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Q28Z18

- SETB1_DROPS

UniProt

Q28Z18 - SETB1_DROPS

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Protein

Histone-lysine N-methyltransferase eggless

Gene

egg

Organism
Drosophila pseudoobscura pseudoobscura (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 in ovary. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting Su(var)205/HP1 to methylated histones. Plays a central role during oogenesis By similarity.By similarity

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi941 – 9411Zinc 1By similarity
Metal bindingi941 – 9411Zinc 2By similarity
Metal bindingi943 – 9431Zinc 1By similarity
Metal bindingi947 – 9471Zinc 1By similarity
Metal bindingi947 – 9471Zinc 3By similarity
Metal bindingi953 – 9531Zinc 1By similarity
Metal bindingi955 – 9551Zinc 2By similarity
Metal bindingi993 – 9931Zinc 2By similarity
Metal bindingi993 – 9931Zinc 3By similarity
Metal bindingi997 – 9971Zinc 2By similarity
Metal bindingi999 – 9991Zinc 3By similarity
Metal bindingi1003 – 10031Zinc 3By similarity
Binding sitei1062 – 10621S-adenosyl-L-methioninePROSITE-ProRule annotation
Binding sitei1064 – 10641S-adenosyl-L-methioninePROSITE-ProRule annotation
Binding sitei1183 – 11831S-adenosyl-L-methioninePROSITE-ProRule annotation
Metal bindingi1189 – 11891Zinc 4By similarity
Metal bindingi1242 – 12421Zinc 4By similarity
Metal bindingi1244 – 12441Zinc 4By similarity
Metal bindingi1249 – 12491Zinc 4By similarity

GO - Molecular functioni

  1. DNA binding Source: InterPro
  2. histone-lysine N-methyltransferase activity Source: UniProtKB
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. multicellular organismal development Source: UniProtKB-KW
  2. negative regulation of transcription during meiosis Source: UniProtKB
  3. oogenesis Source: UniProtKB
  4. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Developmental protein, Methyltransferase, Repressor, Transferase

Keywords - Biological processi

Differentiation, Oogenesis, Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, S-adenosyl-L-methionine, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase eggless (EC:2.1.1.43)
Alternative name(s):
SETDB1 homolog
Gene namesi
Name:egg
ORF Names:GA30484
OrganismiDrosophila pseudoobscura pseudoobscura (Fruit fly)
Taxonomic identifieri46245 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000001819: Chromosome 3, UP000001819: Partially assembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0265021. Dpse\GA30484.

Subcellular locationi

Nucleus By similarity. Chromosome By similarity

GO - Cellular componenti

  1. chromosome Source: UniProtKB-KW
  2. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12541254Histone-lysine N-methyltransferase egglessPRO_0000281823Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi7237.FBpp0278125.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini535 – 60773Tudor 1Add
BLAST
Domaini634 – 69158Tudor 2Add
BLAST
Domaini811 – 87767MBDPROSITE-ProRule annotationAdd
BLAST
Domaini939 – 101173Pre-SETPROSITE-ProRule annotationAdd
BLAST
Domaini1014 – 1229216SETPROSITE-ProRule annotationAdd
BLAST
Domaini1238 – 125417Post-SETPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1024 – 10263S-adenosyl-L-methionine bindingBy similarity
Regioni1186 – 11872S-adenosyl-L-methionine bindingBy similarity

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili391 – 41626Sequence AnalysisAdd
BLAST

Domaini

In the pre-SET domain, Cys residues bind 3 zinc ions that are arranged in a triangular cluster; some of these Cys residues contribute to the binding of two zinc ions within the cluster.By similarity

Sequence similaritiesi

Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.PROSITE-ProRule annotation
Contains 1 MBD (methyl-CpG-binding) domain.PROSITE-ProRule annotation
Contains 1 post-SET domain.PROSITE-ProRule annotation
Contains 1 pre-SET domain.PROSITE-ProRule annotation
Contains 1 SET domain.PROSITE-ProRule annotation
Contains 2 Tudor domains.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiCOG2940.
InParanoidiQ28Z18.
KOiK11421.
OMAiCKCKKNC.

Family and domain databases

Gene3Di3.30.890.10. 1 hit.
InterProiIPR016177. DNA-bd_dom.
IPR001739. Methyl_CpG_DNA-bd.
IPR003616. Post-SET_dom.
IPR007728. Pre-SET_dom.
IPR001214. SET_dom.
[Graphical view]
PfamiPF01429. MBD. 1 hit.
PF05033. Pre-SET. 1 hit.
PF00856. SET. 1 hit.
[Graphical view]
SMARTiSM00317. SET. 1 hit.
[Graphical view]
SUPFAMiSSF54171. SSF54171. 1 hit.
PROSITEiPS50982. MBD. 1 hit.
PS50868. POST_SET. 1 hit.
PS50867. PRE_SET. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q28Z18-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MASESAAMDI LDSAEASLNV ASTALVEKEK KVQPATDETT PEKKAKMEID
60 70 80 90 100
AEMKDLTNDI PNSRKSQEKD PDALEDAKDP EADSSIELLC SPTPAEATDV
110 120 130 140 150
DAMASKTESD NSVELLESPL KSPSSNDVND EELLPLEEKE KPGPAKELEP
160 170 180 190 200
KESEPDSKES SKSEALADSS IELISSPTSD DSLAKEKEVE VKEEHGQQAE
210 220 230 240 250
AQVLQEIPRK ADDSFKLQDD IAMEEDVPVP RSKAMQESKE TQKTSKTTTK
260 270 280 290 300
LEPLVDSIKD AIEDCINCNC KRLKKQYVLA CVAILNFYKV PRKLKRSQYV
310 320 330 340 350
CLDCYDTAVE MYEEYAGLLL AKQPLLLREF KQEQADFVTL DSSDEEEDEK
360 370 380 390 400
TPEKPEFSKN VLDLIENELE DAIKKTLNKV EFSNQFNWSK TILQAKIERL
410 420 430 440 450
AKKFEEVDLQ LAQVQGLADK MHCSVYNSCQ VVHKQLPPLD LHQNICPSDY
460 470 480 490 500
KRLQQLPAAG DIVRPPIKIG ETYYAVKNKA IASWVSVSVM EICDTTTGGG
510 520 530 540 550
VTVKAYKIKY QHMPYPMMKT VAAKHLAYFD PPTVRLPIGT RVIAFFDGTL
560 570 580 590 600
VGGKEKGVVQ SAFYPGIIAE PLKQNNRFRY LIFYDDGYTQ YVHHSDVRLV
610 620 630 640 650
CQASEKVWED VHPASRDFIQ KYVERYAVDR PMVQCTKGQS MNTESNGTWL
660 670 680 690 700
YARVIEVDCS LVLMQFEADK NHTEWIYRGS LRLAPVFKET QNSLNADCAI
710 720 730 740 750
HQMRVPRRTE PFIRYTKEME SSNMQVDQQI RAIARKSTSK SGSPASTAAP
760 770 780 790 800
PTGSSSSSAV RHLNNSTIYV DDDTRPKGQV VHFTAKRNMP PKIFKSHKCN
810 820 830 840 850
PGCPFPMMHR LDSYSPLSKP LLSGWERMFM KQKTKRTVVY RGPCGRNLRN
860 870 880 890 900
MAEVHNYLRL TNNVLNVDNF DFTPDLRCLA EYYIESTIVK EADISKGQEK
910 920 930 940 950
MAIPLVNYYD NTLPPPCEYA KQRIPTEGVN LNLDEEFLVC CDCEDDCSDK
960 970 980 990 1000
ESCACWQLTV TGVRYCNPKK PIEEIGYQYK RLHEGVLTGI YECNSRCKCK
1010 1020 1030 1040 1050
KNCLNRVVQH SLEMKLQVFK TSNRGWGLRC VNDIPKGAFV CIYAGHLLTE
1060 1070 1080 1090 1100
AKANEGGQDA GDEYFADLDY IEVAEQLKEG YESDVERADL DHEDDNYGPD
1110 1120 1130 1140 1150
AEDDDDFRPN NYYQKKKEKL RSSRSNSSST QNTELDSQER TVISFNPNTD
1160 1170 1180 1190 1200
LDETVRENSV RRFFGKDQTP FIMDAKTTGN LGRYFNHSCS PNLFVQNVFV
1210 1220 1230 1240 1250
DTHDLRFPWV GFFASSHIRS GTELTWNYNY EVGVVPNKVL YCQCGAQNCR

VRLL
Length:1,254
Mass (Da):142,107
Last modified:May 14, 2014 - v2
Checksum:iABAC6B755D26C097
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CM000071 Genomic DNA. Translation: EDY69183.2.
RefSeqiXP_002138625.2. XM_002138589.2.

Genome annotation databases

GeneIDi6898620.
KEGGidpo:Dpse_GA30484.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CM000071 Genomic DNA. Translation: EDY69183.2 .
RefSeqi XP_002138625.2. XM_002138589.2.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7237.FBpp0278125.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 6898620.
KEGGi dpo:Dpse_GA30484.

Organism-specific databases

FlyBasei FBgn0265021. Dpse\GA30484.

Phylogenomic databases

eggNOGi COG2940.
InParanoidi Q28Z18.
KOi K11421.
OMAi CKCKKNC.

Family and domain databases

Gene3Di 3.30.890.10. 1 hit.
InterProi IPR016177. DNA-bd_dom.
IPR001739. Methyl_CpG_DNA-bd.
IPR003616. Post-SET_dom.
IPR007728. Pre-SET_dom.
IPR001214. SET_dom.
[Graphical view ]
Pfami PF01429. MBD. 1 hit.
PF05033. Pre-SET. 1 hit.
PF00856. SET. 1 hit.
[Graphical view ]
SMARTi SM00317. SET. 1 hit.
[Graphical view ]
SUPFAMi SSF54171. SSF54171. 1 hit.
PROSITEi PS50982. MBD. 1 hit.
PS50868. POST_SET. 1 hit.
PS50867. PRE_SET. 1 hit.
PS50280. SET. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal, gene, and cis-element evolution."
    Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S., Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O., Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F., Howells S.L.
    , Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A., Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M., Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J., Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y., Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F., Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M., Weinstock G.M., Gibbs R.A.
    Genome Res. 15:1-18(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MV2-25 / Tucson 14011-0121.94.

Entry informationi

Entry nameiSETB1_DROPS
AccessioniPrimary (citable) accession number: Q28Z18
Secondary accession number(s): B5DZD5, B5DZD6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: May 14, 2014
Last modified: October 29, 2014
This is version 66 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3