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Q28Z18

- SETB1_DROPS

UniProt

Q28Z18 - SETB1_DROPS

Protein

Histone-lysine N-methyltransferase eggless

Gene

egg

Organism
Drosophila pseudoobscura pseudoobscura (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 2 (14 May 2014)
      Previous versions | rss
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    Functioni

    Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 in ovary. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting Su(var)205/HP1 to methylated histones. Plays a central role during oogenesis By similarity.By similarity

    Catalytic activityi

    S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi941 – 9411Zinc 1By similarity
    Metal bindingi941 – 9411Zinc 2By similarity
    Metal bindingi943 – 9431Zinc 1By similarity
    Metal bindingi947 – 9471Zinc 1By similarity
    Metal bindingi947 – 9471Zinc 3By similarity
    Metal bindingi953 – 9531Zinc 1By similarity
    Metal bindingi955 – 9551Zinc 2By similarity
    Metal bindingi993 – 9931Zinc 2By similarity
    Metal bindingi993 – 9931Zinc 3By similarity
    Metal bindingi997 – 9971Zinc 2By similarity
    Metal bindingi999 – 9991Zinc 3By similarity
    Metal bindingi1003 – 10031Zinc 3By similarity
    Binding sitei1062 – 10621S-adenosyl-L-methioninePROSITE-ProRule annotation
    Binding sitei1064 – 10641S-adenosyl-L-methioninePROSITE-ProRule annotation
    Binding sitei1183 – 11831S-adenosyl-L-methioninePROSITE-ProRule annotation
    Metal bindingi1189 – 11891Zinc 4By similarity
    Metal bindingi1242 – 12421Zinc 4By similarity
    Metal bindingi1244 – 12441Zinc 4By similarity
    Metal bindingi1249 – 12491Zinc 4By similarity

    GO - Molecular functioni

    1. DNA binding Source: InterPro
    2. histone-lysine N-methyltransferase activity Source: UniProtKB
    3. zinc ion binding Source: InterPro

    GO - Biological processi

    1. multicellular organismal development Source: UniProtKB-KW
    2. negative regulation of transcription during meiosis Source: UniProtKB
    3. oogenesis Source: UniProtKB
    4. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Chromatin regulator, Developmental protein, Methyltransferase, Repressor, Transferase

    Keywords - Biological processi

    Differentiation, Oogenesis, Transcription, Transcription regulation

    Keywords - Ligandi

    Metal-binding, S-adenosyl-L-methionine, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone-lysine N-methyltransferase eggless (EC:2.1.1.43)
    Alternative name(s):
    SETDB1 homolog
    Gene namesi
    Name:egg
    ORF Names:GA30484
    OrganismiDrosophila pseudoobscura pseudoobscura (Fruit fly)
    Taxonomic identifieri46245 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000001819: Chromosome 3, UP000001819: Partially assembled WGS sequence

    Organism-specific databases

    FlyBaseiFBgn0265021. Dpse\GA30484.

    Subcellular locationi

    Nucleus By similarity. Chromosome By similarity

    GO - Cellular componenti

    1. chromosome Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Chromosome, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 12541254Histone-lysine N-methyltransferase egglessPRO_0000281823Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi7237.FBpp0278125.

    Structurei

    3D structure databases

    ProteinModelPortaliQ28Z18.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini535 – 60773Tudor 1Add
    BLAST
    Domaini634 – 69158Tudor 2Add
    BLAST
    Domaini811 – 87767MBDPROSITE-ProRule annotationAdd
    BLAST
    Domaini939 – 101173Pre-SETPROSITE-ProRule annotationAdd
    BLAST
    Domaini1014 – 1229216SETPROSITE-ProRule annotationAdd
    BLAST
    Domaini1238 – 125417Post-SETPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1024 – 10263S-adenosyl-L-methionine bindingBy similarity
    Regioni1186 – 11872S-adenosyl-L-methionine bindingBy similarity

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili391 – 41626Sequence AnalysisAdd
    BLAST

    Domaini

    In the pre-SET domain, Cys residues bind 3 zinc ions that are arranged in a triangular cluster; some of these Cys residues contribute to the binding of two zinc ions within the cluster.By similarity

    Sequence similaritiesi

    Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.PROSITE-ProRule annotation
    Contains 1 MBD (methyl-CpG-binding) domain.PROSITE-ProRule annotation
    Contains 1 post-SET domain.PROSITE-ProRule annotation
    Contains 1 pre-SET domain.PROSITE-ProRule annotation
    Contains 1 SET domain.PROSITE-ProRule annotation
    Contains 2 Tudor domains.Curated

    Keywords - Domaini

    Coiled coil, Repeat

    Phylogenomic databases

    eggNOGiCOG2940.
    InParanoidiQ28Z18.
    KOiK11421.
    OMAiCKCKKNC.
    PhylomeDBiQ28Z18.

