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Q28RK3 (PYRC_JANSC) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Dihydroorotase
Short name=DHOase
EC=3.5.2.3
Gene names
Name:pyrC
Ordered Locus Names:Jann_1742
OrganismJannaschia sp. (strain CCS1) [Complete proteome] [HAMAP]
Taxonomic identifier290400 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhodobacterales › Rhodobacteraceae › Jannaschia

Protein attributes

Sequence length347 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

(S)-dihydroorotate + H2O = N-carbamoyl-L-aspartate. HAMAP MF_00219

Cofactor

Binds 2 zinc ions per subunit By similarity. HAMAP MF_00219

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3. HAMAP MF_00219

Subunit structure

Homodimer By similarity. HAMAP MF_00219

Sequence similarities

Belongs to the DHOase family. Type 1 subfamily.

Ontologies

Keywords
   Biological processPyrimidine biosynthesis
   LigandMetal-binding
Zinc
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processpyrimidine base biosynthetic process

Inferred from electronic annotation. Source: InterPro

pyrimidine nucleotide biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functiondihydroorotase activity

Inferred from electronic annotation. Source: EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 347347Dihydroorotase HAMAP MF_00219
PRO_1000024019

Sites

Metal binding141Zinc 1 By similarity
Metal binding161Zinc 1 By similarity
Metal binding1001Zinc 1; via carbamate group By similarity
Metal binding1001Zinc 2; via carbamate group By similarity
Metal binding1371Zinc 2 By similarity
Metal binding1751Zinc 2 By similarity
Metal binding2481Zinc 1 By similarity

Amino acid modifications

Modified residue1001N6-carboxylysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q28RK3 [UniParc].

Last modified April 4, 2006. Version 1.
Checksum: D0BA18015744F768

FASTA34737,943
        10         20         30         40         50         60 
MTQSLTIRRP DDWHLHLRDG AMMRAVLPET ARHFARAIIM PNLVPPVVTA QDALAYRDRI 

        70         80         90        100        110        120 
EAALPDGADF TPLMTLYLTE QTDPDDVEAA FADGLIHAVK LYPAGATTNS QSGVATLKNV 

       130        140        150        160        170        180 
YPVLERMAQI GLPLCIHGEV TDPQVDIFDR EQAFIDTVLI PLRADLPDLK VTLEHITTSH 

       190        200        210        220        230        240 
GIDYVVGADG DIAGTITTHH LMINRNHMLV GGIRPHYYCL PIVKRASHQH ALRRAATSGH 

       250        260        270        280        290        300 
PRFFLGTDSA PHLDGAKETA CGCAGVFSAT NTMSCLAHVF DEDGALVNLE AFTSLNGPAR 

       310        320        330        340 
YGLAPNAATM TLEKRDHPTN YPAKFDTDDG PLTLFDPSTP LYWHVKD

« Hide

References

[1]"Complete sequence of chromosome of Jannaschia sp. CCS1."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Pitluck S., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Chertkov O., Saunders E., Schmutz J., Larimer F. expand/collapse author list , Land M., Kyrpides N., Lykidis A., Moran M.A., Belas R., Ye W., Buchan A., Gonzalez J.M., Schell M.A., Richardson P.
Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CCS1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000264 Genomic DNA. Translation: ABD54659.1.
RefSeqYP_509684.1. NC_007802.1.

3D structure databases

ProteinModelPortalQ28RK3.
SMRQ28RK3. Positions 2-346.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ28RK3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3934190.
GenomeReviewsGene locus Jann_1742 in contig CP000264_GR.
KEGGjan:Jann_1742.
PATRIC22147208. VBIJanSp43325_1874.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0418.
HOGENOMHBG628648.
OMACLPVAKR.
PhylomeDBQ28RK3.
ProtClustDBPRK05451.

Enzyme and pathway databases

BioCycJSP290400:JANN_1742-MONOMER.

Family and domain databases

HAMAPMF_00219. PyrC_type1.
[Tree]
InterProIPR006680. Amidohydro_1.
IPR004721. DHOdimr.
IPR002195. Dihydroorotase_CS.
[Graphical view]
KOK01465.
PfamPF01979. Amidohydro_1. 1 hit.
[Graphical view]
PIRSFPIRSF001237. DHOdimr. 1 hit.
TIGRFAMsTIGR00856. PyrC_dimer. 1 hit.
PROSITEPS00482. DIHYDROOROTASE_1. 1 hit.
PS00483. DIHYDROOROTASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePYRC_JANSC
AccessionPrimary (citable) accession number: Q28RK3
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 4, 2006
Last modified: January 25, 2012
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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