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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Jannaschia sp. (strain CCS1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei630ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Jann_0411
OrganismiJannaschia sp. (strain CCS1)
Taxonomic identifieri290400 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeJannaschia
Proteomesi
  • UP000008326 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000093551 – 863Leucine--tRNA ligaseAdd BLAST863

Proteomic databases

PRIDEiQ28VD4

Interactioni

Protein-protein interaction databases

STRINGi290400.Jann_0411

Structurei

3D structure databases

ProteinModelPortaliQ28VD4
SMRiQ28VD4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi41 – 51"HIGH" regionAdd BLAST11
Motifi627 – 631"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8T Bacteria
COG0495 LUCA
HOGENOMiHOG000200747
KOiK01869
OMAiTFMVLAP
OrthoDBiPOG091H01JZ

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR015413 Methionyl/Leucyl_tRNA_Synth
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 1 hit
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 2 hits
PF13603 tRNA-synt_1_2, 1 hit
PF09334 tRNA-synt_1g, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q28VD4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRYDPSMIE PKWQKAWAEA GTFTASMEGN KPKYYVLEMF PYPSGRIHIG
60 70 80 90 100
HVRNYTMGDV IARHKKAMGH NVLHPMGFDA FGLAAENAAM DRGIHPKDWT
110 120 130 140 150
YKNMDDMRDQ MRPLGFSIDW SRDLATCDPD YYGQQQALFI DMMEAGLIDR
160 170 180 190 200
KNAVVNWDPV DMTVLANEQV EDGKGWRSGA EVERKELTQW FFKISDYSDE
210 220 230 240 250
LLEALDGLDD WPAKVKLMQA NWIGKSRGLQ FAFGLVEPVG GHDRVDVYTT
260 270 280 290 300
RPDTLLGASF VGISPDHAIA KQLESESEDI AAFCAECRKG GTTAAEVETA
310 320 330 340 350
EKLGFDTGLK VRHPFDTAAQ LPVYIANFIL MDYGTGAIFG CPAHDERDLD
360 370 380 390 400
FARKYDLPVV STYVPIDDEG HVLPEDGGAA YVPPKPDPVR YIRGFAGEEI
410 420 430 440 450
QSGNDAIDAA VTFCEAEGVG QGVTKFRLRD WGLSRQRYWG CPIPVVHCDA
460 470 480 490 500
CGVVPEKKEN LPIELPYDVT FDVPGNPLDR HPTWRNTPCP SCGAPALRET
510 520 530 540 550
DTMDTFVDSS WYFARFTAPH ADTPTSKAEV EYWMNVDQYI GGIEHAILHL
560 570 580 590 600
LYSRFFARAM HITGHLPRKA IEPFDALFTQ GMVTHAIYKT TDAKNRPVYH
610 620 630 640 650
YPETVDLRDG GGYLDDGTAV EIIPSAKMSK SKNNVVDPIE IIKQYGADTA
660 670 680 690 700
RWFVLSDSPP ERDVEWTASG AEAAYKHLGR VWALCDRISE AARSVSEEAQ
710 720 730 740 750
PAAGEHDTAL LREMHKTIRD VTNGVDSFGF NAAIAKLYAF TNTLQKSKAS
760 770 780 790 800
HKAQREAVMT LAQLMAPMTP HLSEDIWAHQ GGDGLIADAP WPVANEAMLV
810 820 830 840 850
ESTVTLPIQI NGKRRSEVTV AKDASKEEVE KRALADDAVV RALDGAAPKK
860
LIVVPGRIVN VVI
Length:863
Mass (Da):95,767
Last modified:April 4, 2006 - v1
Checksum:i5BCB6A77FEE205FF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000264 Genomic DNA Translation: ABD53328.1
RefSeqiWP_011453537.1, NC_007802.1

Genome annotation databases

EnsemblBacteriaiABD53328; ABD53328; Jann_0411
KEGGijan:Jann_0411

Similar proteinsi

Entry informationi

Entry nameiSYL_JANSC
AccessioniPrimary (citable) accession number: Q28VD4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 4, 2006
Last modified: May 23, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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