Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q28Z18 (SETB1_DROPS) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Histone-lysine N-methyltransferase eggless

EC=2.1.1.43
Alternative name(s):
SETDB1 homolog
Gene names
Name:egg
ORF Names:GA30484
OrganismDrosophila pseudoobscura pseudoobscura (Fruit fly) [Reference proteome]
Taxonomic identifier46245 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Protein attributes

Sequence length1314 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 in ovary. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting Su(var)205/HP1 to methylated histones. Plays a central role during oogenesis By similarity.

Catalytic activity

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].

Subcellular location

Nucleus By similarity. Chromosome By similarity.

Sequence similarities

Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.

Contains 1 MBD (methyl-CpG-binding) domain.

Contains 1 post-SET domain.

Contains 1 pre-SET domain.

Contains 1 SET domain.

Contains 2 Tudor domains.

Sequence caution

The sequence EDY69182.1 differs from that shown. Reason: Erroneous gene model prediction.

The sequence EDY69183.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 13141314Histone-lysine N-methyltransferase eggless
PRO_0000281823

Regions

Domain595 – 66773Tudor 1
Domain694 – 75158Tudor 2
Domain871 – 93767MBD
Domain999 – 107173Pre-SET
Domain1074 – 1289216SET
Domain1298 – 131417Post-SET
Coiled coil451 – 47626 Potential

Sequences

Sequence LengthMass (Da)Tools
Q28Z18 [UniParc].

Last modified April 4, 2006. Version 1.
Checksum: 734E68538BB197CF

FASTA1,314148,837
        10         20         30         40         50         60 
MASESAAMDI LDSAEASLNV ASTALVEKEK KVQPATDETT PEKKAKMEID AEMKDLTNDI 

        70         80         90        100        110        120 
PNSRKSQEKD PDALEDAKDP EADSSIELLC SPTPAEATDV DAMASKTESD NSVELLESPL 

       130        140        150        160        170        180 
KSPSSNDVND EELLPLEEKE KPGPAKELEP KESEPDSKES SKSEALADSS IELISSPTSD 

       190        200        210        220        230        240 
DSLAKEKEVE VKEEHGQQAE AQVLQEIPRK ADDSFKLQDD IAMEEDVPVP RSKAMQESKE 

       250        260        270        280        290        300 
TQKTSKTTTK LEPLVDSIKD AIEGEPKDKR NNNVDSIESH IESAKKSDNE ILAVDLEIGS 

       310        320        330        340        350        360 
PPKEAEEKSK TDFSWDGRIS YNKDCINCNC KRLKKQYVLA CVAILNFYKV PRKLKRSQYV 

       370        380        390        400        410        420 
CLDCYDTAVE MYEEYAGLLL AKQPLLLREF KQEQADFVTL DSSDEEEDEK TPEKPEFSKN 

       430        440        450        460        470        480 
VLDLIENELE DAIKKTLNKV EFSNQFNWSK TILQAKIERL AKKFEEVDLQ LAQVQGLADK 

       490        500        510        520        530        540 
MHCSVYNSCQ VVHKQLPPLD LHQNICPSDY KRLQQLPAAG DIVRPPIKIG ETYYAVKNKA 

       550        560        570        580        590        600 
IASWVSVSVM EICDTTTGGG VTVKAYKIKY QHMPYPMMKT VAAKHLAYFD PPTVRLPIGT 

       610        620        630        640        650        660 
RVIAFFDGTL VGGKEKGVVQ SAFYPGIIAE PLKQNNRFRY LIFYDDGYTQ YVHHSDVRLV 

       670        680        690        700        710        720 
CQASEKVWED VHPASRDFIQ KYVERYAVDR PMVQCTKGQS MNTESNGTWL YARVIEVDCS 

       730        740        750        760        770        780 
LVLMQFEADK NHTEWIYRGS LRLAPVFKET QNSLNADCAI HQMRVPRRTE PFIRYTKEME 

       790        800        810        820        830        840 
SSNMQVDQQI RAIARKSTSK SGSPASTAAP PTGSSSSSAV RHLNNSTIYV DDDTRPKGQV 

       850        860        870        880        890        900 
VHFTAKRNMP PKIFKSHKCN PGCPFPMMHR LDSYSPLSKP LLSGWERMFM KQKTKRTVVY 

       910        920        930        940        950        960 
RGPCGRNLRN MAEVHNYLRL TNNVLNVDNF DFTPDLRCLA EYYIESTIVK EADISKGQEK 

       970        980        990       1000       1010       1020 
MAIPLVNYYD NTLPPPCEYA KQRIPTEGVN LNLDEEFLVC CDCEDDCSDK ESCACWQLTV 

      1030       1040       1050       1060       1070       1080 
TGVRYCNPKK PIEEIGYQYK RLHEGVLTGI YECNSRCKCK KNCLNRVVQH SLEMKLQVFK 

      1090       1100       1110       1120       1130       1140 
TSNRGWGLRC VNDIPKGAFV CIYAGHLLTE AKANEGGQDA GDEYFADLDY IEVAEQLKEG 

      1150       1160       1170       1180       1190       1200 
YESDVERADL DHEDDNYGPD AEDDDDFRPN NYYQKKKEKL RSSRSNSSST QNTELDSQER 

      1210       1220       1230       1240       1250       1260 
TVISFNPNTD LDETVRENSV RRFFGKDQTP FIMDAKTTGN LGRYFNHSCS PNLFVQNVFV 

      1270       1280       1290       1300       1310 
DTHDLRFPWV GFFASSHIRS GTELTWNYNY EVGVVPNKVL YCQCGAQNCR VRLL 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CM000071 Genomic DNA. Translation: EDY69182.1. Sequence problems.
CM000071 Genomic DNA. Translation: EDY69183.1. Sequence problems.
RefSeqXP_002138625.2. XM_002138589.2.

3D structure databases

ProteinModelPortalQ28Z18.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING7237.FBpp0278125.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6898620.
KEGGdpo:Dpse_GA30484.

Organism-specific databases

FlyBaseFBgn0265021. Dpse\GA30484.

Phylogenomic databases

eggNOGCOG2940.
InParanoidQ28Z18.
KOK11421.
OMACKCKKNC.

Family and domain databases

Gene3D3.30.890.10. 1 hit.
InterProIPR016177. DNA-bd_dom.
IPR001739. Methyl_CpG_DNA-bd.
IPR003616. Post-SET_dom.
IPR007728. Pre-SET_dom.
IPR001214. SET_dom.
[Graphical view]
PfamPF01429. MBD. 1 hit.
PF05033. Pre-SET. 1 hit.
PF00856. SET. 1 hit.
[Graphical view]
SMARTSM00317. SET. 1 hit.
[Graphical view]
SUPFAMSSF54171. SSF54171. 1 hit.
PROSITEPS50982. MBD. 1 hit.
PS50868. POST_SET. 1 hit.
PS50867. PRE_SET. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSETB1_DROPS
AccessionPrimary (citable) accession number: Q28Z18
Secondary accession number(s): B5DZD5, B5DZD6
Entry history
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: April 4, 2006
Last modified: February 19, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase