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Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Jannaschia sp. (strain CCS1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciJSP290400:GI1R-3664-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-proteinUniRule annotation
Glycine decarboxylaseUniRule annotation
Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
Gene namesi
Name:gcvPUniRule annotation
Ordered Locus Names:Jann_3622
OrganismiJannaschia sp. (strain CCS1)
Taxonomic identifieri290400 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeJannaschia
ProteomesiUP000008326 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 943943Glycine dehydrogenase (decarboxylating)PRO_1000045585Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei695 – 6951N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

STRINGi290400.Jann_3622.

Structurei

3D structure databases

ProteinModelPortaliQ28L73.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiMAGMYAV.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR003437. GcvP.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q28L73-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPWTTTDYDP TDFANRRHIG PSPAEMAEML EFVGADSLDA LIDDTVPASI
60 70 80 90 100
RQAGALDWAA MSEAELLDHM RAIADKNKPM VSMIGQGYFG THTPPAIQRN
110 120 130 140 150
VLENPAWYTA YTPYQPEIAQ GRLEALLNFQ TMVADLTGLP VANASLLDEA
160 170 180 190 200
TAAAEAMVMA QRASKSKART FFVDETCHPQ TIAVIQTRAE PLGIEVRVGD
210 220 230 240 250
AAMLDADAVF GAIFQYPCTF GGLRDPSAQI EALHEAKAIA VVATDLLALT
260 270 280 290 300
VLKEPGAMGA DIAVGSAQRF GVPLGYGGPH AAFMSCRDAL KRSLPGRIVG
310 320 330 340 350
VSVDSHGQNA YRLSLQTREQ HIRREKATSN VCTAQALLAV MASFYAVFHG
360 370 380 390 400
PKGLRAIAER VHMRAVRLAA SLSAGGFAPD NDTFFDTLTV HVGDKQSRIM
410 420 430 440 450
AAAVARGINL RDVGADRIGI SVDEVTTDAH IEAVCRAFGV LKAPAPKAPA
460 470 480 490 500
ISDDLLRMSD YLTHPIFHMN RAESEMMRYM RRLSDRDLAL DRAMIPLGSC
510 520 530 540 550
TMKLNAAVEM MPITWPEFGN LHPFAPADQA EGYAEMLEDL SAKLCDITGY
560 570 580 590 600
DAMSMQPNSG AQGEYAGLLT IAAYHRARGE TRNICLIPVS AHGTNPASAQ
610 620 630 640 650
MAGMQVVVVK SQEDGDIDLV DFRAKAEAAG DKLAACMITY PSTHGVFEES
660 670 680 690 700
VREVCEITHE LGGQVYLDGA NLNAMVGLSK PGELGADVSH LNLHKTFCIP
710 720 730 740 750
HGGGGPGMGP IGVKAHLAPH LPGHPETGGT QGPVSAAPYG SASILPISYA
760 770 780 790 800
YVHLMGGSGL TQATKVAILG ANYIAKRLEG DYGVLFKGKT GRVAHECILD
810 820 830 840 850
TRPFAEAGIT VDDIAKRLMD HGFHAPTMSW PVAGTLMVEP TESETKAELD
860 870 880 890 900
RFITAMQAIR AEIAEVEDGL PAGDSPLHHA PHTMEDLVRD WDRAYTREQG
910 920 930 940
CFPPGAFRVD KYWPPVNRVD NVAGDRNLIC TCPPLEEYLD AAE
Length:943
Mass (Da):101,257
Last modified:April 4, 2006 - v1
Checksum:i962EB20AE215A569
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000264 Genomic DNA. Translation: ABD56539.1.
RefSeqiWP_011456739.1. NC_007802.1.

Genome annotation databases

EnsemblBacteriaiABD56539; ABD56539; Jann_3622.
KEGGijan:Jann_3622.
PATRICi22151148. VBIJanSp43325_3819.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000264 Genomic DNA. Translation: ABD56539.1.
RefSeqiWP_011456739.1. NC_007802.1.

3D structure databases

ProteinModelPortaliQ28L73.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi290400.Jann_3622.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABD56539; ABD56539; Jann_3622.
KEGGijan:Jann_3622.
PATRICi22151148. VBIJanSp43325_3819.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiMAGMYAV.
OrthoDBiEOG6HMXDX.

Enzyme and pathway databases

BioCyciJSP290400:GI1R-3664-MONOMER.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR003437. GcvP.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CCS1.

Entry informationi

Entry nameiGCSP_JANSC
AccessioniPrimary (citable) accession number: Q28L73
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 4, 2006
Last modified: July 22, 2015
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.