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Q28IH7 (Q28IH7_XENTR) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Adenosylhomocysteinase RuleBase RU000548
EC=3.3.1.1 RuleBase RU000548
Gene names
Name:ahcy EMBL CAJ82626.1 Ensembl ENSXETP00000042223 Xenbase XB-FEAT-950016 Xenbase XB-GENE-950017 Xenbase XB-FEAT-950017
Synonyms:LOC733486 EMBL AAI35906.1
ORF Names:TNeu074f18.1-001 EMBL CAJ82626.1
OrganismXenopus tropicalis (Western clawed frog) (Silurana tropicalis) EMBL CAJ82626.1
Taxonomic identifier8364 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Silurana

Protein attributes

Sequence length433 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine. RuleBase RU000548

Cofactor

NAD By similarity. RuleBase RU000548

Pathway

Amino-acid biosynthesis; homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1. RuleBase RU000548

Sequence similarities

Belongs to the adenosylhomocysteinase family. RuleBase RU004166

Ontologies

Keywords
   Biological processOne-carbon metabolism RuleBase RU000548
   LigandNAD RuleBase RU000548
   Molecular functionHydrolase RuleBase RU000548 EMBL CAJ82626.1
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processone-carbon metabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionadenosylhomocysteinase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Binding site571Substrate By similarity PIRSR PIRSR001109-1
Binding site1321Substrate By similarity PIRSR PIRSR001109-1
Binding site1571Substrate By similarity PIRSR PIRSR001109-1
Binding site1871Substrate By similarity PIRSR PIRSR001109-1
Binding site1911Substrate By similarity PIRSR PIRSR001109-1

Sequences

Sequence LengthMass (Da)Tools
Q28IH7 [UniParc].

Last modified April 4, 2006. Version 1.
Checksum: 6FFF4D0A3DDE6E0C

FASTA43347,749
        10         20         30         40         50         60 
MSDKLSYKVA DISLAEWGRK AIEIAENEMP GLMKMREMYS ESKPLKGARI AGCLHMTLQT 

        70         80         90        100        110        120 
AVLIETLTAL GAEVQWSSCN IFSTQDHAAA AIAKTGVPVY AWKGETDEEY IWCIDQTLYF 

       130        140        150        160        170        180 
KDGKPLNMIL DDGGDLTNLV HTKYPQLLKG IKGISEETTT GVHNLYKMKA SGTLQVPAIN 

       190        200        210        220        230        240 
VNDSVTKSKF DNLYGCRESL IDGIKRATDV MIAGKVAVVA GYGDVGKGCA QALRAFGARV 

       250        260        270        280        290        300 
IITEIDPINA LQAAMEGYEV TTMEEASKEG NIFVTTTGCT DIVEGSHFEN MKDDSIVCNI 

       310        320        330        340        350        360 
GHFDCELDVK WLNDNAVKKV NIKPQVDRYL LKNGRHIILL AEGRLVNLGC AMGHPSFVMS 

       370        380        390        400        410        420 
NSFTNQVMAQ IELWTNNDKY PVGVYFLPKK LDEAVAAAHL DKLGVKLTKL TDKQAKYLGL 

       430 
EKEGPFKPDH YRY

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AAMC01016819 Genomic DNA. No translation available.
AAMC01016820 Genomic DNA. No translation available.
BC135905 mRNA. Translation: AAI35906.1.
CR760385 mRNA. Translation: CAJ82626.1.
RefSeqNP_001037894.1. NM_001044429.1.
UniGeneStr.51869.

3D structure databases

ProteinModelPortalQ28IH7.
SMRQ28IH7. Positions 3-433.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ28IH7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSXETT00000042223; ENSXETP00000042223; ENSXETG00000019486.
GeneID733486.
KEGGxtr:733486.
NMPDRfig|8364.3.peg.4480.

Organism-specific databases

CTD191.
XenbaseXB-GENE-950017. ahcy.

Phylogenomic databases

eggNOGveNOG04106.
GeneTreeENSGT00390000003626.
HOVERGENHBG005041.
OMASAQVWVT.
OrthoDBEOG4MW862.

Gene expression databases

BgeeQ28IH7.

Family and domain databases

HAMAPMF_00563. AdoHcyase.
[Tree]
InterProIPR000043. Adenosylhomocysteinase.
IPR015878. Ado_hCys_hydrolase_NAD-bd.
IPR020082. S-Ado-L-homoCys_hydrolase_CS.
[Graphical view]
KOK01251.
PANTHERPTHR23420. Ad_hcy_hydrolase. 1 hit.
PfamPF05221. AdoHcyase. 1 hit.
PF00670. AdoHcyase_NAD. 1 hit.
[Graphical view]
PIRSFPIRSF001109. Ad_hcy_hydrolase. 1 hit.
SMARTSM00996. AdoHcyase. 1 hit.
SM00997. AdoHcyase_NAD. 1 hit.
[Graphical view]
TIGRFAMsTIGR00936. AhcY. 1 hit.
PROSITEPS00738. ADOHCYASE_1. 1 hit.
PS00739. ADOHCYASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ28IH7_XENTR
AccessionPrimary (citable) accession number: Q28IH7
Entry history
Integrated into UniProtKB/TrEMBL: April 4, 2006
Last sequence update: April 4, 2006
Last modified: January 25, 2012
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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