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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Jannaschia sp. (strain CCS1)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi67 – 748ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciJSP290400:GI1R-989-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:Jann_0981
OrganismiJannaschia sp. (strain CCS1)
Taxonomic identifieri290400 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeJannaschia
ProteomesiUP000008326 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 558558Formate--tetrahydrofolate ligasePRO_0000300524Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi290400.Jann_0981.

Structurei

3D structure databases

ProteinModelPortaliQ28TR4.
SMRiQ28TR4. Positions 6-556.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiCMVKTHL.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q28TR4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGYKSDIEIA REAVKRPIQE IGAKIGIESA DLLPYGHDKA KVSQSFINSV
60 70 80 90 100
QNRDNGHLIL VTAINPTPAG EGKTTTTVGL GDGLNRIGKN AMVCIREASL
110 120 130 140 150
GPNFGMKGGA AGGGYAQVVP MEEMNLHFTG DFHAITSAHS LLSAMIDNHI
160 170 180 190 200
YWGNELEIDV RRVVWRRVVD MNDRALRQIT ASLGGVANGF PREAGFDITV
210 220 230 240 250
ASEVMAILCL AKDLKDLQER LGAMIVAYRR DRSPVFARDI KADGAMTVLL
260 270 280 290 300
KDAMQPNIVQ TLENNPAFVH GGPFANIAHG CNSVIATTTA LKLCDYVVTE
310 320 330 340 350
AGFGADLGAE KFLNIKCRKA GLAPSVVVVV ATVRAMKMNG GVAKADLGAE
360 370 380 390 400
NVDAVQNGCA NLGRHIENVK SFGVPVVVAI NHFVTDTDAE VQAVKDYVAS
410 420 430 440 450
QGAEAVLSRH WELGSEGSAP LAEKVVEVIE KGEANFQTLY PDDMPLAEKI
460 470 480 490 500
QAVCKGIYRA DEAVMDKKIL DQLKLWEDQG YGKLPVCMAK TQYSFTTDPN
510 520 530 540 550
ERGAPTGFTI PVREVRLSAG AGFIVAVCGE IMTMPGLPRK PSAEAIHLND

DGQIEGLF
Length:558
Mass (Da):59,829
Last modified:April 3, 2006 - v1
Checksum:i43B552E4D4B6E164
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000264 Genomic DNA. Translation: ABD53898.1.
RefSeqiWP_011454106.1. NC_007802.1.
YP_508923.1. NC_007802.1.

Genome annotation databases

EnsemblBacteriaiABD53898; ABD53898; Jann_0981.
GeneIDi3933425.
KEGGijan:Jann_0981.
PATRICi22145634. VBIJanSp43325_1089.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000264 Genomic DNA. Translation: ABD53898.1.
RefSeqiWP_011454106.1. NC_007802.1.
YP_508923.1. NC_007802.1.

3D structure databases

ProteinModelPortaliQ28TR4.
SMRiQ28TR4. Positions 6-556.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi290400.Jann_0981.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABD53898; ABD53898; Jann_0981.
GeneIDi3933425.
KEGGijan:Jann_0981.
PATRICi22145634. VBIJanSp43325_1089.

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiCMVKTHL.
OrthoDBiEOG6PCPSP.

Enzyme and pathway databases

UniPathwayiUPA00193.
BioCyciJSP290400:GI1R-989-MONOMER.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CCS1.

Entry informationi

Entry nameiFTHS_JANSC
AccessioniPrimary (citable) accession number: Q28TR4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 10, 2007
Last sequence update: April 3, 2006
Last modified: January 6, 2015
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.