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Q28VU8

- UPPP_JANSC

UniProt

Q28VU8 - UPPP_JANSC

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Protein
Undecaprenyl-diphosphatase
Gene
uppP, Jann_0247
Organism
Jannaschia sp. (strain CCS1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity.UniRule annotation

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

  1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. dephosphorylation Source: InterPro
  2. peptidoglycan biosynthetic process Source: UniProtKB-KW
  3. regulation of cell shape Source: UniProtKB-KW
  4. response to antibiotic Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciJSP290400:GI1R-249-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphatase (EC:3.6.1.27)
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene namesi
Name:uppP
Ordered Locus Names:Jann_0247
OrganismiJannaschia sp. (strain CCS1)
Taxonomic identifieri290400 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeJannaschia
ProteomesiUP000008326: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1 – 2121Helical; Reviewed prediction
Add
BLAST
Transmembranei40 – 6021Helical; Reviewed prediction
Add
BLAST
Transmembranei85 – 10521Helical; Reviewed prediction
Add
BLAST
Transmembranei112 – 13221Helical; Reviewed prediction
Add
BLAST
Transmembranei189 – 20921Helical; Reviewed prediction
Add
BLAST
Transmembranei219 – 23921Helical; Reviewed prediction
Add
BLAST
Transmembranei245 – 26521Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 267267Undecaprenyl-diphosphataseUniRule annotation
PRO_0000250239Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi290400.Jann_0247.

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1968.
HOGENOMiHOG000218357.
KOiK06153.
OMAiWAVFHES.
OrthoDBiEOG6QP13M.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q28VU8-1 [UniParc]FASTAAdd to Basket

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MSLFTLFLLA LVQGITEFLP ISSSGHLILL PNLLGIEDQG QAIDVAVHVG    50
TLGAVILYFW RDVKAAIAGT PRLLTGRIDT PGAKLAFLLI IATIPVIIFG 100
LFLEVTGIYD SLRSIAVIGW TMLIFGLVLY WADQRGGTEK QSDDWSLRDA 150
VTMGLWQAVA LIPGTSRSGI TITAARFLGY DRESAARVAM LMSIPTIIAT 200
GVFAGAEVIA TADAQTARDG AIAAALSFLA ALAALTLMFR LLKSVSFTPY 250
VIYRVILGVI LLVIAYA 267
Length:267
Mass (Da):28,501
Last modified:April 4, 2006 - v1
Checksum:i56EF129CD1E49CC0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000264 Genomic DNA. Translation: ABD53164.1.
RefSeqiWP_011453373.1. NC_007802.1.
YP_508189.1. NC_007802.1.

Genome annotation databases

EnsemblBacteriaiABD53164; ABD53164; Jann_0247.
GeneIDi3932685.
KEGGijan:Jann_0247.
PATRICi22144084. VBIJanSp43325_0319.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000264 Genomic DNA. Translation: ABD53164.1 .
RefSeqi WP_011453373.1. NC_007802.1.
YP_508189.1. NC_007802.1.

3D structure databases

ModBasei Search...

Protein-protein interaction databases

STRINGi 290400.Jann_0247.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABD53164 ; ABD53164 ; Jann_0247 .
GeneIDi 3932685.
KEGGi jan:Jann_0247.
PATRICi 22144084. VBIJanSp43325_0319.

Phylogenomic databases

eggNOGi COG1968.
HOGENOMi HOG000218357.
KOi K06153.
OMAi WAVFHES.
OrthoDBi EOG6QP13M.

Enzyme and pathway databases

BioCyci JSP290400:GI1R-249-MONOMER.

Family and domain databases

HAMAPi MF_01006. Undec_diphosphatase.
InterProi IPR003824. UppP.
[Graphical view ]
Pfami PF02673. BacA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CCS1.

Entry informationi

Entry nameiUPPP_JANSC
AccessioniPrimary (citable) accession number: Q28VU8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: April 4, 2006
Last modified: September 3, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi