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Q28R88

- GCH4_JANSC

UniProt

Q28R88 - GCH4_JANSC

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Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Jannaschia sp. (strain CCS1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei222 – 2221May be catalytically importantUniRule annotation

GO - Molecular functioni

  1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciJSP290400:GI1R-1872-MONOMER.
UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
Gene namesi
Name:folE2UniRule annotation
Ordered Locus Names:Jann_1857
OrganismiJannaschia sp. (strain CCS1)
Taxonomic identifieri290400 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeJannaschia
ProteomesiUP000008326: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 362362GTP cyclohydrolase FolE2PRO_0000289494Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi290400.Jann_1857.

Structurei

3D structure databases

ProteinModelPortaliQ28R88.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase IV family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1469.
HOGENOMiHOG000247517.
KOiK09007.
OMAiLSGWQYY.
OrthoDBiEOG6X6RBH.

Family and domain databases

HAMAPiMF_01527_B. GTP_cyclohydrol_B.
InterProiIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamiPF02649. GCHY-1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q28R88-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNVHVKTADQ TPSTVQAQDA LAILSAWASE ASADQIDALD PGIARLVRVQ
60 70 80 90 100
AYPDLRAEYP GDFTVDEAYR ATLPDLQNGP ASLIKGANRR IQHVGISNFR
110 120 130 140 150
LPIRYAVQDG SEVMLETSVT GTVSLEADQK GINMSRIMRS FYKHADASFG
160 170 180 190 200
FDVIEAALDD YKADLGSFDA RIQMRLSYPM KVDSLRSGLS GWQYYDIALE
210 220 230 240 250
LVERGGVRQR IVHLDYVYSS TCPCSLELSE HARATRGQLA TPHSQRSVAR
260 270 280 290 300
ISVELQGQGV WFEDLIEMAR SGVPTETQVM VKREDEQAFA ELNAANPIFV
310 320 330 340 350
EDAARLFAEQ LQAHSGVGDF RVMASHQESL HSHDAVSLLT EGDTFAEVSL
360
DPKLFPSLIH VG
Length:362
Mass (Da):39,886
Last modified:April 4, 2006 - v1
Checksum:iE2F9E3878234C04E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000264 Genomic DNA. Translation: ABD54774.1.
RefSeqiWP_011454979.1. NC_007802.1.
YP_509799.1. NC_007802.1.

Genome annotation databases

EnsemblBacteriaiABD54774; ABD54774; Jann_1857.
GeneIDi3934308.
KEGGijan:Jann_1857.
PATRICi22147452. VBIJanSp43325_1993.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000264 Genomic DNA. Translation: ABD54774.1 .
RefSeqi WP_011454979.1. NC_007802.1.
YP_509799.1. NC_007802.1.

3D structure databases

ProteinModelPortali Q28R88.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 290400.Jann_1857.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABD54774 ; ABD54774 ; Jann_1857 .
GeneIDi 3934308.
KEGGi jan:Jann_1857.
PATRICi 22147452. VBIJanSp43325_1993.

Phylogenomic databases

eggNOGi COG1469.
HOGENOMi HOG000247517.
KOi K09007.
OMAi LSGWQYY.
OrthoDBi EOG6X6RBH.

Enzyme and pathway databases

UniPathwayi UPA00848 ; UER00151 .
BioCyci JSP290400:GI1R-1872-MONOMER.

Family and domain databases

HAMAPi MF_01527_B. GTP_cyclohydrol_B.
InterProi IPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view ]
Pfami PF02649. GCHY-1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CCS1.

Entry informationi

Entry nameiGCH4_JANSC
AccessioniPrimary (citable) accession number: Q28R88
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: April 4, 2006
Last modified: October 1, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3