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Q28K03 (PUR9_JANSC) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Bifunctional purine biosynthesis protein PurH

Including the following 2 domains:

  1. Phosphoribosylaminoimidazolecarboxamide formyltransferase
    EC=2.1.2.3
    Alternative name(s):
    AICAR transformylase
  2. IMP cyclohydrolase
    EC=3.5.4.10
    Alternative name(s):
    ATIC
    IMP synthase
    Inosinicase
Gene names
Name:purH
Ordered Locus Names:Jann_4042
OrganismJannaschia sp. (strain CCS1) [Complete proteome] [HAMAP]
Taxonomic identifier290400 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeJannaschia

Protein attributes

Sequence length532 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. HAMAP-Rule MF_00139

IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. HAMAP-Rule MF_00139

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1. HAMAP-Rule MF_00139

Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1.

Domain

The IMP cyclohydrolase activity resides in the N-terminal region By similarity. HAMAP-Rule MF_00139

Sequence similarities

Belongs to the PurH family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 532532Bifunctional purine biosynthesis protein PurH HAMAP-Rule MF_00139
PRO_1000057898

Sequences

Sequence LengthMass (Da)Tools
Q28K03 [UniParc].

Last modified April 4, 2006. Version 1.
Checksum: 23BB29C4C471F9D9

FASTA53255,404
        10         20         30         40         50         60 
MTDPAPLTRA LLSVSDKTGL IEFATDLSSR GVELLSTGGT AKALREAGLD VRDVSEVTGF 

        70         80         90        100        110        120 
PEMMDGRVKT LHPMIHGGLL ALRDNDAHVA AMKEHGIGAI DLLVVNLYPF EATVAAGADY 

       130        140        150        160        170        180 
DTCIENIDIG GPAMIRAAAK NHGAVTVLTD SSQYAGLLSE LDANANKGGG TSFQFRQRMA 

       190        200        210        220        230        240 
QAAYGRTAAY DAAVSSWMAG AAEIKTPPHR AFAGSLAQEM RYGENPHQKA AFYLDGSSRP 

       250        260        270        280        290        300 
GVATAQQHQG KALSYNNIND TDAAFELVSE FAPDDGPAVA IIKHANPSGV ARGNSLAEAY 

       310        320        330        340        350        360 
KAAFDCDRTS AFGGIVALNQ TLDAATAEEI VQIFTEVVIA PDADEDAKAI FAAKKNLRLL 

       370        380        390        400        410        420 
TTGGLPDPRA PMVAYKQVAG GLLVQDKDTG HVDPELLEVV TKRAPSAQEL ADLRFAWTVA 

       430        440        450        460        470        480 
KHTKSNAIIY AKGGATVGIG AGQMSRVDSS TIAALKAARM GTECGMADTP AKGSVVASDA 

       490        500        510        520        530 
FFPFADGLLA AAEAGATAVI QPGGSMRDAD VIAAADEAGL AMVFTGMRHF RH 

« Hide

References

[1]"Complete sequence of chromosome of Jannaschia sp. CCS1."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Pitluck S., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Chertkov O., Saunders E., Schmutz J., Larimer F. expand/collapse author list , Land M., Kyrpides N., Lykidis A., Moran M.A., Belas R., Ye W., Buchan A., Gonzalez J.M., Schell M.A., Richardson P.
Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CCS1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000264 Genomic DNA. Translation: ABD56959.1.
RefSeqYP_511984.1. NC_007802.1.

3D structure databases

ProteinModelPortalQ28K03.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING290400.Jann_4042.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABD56959; ABD56959; Jann_4042.
GeneID3936530.
KEGGjan:Jann_4042.
PATRIC22152042. VBIJanSp43325_4257.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0138.
HOGENOMHOG000230373.
KOK00602.
OMACGVATGP.
OrthoDBEOG6QCDFF.

Enzyme and pathway databases

BioCycJSP290400:GI1R-4094-MONOMER.
UniPathwayUPA00074; UER00133.
UPA00074; UER00135.

Family and domain databases

Gene3D3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPMF_00139. PurH.
InterProIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERPTHR11692. PTHR11692. 1 hit.
PfamPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsTIGR00355. purH. 1 hit.
ProtoNetSearch...

Entry information

Entry namePUR9_JANSC
AccessionPrimary (citable) accession number: Q28K03
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: April 4, 2006
Last modified: May 14, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways