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Q28Z18

- SETB1_DROPS

UniProt

Q28Z18 - SETB1_DROPS

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Protein

Histone-lysine N-methyltransferase eggless

Gene
egg, GA30484
Organism
Drosophila pseudoobscura pseudoobscura (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 in ovary. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting Su(var)205/HP1 to methylated histones. Plays a central role during oogenesis By similarity.

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi941 – 9411Zinc 1 By similarity
Metal bindingi941 – 9411Zinc 2 By similarity
Metal bindingi943 – 9431Zinc 1 By similarity
Metal bindingi947 – 9471Zinc 1 By similarity
Metal bindingi947 – 9471Zinc 3 By similarity
Metal bindingi953 – 9531Zinc 1 By similarity
Metal bindingi955 – 9551Zinc 2 By similarity
Metal bindingi993 – 9931Zinc 2 By similarity
Metal bindingi993 – 9931Zinc 3 By similarity
Metal bindingi997 – 9971Zinc 2 By similarity
Metal bindingi999 – 9991Zinc 3 By similarity
Metal bindingi1003 – 10031Zinc 3 By similarity
Binding sitei1062 – 10621S-adenosyl-L-methionine By similarity
Binding sitei1064 – 10641S-adenosyl-L-methionine By similarity
Binding sitei1183 – 11831S-adenosyl-L-methionine By similarity
Metal bindingi1189 – 11891Zinc 4 By similarity
Metal bindingi1242 – 12421Zinc 4 By similarity
Metal bindingi1244 – 12441Zinc 4 By similarity
Metal bindingi1249 – 12491Zinc 4 By similarity

GO - Molecular functioni

  1. DNA binding Source: InterPro
  2. histone-lysine N-methyltransferase activity Source: UniProtKB
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. multicellular organismal development Source: UniProtKB-KW
  2. negative regulation of transcription during meiosis Source: UniProtKB
  3. oogenesis Source: UniProtKB
  4. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Developmental protein, Methyltransferase, Repressor, Transferase

Keywords - Biological processi

Differentiation, Oogenesis, Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, S-adenosyl-L-methionine, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase eggless (EC:2.1.1.43)
Alternative name(s):
SETDB1 homolog
Gene namesi
Name:egg
ORF Names:GA30484
OrganismiDrosophila pseudoobscura pseudoobscura (Fruit fly)
Taxonomic identifieri46245 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000001819: Chromosome 3, UP000001819: Partially assembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0265021. Dpse\GA30484.

Subcellular locationi

Nucleus By similarity. Chromosome By similarity

GO - Cellular componenti

  1. chromosome Source: UniProtKB-SubCell
  2. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12541254Histone-lysine N-methyltransferase egglessPRO_0000281823Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi7237.FBpp0278125.

Structurei

3D structure databases

ProteinModelPortaliQ28Z18.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini535 – 60773Tudor 1Add
BLAST
Domaini634 – 69158Tudor 2Add
BLAST
Domaini811 – 87767MBDAdd
BLAST
Domaini939 – 101173Pre-SETAdd
BLAST
Domaini1014 – 1229216SETAdd
BLAST
Domaini1238 – 125417Post-SETAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1024 – 10263S-adenosyl-L-methionine binding By similarity
Regioni1186 – 11872S-adenosyl-L-methionine binding By similarity

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili391 – 41626 Reviewed predictionAdd
BLAST

Domaini

In the pre-SET domain, Cys residues bind 3 zinc ions that are arranged in a triangular cluster; some of these Cys residues contribute to the binding of two zinc ions within the cluster By similarity.

Sequence similaritiesi

Contains 1 post-SET domain.
Contains 1 pre-SET domain.
Contains 1 SET domain.
Contains 2 Tudor domains.

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiCOG2940.
InParanoidiQ28Z18.
KOiK11421.
OMAiCKCKKNC.
PhylomeDBiQ28Z18.

Family and domain databases

Gene3Di3.30.890.10. 1 hit.
InterProiIPR016177. DNA-bd_dom.
IPR001739. Methyl_CpG_DNA-bd.
IPR003616. Post-SET_dom.
IPR007728. Pre-SET_dom.
IPR001214. SET_dom.
[Graphical view]
PfamiPF01429. MBD. 1 hit.
PF05033. Pre-SET. 1 hit.
PF00856. SET. 1 hit.
[Graphical view]
SMARTiSM00317. SET. 1 hit.
[Graphical view]
SUPFAMiSSF54171. SSF54171. 1 hit.
PROSITEiPS50982. MBD. 1 hit.
PS50868. POST_SET. 1 hit.
PS50867. PRE_SET. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q28Z18-1 [UniParc]FASTAAdd to Basket

