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Q28R88 (GCH4_JANSC) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GTP cyclohydrolase FolE2

EC=3.5.4.16
Gene names
Name:folE2
Ordered Locus Names:Jann_1857
OrganismJannaschia sp. (strain CCS1) [Complete proteome] [HAMAP]
Taxonomic identifier290400 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeJannaschia

Protein attributes

Sequence length362 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Converts GTP to 7,8-dihydroneopterin triphosphate By similarity. HAMAP-Rule MF_01527

Catalytic activity

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. HAMAP-Rule MF_01527

Pathway

Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. HAMAP-Rule MF_01527

Sequence similarities

Belongs to the GTP cyclohydrolase IV family.

Ontologies

Keywords
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_process7,8-dihydroneopterin 3'-triphosphate biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionGTP cyclohydrolase I activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 362362GTP cyclohydrolase FolE2 HAMAP-Rule MF_01527
PRO_0000289494

Sites

Site2221May be catalytically important By similarity

Sequences

Sequence LengthMass (Da)Tools
Q28R88 [UniParc].

Last modified April 4, 2006. Version 1.
Checksum: E2F9E3878234C04E

FASTA36239,886
        10         20         30         40         50         60 
MNVHVKTADQ TPSTVQAQDA LAILSAWASE ASADQIDALD PGIARLVRVQ AYPDLRAEYP 

        70         80         90        100        110        120 
GDFTVDEAYR ATLPDLQNGP ASLIKGANRR IQHVGISNFR LPIRYAVQDG SEVMLETSVT 

       130        140        150        160        170        180 
GTVSLEADQK GINMSRIMRS FYKHADASFG FDVIEAALDD YKADLGSFDA RIQMRLSYPM 

       190        200        210        220        230        240 
KVDSLRSGLS GWQYYDIALE LVERGGVRQR IVHLDYVYSS TCPCSLELSE HARATRGQLA 

       250        260        270        280        290        300 
TPHSQRSVAR ISVELQGQGV WFEDLIEMAR SGVPTETQVM VKREDEQAFA ELNAANPIFV 

       310        320        330        340        350        360 
EDAARLFAEQ LQAHSGVGDF RVMASHQESL HSHDAVSLLT EGDTFAEVSL DPKLFPSLIH 


VG 

« Hide

References

[1]"Complete sequence of chromosome of Jannaschia sp. CCS1."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Pitluck S., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Chertkov O., Saunders E., Schmutz J., Larimer F. expand/collapse author list , Land M., Kyrpides N., Lykidis A., Moran M.A., Belas R., Ye W., Buchan A., Gonzalez J.M., Schell M.A., Richardson P.
Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CCS1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000264 Genomic DNA. Translation: ABD54774.1.
RefSeqYP_509799.1. NC_007802.1.

3D structure databases

ProteinModelPortalQ28R88.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING290400.Jann_1857.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABD54774; ABD54774; Jann_1857.
GeneID3934308.
KEGGjan:Jann_1857.
PATRIC22147452. VBIJanSp43325_1993.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1469.
HOGENOMHOG000247517.
KOK09007.
OMALSGWQYY.
OrthoDBEOG6X6RBH.

Enzyme and pathway databases

BioCycJSP290400:GI1R-1872-MONOMER.
UniPathwayUPA00848; UER00151.

Family and domain databases

HAMAPMF_01527_B. GTP_cyclohydrol_B.
InterProIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamPF02649. GCHY-1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGCH4_JANSC
AccessionPrimary (citable) accession number: Q28R88
Entry history
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: April 4, 2006
Last modified: May 14, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways