Reviewed, UniProtKB/Swiss-Prot Q28WA7 (DXS1_JANSC)

Names and origin

Protein names

Recommended name:
    1-deoxy-D-xylulose-5-phosphate synthase 1
    EC=2.2.1.7
Alternative name(s):
    1-deoxyxylulose-5-phosphate synthase 1
      Short name=DXP synthase 1
      Short name=DXPS 1

Gene names

Name:	dxs1
Ordered Locus Names:	Jann_0088

Organism

Jannaschia sp. (strain CCS1) [Complete proteome] [HAMAP]

Taxonomic identifier

290400 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhodobacterales › Rhodobacteraceae › Jannaschia

Protein attributes

Sequence length	639 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) By similarity.
Catalytic activity	Pyruvate + D-glyceraldehyde 3-phosphate = 1-deoxy-D-xylulose 5-phosphate + CO2. HAMAP MF_00315
Cofactor	Binds 1 thiamine pyrophosphate per subunit By similarity.
Pathway	Metabolic intermediate biosynthesis; 1-deoxy-D-xylulose 5-phosphate biosynthesis; 1-deoxy-D-xylulose 5-phosphate from D-glyceraldehyde 3-phosphate and pyruvate: step 1/1. HAMAP MF_00315
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the transketolase family. DXPS subfamily.

Ontologies

Keywords
Biological process	Isoprene biosynthesis Thiamine biosynthesis
Ligand	Thiamine pyrophosphate
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	terpenoid biosynthetic process Inferred from electronic annotation. Source: HAMAP thiamin biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	1-deoxy-D-xylulose-5-phosphate synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 639	639	1-deoxy-D-xylulose-5-phosphate synthase 1 HAMAP MF_00315		PRO_0000256431

Sequences

	Sequence		Length	Mass (Da)
	Q28WA7-1 [UniParc]. Last modified April 4, 2006. Version 1. Checksum: A655B3A2BAF24847	FASTA	639	68,187
	10 20 30 40 50 60 MSDRPSTPLL DNVQSPNDLK GLSDFDLKRL ADELRAEMIW TVSKTGGHFG AGLGVVELTV 70 80 90 100 110 120 ALHSVFDTPR DKLVWDVSHQ CYPHKILTGR RDQMLTIRQK DGLSGFTKRS ESPFDPFGAA 130 140 150 160 170 180 HSSTSISAAL GFAVARDLGG DSDTGHGDAI AVIGDGAMSG GMAFEAMNNA GHLGKRLIVI 190 200 210 220 230 240 LNDNEMSIAP PTGALSSYLS RLYAGAPFQE FKAAAKGAVS LLPEPFQEGA RRAKELLKSA 250 260 270 280 290 300 TVGGTLFEEL GFSYVGPIDG HDMESLLSVL RTVKARADGP ILIHAITKKG KGYSEHRADR 310 320 330 340 350 360 GHATAKFNIA TGEQVKAPSN APSYTKVFAQ SLIAEAEDDP KVVAVTAAMP DGTGLDLFAE 370 380 390 400 410 420 RFPSRCFDVG IAEQHGVTFA AGMAAGGLKP FAAIYSTFLQ RGYDQVVHDV AIQRLPVRFA 430 440 450 460 470 480 IDRAGLVGAD GCTHAGSYDI SYLANLPGFV VMAAADEAEL RHMVRTALEI DDRPSAFRFP 490 500 510 520 530 540 RGEGMGVDMP DRGTALEIGK GRMISEGNRV AILNFGTRLK EVQEAAETLS QRGITPTIAD 550 560 570 580 590 600 ARFAKPLDEA LILQLARHHE ALITVEEGAV GGFGSHVAHL LAENAVFDTG IKYRSMVLPD 610 620 630 IFIDQASPKD MYAVAGMNAE DIVAKVLTTL GVEVLSQRA

References

[1]

"Complete sequence of chromosome of Jannaschia sp. CCS1." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Pitluck S., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Chertkov O., Saunders E., Schmutz J., Larimer F. , Land M., Kyrpides N., Lykidis A., Moran M.A., Belas R., Ye W., Buchan A., Gonzalez J.M., Schell M.A., Richardson P. Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000264 Genomic DNA. Translation: ABD53005.1.
RefSeq	YP_508030.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q28WA7.
Genome annotation databases
GeneID	3932524.
GenomeReviews	Gene locus Jann_0088 in contig CP000264_GR.
KEGG	jan:Jann_0088.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q28WA7.
OMA	QRFPDRY.
Enzyme and pathway databases
BioCyc	JSP290400:JANN_0088-MON.
Family and domain databases
HAMAP	MF_00315. [Tree]
InterPro	IPR005477. Dxylulose-5-P_synthase. IPR015941. Transketolase-like_C. IPR005475. Transketolase-like_Pyr-bd. IPR005476. Transketolase_C. IPR005474. Transketolase_N. [Graphical view]
Gene3D	G3DSA:3.40.50.920. Transketo_C_like. 1 hit.
Pfam	PF02779. Transket_pyr. 1 hit. PF02780. Transketolase_C. 1 hit. [Graphical view]
TIGRFAMs	TIGR00204. dxs. 1 hit.
PROSITE	PS00801. TRANSKETOLASE_1. False negative. PS00802. TRANSKETOLASE_2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DXS1_JANSC

Accession

Primary (citable) accession number: Q28WA7

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
Last sequence update:	April 4, 2006
Last modified:	November 3, 2009
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)