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Q28L73

- GCSP_JANSC

UniProt

Q28L73 - GCSP_JANSC

Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Jannaschia sp. (strain CCS1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 1 (04 Apr 2006)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciJSP290400:GI1R-3664-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-proteinUniRule annotation
    Glycine decarboxylaseUniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
    Gene namesi
    Name:gcvPUniRule annotation
    Ordered Locus Names:Jann_3622
    OrganismiJannaschia sp. (strain CCS1)
    Taxonomic identifieri290400 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeJannaschia
    ProteomesiUP000008326: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 943943Glycine dehydrogenase (decarboxylating)PRO_1000045585Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei695 – 6951N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

    Protein-protein interaction databases

    STRINGi290400.Jann_3622.

    Structurei

    3D structure databases

    ProteinModelPortaliQ28L73.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1003.
    HOGENOMiHOG000239369.
    KOiK00281.
    OMAiTAYLTHP.
    OrthoDBiEOG6HMXDX.

    Family and domain databases

    Gene3Di3.40.640.10. 2 hits.
    HAMAPiMF_00711. GcvP.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 2 hits.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 3 hits.
    TIGRFAMsiTIGR00461. gcvP. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q28L73-1 [UniParc]FASTAAdd to Basket

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    MPWTTTDYDP TDFANRRHIG PSPAEMAEML EFVGADSLDA LIDDTVPASI    50
    RQAGALDWAA MSEAELLDHM RAIADKNKPM VSMIGQGYFG THTPPAIQRN 100
    VLENPAWYTA YTPYQPEIAQ GRLEALLNFQ TMVADLTGLP VANASLLDEA 150
    TAAAEAMVMA QRASKSKART FFVDETCHPQ TIAVIQTRAE PLGIEVRVGD 200
    AAMLDADAVF GAIFQYPCTF GGLRDPSAQI EALHEAKAIA VVATDLLALT 250
    VLKEPGAMGA DIAVGSAQRF GVPLGYGGPH AAFMSCRDAL KRSLPGRIVG 300
    VSVDSHGQNA YRLSLQTREQ HIRREKATSN VCTAQALLAV MASFYAVFHG 350
    PKGLRAIAER VHMRAVRLAA SLSAGGFAPD NDTFFDTLTV HVGDKQSRIM 400
    AAAVARGINL RDVGADRIGI SVDEVTTDAH IEAVCRAFGV LKAPAPKAPA 450
    ISDDLLRMSD YLTHPIFHMN RAESEMMRYM RRLSDRDLAL DRAMIPLGSC 500
    TMKLNAAVEM MPITWPEFGN LHPFAPADQA EGYAEMLEDL SAKLCDITGY 550
    DAMSMQPNSG AQGEYAGLLT IAAYHRARGE TRNICLIPVS AHGTNPASAQ 600
    MAGMQVVVVK SQEDGDIDLV DFRAKAEAAG DKLAACMITY PSTHGVFEES 650
    VREVCEITHE LGGQVYLDGA NLNAMVGLSK PGELGADVSH LNLHKTFCIP 700
    HGGGGPGMGP IGVKAHLAPH LPGHPETGGT QGPVSAAPYG SASILPISYA 750
    YVHLMGGSGL TQATKVAILG ANYIAKRLEG DYGVLFKGKT GRVAHECILD 800
    TRPFAEAGIT VDDIAKRLMD HGFHAPTMSW PVAGTLMVEP TESETKAELD 850
    RFITAMQAIR AEIAEVEDGL PAGDSPLHHA PHTMEDLVRD WDRAYTREQG 900
    CFPPGAFRVD KYWPPVNRVD NVAGDRNLIC TCPPLEEYLD AAE 943
    Length:943
    Mass (Da):101,257
    Last modified:April 4, 2006 - v1
    Checksum:i962EB20AE215A569
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000264 Genomic DNA. Translation: ABD56539.1.
    RefSeqiWP_011456739.1. NC_007802.1.
    YP_511564.1. NC_007802.1.

    Genome annotation databases

    EnsemblBacteriaiABD56539; ABD56539; Jann_3622.
    GeneIDi3936100.
    KEGGijan:Jann_3622.
    PATRICi22151148. VBIJanSp43325_3819.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000264 Genomic DNA. Translation: ABD56539.1 .
    RefSeqi WP_011456739.1. NC_007802.1.
    YP_511564.1. NC_007802.1.

    3D structure databases

    ProteinModelPortali Q28L73.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 290400.Jann_3622.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABD56539 ; ABD56539 ; Jann_3622 .
    GeneIDi 3936100.
    KEGGi jan:Jann_3622.
    PATRICi 22151148. VBIJanSp43325_3819.

    Phylogenomic databases

    eggNOGi COG1003.
    HOGENOMi HOG000239369.
    KOi K00281.
    OMAi TAYLTHP.
    OrthoDBi EOG6HMXDX.

    Enzyme and pathway databases

    BioCyci JSP290400:GI1R-3664-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 2 hits.
    HAMAPi MF_00711. GcvP.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 3 hits.
    TIGRFAMsi TIGR00461. gcvP. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CCS1.

    Entry informationi

    Entry nameiGCSP_JANSC
    AccessioniPrimary (citable) accession number: Q28L73
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: April 4, 2006
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3