Reviewed, UniProtKB/Swiss-Prot Q28J83 (DOPD_XENTR)

Names and origin

Protein names

Recommended name:
    D-dopachrome decarboxylase
    EC=4.1.1.84
Alternative name(s):
    D-dopachrome tautomerase

Gene names

Name:	ddt
ORF Names:	TNeu063o20.1

Organism

Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)

Taxonomic identifier

8364 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Silurana

Protein attributes

Sequence length	118 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Tautomerization of D-dopachrome with decarboxylation to give 5,6-dihydroxyindole (DHI) By similarity.
Catalytic activity	D-dopachrome = 5,6-dihydroxyindole + CO2.
Subunit structure	Homotrimer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the MIF family.

Ontologies

Keywords
Biological process	Melanin biosynthesis
Cellular component	Cytoplasm
Molecular function	Lyase
PTM	Acetylation
Gene Ontology (GO)
Biological process	melanin biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	D-dopachrome decarboxylase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 118	117	D-dopachrome decarboxylase		PRO_0000337237
Amino acid modifications
	Modified residue	2	1	N-acetylproline By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q28J83-1 [UniParc]. Last modified April 4, 2006. Version 1. Checksum: 2E817F5D83E17885	FASTA	118	12,961
	10 20 30 40 50 60 MPFVELDTNL PPQQVPQDLA EKLCSATATI LSKPRERVNV TVRTGVSMVV GGSCAPCTQL 70 80 90 100 110 LVSSIGVVGT AEQNKEHSAK FFQFLTENMG LEQDRILLRF VPLEPWQVGK KATVMTFL

References

[1]	Sanger Xenopus tropicalis EST/cDNA project Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Neurula.
[2]	NIH - Xenopus Gene Collection (XGC) project Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Embryo.

Cross-references

Sequence databases
EMBLGenBankDDBJ	CR760012 mRNA. Translation: CAJ83351.1. BC135935 mRNA. Translation: AAI35936.1.
RefSeq	NP_001017261.1.
UniGene	Str.57256
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	550015.
KEGG	xtr:550015.
Organism-specific databases
CTD	550015.
Xenbase	XB-FEAT-976098. ddt.
Phylogenomic databases
HOVERGEN	Q28J83.
OMA	ETNLPAS.
Family and domain databases
InterPro	IPR001398. Macrophage_inhib_fac. IPR019829. Macrophage_inhib_fac_CS. IPR014347. Tautomerase. [Graphical view]
Gene3D	G3DSA:3.30.429.10. Tautomerase. 1 hit.
PANTHER	PTHR11954. MIF. 1 hit.
Pfam	PF01187. MIF. 1 hit. [Graphical view]
ProDom	PD004816. MIF. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS01158. MIF. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DOPD_XENTR

Accession

Primary (citable) accession number: Q28J83

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	April 4, 2006
Last modified:	November 3, 2009
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Xenopus annotation project