Q28ZN7 (Q28ZN7_DROPS) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Proteasome subunit alpha type RuleBase RU000551
EC=3.4.25.1 RuleBase RU000551

Gene names

Name:	GA15805 FlyBase FBgn0075822
Synonyms:	Dpse\GA15805 EMBL EAL25576.1
ORF Names:	Dpse_GA15805 EMBL EAL25576.1

Organism

Drosophila pseudoobscura pseudoobscura (Fruit fly)

Taxonomic identifier

46245 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	244 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity By similarity. RuleBase RU000551
Catalytic activity	Cleavage of peptide bonds with very broad specificity. RuleBase RU000551
Subunit structure	The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits By similarity. RuleBase RU000551
Subcellular location	Cytoplasm. Nucleus By similarity RuleBase RU000551.
Sequence similarities	Belongs to the peptidase T1A family. RuleBase RU000551

Ontologies

Keywords
Cellular component	Cytoplasm RuleBase RU000551 Nucleus RuleBase RU000551 SAAS SAAS000426 Proteasome RuleBase RU000551
Molecular function	Hydrolase Protease Threonine protease RuleBase RU000551
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	ubiquitin-dependent protein catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell proteasome core complex, alpha-subunit complex Inferred from electronic annotation. Source: InterPro
Molecular function	threonine-type endopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q28ZN7 [UniParc]. Last modified April 4, 2006. Version 1. Checksum: B770EB3E115ED932	FASTA	244	27,165
	10 20 30 40 50 60 MSRGSSAGFD RHITIFSPEG RLYQVEYAFK AISQENITTV ALKSGDCAVV ATQKKVTEKN 70 80 90 100 110 120 IVPESVTHLF RITKEIGCAM TGRIADARSQ VQKARYEAAN FRYKYGYEMP VDVLCRRIAD 130 140 150 160 170 180 INQVYTQNAE MRPLGCSMVL IAYDDEIGPS VYKTDPAGYF SGFKACSVGA KVLEANSYLE 190 200 210 220 230 240 KKYKNNLSEE KAIQLAITCL STVLAIDFKP NGIEIGVVSK TNPSFRTLDE KEIEEHLTKI AEKD

References

[1]

"Comparative genome sequencing of Drosophila pseudoobscura: chromosomal, gene, and cis-element evolution." Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S., Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O., Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F., Howells S.L. , Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A., Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M., Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J., Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y., Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F., Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M., Weinstock G.M., Gibbs R.A. Genome Res. 15:1-18(2005) [PubMed: 15632085] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MV2-25 / Tucson 14011-0121.94.

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Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CM000071 Genomic DNA. Translation: EAL25576.1.
RefSeq	XP_001361000.1. XM_001360963.2.
3D structure databases
ProteinModelPortal	Q28ZN7.
SMR	Q28ZN7. Positions 2-243.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4804438.
GenomeReviews	Gene locus GA15805 in contig CM000071_GR.
KEGG	dpo:Dpse_GA15805.
Organism-specific databases
FlyBase	FBgn0075822. Dpse\GA15805.
Phylogenomic databases
InParanoid	Q28ZN7.
OMA	GKDCAVV.
OrthoDB	EOG4ZW3SZ.
PhylomeDB	Q28ZN7.
Family and domain databases
InterPro	IPR000426. Proteasome_asu_N. IPR023332. Proteasome_suA-type. IPR001353. Proteasome_sua/b. [Graphical view]
KO	K02730.
Pfam	PF00227. Proteasome. 1 hit. PF10584. Proteasome_A_N. 1 hit. [Graphical view]
SMART	SM00948. Proteasome_A_N. 1 hit. [Graphical view]
PROSITE	PS00388. PROTEASOME_A_1. 1 hit. PS51475. PROTEASOME_A_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q28ZN7_DROPS

Accession

Primary (citable) accession number: Q28ZN7

Entry history

Integrated into UniProtKB/TrEMBL:	April 4, 2006
Last sequence update:	April 4, 2006
Last modified:	January 25, 2012
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)