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Protein

Shikimate dehydrogenase (NADP(+))

Gene

aroE

Organism
Jannaschia sp. (strain CCS1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).UniRule annotation

Catalytic activityi

Shikimate + NADP+ = 3-dehydroshikimate + NADPH.UniRule annotation

Pathwayi: chorismate biosynthesis

This protein is involved in step 4 of the subpathway that synthesizes chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate.UniRule annotation
Proteins known to be involved in the 7 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. 3-dehydroquinate synthase (aroB)
  3. 3-dehydroquinate dehydratase (aroQ)
  4. Shikimate dehydrogenase (NADP(+)) (aroE)
  5. Shikimate kinase (aroK), Shikimate kinase (aroK)
  6. 3-phosphoshikimate 1-carboxyvinyltransferase (aroA)
  7. Chorismate synthase (aroC)
This subpathway is part of the pathway chorismate biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate, the pathway chorismate biosynthesis and in Metabolic intermediate biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei66ShikimateUniRule annotation1
Active sitei70Proton acceptorUniRule annotation1
Binding sitei82NADPUniRule annotation1
Binding sitei91ShikimateUniRule annotation1
Binding sitei107ShikimateUniRule annotation1
Binding sitei222NADP; via carbonyl oxygenUniRule annotation1
Binding sitei224ShikimateUniRule annotation1
Binding sitei245NADP; via carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi133 – 137NADPUniRule annotation5
Nucleotide bindingi157 – 162NADPUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processAmino-acid biosynthesis, Aromatic amino acid biosynthesis
LigandNADP

Enzyme and pathway databases

UniPathwayiUPA00053; UER00087

Names & Taxonomyi

Protein namesi
Recommended name:
Shikimate dehydrogenase (NADP(+))UniRule annotation (EC:1.1.1.25UniRule annotation)
Short name:
SDHUniRule annotation
Gene namesi
Name:aroEUniRule annotation
Ordered Locus Names:Jann_0196
OrganismiJannaschia sp. (strain CCS1)
Taxonomic identifieri290400 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeJannaschia
Proteomesi
  • UP000008326 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003251261 – 278Shikimate dehydrogenase (NADP(+))Add BLAST278

Proteomic databases

PRIDEiQ28VZ9

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi290400.Jann_0196

Structurei

3D structure databases

ProteinModelPortaliQ28VZ9
SMRiQ28VZ9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni19 – 21Shikimate bindingUniRule annotation3

Sequence similaritiesi

Belongs to the shikimate dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105E2X Bacteria
COG0169 LUCA
HOGENOMiHOG000237875
KOiK00014
OMAiIPHKERA
OrthoDBiPOG091H02DY

Family and domain databases

HAMAPiMF_00222 Shikimate_DH_AroE, 1 hit
InterProiView protein in InterPro
IPR036291 NAD(P)-bd_dom_sf
IPR011342 Shikimate_DH
IPR013708 Shikimate_DH-bd_N
IPR022893 Shikimate_DH_fam
IPR006151 Shikm_DH/Glu-tRNA_Rdtase
PfamiView protein in Pfam
PF01488 Shikimate_DH, 1 hit
PF08501 Shikimate_dh_N, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR00507 aroE, 1 hit

Sequencei

Sequence statusi: Complete.

Q28VZ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTRDTIPLAG VIGDPISHSL SPRLHGHWLR RYGLQGHYVP LHVNHANLET
60 70 80 90 100
VLRTLPLMGF VGVNVTLPHK EHVLSIADSV TDRAALIGAA NTLTFTANEQ
110 120 130 140 150
IQADNTDGMG FLSNIRQALP GWSASAGPAL VLGSGGAAKA IVSALVSDGA
160 170 180 190 200
PVVHVANRTR ARADGLKEQF GARVSPSDWT HIPDLIGDAA LIVNTTSLGM
210 220 230 240 250
AGQSPLSLDL SRLSPPTVVT DIVYAPLQTN LLRDASIRGC ETVDGLGMLL
260 270
HQAVPGFERW FNYTPTVDED LREAVLAG
Length:278
Mass (Da):29,474
Last modified:April 4, 2006 - v1
Checksum:iCBD6EC43F8E03388
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000264 Genomic DNA Translation: ABD53113.1
RefSeqiWP_011453322.1, NC_007802.1

Genome annotation databases

EnsemblBacteriaiABD53113; ABD53113; Jann_0196
KEGGijan:Jann_0196

Similar proteinsi

Entry informationi

Entry nameiAROE_JANSC
AccessioniPrimary (citable) accession number: Q28VZ9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: April 4, 2006
Last modified: May 23, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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