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Q28RA9

- PUR5_JANSC

UniProt

Q28RA9 - PUR5_JANSC

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Protein
Phosphoribosylformylglycinamidine cyclo-ligase
Gene
purM, Jann_1836
Organism
Jannaschia sp. (strain CCS1)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Purine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciJSP290400:GI1R-1851-MONOMER.
UniPathwayiUPA00074; UER00129.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligase (EC:6.3.3.1)
Alternative name(s):
AIR synthase
AIRS
Phosphoribosyl-aminoimidazole synthetase
Gene namesi
Name:purM
Ordered Locus Names:Jann_1836
OrganismiJannaschia sp. (strain CCS1)
Taxonomic identifieri290400 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeJannaschia
ProteomesiUP000008326: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 349349Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotation
PRO_0000258362Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi290400.Jann_1836.

Structurei

3D structure databases

ProteinModelPortaliQ28RA9.
SMRiQ28RA9. Positions 8-346.

Family & Domainsi

Sequence similaritiesi

Belongs to the AIR synthase family.

Phylogenomic databases

eggNOGiCOG0150.
HOGENOMiHOG000229090.
KOiK01933.
OMAiISAHEMH.
OrthoDBiEOG61CM1V.

Family and domain databases

Gene3Di3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPiMF_00741_B. AIRS_B.
InterProiIPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view]
PfamiPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view]
SUPFAMiSSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsiTIGR00878. purM. 1 hit.

Sequencei

Sequence statusi: Complete.

Q28RA9-1 [UniParc]FASTAAdd to Basket

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MTDSKPDALT YADAGVDIDA GNALVDRIKP AAAATNRAGV MAGLGGFGAL    50
FDLKAAGYDD PVLVAATDGV GTKLKIAIDT GNFDTIGVDL VAMCVNDLVC 100
QGAEPLFFLD YFATGKLDVD DAARIVEGIA AGCKASGCAL IGGETAEMPG 150
MYAPGDFDLA GFSVGAMERG RALPDGVAEG DVLLGLASDG VHSNGYSLVR 200
RVVERSGLAW DAPAPFAQSS LGEALLAPTR LYVQPALAAI RAGGVHALAH 250
ITGGGLTENI PRVLPDGLGV DIDLSSWSLP PVFGWLAQEG ALDQAELLKT 300
FNAGLGMVLV VSADAVDGLT WTLEDAGESV HRIGTVTAGA GVRYSGSLG 349
Length:349
Mass (Da):35,418
Last modified:April 4, 2006 - v1
Checksum:i123016D0B626BB29
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000264 Genomic DNA. Translation: ABD54753.1.
RefSeqiWP_011454958.1. NC_007802.1.
YP_509778.1. NC_007802.1.

Genome annotation databases

EnsemblBacteriaiABD54753; ABD54753; Jann_1836.
GeneIDi3934287.
KEGGijan:Jann_1836.
PATRICi22147404. VBIJanSp43325_1969.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000264 Genomic DNA. Translation: ABD54753.1 .
RefSeqi WP_011454958.1. NC_007802.1.
YP_509778.1. NC_007802.1.

3D structure databases

ProteinModelPortali Q28RA9.
SMRi Q28RA9. Positions 8-346.
ModBasei Search...

Protein-protein interaction databases

STRINGi 290400.Jann_1836.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABD54753 ; ABD54753 ; Jann_1836 .
GeneIDi 3934287.
KEGGi jan:Jann_1836.
PATRICi 22147404. VBIJanSp43325_1969.

Phylogenomic databases

eggNOGi COG0150.
HOGENOMi HOG000229090.
KOi K01933.
OMAi ISAHEMH.
OrthoDBi EOG61CM1V.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00129 .
BioCyci JSP290400:GI1R-1851-MONOMER.

Family and domain databases

Gene3Di 3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPi MF_00741_B. AIRS_B.
InterProi IPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view ]
Pfami PF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view ]
SUPFAMi SSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsi TIGR00878. purM. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CCS1.

Entry informationi

Entry nameiPUR5_JANSC
AccessioniPrimary (citable) accession number: Q28RA9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: April 4, 2006
Last modified: September 3, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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