Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q28TR4

- FTHS_JANSC

UniProt

Q28TR4 - FTHS_JANSC

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Jannaschia sp. (strain CCS1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 52 (01 Oct 2014)
      Sequence version 1 (04 Apr 2006)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi67 – 748ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciJSP290400:GI1R-989-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:Jann_0981
    OrganismiJannaschia sp. (strain CCS1)
    Taxonomic identifieri290400 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeJannaschia
    ProteomesiUP000008326: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 558558Formate--tetrahydrofolate ligasePRO_0000300524Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi290400.Jann_0981.

    Structurei

    3D structure databases

    ProteinModelPortaliQ28TR4.
    SMRiQ28TR4. Positions 6-556.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OMAiACEEETE.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q28TR4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGYKSDIEIA REAVKRPIQE IGAKIGIESA DLLPYGHDKA KVSQSFINSV    50
    QNRDNGHLIL VTAINPTPAG EGKTTTTVGL GDGLNRIGKN AMVCIREASL 100
    GPNFGMKGGA AGGGYAQVVP MEEMNLHFTG DFHAITSAHS LLSAMIDNHI 150
    YWGNELEIDV RRVVWRRVVD MNDRALRQIT ASLGGVANGF PREAGFDITV 200
    ASEVMAILCL AKDLKDLQER LGAMIVAYRR DRSPVFARDI KADGAMTVLL 250
    KDAMQPNIVQ TLENNPAFVH GGPFANIAHG CNSVIATTTA LKLCDYVVTE 300
    AGFGADLGAE KFLNIKCRKA GLAPSVVVVV ATVRAMKMNG GVAKADLGAE 350
    NVDAVQNGCA NLGRHIENVK SFGVPVVVAI NHFVTDTDAE VQAVKDYVAS 400
    QGAEAVLSRH WELGSEGSAP LAEKVVEVIE KGEANFQTLY PDDMPLAEKI 450
    QAVCKGIYRA DEAVMDKKIL DQLKLWEDQG YGKLPVCMAK TQYSFTTDPN 500
    ERGAPTGFTI PVREVRLSAG AGFIVAVCGE IMTMPGLPRK PSAEAIHLND 550
    DGQIEGLF 558
    Length:558
    Mass (Da):59,829
    Last modified:April 4, 2006 - v1
    Checksum:i43B552E4D4B6E164
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000264 Genomic DNA. Translation: ABD53898.1.
    RefSeqiWP_011454106.1. NC_007802.1.
    YP_508923.1. NC_007802.1.

    Genome annotation databases

    EnsemblBacteriaiABD53898; ABD53898; Jann_0981.
    GeneIDi3933425.
    KEGGijan:Jann_0981.
    PATRICi22145634. VBIJanSp43325_1089.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000264 Genomic DNA. Translation: ABD53898.1 .
    RefSeqi WP_011454106.1. NC_007802.1.
    YP_508923.1. NC_007802.1.

    3D structure databases

    ProteinModelPortali Q28TR4.
    SMRi Q28TR4. Positions 6-556.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 290400.Jann_0981.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABD53898 ; ABD53898 ; Jann_0981 .
    GeneIDi 3933425.
    KEGGi jan:Jann_0981.
    PATRICi 22145634. VBIJanSp43325_1089.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OMAi ACEEETE.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci JSP290400:GI1R-989-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CCS1.

    Entry informationi

    Entry nameiFTHS_JANSC
    AccessioniPrimary (citable) accession number: Q28TR4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: April 4, 2006
    Last modified: October 1, 2014
    This is version 52 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3