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Protein

Protein Wnt-11b-2

Gene

wnt11b-2

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Ligand for the frizzled7 transmembrane receptor. Primarily acts via non-canonical Wnt pathways mediated by either Ca2+ and PKC, or by JNK and dvl2/dsh. Depending on the cellular context, can also signal via the canonical Wnt pathway mediated by beta-catenin and dvl2/dsh. May also inhibit canonical Wnt signaling. Maternally initiates dorsal/ventral axis formation by a canonical route, which signals via lrp6. In a complex with wnt5a, activates the canonical and non-canonical processes involved in axis formation. In the non-canonical pathway, acts through fzd7/fz7 to induce phosphorylation of dvl2/dsh. Signals through a non-canonical Wnt pathway to regulate convergent extension movements during gastrulation. Interactions with the secreted Wnt antagonist sfrp5 to coordinate foregut development, acting via a non-canonical wnt pathway whereby sfrp5 restricts wnt11b activity to prevent inappropriate foregut formation. Mediates cardiogenesis via non-canonical Wnt signaling involving JNK-activation and PKC. Acts redundantly with wnt11/wnt11r during pronephros induction (By similarity).By similarity

Miscellaneous

Xenopus and other lower vertebrates contain duplicated wnt11 genes (wnt11 and wnt11b) resulting from an ancient gene duplication event, but the second copy has since been lost in mammals. In addition, X.tropicalis has two very similar wnt11b genes suggesting a further recent duplication event.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processGastrulation, Wnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Wnt-11b-21 Publication
Gene namesi
Name:wnt11b-21 Publication
Synonyms:wnt11Imported, wnt11bImported
ORF Names:TNeu076g04.1
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
Proteomesi
  • UP000008143 Componenti: Unassembled WGS sequence

Organism-specific databases

XenbaseiXB-GENE-5858981 wnt11b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000039720923 – 353Protein Wnt-11b-2Sequence analysisAdd BLAST331

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi31N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi38N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi78 ↔ 89By similarity
Glycosylationi88N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi128 ↔ 136By similarity
Disulfide bondi138 ↔ 155By similarity
Disulfide bondi208 ↔ 222By similarity
Disulfide bondi210 ↔ 217By similarity
Lipidationi214O-palmitoleoyl serine; by PORCNBy similarity1
Modified residuei274SulfotyrosineBy similarity1
Modified residuei281SulfotyrosineBy similarity1
Disulfide bondi298 ↔ 313By similarity
Glycosylationi299N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi328 ↔ 343By similarity
Disulfide bondi330 ↔ 340By similarity
Disulfide bondi335 ↔ 336By similarity

Post-translational modificationi

Glycosylation is required for protein secretion.By similarity
Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Sulfation

Proteomic databases

PaxDbiQ28J82
PRIDEiQ28J82

Interactioni

Subunit structurei

Homodimer. Secreted homodimers form a complex with wnt5a homodimers; tyrosine sulfation of both wnt11 and wnt5a by tpst1 is required for this interaction. Interacts with the transmembrane receptor fzd7/fz7. Interacts with lrp6 and ryk. Interacts with tdgf1/frl1. Interacts weakly with frzb1 and strongly with frzb2/crescent. Interaction with frzb2/crescent antagonizes wnt11 function in the neuroectoderm, but enhances it in mesodermal tissue (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi8364.ENSXETP00000050201

Structurei

3D structure databases

ProteinModelPortaliQ28J82
SMRiQ28J82
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi308 – 343Cys-richSequence analysisAdd BLAST36

Sequence similaritiesi

Belongs to the Wnt family.Sequence analysis

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3913 Eukaryota
ENOG410XQZ1 LUCA
HOVERGENiHBG001595
InParanoidiQ28J82
KOiK01384
OrthoDBiEOG091G0OFF

Family and domain databases

InterProiView protein in InterPro
IPR005817 Wnt
IPR018161 Wnt_CS
PANTHERiPTHR12027 PTHR12027, 1 hit
PfamiView protein in Pfam
PF00110 wnt, 1 hit
PRINTSiPR01349 WNTPROTEIN
SMARTiView protein in SMART
SM00097 WNT1, 1 hit
PROSITEiView protein in PROSITE
PS00246 WNT1, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q28J82-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALIRHCVTL LLILCCSRLC GAIQWLGLTV NGSRVAWNES EHCRLLDGLV
60 70 80 90 100
PEQSQLCKRN LELMQSVVNA AKQAKLTCQM TFSDMRWNCS SVENAPNFTP
110 120 130 140 150
DLSKGTRESA FVYALASATI SHTIARACAS GELPTCSCGA TPAEVPGTGF
160 170 180 190 200
RWGGCGDNLH YGLNMGSAFV DAPMKSSKSG GTQATKMINL HNNAVGRQVL
210 220 230 240 250
MDSLETKCKC HGVSGSCSVK TCWKGLQDLP HIANELKSKY LGATKVIHRQ
260 270 280 290 300
TGTRRQLVPR ELDIRPVRES ELVYLVSSPD YCAKNPKLGS YGTQDRVCNK
310 320 330 340 350
TSVGSDSCNL MCCGRGYNAY TETIVERCQC KYYWCCYVMC KKCERTVERY

VCK
Length:353
Mass (Da):38,858
Last modified:April 4, 2006 - v1
Checksum:iF43C1FCAABB7166B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR760014 mRNA Translation: CAJ82831.1
RefSeqiNP_001016735.1, NM_001016735.2
UniGeneiStr.27098

Genome annotation databases

GeneIDi549489
KEGGixtr:549489

Similar proteinsi

Entry informationi

Entry nameiW11B2_XENTR
AccessioniPrimary (citable) accession number: Q28J82
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 10, 2010
Last sequence update: April 4, 2006
Last modified: May 23, 2018
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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