Reviewed, UniProtKB/Swiss-Prot Q28HW9 (DULRD_XENTR)

Names and origin

Protein names

Recommended name:
    Serine/threonine-protein phosphatase dullard
    EC=3.1.3.16

Gene names

Name:	dullard
ORF Names:	TEgg035l07.1

Organism

Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)

Taxonomic identifier

8364 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Silurana

Protein attributes

Sequence length	244 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Serine/threonine phosphatase which may be required for proper nuclear membrane morphology. Induces neuronal differentiation by antagonizing BMP signaling. Acts both by dephosphorylating BMPR1A and by promoting BMPR2 proteasomal degradation By similarity.
Catalytic activity	A phosphoprotein + H2O = a protein + phosphate.
Subunit structure	Interacts with bmpr1a, bmpr1b and bmpr2 By similarity.
Subcellular location	Membrane; Single-pass membrane protein Potential. Cytoplasm › perinuclear region By similarity.
Sequence similarities	Belongs to the dullard family. Contains 1 FCP1 homology domain.

Ontologies

Keywords
Biological process	Differentiation Neurogenesis
Cellular component	Cytoplasm Membrane
Domain	Transmembrane
Molecular function	Developmental protein Hydrolase Protein phosphatase
Gene Ontology (GO)
Biological process	cell differentiation Inferred from electronic annotation. Source: UniProtKB-KW nervous system development Inferred from electronic annotation. Source: UniProtKB-KW nuclear envelope organization Inferred from sequence or structural similarity. Source: UniProtKB
Cellular component	endoplasmic reticulum membrane Inferred from sequence or structural similarity. Source: UniProtKB integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW nuclear envelope Inferred from sequence or structural similarity. Source: UniProtKB perinuclear region of cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	protein serine/threonine phosphatase activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 244	244	Serine/threonine-protein phosphatase dullard		PRO_0000297973
Regions
	Transmembrane	7 – 29	23	Potential
	Domain	57 – 224	168	FCP1 homology

Sequences

	Sequence		Length	Mass (Da)
	Q28HW9-1 [UniParc]. Last modified April 4, 2006. Version 1. Checksum: 92C5AD45DEB2BD73	FASTA	244	28,149
	10 20 30 40 50 60 MMRTPGLLGL RGFVAFAAKL WSFVLYLLRR QVRTIIQYQT VRYDVLPLSP ASRNRLSQVK 70 80 90 100 110 120 RKVLVLDLDE TLIHSHHDGV LRPTVRPGTP PDFILKVVID KHPVRFFVHK RPHVDFFLEV 130 140 150 160 170 180 VSQWYELVVF TASMEIYGSA VADKLDNNRG VLRRRFYRQH CTLELGSYIK DLSVVHSDLS 190 200 210 220 230 240 SVVILDNSPG AYRSHPDNAI PIKSWFSDPS DTALLNLLPM LDALRFTADV RSVLSRNLHQ HRLW

References

[1]	Sanger Xenopus tropicalis EST/cDNA project Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Egg.

Cross-references

Sequence databases
EMBLGenBankDDBJ	CR760700 mRNA. Translation: CAJ82232.1.
RefSeq	NP_001017177.1.
UniGene	Str.45358
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	549931.
KEGG	xtr:549931.
Organism-specific databases
Xenbase	XB-FEAT-5939295. dullard.
Phylogenomic databases
HOVERGEN	Q28HW9.
Enzyme and pathway databases
BRENDA	3.1.3.16. 279072.
Family and domain databases
InterPro	IPR011948. Dullard. IPR004274. NIF. [Graphical view]
Pfam	PF03031. NIF. 1 hit. [Graphical view]
SMART	SM00577. CPDc. 1 hit. [Graphical view]
TIGRFAMs	TIGR02251. HIF-SF_euk. 1 hit.
PROSITE	PS50969. FCP1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DULRD_XENTR

Accession

Primary (citable) accession number: Q28HW9

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 21, 2007
Last sequence update:	April 4, 2006
Last modified:	June 16, 2009
This is version 18 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Xenopus annotation project