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Q28U77

- MDH_JANSC

UniProt

Q28U77 - MDH_JANSC

Protein

Malate dehydrogenase

Gene

mdh

Organism
Jannaschia sp. (strain CCS1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 58 (01 Oct 2014)
      Sequence version 1 (04 Apr 2006)
      Previous versions | rss
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    Functioni

    Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotation

    Catalytic activityi

    (S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei34 – 341NADUniRule annotation
    Binding sitei83 – 831SubstrateUniRule annotation
    Binding sitei89 – 891SubstrateUniRule annotation
    Binding sitei96 – 961NADUniRule annotation
    Binding sitei121 – 1211SubstrateUniRule annotation
    Binding sitei152 – 1521SubstrateUniRule annotation
    Active sitei176 – 1761Proton acceptorUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi10 – 156NADUniRule annotation
    Nucleotide bindingi119 – 1213NADUniRule annotation

    GO - Molecular functioni

    1. L-malate dehydrogenase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. cellular carbohydrate metabolic process Source: InterPro
    2. malate metabolic process Source: InterPro
    3. tricarboxylic acid cycle Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Tricarboxylic acid cycle

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciJSP290400:GI1R-825-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
    Gene namesi
    Name:mdhUniRule annotation
    Ordered Locus Names:Jann_0818
    OrganismiJannaschia sp. (strain CCS1)
    Taxonomic identifieri290400 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeJannaschia
    ProteomesiUP000008326: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 320320Malate dehydrogenasePRO_0000241951Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi290400.Jann_0818.

    Structurei

    3D structure databases

    ProteinModelPortaliQ28U77.
    SMRiQ28U77. Positions 3-314.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LDH/MDH superfamily. MDH type 3 family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0039.
    HOGENOMiHOG000213794.
    KOiK00024.
    OMAiLDLMEAQ.
    OrthoDBiEOG6091FG.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    3.90.110.10. 1 hit.
    HAMAPiMF_00487. Malate_dehydrog_3.
    InterProiIPR001557. L-lactate/malate_DH.
    IPR022383. Lactate/malate_DH_C.
    IPR001236. Lactate/malate_DH_N.
    IPR015955. Lactate_DH/Glyco_Ohase_4_C.
    IPR011275. Malate_DH_type3.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR11540. PTHR11540. 1 hit.
    PfamiPF02866. Ldh_1_C. 1 hit.
    PF00056. Ldh_1_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
    PRINTSiPR00086. LLDHDRGNASE.
    SUPFAMiSSF56327. SSF56327. 1 hit.
    TIGRFAMsiTIGR01763. MalateDH_bact. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q28U77-1 [UniParc]FASTAAdd to Basket

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    MARPKIALIG AGQIGGTLAH LAALKELGDV VLFDIAEGVP QGKALDIAES    50
    GPSEKFDADM SGTNDYADIA GADVCIVTAG VARKPGMSRD DLLGINLKVM 100
    KSVGEGIRDN APDAFVICIT NPLDAMVWAL REFSGLPHHK VCGMAGVLDS 150
    ARFRHFLADE FNVSMKDVTA FVLGGHGDTM VPLTRYSTVA GIPLPDLIEM 200
    GWTTQEKMDA IVQRTRDGGA EIVGLLKTGS AFYAPATSAI EMAEAYLKDQ 250
    KRVLPCAAYV DGALGLKGMY VGVPTVIGAG GVERVVDINM TKDEQAMFDN 300
    SVAAVNGLVE ACKAIDETLS 320
    Length:320
    Mass (Da):33,647
    Last modified:April 4, 2006 - v1
    Checksum:iE09B145ADD19FEBB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000264 Genomic DNA. Translation: ABD53735.1.
    RefSeqiWP_011453943.1. NC_007802.1.
    YP_508760.1. NC_007802.1.

    Genome annotation databases

    EnsemblBacteriaiABD53735; ABD53735; Jann_0818.
    GeneIDi3933261.
    KEGGijan:Jann_0818.
    PATRICi22145294. VBIJanSp43325_0920.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000264 Genomic DNA. Translation: ABD53735.1 .
    RefSeqi WP_011453943.1. NC_007802.1.
    YP_508760.1. NC_007802.1.

    3D structure databases

    ProteinModelPortali Q28U77.
    SMRi Q28U77. Positions 3-314.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 290400.Jann_0818.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABD53735 ; ABD53735 ; Jann_0818 .
    GeneIDi 3933261.
    KEGGi jan:Jann_0818.
    PATRICi 22145294. VBIJanSp43325_0920.

    Phylogenomic databases

    eggNOGi COG0039.
    HOGENOMi HOG000213794.
    KOi K00024.
    OMAi LDLMEAQ.
    OrthoDBi EOG6091FG.

    Enzyme and pathway databases

    BioCyci JSP290400:GI1R-825-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    3.90.110.10. 1 hit.
    HAMAPi MF_00487. Malate_dehydrog_3.
    InterProi IPR001557. L-lactate/malate_DH.
    IPR022383. Lactate/malate_DH_C.
    IPR001236. Lactate/malate_DH_N.
    IPR015955. Lactate_DH/Glyco_Ohase_4_C.
    IPR011275. Malate_DH_type3.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR11540. PTHR11540. 1 hit.
    Pfami PF02866. Ldh_1_C. 1 hit.
    PF00056. Ldh_1_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
    PRINTSi PR00086. LLDHDRGNASE.
    SUPFAMi SSF56327. SSF56327. 1 hit.
    TIGRFAMsi TIGR01763. MalateDH_bact. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CCS1.

    Entry informationi

    Entry nameiMDH_JANSC
    AccessioniPrimary (citable) accession number: Q28U77
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 27, 2006
    Last sequence update: April 4, 2006
    Last modified: October 1, 2014
    This is version 58 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3