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Q28UI8

- TRMB_JANSC

UniProt

Q28UI8 - TRMB_JANSC

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Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene
trmB, Jann_0707
Organism
Jannaschia sp. (strain CCS1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA By similarity.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei67 – 671S-adenosyl-L-methionine By similarity
Binding sitei92 – 921S-adenosyl-L-methionine By similarity
Binding sitei119 – 1191S-adenosyl-L-methionine By similarity
Active sitei141 – 1411 By similarity
Binding sitei141 – 1411S-adenosyl-L-methionine By similarity
Binding sitei145 – 1451Substrate By similarity
Binding sitei177 – 1771Substrate By similarity

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciJSP290400:GI1R-714-MONOMER.
UniPathwayiUPA00989.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferase (EC:2.1.1.33)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferase
tRNA(m7G46)-methyltransferase
Gene namesi
Name:trmB
Ordered Locus Names:Jann_0707
OrganismiJannaschia sp. (strain CCS1)
Taxonomic identifieri290400 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeJannaschia
ProteomesiUP000008326: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 237237tRNA (guanine-N(7)-)-methyltransferaseUniRule annotationPRO_0000288160Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi290400.Jann_0707.

Structurei

3D structure databases

ProteinModelPortaliQ28UI8.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni214 – 2174Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0220.
HOGENOMiHOG000073969.
KOiK03439.
OrthoDBiEOG6K6VBC.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01057. tRNA_methyltr_TrmB.
InterProiIPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view]
PfamiPF02390. Methyltransf_4. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q28UI8-1 [UniParc]FASTAAdd to Basket

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MTDPHPNRPH RNFYGRRKGH DLRDSQERYL AEDLAKLSPG AVDWDVNPDR    50
TPLDLKERFG GKDIWLEVGF GGGEHLVHQA ASNPDVAIIG CEPYINGVAM 100
LLGKIRAAGV GNLAVYPGDA RDLFDVLPKG SVAKAFLLYP DPWPKARHHR 150
RRFVTTEHLE PLHRAMRPGA EFRVATDIED YVRQTMEEVP KAGFEWLAEA 200
ASDWREPWCD WVSTRYEQKA LREGRVPHYM TFQKRSL 237
Length:237
Mass (Da):27,122
Last modified:May 29, 2007 - v2
Checksum:i7A01AC4EF14C8C80
GO

Sequence cautioni

The sequence ABD53624.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000264 Genomic DNA. Translation: ABD53624.1. Different initiation.
RefSeqiWP_011453832.1. NC_007802.1.
YP_508649.1. NC_007802.1.

Genome annotation databases

EnsemblBacteriaiABD53624; ABD53624; Jann_0707.
GeneIDi3933150.
KEGGijan:Jann_0707.
PATRICi22145050. VBIJanSp43325_0798.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000264 Genomic DNA. Translation: ABD53624.1 . Different initiation.
RefSeqi WP_011453832.1. NC_007802.1.
YP_508649.1. NC_007802.1.

3D structure databases

ProteinModelPortali Q28UI8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 290400.Jann_0707.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABD53624 ; ABD53624 ; Jann_0707 .
GeneIDi 3933150.
KEGGi jan:Jann_0707.
PATRICi 22145050. VBIJanSp43325_0798.

Phylogenomic databases

eggNOGi COG0220.
HOGENOMi HOG000073969.
KOi K03439.
OrthoDBi EOG6K6VBC.

Enzyme and pathway databases

UniPathwayi UPA00989 .
BioCyci JSP290400:GI1R-714-MONOMER.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
HAMAPi MF_01057. tRNA_methyltr_TrmB.
InterProi IPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view ]
Pfami PF02390. Methyltransf_4. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CCS1.

Entry informationi

Entry nameiTRMB_JANSC
AccessioniPrimary (citable) accession number: Q28UI8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 29, 2007
Last modified: September 3, 2014
This is version 51 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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