Q28W25 (DXS2_JANSC) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
1-deoxy-D-xylulose-5-phosphate synthase 2
EC=2.2.1.7

Alternative name(s):
1-deoxyxylulose-5-phosphate synthase 2
Short name=DXP synthase 2
Short name=DXPS 2

Gene names

Name:	dxs2
Ordered Locus Names:	Jann_0170

Organism

Jannaschia sp. (strain CCS1) [Complete proteome] [HAMAP]

Taxonomic identifier

290400 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhodobacterales › Rhodobacteraceae › Jannaschia

Protein attributes

Sequence length	636 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) By similarity. HAMAP MF_00315
Catalytic activity	Pyruvate + D-glyceraldehyde 3-phosphate = 1-deoxy-D-xylulose 5-phosphate + CO2. HAMAP MF_00315
Cofactor	Binds 1 thiamine pyrophosphate per subunit By similarity.
Pathway	Metabolic intermediate biosynthesis; 1-deoxy-D-xylulose 5-phosphate biosynthesis; 1-deoxy-D-xylulose 5-phosphate from D-glyceraldehyde 3-phosphate and pyruvate: step 1/1. HAMAP MF_00315
Subunit structure	Homodimer By similarity. HAMAP MF_00315
Sequence similarities	Belongs to the transketolase family. DXPS subfamily.

Ontologies

Keywords
Biological process	Isoprene biosynthesis Thiamine biosynthesis
Ligand	Thiamine pyrophosphate
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	terpenoid biosynthetic process Inferred from electronic annotation. Source: InterPro thiamine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	1-deoxy-D-xylulose-5-phosphate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 636	636	1-deoxy-D-xylulose-5-phosphate synthase 2 HAMAP MF_00315		PRO_0000256432

Sequences

	Sequence		Length	Mass (Da)
	Q28W25 [UniParc]. Last modified April 4, 2006. Version 1. Checksum: 1A2377809ECD39F2	FASTA	636	66,801
	10 20 30 40 50 60 MDRPHTPILD QVNYPSDLRR MSNADLAQCA DELRAEVISA VSETGGHLGS SLGVVELSVA 70 80 90 100 110 120 IHAVFNTPYD KLVWDVGHQC YPHKVLTGRR DRIRTLRQKD GLSGFTKRSE SEYDPFGAAH 130 140 150 160 170 180 SSTSISAALG FAAAQDLGEA TGDGIAVIGD GSISAGMAYE ALNNAGDLGK RLFVILNDNE 190 200 210 220 230 240 MSIAPPVGAM SKYLTDLSAK SPLATLKDIA DGVASHLPEP IRQGAERARE LVTGHQPSAT 250 260 270 280 290 300 LFEHLGFTYI GPVDGHDMEE LLTTLRAAKA RATGPVLIHA VTVKGKGYSP AELSDDCYHG 310 320 330 340 350 360 VAKFDVATGQ QKKSAPNAPS YTSVFGQTLL NMAEADSRIV GVTAAMPGGT GISTLQKAKP 370 380 390 400 410 420 NRVFDVGIAE QHAVTFSAGM AAGGLKPFCA IYSSFLQRGY DQIVHDVALQ SLPVRFMIDR 430 440 450 460 470 480 AGLVGADGPT HAGAFDIGYL SALPNMTVMA CADEAELVHM MATAAAHNDG PIALRYPRGE 490 500 510 520 530 540 GTGVALPDQG DVLEIGKGRV IQDGHDVAIL SFGAHLEEAK DAATALEARG LSVTVADARF 550 560 570 580 590 600 AKPLDTTLID DLMTKHSALI TVEQGAVLGF GGLVLHHLAA TGQLDGRCAV RTLHLPDRFI 610 620 630 DQASPAEMYA DAGLTADDIA QAALEAMGVE VLAARA

References

[1]

"Complete sequence of chromosome of Jannaschia sp. CCS1." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Pitluck S., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Chertkov O., Saunders E., Schmutz J., Larimer F. , Land M., Kyrpides N., Lykidis A., Moran M.A., Belas R., Ye W., Buchan A., Gonzalez J.M., Schell M.A., Richardson P. Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CCS1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000264 Genomic DNA. Translation: ABD53087.1.
RefSeq	YP_508112.1. NC_007802.1.
3D structure databases
ProteinModelPortal	Q28W25.
ModBase	Search...
Protein-protein interaction databases
STRING	Q28W25.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3932607.
GenomeReviews	Gene locus Jann_0170 in contig CP000264_GR.
KEGG	jan:Jann_0170.
PATRIC	22143936. VBIJanSp43325_0246.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1154.
HOGENOM	HBG571647.
OMA	YPRGAFI.
PhylomeDB	Q28W25.
ProtClustDB	PRK12571.
Enzyme and pathway databases
BioCyc	JSP290400:JANN_0170-MONOMER.
Family and domain databases
HAMAP	MF_00315. DXP_synth. [Tree]
InterPro	IPR005477. Dxylulose-5-P_synthase. IPR009014. Transketo_C/Pyr-ferredox_oxred. IPR015941. Transketolase-like_C. IPR005475. Transketolase-like_Pyr-bd. IPR020826. Transketolase_BS. IPR005476. Transketolase_C. IPR005474. Transketolase_N. [Graphical view]
Gene3D	G3DSA:3.40.50.920. Transketo_C_like. 1 hit.
KO	K01662.
Pfam	PF02779. Transket_pyr. 1 hit. PF02780. Transketolase_C. 1 hit. [Graphical view]
SMART	SM00861. Transket_pyr. 1 hit. [Graphical view]
SUPFAM	SSF52922. Transketo_C_like. 1 hit.
TIGRFAMs	TIGR00204. Dxs. 1 hit.
PROSITE	PS00801. TRANSKETOLASE_1. 1 hit. PS00802. TRANSKETOLASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DXS2_JANSC

Accession

Primary (citable) accession number: Q28W25

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
Last sequence update:	April 4, 2006
Last modified:	January 25, 2012
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program