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MASESAAMDI LDSAEASLNV ASTALVEKEK KVQPATDETT PEKKAKMEID     50
AEMKDLTNDI PNSRKSQEKD PDALEDAKDP EADSSIELLC SPTPAEATDV 100
DAMASKTESD NSVELLESPL KSPSSNDVND EELLPLEEKE KPGPAKELEP 150
KESEPDSKES SKSEALADSS IELISSPTSD DSLAKEKEVE VKEEHGQQAE 200
AQVLQEIPRK ADDSFKLQDD IAMEEDVPVP RSKAMQESKE TQKTSKTTTK 250
LEPLVDSIKD AIEDCINCNC KRLKKQYVLA CVAILNFYKV PRKLKRSQYV 300
CLDCYDTAVE MYEEYAGLLL AKQPLLLREF KQEQADFVTL DSSDEEEDEK 350
TPEKPEFSKN VLDLIENELE DAIKKTLNKV EFSNQFNWSK TILQAKIERL 400
AKKFEEVDLQ LAQVQGLADK MHCSVYNSCQ VVHKQLPPLD LHQNICPSDY 450
KRLQQLPAAG DIVRPPIKIG ETYYAVKNKA IASWVSVSVM EICDTTTGGG 500
VTVKAYKIKY QHMPYPMMKT VAAKHLAYFD PPTVRLPIGT RVIAFFDGTL 550
VGGKEKGVVQ SAFYPGIIAE PLKQNNRFRY LIFYDDGYTQ YVHHSDVRLV 600
CQASEKVWED VHPASRDFIQ KYVERYAVDR PMVQCTKGQS MNTESNGTWL 650
YARVIEVDCS LVLMQFEADK NHTEWIYRGS LRLAPVFKET QNSLNADCAI 700
HQMRVPRRTE PFIRYTKEME SSNMQVDQQI RAIARKSTSK SGSPASTAAP 750
PTGSSSSSAV RHLNNSTIYV DDDTRPKGQV VHFTAKRNMP PKIFKSHKCN 800
PGCPFPMMHR LDSYSPLSKP LLSGWERMFM KQKTKRTVVY RGPCGRNLRN 850
MAEVHNYLRL TNNVLNVDNF DFTPDLRCLA EYYIESTIVK EADISKGQEK 900
MAIPLVNYYD NTLPPPCEYA KQRIPTEGVN LNLDEEFLVC CDCEDDCSDK 950
ESCACWQLTV TGVRYCNPKK PIEEIGYQYK RLHEGVLTGI YECNSRCKCK 1000
KNCLNRVVQH SLEMKLQVFK TSNRGWGLRC VNDIPKGAFV CIYAGHLLTE 1050
AKANEGGQDA GDEYFADLDY IEVAEQLKEG YESDVERADL DHEDDNYGPD 1100
AEDDDDFRPN NYYQKKKEKL RSSRSNSSST QNTELDSQER TVISFNPNTD 1150
LDETVRENSV RRFFGKDQTP FIMDAKTTGN LGRYFNHSCS PNLFVQNVFV 1200
DTHDLRFPWV GFFASSHIRS GTELTWNYNY EVGVVPNKVL YCQCGAQNCR 1250
VRLL 1254
Length:1,254
Mass (Da):142,107
Last modified:May 14, 2014 - v2
Checksum:iABAC6B755D26C097
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CM000071 Genomic DNA. Translation: EDY69183.2.
RefSeqiXP_002138625.2. XM_002138589.2.

Genome annotation databases

GeneIDi6898620.
KEGGidpo:Dpse_GA30484.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CM000071 Genomic DNA. Translation: EDY69183.2 .
RefSeqi XP_002138625.2. XM_002138589.2.

3D structure databases

ProteinModelPortali Q28Z18.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7237.FBpp0278125.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 6898620.
KEGGi dpo:Dpse_GA30484.

Organism-specific databases

FlyBasei FBgn0265021. Dpse\GA30484.

Phylogenomic databases

eggNOGi COG2940.
InParanoidi Q28Z18.
KOi K11421.
OMAi CKCKKNC.
PhylomeDBi Q28Z18.

Family and domain databases

Gene3Di 3.30.890.10. 1 hit.
InterProi IPR016177. DNA-bd_dom.
IPR001739. Methyl_CpG_DNA-bd.
IPR003616. Post-SET_dom.
IPR007728. Pre-SET_dom.
IPR001214. SET_dom.
[Graphical view ]
Pfami PF01429. MBD. 1 hit.
PF05033. Pre-SET. 1 hit.
PF00856. SET. 1 hit.
[Graphical view ]
SMARTi SM00317. SET. 1 hit.
[Graphical view ]
SUPFAMi SSF54171. SSF54171. 1 hit.
PROSITEi PS50982. MBD. 1 hit.
PS50868. POST_SET. 1 hit.
PS50867. PRE_SET. 1 hit.
PS50280. SET. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal, gene, and cis-element evolution."
    Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S., Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O., Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F., Howells S.L.
    , Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A., Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M., Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J., Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y., Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F., Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M., Weinstock G.M., Gibbs R.A.
    Genome Res. 15:1-18(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MV2-25 / Tucson 14011-0121.94.

Entry informationi

Entry nameiSETB1_DROPS
AccessioniPrimary (citable) accession number: Q28Z18
Secondary accession number(s): B5DZD5, B5DZD6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: May 14, 2014
Last modified: July 9, 2014
This is version 64 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi