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Q28SE8

- 3HAO_JANSC

UniProt

Q28SE8 - 3HAO_JANSC

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Protein
3-hydroxyanthranilate 3,4-dioxygenase
Gene
nbaC, Jann_1447
Organism
Jannaschia sp. (strain CCS1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate By similarity.UniRule annotation

Catalytic activityi

3-hydroxyanthranilate + O2 = 2-amino-3-carboxymuconate semialdehyde.UniRule annotation

Cofactori

Binds 2 Fe2+ ions per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei46 – 461Dioxygen By similarity
Metal bindingi50 – 501Iron 1; catalytic By similarity
Metal bindingi56 – 561Iron 1; catalytic By similarity
Binding sitei56 – 561Substrate By similarity
Metal bindingi94 – 941Iron 1; catalytic By similarity
Binding sitei98 – 981Substrate By similarity
Binding sitei109 – 1091Substrate By similarity
Metal bindingi124 – 1241Iron 2 By similarity
Metal bindingi127 – 1271Iron 2 By similarity
Metal bindingi161 – 1611Iron 2 By similarity
Metal bindingi164 – 1641Iron 2 By similarity

GO - Molecular functioni

  1. 3-hydroxyanthranilate 3,4-dioxygenase activity Source: UniProtKB-HAMAP
  2. ferrous iron binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' NAD biosynthetic process from tryptophan Source: UniProtKB-HAMAP
  2. anthranilate metabolic process Source: UniProtKB-HAMAP
  3. quinolinate biosynthetic process Source: UniProtKB-HAMAP
  4. tryptophan catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Dioxygenase, Oxidoreductase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciJSP290400:GI1R-1458-MONOMER.
UniPathwayiUPA00253; UER00330.

Names & Taxonomyi

Protein namesi
Recommended name:
3-hydroxyanthranilate 3,4-dioxygenase (EC:1.13.11.6)
Alternative name(s):
3-hydroxyanthranilate oxygenase
Short name:
3-HAO
3-hydroxyanthranilic acid dioxygenase
Short name:
HAD
Gene namesi
Name:nbaC
Ordered Locus Names:Jann_1447
OrganismiJannaschia sp. (strain CCS1)
Taxonomic identifieri290400 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeJannaschia
ProteomesiUP000008326: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 1801803-hydroxyanthranilate 3,4-dioxygenaseUniRule annotation
PRO_0000245475Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi290400.Jann_1447.

Structurei

3D structure databases

ProteinModelPortaliQ28SE8.
SMRiQ28SE8. Positions 5-171.

Family & Domainsi

Sequence similaritiesi

Belongs to the 3-HAO family.

Phylogenomic databases

eggNOGiNOG77058.
HOGENOMiHOG000218448.
KOiK00452.
OMAiRYEETIG.
OrthoDBiEOG6PW234.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
HAMAPiMF_00825. 3_HAO.
InterProiIPR010329. 3hydroanth_dOase.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PANTHERiPTHR15497. PTHR15497. 1 hit.
PfamiPF06052. 3-HAO. 1 hit.
[Graphical view]
SUPFAMiSSF51182. SSF51182. 1 hit.
TIGRFAMsiTIGR03037. anthran_nbaC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q28SE8-1 [UniParc]FASTAAdd to Basket

« Hide

MARLSAFNFK AWIDEHRHLL KPPVGNKMVY EDADLMVTVV GGPNKRTDYH    50
DDPVEEFFYQ LEGDMVLKLY DGEEFYDVPI REGEIFLLPP HMRHSPQRPQ 100
EGSVGLVIEA KRPEGAADAI EWYCFNCGNL VHRAELMLTS IVDDLPPVYQ 150
AFYASEEART CGSCGEVHPG KEPPEGWVTL 180
Length:180
Mass (Da):20,439
Last modified:April 4, 2006 - v1
Checksum:i8D3A2D7DAE75842F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000264 Genomic DNA. Translation: ABD54364.1.
RefSeqiWP_011454571.1. NC_007802.1.
YP_509389.1. NC_007802.1.

Genome annotation databases

EnsemblBacteriaiABD54364; ABD54364; Jann_1447.
GeneIDi3933894.
KEGGijan:Jann_1447.
PATRICi22146600. VBIJanSp43325_1571.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000264 Genomic DNA. Translation: ABD54364.1 .
RefSeqi WP_011454571.1. NC_007802.1.
YP_509389.1. NC_007802.1.

3D structure databases

ProteinModelPortali Q28SE8.
SMRi Q28SE8. Positions 5-171.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 290400.Jann_1447.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABD54364 ; ABD54364 ; Jann_1447 .
GeneIDi 3933894.
KEGGi jan:Jann_1447.
PATRICi 22146600. VBIJanSp43325_1571.

Phylogenomic databases

eggNOGi NOG77058.
HOGENOMi HOG000218448.
KOi K00452.
OMAi RYEETIG.
OrthoDBi EOG6PW234.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00330 .
BioCyci JSP290400:GI1R-1458-MONOMER.

Family and domain databases

Gene3Di 2.60.120.10. 1 hit.
HAMAPi MF_00825. 3_HAO.
InterProi IPR010329. 3hydroanth_dOase.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view ]
PANTHERi PTHR15497. PTHR15497. 1 hit.
Pfami PF06052. 3-HAO. 1 hit.
[Graphical view ]
SUPFAMi SSF51182. SSF51182. 1 hit.
TIGRFAMsi TIGR03037. anthran_nbaC. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CCS1.

Entry informationi

Entry namei3HAO_JANSC
AccessioniPrimary (citable) accession number: Q28SE8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: April 4, 2006
Last modified: September 3, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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