    Family and domain databases

    Gene3Di3.30.890.10. 1 hit.
    InterProiIPR016177. DNA-bd_dom.
    IPR001739. Methyl_CpG_DNA-bd.
    IPR003616. Post-SET_dom.
    IPR007728. Pre-SET_dom.
    IPR001214. SET_dom.
    [Graphical view]
    PfamiPF01429. MBD. 1 hit.
    PF05033. Pre-SET. 1 hit.
    PF00856. SET. 1 hit.
    [Graphical view]
    SMARTiSM00317. SET. 1 hit.
    [Graphical view]
    SUPFAMiSSF54171. SSF54171. 1 hit.
    PROSITEiPS50982. MBD. 1 hit.
    PS50868. POST_SET. 1 hit.
    PS50867. PRE_SET. 1 hit.
    PS50280. SET. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q28Z18-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASESAAMDI LDSAEASLNV ASTALVEKEK KVQPATDETT PEKKAKMEID     50
    AEMKDLTNDI PNSRKSQEKD PDALEDAKDP EADSSIELLC SPTPAEATDV 100
    DAMASKTESD NSVELLESPL KSPSSNDVND EELLPLEEKE KPGPAKELEP 150
    KESEPDSKES SKSEALADSS IELISSPTSD DSLAKEKEVE VKEEHGQQAE 200
    AQVLQEIPRK ADDSFKLQDD IAMEEDVPVP RSKAMQESKE TQKTSKTTTK 250
    LEPLVDSIKD AIEDCINCNC KRLKKQYVLA CVAILNFYKV PRKLKRSQYV 300
    CLDCYDTAVE MYEEYAGLLL AKQPLLLREF KQEQADFVTL DSSDEEEDEK 350
    TPEKPEFSKN VLDLIENELE DAIKKTLNKV EFSNQFNWSK TILQAKIERL 400
    AKKFEEVDLQ LAQVQGLADK MHCSVYNSCQ VVHKQLPPLD LHQNICPSDY 450
    KRLQQLPAAG DIVRPPIKIG ETYYAVKNKA IASWVSVSVM EICDTTTGGG 500
    VTVKAYKIKY QHMPYPMMKT VAAKHLAYFD PPTVRLPIGT RVIAFFDGTL 550
    VGGKEKGVVQ SAFYPGIIAE PLKQNNRFRY LIFYDDGYTQ YVHHSDVRLV 600
    CQASEKVWED VHPASRDFIQ KYVERYAVDR PMVQCTKGQS MNTESNGTWL 650
    YARVIEVDCS LVLMQFEADK NHTEWIYRGS LRLAPVFKET QNSLNADCAI 700
    HQMRVPRRTE PFIRYTKEME SSNMQVDQQI RAIARKSTSK SGSPASTAAP 750
    PTGSSSSSAV RHLNNSTIYV DDDTRPKGQV VHFTAKRNMP PKIFKSHKCN 800
    PGCPFPMMHR LDSYSPLSKP LLSGWERMFM KQKTKRTVVY RGPCGRNLRN 850
    MAEVHNYLRL TNNVLNVDNF DFTPDLRCLA EYYIESTIVK EADISKGQEK 900
    MAIPLVNYYD NTLPPPCEYA KQRIPTEGVN LNLDEEFLVC CDCEDDCSDK 950
    ESCACWQLTV TGVRYCNPKK PIEEIGYQYK RLHEGVLTGI YECNSRCKCK 1000
    KNCLNRVVQH SLEMKLQVFK TSNRGWGLRC VNDIPKGAFV CIYAGHLLTE 1050
    AKANEGGQDA GDEYFADLDY IEVAEQLKEG YESDVERADL DHEDDNYGPD 1100
    AEDDDDFRPN NYYQKKKEKL RSSRSNSSST QNTELDSQER TVISFNPNTD 1150
    LDETVRENSV RRFFGKDQTP FIMDAKTTGN LGRYFNHSCS PNLFVQNVFV 1200
    DTHDLRFPWV GFFASSHIRS GTELTWNYNY EVGVVPNKVL YCQCGAQNCR 1250
    VRLL 1254
    Length:1,254
    Mass (Da):142,107
    Last modified:May 14, 2014 - v2
    Checksum:iABAC6B755D26C097
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CM000071 Genomic DNA. Translation: EDY69183.2.
    RefSeqiXP_002138625.2. XM_002138589.2.

    Genome annotation databases

    GeneIDi6898620.
    KEGGidpo:Dpse_GA30484.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CM000071 Genomic DNA. Translation: EDY69183.2 .
    RefSeqi XP_002138625.2. XM_002138589.2.

    3D structure databases

    ProteinModelPortali Q28Z18.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7237.FBpp0278125.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 6898620.
    KEGGi dpo:Dpse_GA30484.

    Organism-specific databases

    FlyBasei FBgn0265021. Dpse\GA30484.

    Phylogenomic databases

    eggNOGi COG2940.
    InParanoidi Q28Z18.
    KOi K11421.
    OMAi CKCKKNC.
    PhylomeDBi Q28Z18.

    Family and domain databases

    Gene3Di 3.30.890.10. 1 hit.
    InterProi IPR016177. DNA-bd_dom.
    IPR001739. Methyl_CpG_DNA-bd.
    IPR003616. Post-SET_dom.
    IPR007728. Pre-SET_dom.
    IPR001214. SET_dom.
    [Graphical view ]
    Pfami PF01429. MBD. 1 hit.
    PF05033. Pre-SET. 1 hit.
    PF00856. SET. 1 hit.
    [Graphical view ]
    SMARTi SM00317. SET. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54171. SSF54171. 1 hit.
    PROSITEi PS50982. MBD. 1 hit.
    PS50868. POST_SET. 1 hit.
    PS50867. PRE_SET. 1 hit.
    PS50280. SET. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal, gene, and cis-element evolution."
      Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S., Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O., Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F., Howells S.L.
      , Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A., Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M., Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J., Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y., Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F., Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M., Weinstock G.M., Gibbs R.A.
      Genome Res. 15:1-18(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MV2-25 / Tucson 14011-0121.94.

    Entry informationi

    Entry nameiSETB1_DROPS
    AccessioniPrimary (citable) accession number: Q28Z18
    Secondary accession number(s): B5DZD5, B5DZD6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 3, 2007
    Last sequence update: May 14, 2014
    Last modified: October 1, 2014
    This is version 65 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3