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Q28K03

- PUR9_JANSC

UniProt

Q28K03 - PUR9_JANSC

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Protein

Bifunctional purine biosynthesis protein PurH

Gene
purH, Jann_4042
Organism
Jannaschia sp. (strain CCS1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

BioCyciJSP290400:GI1R-4094-MONOMER.
UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurH
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC:2.1.2.3)
Alternative name(s):
AICAR transformylase
IMP cyclohydrolase (EC:3.5.4.10)
Alternative name(s):
ATIC
IMP synthase
Inosinicase
Gene namesi
Name:purH
Ordered Locus Names:Jann_4042
OrganismiJannaschia sp. (strain CCS1)
Taxonomic identifieri290400 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeJannaschia
ProteomesiUP000008326: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 532532Bifunctional purine biosynthesis protein PurHUniRule annotationPRO_1000057898Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi290400.Jann_4042.

Structurei

3D structure databases

ProteinModelPortaliQ28K03.

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region By similarity.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.

Phylogenomic databases

eggNOGiCOG0138.
HOGENOMiHOG000230373.
KOiK00602.
OMAiCGVATGP.
OrthoDBiEOG6QCDFF.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q28K03-1 [UniParc]FASTAAdd to Basket

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MTDPAPLTRA LLSVSDKTGL IEFATDLSSR GVELLSTGGT AKALREAGLD    50
VRDVSEVTGF PEMMDGRVKT LHPMIHGGLL ALRDNDAHVA AMKEHGIGAI 100
DLLVVNLYPF EATVAAGADY DTCIENIDIG GPAMIRAAAK NHGAVTVLTD 150
SSQYAGLLSE LDANANKGGG TSFQFRQRMA QAAYGRTAAY DAAVSSWMAG 200
AAEIKTPPHR AFAGSLAQEM RYGENPHQKA AFYLDGSSRP GVATAQQHQG 250
KALSYNNIND TDAAFELVSE FAPDDGPAVA IIKHANPSGV ARGNSLAEAY 300
KAAFDCDRTS AFGGIVALNQ TLDAATAEEI VQIFTEVVIA PDADEDAKAI 350
FAAKKNLRLL TTGGLPDPRA PMVAYKQVAG GLLVQDKDTG HVDPELLEVV 400
TKRAPSAQEL ADLRFAWTVA KHTKSNAIIY AKGGATVGIG AGQMSRVDSS 450
TIAALKAARM GTECGMADTP AKGSVVASDA FFPFADGLLA AAEAGATAVI 500
QPGGSMRDAD VIAAADEAGL AMVFTGMRHF RH 532
Length:532
Mass (Da):55,404
Last modified:April 4, 2006 - v1
Checksum:i23BB29C4C471F9D9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000264 Genomic DNA. Translation: ABD56959.1.
RefSeqiWP_011457155.1. NC_007802.1.
YP_511984.1. NC_007802.1.

Genome annotation databases

EnsemblBacteriaiABD56959; ABD56959; Jann_4042.
GeneIDi3936530.
KEGGijan:Jann_4042.
PATRICi22152042. VBIJanSp43325_4257.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000264 Genomic DNA. Translation: ABD56959.1 .
RefSeqi WP_011457155.1. NC_007802.1.
YP_511984.1. NC_007802.1.

3D structure databases

ProteinModelPortali Q28K03.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 290400.Jann_4042.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABD56959 ; ABD56959 ; Jann_4042 .
GeneIDi 3936530.
KEGGi jan:Jann_4042.
PATRICi 22152042. VBIJanSp43325_4257.

Phylogenomic databases

eggNOGi COG0138.
HOGENOMi HOG000230373.
KOi K00602.
OMAi CGVATGP.
OrthoDBi EOG6QCDFF.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .
BioCyci JSP290400:GI1R-4094-MONOMER.

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CCS1.

Entry informationi

Entry nameiPUR9_JANSC
AccessioniPrimary (citable) accession number: Q28K03
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: April 4, 2006
Last modified: September 3, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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