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Q28R88

- GCH4_JANSC

UniProt

Q28R88 - GCH4_JANSC

Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Jannaschia sp. (strain CCS1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 1 (04 Apr 2006)
      Previous versions | rss
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    • Comment

    Functioni

    Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

    Catalytic activityi

    GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei222 – 2221May be catalytically importantUniRule annotation

    GO - Molecular functioni

    1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    BioCyciJSP290400:GI1R-1872-MONOMER.
    UniPathwayiUPA00848; UER00151.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
    Gene namesi
    Name:folE2UniRule annotation
    Ordered Locus Names:Jann_1857
    OrganismiJannaschia sp. (strain CCS1)
    Taxonomic identifieri290400 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeJannaschia
    ProteomesiUP000008326: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 362362GTP cyclohydrolase FolE2PRO_0000289494Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi290400.Jann_1857.

    Structurei

    3D structure databases

    ProteinModelPortaliQ28R88.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GTP cyclohydrolase IV family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1469.
    HOGENOMiHOG000247517.
    KOiK09007.
    OMAiLSGWQYY.
    OrthoDBiEOG6X6RBH.

    Family and domain databases

    HAMAPiMF_01527_B. GTP_cyclohydrol_B.
    InterProiIPR022838. GTP_cyclohydrolase_FolE2.
    IPR003801. GTP_cyclohydrolase_FolE2/MptA.
    [Graphical view]
    PfamiPF02649. GCHY-1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q28R88-1 [UniParc]FASTAAdd to Basket

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    MNVHVKTADQ TPSTVQAQDA LAILSAWASE ASADQIDALD PGIARLVRVQ    50
    AYPDLRAEYP GDFTVDEAYR ATLPDLQNGP ASLIKGANRR IQHVGISNFR 100
    LPIRYAVQDG SEVMLETSVT GTVSLEADQK GINMSRIMRS FYKHADASFG 150
    FDVIEAALDD YKADLGSFDA RIQMRLSYPM KVDSLRSGLS GWQYYDIALE 200
    LVERGGVRQR IVHLDYVYSS TCPCSLELSE HARATRGQLA TPHSQRSVAR 250
    ISVELQGQGV WFEDLIEMAR SGVPTETQVM VKREDEQAFA ELNAANPIFV 300
    EDAARLFAEQ LQAHSGVGDF RVMASHQESL HSHDAVSLLT EGDTFAEVSL 350
    DPKLFPSLIH VG 362
    Length:362
    Mass (Da):39,886
    Last modified:April 4, 2006 - v1
    Checksum:iE2F9E3878234C04E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000264 Genomic DNA. Translation: ABD54774.1.
    RefSeqiWP_011454979.1. NC_007802.1.
    YP_509799.1. NC_007802.1.

    Genome annotation databases

    EnsemblBacteriaiABD54774; ABD54774; Jann_1857.
    GeneIDi3934308.
    KEGGijan:Jann_1857.
    PATRICi22147452. VBIJanSp43325_1993.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000264 Genomic DNA. Translation: ABD54774.1 .
    RefSeqi WP_011454979.1. NC_007802.1.
    YP_509799.1. NC_007802.1.

    3D structure databases

    ProteinModelPortali Q28R88.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 290400.Jann_1857.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABD54774 ; ABD54774 ; Jann_1857 .
    GeneIDi 3934308.
    KEGGi jan:Jann_1857.
    PATRICi 22147452. VBIJanSp43325_1993.

    Phylogenomic databases

    eggNOGi COG1469.
    HOGENOMi HOG000247517.
    KOi K09007.
    OMAi LSGWQYY.
    OrthoDBi EOG6X6RBH.

    Enzyme and pathway databases

    UniPathwayi UPA00848 ; UER00151 .
    BioCyci JSP290400:GI1R-1872-MONOMER.

    Family and domain databases

    HAMAPi MF_01527_B. GTP_cyclohydrol_B.
    InterProi IPR022838. GTP_cyclohydrolase_FolE2.
    IPR003801. GTP_cyclohydrolase_FolE2/MptA.
    [Graphical view ]
    Pfami PF02649. GCHY-1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CCS1.

    Entry informationi

    Entry nameiGCH4_JANSC
    AccessioniPrimary (citable) accession number: Q28R88
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2007
    Last sequence update: April 4, 2006
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3