ID   DULRD_XENTR             Reviewed;         244 AA.
AC   Q28HW9;
DT   21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   16-JUN-2009, entry version 18.
DE   RecName: Full=Serine/threonine-protein phosphatase dullard;
DE            EC=3.1.3.16;
GN   Name=dullard; ORFNames=TEgg035l07.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Amphibia; Batrachia; Anura; Mesobatrachia; Pipoidea; Pipidae;
OC   Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Egg;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Serine/threonine phosphatase which may be required for
CC       proper nuclear membrane morphology. Induces neuronal
CC       differentiation by antagonizing BMP signaling. Acts both by
CC       dephosphorylating BMPR1A and by promoting BMPR2 proteasomal
CC       degradation (By similarity).
CC   -!- CATALYTIC ACTIVITY: A phosphoprotein + H(2)O = a protein +
CC       phosphate.
CC   -!- SUBUNIT: Interacts with bmpr1a, bmpr1b and bmpr2 (By similarity).
CC   -!- SUBCELLULAR LOCATION: Membrane; Single-pass membrane protein
CC       (Potential). Cytoplasm, perinuclear region (By similarity).
CC   -!- SIMILARITY: Belongs to the dullard family.
CC   -!- SIMILARITY: Contains 1 FCP1 homology domain.
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DR   EMBL; CR760700; CAJ82232.1; -; mRNA.
DR   RefSeq; NP_001017177.1; -.
DR   UniGene; Str.45358; -.
DR   GeneID; 549931; -.
DR   KEGG; xtr:549931; -.
DR   Xenbase; XB-FEAT-5939295; dullard.
DR   HOVERGEN; Q28HW9; -.
DR   BRENDA; 3.1.3.16; 279072.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; ISS:UniProtKB.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005635; C:nuclear envelope; ISS:UniProtKB.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004722; F:protein serine/threonine phosphatase activity; ISS:UniProtKB.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR   GO; GO:0006998; P:nuclear envelope organization; ISS:UniProtKB.
DR   InterPro; IPR011948; Dullard.
DR   InterPro; IPR004274; NIF.
DR   Pfam; PF03031; NIF; 1.
DR   SMART; SM00577; CPDc; 1.
DR   TIGRFAMs; TIGR02251; HIF-SF_euk; 1.
DR   PROSITE; PS50969; FCP1; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Developmental protein; Differentiation; Hydrolase;
KW   Membrane; Neurogenesis; Protein phosphatase; Transmembrane.
FT   CHAIN         1    244       Serine/threonine-protein phosphatase
FT                                dullard.
FT                                /FTId=PRO_0000297973.
FT   TRANSMEM      7     29       Potential.
FT   DOMAIN       57    224       FCP1 homology.
SQ   SEQUENCE   244 AA;  28149 MW;  92C5AD45DEB2BD73 CRC64;
     MMRTPGLLGL RGFVAFAAKL WSFVLYLLRR QVRTIIQYQT VRYDVLPLSP ASRNRLSQVK
     RKVLVLDLDE TLIHSHHDGV LRPTVRPGTP PDFILKVVID KHPVRFFVHK RPHVDFFLEV
     VSQWYELVVF TASMEIYGSA VADKLDNNRG VLRRRFYRQH CTLELGSYIK DLSVVHSDLS
     SVVILDNSPG AYRSHPDNAI PIKSWFSDPS DTALLNLLPM LDALRFTADV RSVLSRNLHQ
     HRLW
//