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Q28L73 (GCSP_JANSC) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycine dehydrogenase (decarboxylating)

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene names
Name:gcvP
Ordered Locus Names:Jann_3622
OrganismJannaschia sp. (strain CCS1) [Complete proteome] [HAMAP]
Taxonomic identifier290400 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeJannaschia

Protein attributes

Sequence length943 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00711

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00711

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00711

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Sequence similarities

Belongs to the GcvP family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 943943Glycine dehydrogenase (decarboxylating) HAMAP-Rule MF_00711
PRO_1000045585

Amino acid modifications

Modified residue6951N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q28L73 [UniParc].

Last modified April 4, 2006. Version 1.
Checksum: 962EB20AE215A569

FASTA943101,257
        10         20         30         40         50         60 
MPWTTTDYDP TDFANRRHIG PSPAEMAEML EFVGADSLDA LIDDTVPASI RQAGALDWAA 

        70         80         90        100        110        120 
MSEAELLDHM RAIADKNKPM VSMIGQGYFG THTPPAIQRN VLENPAWYTA YTPYQPEIAQ 

       130        140        150        160        170        180 
GRLEALLNFQ TMVADLTGLP VANASLLDEA TAAAEAMVMA QRASKSKART FFVDETCHPQ 

       190        200        210        220        230        240 
TIAVIQTRAE PLGIEVRVGD AAMLDADAVF GAIFQYPCTF GGLRDPSAQI EALHEAKAIA 

       250        260        270        280        290        300 
VVATDLLALT VLKEPGAMGA DIAVGSAQRF GVPLGYGGPH AAFMSCRDAL KRSLPGRIVG 

       310        320        330        340        350        360 
VSVDSHGQNA YRLSLQTREQ HIRREKATSN VCTAQALLAV MASFYAVFHG PKGLRAIAER 

       370        380        390        400        410        420 
VHMRAVRLAA SLSAGGFAPD NDTFFDTLTV HVGDKQSRIM AAAVARGINL RDVGADRIGI 

       430        440        450        460        470        480 
SVDEVTTDAH IEAVCRAFGV LKAPAPKAPA ISDDLLRMSD YLTHPIFHMN RAESEMMRYM 

       490        500        510        520        530        540 
RRLSDRDLAL DRAMIPLGSC TMKLNAAVEM MPITWPEFGN LHPFAPADQA EGYAEMLEDL 

       550        560        570        580        590        600 
SAKLCDITGY DAMSMQPNSG AQGEYAGLLT IAAYHRARGE TRNICLIPVS AHGTNPASAQ 

       610        620        630        640        650        660 
MAGMQVVVVK SQEDGDIDLV DFRAKAEAAG DKLAACMITY PSTHGVFEES VREVCEITHE 

       670        680        690        700        710        720 
LGGQVYLDGA NLNAMVGLSK PGELGADVSH LNLHKTFCIP HGGGGPGMGP IGVKAHLAPH 

       730        740        750        760        770        780 
LPGHPETGGT QGPVSAAPYG SASILPISYA YVHLMGGSGL TQATKVAILG ANYIAKRLEG 

       790        800        810        820        830        840 
DYGVLFKGKT GRVAHECILD TRPFAEAGIT VDDIAKRLMD HGFHAPTMSW PVAGTLMVEP 

       850        860        870        880        890        900 
TESETKAELD RFITAMQAIR AEIAEVEDGL PAGDSPLHHA PHTMEDLVRD WDRAYTREQG 

       910        920        930        940 
CFPPGAFRVD KYWPPVNRVD NVAGDRNLIC TCPPLEEYLD AAE 

« Hide

References

[1]"Complete sequence of chromosome of Jannaschia sp. CCS1."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Pitluck S., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Chertkov O., Saunders E., Schmutz J., Larimer F. expand/collapse author list , Land M., Kyrpides N., Lykidis A., Moran M.A., Belas R., Ye W., Buchan A., Gonzalez J.M., Schell M.A., Richardson P.
Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CCS1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000264 Genomic DNA. Translation: ABD56539.1.
RefSeqYP_511564.1. NC_007802.1.

3D structure databases

ProteinModelPortalQ28L73.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING290400.Jann_3622.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABD56539; ABD56539; Jann_3622.
GeneID3936100.
KEGGjan:Jann_3622.
PATRIC22151148. VBIJanSp43325_3819.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1003.
HOGENOMHOG000239369.
KOK00281.
OMAQTMVCDL.
OrthoDBEOG6HMXDX.
ProtClustDBPRK05367.

Enzyme and pathway databases

BioCycJSP290400:GI1R-3664-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 2 hits.
HAMAPMF_00711. GcvP.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMSSF53383. SSF53383. 3 hits.
TIGRFAMsTIGR00461. gcvP. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSP_JANSC
AccessionPrimary (citable) accession number: Q28L73
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 4, 2006
Last modified: February 19, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families