTDⁱ

1909

Phylogenomic databases

eggNOGⁱ	KOG3656 Eukaryota ENOG410XRW9 LUCA
HOGENOMⁱ	HOG000272623
HOVERGENⁱ	HBG051443
InParanoidⁱ	Q29010
KEGG Orthology (KO) More...KOⁱ	K04197

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q29010

PROⁱ

PR:Q29010

Family and domain databases

InterProⁱ	View protein in InterPro IPR000499 Endthln_rcpt IPR002175 ETA_rcpt IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00001 7tm_1, 1 hit
PRINTSⁱ	PR00570 ENDOTHELINAR PR00366 ENDOTHELINR PR00237 GPCRRHODOPSN
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	EDNRA_PIG
Accessionⁱ	Q29010Primary (citable) accession number: Q29010
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
	Last sequence update:	November 1, 1996
	Last modified:	April 25, 2018
	This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q29010 (EDNRA_PIG)

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Endothelin-1 receptor

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Plasma Membrane

Other locations

Topology

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