Reviewed, UniProtKB/Swiss-Prot Q28SE8 (3HAO_JANSC)

Names and origin

Protein names

Recommended name:
    3-hydroxyanthranilate 3,4-dioxygenase
    EC=1.13.11.6
Alternative name(s):
    3-hydroxyanthranilic acid dioxygenase
      Short name=HAD
    3-hydroxyanthranilate oxygenase
      Short name=3-HAO

Gene names

Ordered Locus Names:

Jann_1447

Organism

Jannaschia sp. (strain CCS1) [Complete proteome] [HAMAP]

Taxonomic identifier

290400 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhodobacterales › Rhodobacteraceae › Jannaschia

Protein attributes

Sequence length	180 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate By similarity.
Catalytic activity	3-hydroxyanthranilate + O2 = 2-amino-3-carboxymuconate semialdehyde. HAMAP MF_00825
Cofactor	Binds 2 Fe2+ ions per subunit By similarity.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the 3-HAO family.

Ontologies

Keywords
Ligand	Iron Metal-binding
Molecular function	Dioxygenase Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	3-hydroxyanthranilate 3,4-dioxygenase activity Inferred from electronic annotation. Source: HAMAP ferrous iron binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 180	180	3-hydroxyanthranilate 3,4-dioxygenase HAMAP MF_00825		PRO_0000245475
Sites
	Metal binding	50	1	Iron 1; catalytic By similarity
	Metal binding	56	1	Iron 1; catalytic By similarity
	Metal binding	94	1	Iron 1; catalytic By similarity
	Metal binding	124	1	Iron 2 By similarity
	Metal binding	127	1	Iron 2 By similarity
	Metal binding	161	1	Iron 2 By similarity
	Metal binding	164	1	Iron 2 By similarity
	Binding site	46	1	Dioxygen By similarity
	Binding site	56	1	Substrate By similarity
	Binding site	98	1	Substrate By similarity
	Binding site	109	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q28SE8-1 [UniParc]. Last modified April 4, 2006. Version 1. Checksum: 8D3A2D7DAE75842F	FASTA	180	20,439
	10 20 30 40 50 60 MARLSAFNFK AWIDEHRHLL KPPVGNKMVY EDADLMVTVV GGPNKRTDYH DDPVEEFFYQ 70 80 90 100 110 120 LEGDMVLKLY DGEEFYDVPI REGEIFLLPP HMRHSPQRPQ EGSVGLVIEA KRPEGAADAI 130 140 150 160 170 180 EWYCFNCGNL VHRAELMLTS IVDDLPPVYQ AFYASEEART CGSCGEVHPG KEPPEGWVTL

References

[1]

"Complete sequence of chromosome of Jannaschia sp. CCS1." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Pitluck S., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Chertkov O., Saunders E., Schmutz J., Larimer F. , Land M., Kyrpides N., Lykidis A., Moran M.A., Belas R., Ye W., Buchan A., Gonzalez J.M., Schell M.A., Richardson P. Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000264 Genomic DNA. Translation: ABD54364.1.
RefSeq	YP_509389.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q28SE8.
Genome annotation databases
GeneID	3933894.
GenomeReviews	Gene locus Jann_1447 in contig CP000264_GR.
KEGG	jan:Jann_1447.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q28SE8.
OMA	RHSPQRP.
Enzyme and pathway databases
BioCyc	JSP290400:JANN_1447-MON.
Family and domain databases
HAMAP	MF_00825. [Tree]
InterPro	IPR010329. 3hydroanth_dOase. [Graphical view]
Pfam	PF06052. 3-HAO. 1 hit. [Graphical view]
TIGRFAMs	TIGR03037. anthran_nbaC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

3HAO_JANSC

Accession

Primary (citable) accession number: Q28SE8

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 11, 2006
Last sequence update:	April 4, 2006
Last modified:	November 3, 2009
This is version 24 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)