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Q28UI8

- TRMB_JANSC

UniProt

Q28UI8 - TRMB_JANSC

Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

trmB

Organism
Jannaschia sp. (strain CCS1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 52 (01 Oct 2014)
      Sequence version 2 (29 May 2007)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

    Catalytic activityi

    S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei67 – 671S-adenosyl-L-methionineUniRule annotation
    Binding sitei92 – 921S-adenosyl-L-methionineUniRule annotation
    Binding sitei119 – 1191S-adenosyl-L-methionineUniRule annotation
    Active sitei141 – 1411By similarity
    Binding sitei141 – 1411S-adenosyl-L-methionineUniRule annotation
    Binding sitei145 – 1451SubstrateUniRule annotation
    Binding sitei177 – 1771SubstrateUniRule annotation

    GO - Molecular functioni

    1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    tRNA processing

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Enzyme and pathway databases

    BioCyciJSP290400:GI1R-714-MONOMER.
    UniPathwayiUPA00989.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
    Alternative name(s):
    tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
    tRNA(m7G46)-methyltransferaseUniRule annotation
    Gene namesi
    Name:trmBUniRule annotation
    Ordered Locus Names:Jann_0707
    OrganismiJannaschia sp. (strain CCS1)
    Taxonomic identifieri290400 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeJannaschia
    ProteomesiUP000008326: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 237237tRNA (guanine-N(7)-)-methyltransferasePRO_0000288160Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi290400.Jann_0707.

    Structurei

    3D structure databases

    ProteinModelPortaliQ28UI8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni214 – 2174Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0220.
    HOGENOMiHOG000073969.
    KOiK03439.
    OrthoDBiEOG6K6VBC.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    HAMAPiMF_01057. tRNA_methyltr_TrmB.
    InterProiIPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view]
    PfamiPF02390. Methyltransf_4. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 1 hit.
    PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q28UI8-1 [UniParc]FASTAAdd to Basket

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    MTDPHPNRPH RNFYGRRKGH DLRDSQERYL AEDLAKLSPG AVDWDVNPDR    50
    TPLDLKERFG GKDIWLEVGF GGGEHLVHQA ASNPDVAIIG CEPYINGVAM 100
    LLGKIRAAGV GNLAVYPGDA RDLFDVLPKG SVAKAFLLYP DPWPKARHHR 150
    RRFVTTEHLE PLHRAMRPGA EFRVATDIED YVRQTMEEVP KAGFEWLAEA 200
    ASDWREPWCD WVSTRYEQKA LREGRVPHYM TFQKRSL 237
    Length:237
    Mass (Da):27,122
    Last modified:May 29, 2007 - v2
    Checksum:i7A01AC4EF14C8C80
    GO

    Sequence cautioni

    The sequence ABD53624.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000264 Genomic DNA. Translation: ABD53624.1. Different initiation.
    RefSeqiWP_011453832.1. NC_007802.1.
    YP_508649.1. NC_007802.1.

    Genome annotation databases

    EnsemblBacteriaiABD53624; ABD53624; Jann_0707.
    GeneIDi3933150.
    KEGGijan:Jann_0707.
    PATRICi22145050. VBIJanSp43325_0798.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000264 Genomic DNA. Translation: ABD53624.1 . Different initiation.
    RefSeqi WP_011453832.1. NC_007802.1.
    YP_508649.1. NC_007802.1.

    3D structure databases

    ProteinModelPortali Q28UI8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 290400.Jann_0707.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABD53624 ; ABD53624 ; Jann_0707 .
    GeneIDi 3933150.
    KEGGi jan:Jann_0707.
    PATRICi 22145050. VBIJanSp43325_0798.

    Phylogenomic databases

    eggNOGi COG0220.
    HOGENOMi HOG000073969.
    KOi K03439.
    OrthoDBi EOG6K6VBC.

    Enzyme and pathway databases

    UniPathwayi UPA00989 .
    BioCyci JSP290400:GI1R-714-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    HAMAPi MF_01057. tRNA_methyltr_TrmB.
    InterProi IPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view ]
    Pfami PF02390. Methyltransf_4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 1 hit.
    PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CCS1.

    Entry informationi

    Entry nameiTRMB_JANSC
    AccessioniPrimary (citable) accession number: Q28UI8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2007
    Last sequence update: May 29, 2007
    Last modified: October 1, 2014
    This is version 52 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3