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Q28TR4

- FTHS_JANSC

UniProt

Q28TR4 - FTHS_JANSC

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Protein

Formate--tetrahydrofolate ligase

Gene
fhs, Jann_0981
Organism
Jannaschia sp. (strain CCS1)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi67 – 748ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciJSP290400:GI1R-989-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase (EC:6.3.4.3)
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name:
FHS
Short name:
FTHFS
Gene namesi
Name:fhs
Ordered Locus Names:Jann_0981
OrganismiJannaschia sp. (strain CCS1)
Taxonomic identifieri290400 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeJannaschia
ProteomesiUP000008326: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 558558Formate--tetrahydrofolate ligaseUniRule annotationPRO_0000300524Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi290400.Jann_0981.

Structurei

3D structure databases

ProteinModelPortaliQ28TR4.
SMRiQ28TR4. Positions 6-556.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiACEEETE.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q28TR4-1 [UniParc]FASTAAdd to Basket

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MGYKSDIEIA REAVKRPIQE IGAKIGIESA DLLPYGHDKA KVSQSFINSV    50
QNRDNGHLIL VTAINPTPAG EGKTTTTVGL GDGLNRIGKN AMVCIREASL 100
GPNFGMKGGA AGGGYAQVVP MEEMNLHFTG DFHAITSAHS LLSAMIDNHI 150
YWGNELEIDV RRVVWRRVVD MNDRALRQIT ASLGGVANGF PREAGFDITV 200
ASEVMAILCL AKDLKDLQER LGAMIVAYRR DRSPVFARDI KADGAMTVLL 250
KDAMQPNIVQ TLENNPAFVH GGPFANIAHG CNSVIATTTA LKLCDYVVTE 300
AGFGADLGAE KFLNIKCRKA GLAPSVVVVV ATVRAMKMNG GVAKADLGAE 350
NVDAVQNGCA NLGRHIENVK SFGVPVVVAI NHFVTDTDAE VQAVKDYVAS 400
QGAEAVLSRH WELGSEGSAP LAEKVVEVIE KGEANFQTLY PDDMPLAEKI 450
QAVCKGIYRA DEAVMDKKIL DQLKLWEDQG YGKLPVCMAK TQYSFTTDPN 500
ERGAPTGFTI PVREVRLSAG AGFIVAVCGE IMTMPGLPRK PSAEAIHLND 550
DGQIEGLF 558
Length:558
Mass (Da):59,829
Last modified:April 4, 2006 - v1
Checksum:i43B552E4D4B6E164
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000264 Genomic DNA. Translation: ABD53898.1.
RefSeqiWP_011454106.1. NC_007802.1.
YP_508923.1. NC_007802.1.

Genome annotation databases

EnsemblBacteriaiABD53898; ABD53898; Jann_0981.
GeneIDi3933425.
KEGGijan:Jann_0981.
PATRICi22145634. VBIJanSp43325_1089.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000264 Genomic DNA. Translation: ABD53898.1 .
RefSeqi WP_011454106.1. NC_007802.1.
YP_508923.1. NC_007802.1.

3D structure databases

ProteinModelPortali Q28TR4.
SMRi Q28TR4. Positions 6-556.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 290400.Jann_0981.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABD53898 ; ABD53898 ; Jann_0981 .
GeneIDi 3933425.
KEGGi jan:Jann_0981.
PATRICi 22145634. VBIJanSp43325_1089.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi ACEEETE.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci JSP290400:GI1R-989-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CCS1.

Entry informationi

Entry nameiFTHS_JANSC
AccessioniPrimary (citable) accession number: Q28TR4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: April 4, 2006
Last modified: September 3, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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