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Protein

Cold-inducible RNA-binding protein

Gene

cirbp

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Cold-inducible mRNA binding protein. Acts cooperatively with elavl1/elrA to stabilize AU-rich element (ARE)-containing mRNAs by binding to themm and inhibiting their deadenylation. Essential for embryonic gastrulation and neural development, acting to maintain the expression of a set of adhesion molecules, and cell movement during embryogenesis. Required for pronephros development (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Stress response

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cold-inducible RNA-binding proteinImported
Alternative name(s):
Glycine-rich RNA-binding protein CIRPBy similarity
Gene namesi
Name:cirbpImported
ORF Names:TNeu081o03.1
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
Proteomesi
  • UP000008143 Componenti: Unassembled WGS sequence

Organism-specific databases

XenbaseiXB-GENE-492781. cirbp.

Subcellular locationi

  • Nucleusnucleoplasm By similarity
  • Cytoplasm By similarity

  • Note: Shuttles between the nucleus and cytoplasm. Predominantly cytoplasmic in oocytes. Translocates from the nucleus to the cytoplasm upon arginine methylation (By similarity).By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003909311 – 166Cold-inducible RNA-binding proteinAdd BLAST166

Post-translational modificationi

Methylated on arginine residues within RGG motifs. Methylation by prmt1 promotes cytoplasmic accumulation (By similarity).By similarity

Keywords - PTMi

Methylation

Interactioni

Subunit structurei

Interacts with prmt1. Interacts with elavl1/elrA (via RRM3). Associates with ribosomes (By similarity).By similarity

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ28IQ9.
SMRiQ28IQ9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 84RRMPROSITE-ProRule annotationAdd BLAST79

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi91 – 153Gly-richSequence analysisAdd BLAST63

Domaini

The glycine-rich domain, which contains a number of RGG motifs, is necessary to regulate nucleocytoplasmic localization.By similarity

Sequence similaritiesi

Contains 1 RRM (RNA recognition motif) domain.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000276232.
HOVERGENiHBG107480.
InParanoidiQ28IQ9.
KOiK13195.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR003954. RRM_dom_euk.
[Graphical view]
PfamiPF00076. RRM_1. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 1 hit.
SM00361. RRM_1. 1 hit.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
PROSITEiPS50102. RRM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q28IQ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSCDEGKLFV GGLNFETTEE SLEQVFSKYG QVAEVVVVKD RESKRSRGFG
60 70 80 90 100
FVTFENPEDA KDAMMAMNGK SVDGRQIRVD QAGKSSNDRR GGYRGGSSGG
110 120 130 140 150
RGFFRGGRGR GGGGDRGYGG SSRFENRSGG YQSSGSRDYY GRSHGSYGDR
160
SGGSYRDSYD SYTTQE
Length:166
Mass (Da):18,002
Last modified:April 4, 2006 - v1
Checksum:i8B749CFF5395956D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR760272 mRNA. Translation: CAJ83306.1.
RefSeqiNP_001017228.1. NM_001017228.3.
UniGeneiStr.26251.
Str.27235.

Genome annotation databases

GeneIDi549982.
KEGGixtr:549982.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR760272 mRNA. Translation: CAJ83306.1.
RefSeqiNP_001017228.1. NM_001017228.3.
UniGeneiStr.26251.
Str.27235.

3D structure databases

ProteinModelPortaliQ28IQ9.
SMRiQ28IQ9.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi549982.
KEGGixtr:549982.

Organism-specific databases

CTDi1153.
XenbaseiXB-GENE-492781. cirbp.

Phylogenomic databases

HOGENOMiHOG000276232.
HOVERGENiHBG107480.
InParanoidiQ28IQ9.
KOiK13195.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR003954. RRM_dom_euk.
[Graphical view]
PfamiPF00076. RRM_1. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 1 hit.
SM00361. RRM_1. 1 hit.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
PROSITEiPS50102. RRM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCIRBP_XENTR
AccessioniPrimary (citable) accession number: Q28IQ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 19, 2010
Last sequence update: April 4, 2006
Last modified: November 2, 2016
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.