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Protein

Thymidylate kinase

Gene

tmk

Organism
Jannaschia sp. (strain CCS1)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.UniRule annotation

Catalytic activityi

ATP + dTMP = ADP + dTDP.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 178ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Nucleotide biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciJSP290400:GI1R-1287-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidylate kinaseUniRule annotation (EC:2.7.4.9UniRule annotation)
Alternative name(s):
dTMP kinaseUniRule annotation
Gene namesi
Name:tmkUniRule annotation
Ordered Locus Names:Jann_1277
OrganismiJannaschia sp. (strain CCS1)
Taxonomic identifieri290400 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeJannaschia
Proteomesi
  • UP000008326 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 208208Thymidylate kinasePRO_1000023204Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi290400.Jann_1277.

Structurei

3D structure databases

ProteinModelPortaliQ28SW8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidylate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108ZMD. Bacteria.
COG0125. LUCA.
HOGENOMiHOG000229078.
KOiK00943.
OMAiDRWSAET.
OrthoDBiEOG64JFSH.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00165. Thymidylate_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR018095. Thymidylate_kin_CS.
IPR018094. Thymidylate_kinase.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00041. DTMP_kinase. 1 hit.
PROSITEiPS01331. THYMIDYLATE_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q28SW8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPLFISLEG IDGSGKSTQT ARLVDWLRVR GRDPLQTREP GGSEGAEEIR
60 70 80 90 100
RLLVEGDPDR WSAETEILLF TAARRDHLER TIRPALASGR DVVTDRFADS
110 120 130 140 150
TRVYQGATRG ALRGLVDRIH AEAIEAEPDL TLILDMDPEL ALSRGLARDS
160 170 180 190 200
GEDRFEDFGL PFQQKLRAGF QALAREYPDR CHIVDASADP DAIAHTIQTI

VGQRLAEA
Length:208
Mass (Da):23,025
Last modified:April 4, 2006 - v1
Checksum:i10DB38EA3A821A67
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000264 Genomic DNA. Translation: ABD54194.1.
RefSeqiWP_011454401.1. NC_007802.1.

Genome annotation databases

EnsemblBacteriaiABD54194; ABD54194; Jann_1277.
KEGGijan:Jann_1277.
PATRICi22146256. VBIJanSp43325_1400.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000264 Genomic DNA. Translation: ABD54194.1.
RefSeqiWP_011454401.1. NC_007802.1.

3D structure databases

ProteinModelPortaliQ28SW8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi290400.Jann_1277.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABD54194; ABD54194; Jann_1277.
KEGGijan:Jann_1277.
PATRICi22146256. VBIJanSp43325_1400.

Phylogenomic databases

eggNOGiENOG4108ZMD. Bacteria.
COG0125. LUCA.
HOGENOMiHOG000229078.
KOiK00943.
OMAiDRWSAET.
OrthoDBiEOG64JFSH.

Enzyme and pathway databases

BioCyciJSP290400:GI1R-1287-MONOMER.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00165. Thymidylate_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR018095. Thymidylate_kin_CS.
IPR018094. Thymidylate_kinase.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00041. DTMP_kinase. 1 hit.
PROSITEiPS01331. THYMIDYLATE_KINASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CCS1.

Entry informationi

Entry nameiKTHY_JANSC
AccessioniPrimary (citable) accession number: Q28SW8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 4, 2006
Last modified: December 9, 2015
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.