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Q28VU8

- UPPP_JANSC

UniProt

Q28VU8 - UPPP_JANSC

Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Jannaschia sp. (strain CCS1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 58 (01 Oct 2014)
      Sequence version 1 (04 Apr 2006)
      Previous versions | rss
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    Functioni

    Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

    Catalytic activityi

    Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

    GO - Molecular functioni

    1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. dephosphorylation Source: InterPro
    2. peptidoglycan biosynthetic process Source: UniProtKB-KW
    3. regulation of cell shape Source: UniProtKB-KW
    4. response to antibiotic Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

    Enzyme and pathway databases

    BioCyciJSP290400:GI1R-249-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)
    Alternative name(s):
    Bacitracin resistance proteinUniRule annotation
    Undecaprenyl pyrophosphate phosphataseUniRule annotation
    Gene namesi
    Name:uppPUniRule annotation
    Ordered Locus Names:Jann_0247
    OrganismiJannaschia sp. (strain CCS1)
    Taxonomic identifieri290400 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeJannaschia
    ProteomesiUP000008326: Chromosome

    Subcellular locationi

    Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 267267Undecaprenyl-diphosphatasePRO_0000250239Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi290400.Jann_0247.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei1 – 2121HelicalUniRule annotationAdd
    BLAST
    Transmembranei40 – 6021HelicalUniRule annotationAdd
    BLAST
    Transmembranei85 – 10521HelicalUniRule annotationAdd
    BLAST
    Transmembranei112 – 13221HelicalUniRule annotationAdd
    BLAST
    Transmembranei189 – 20921HelicalUniRule annotationAdd
    BLAST
    Transmembranei219 – 23921HelicalUniRule annotationAdd
    BLAST
    Transmembranei245 – 26521HelicalUniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UppP family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1968.
    HOGENOMiHOG000218357.
    KOiK06153.
    OMAiWAVFHES.
    OrthoDBiEOG6QP13M.

    Family and domain databases

    HAMAPiMF_01006. Undec_diphosphatase.
    InterProiIPR003824. UppP.
    [Graphical view]
    PfamiPF02673. BacA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q28VU8-1 [UniParc]FASTAAdd to Basket

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    MSLFTLFLLA LVQGITEFLP ISSSGHLILL PNLLGIEDQG QAIDVAVHVG    50
    TLGAVILYFW RDVKAAIAGT PRLLTGRIDT PGAKLAFLLI IATIPVIIFG 100
    LFLEVTGIYD SLRSIAVIGW TMLIFGLVLY WADQRGGTEK QSDDWSLRDA 150
    VTMGLWQAVA LIPGTSRSGI TITAARFLGY DRESAARVAM LMSIPTIIAT 200
    GVFAGAEVIA TADAQTARDG AIAAALSFLA ALAALTLMFR LLKSVSFTPY 250
    VIYRVILGVI LLVIAYA 267
    Length:267
    Mass (Da):28,501
    Last modified:April 4, 2006 - v1
    Checksum:i56EF129CD1E49CC0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000264 Genomic DNA. Translation: ABD53164.1.
    RefSeqiWP_011453373.1. NC_007802.1.
    YP_508189.1. NC_007802.1.

    Genome annotation databases

    EnsemblBacteriaiABD53164; ABD53164; Jann_0247.
    GeneIDi3932685.
    KEGGijan:Jann_0247.
    PATRICi22144084. VBIJanSp43325_0319.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000264 Genomic DNA. Translation: ABD53164.1 .
    RefSeqi WP_011453373.1. NC_007802.1.
    YP_508189.1. NC_007802.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 290400.Jann_0247.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABD53164 ; ABD53164 ; Jann_0247 .
    GeneIDi 3932685.
    KEGGi jan:Jann_0247.
    PATRICi 22144084. VBIJanSp43325_0319.

    Phylogenomic databases

    eggNOGi COG1968.
    HOGENOMi HOG000218357.
    KOi K06153.
    OMAi WAVFHES.
    OrthoDBi EOG6QP13M.

    Enzyme and pathway databases

    BioCyci JSP290400:GI1R-249-MONOMER.

    Family and domain databases

    HAMAPi MF_01006. Undec_diphosphatase.
    InterProi IPR003824. UppP.
    [Graphical view ]
    Pfami PF02673. BacA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CCS1.

    Entry informationi

    Entry nameiUPPP_JANSC
    AccessioniPrimary (citable) accession number: Q28VU8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 19, 2006
    Last sequence update: April 4, 2006
    Last modified: October 1, 2014
    This is version 58 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3