Q28UI7 (AROA_JANSC) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
3-phosphoshikimate 1-carboxyvinyltransferase
EC=2.5.1.19

Alternative name(s):
5-enolpyruvylshikimate-3-phosphate synthase
Short name=EPSP synthase
Short name=EPSPS

Gene names

Name:	aroA
Ordered Locus Names:	Jann_0708

Organism

Jannaschia sp. (strain CCS1) [Complete proteome] [HAMAP]

Taxonomic identifier

290400 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhodobacterales › Rhodobacteraceae › Jannaschia

Protein attributes

Sequence length	450 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate. HAMAP MF_00210
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7. HAMAP MF_00210
Subunit structure	Monomer By similarity. HAMAP MF_00210
Subcellular location	Cytoplasm By similarity HAMAP MF_00210.
Sequence similarities	Belongs to the EPSP synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-phosphoshikimate 1-carboxyvinyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 450	450	3-phosphoshikimate 1-carboxyvinyltransferase HAMAP MF_00210		PRO_1000058601

Sequences

	Sequence		Length	Mass (Da)
	Q28UI7 [UniParc]. Last modified April 4, 2006. Version 1. Checksum: 4FF5A78472C1AAB0	FASTA	450	47,050
	10 20 30 40 50 60 MSAHGDPKPM TARKGGALTG TAEVPGDKSI SHRSLIFGAM AVGETRVTGL LEGQDVLDTA 70 80 90 100 110 120 SAMRAFGAEV AREDDGTWSI HGVGVGGFVE PDDVLDCGNS GTGVRLLMGA MATTPISVTF 130 140 150 160 170 180 TGDASLRSRP MARVTDPLAL FGTRAYGRAQ GRLPMTLVGA EAPMPVRYAT PVPSAQVKSA 190 200 210 220 230 240 VLLAGLNAPG ETVVIEAEAT RDHSERMLAG FGAQISTEVT QEGRVITLTG QPELTPQVIA 250 260 270 280 290 300 VPRDPSSAAF PVCAAIITEG SDVLVPNIGL NPTRAGLFET LRDMGADLTY ENPREEGGEP 310 320 330 340 350 360 VADLRAKFSP DMKGIEVPPE RAASMIDEYP ILSVVAANAE GTTVMRGVKE LRVKESDRIA 370 380 390 400 410 420 AMADGLRLNG IEVEDGPDWW IVHGRGPGGM AGGATVATHL DHRIAMSFLC AGFASQQGIT 430 440 450 IDDSGPIATS FPIFEPLMRD LGARLDRANA

References

[1]

"Complete sequence of chromosome of Jannaschia sp. CCS1." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Pitluck S., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Chertkov O., Saunders E., Schmutz J., Larimer F. , Land M., Kyrpides N., Lykidis A., Moran M.A., Belas R., Ye W., Buchan A., Gonzalez J.M., Schell M.A., Richardson P. Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CCS1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000264 Genomic DNA. Translation: ABD53625.1.
RefSeq	YP_508650.1. NC_007802.1.
3D structure databases
ProteinModelPortal	Q28UI7.
SMR	Q28UI7. Positions 8-447.
ModBase	Search...
Protein-protein interaction databases
STRING	Q28UI7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3933151.
GenomeReviews	Gene locus Jann_0708 in contig CP000264_GR.
KEGG	jan:Jann_0708.
PATRIC	22145052. VBIJanSp43325_0799.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0128.
HOGENOM	HBG646626.
OMA	VVMVMAT.
PhylomeDB	Q28UI7.
ProtClustDB	PRK02427.
Enzyme and pathway databases
BioCyc	JSP290400:JANN_0708-MONOMER.
Family and domain databases
HAMAP	MF_00210. EPSP_synth. [Tree]
InterPro	IPR001986. Enolpyruvate_Tfrase_dom. IPR006264. EPSP_synthase. IPR023193. EPSP_synthase_CS. IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b. [Graphical view]
Gene3D	G3DSA:3.65.10.10. EPSP_synthase. 2 hits.
KO	K00800.
Pfam	PF00275. EPSP_synthase. 1 hit. [Graphical view]
PIRSF	PIRSF000505. EPSPS. 1 hit.
SUPFAM	SSF55205. RNA3'_cycl/enolpyr_transf_A/B. 1 hit.
TIGRFAMs	TIGR01356. AroA. 1 hit.
PROSITE	PS00104. EPSP_SYNTHASE_1. 1 hit. PS00885. EPSP_SYNTHASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROA_JANSC

Accession

Primary (citable) accession number: Q28UI7

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	April 4, 2006
Last modified:	January 25, 2012
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program