Reviewed,
UniProtKB/Swiss-Prot Q28HW9 (DULRD_XENTR)
Last modified
June 16, 2009.
Version 18.
History...
Clusters with 100%,
90%,
50% identity |
Documents (1) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Serine/threonine-protein phosphatase dullard EC=3.1.3.16 | ||||
| Gene names |
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| Organism | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | ||||
| Taxonomic identifier | 8364 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Silurana |
Protein attributes
| Sequence length | 244 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Serine/threonine phosphatase which may be required for proper nuclear membrane morphology. Induces neuronal differentiation by antagonizing BMP signaling. Acts both by dephosphorylating BMPR1A and by promoting BMPR2 proteasomal degradation By similarity. |
| Catalytic activity | A phosphoprotein + H2O = a protein + phosphate. |
| Subunit structure | Interacts with bmpr1a, bmpr1b and bmpr2 By similarity. |
| Subcellular location | Membrane; Single-pass membrane protein Potential. Cytoplasm › perinuclear region By similarity. |
| Sequence similarities | Belongs to the dullard family. Contains 1 FCP1 homology domain. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Differentiation Neurogenesis |
| Cellular component | Cytoplasm Membrane |
| Domain | Transmembrane |
| Molecular function | Developmental protein Hydrolase Protein phosphatase |
| Gene Ontology (GO) | |
| Biological process | cell differentiation Inferred from electronic annotation. Source: UniProtKB-KW nervous system developmentInferred from electronic annotation. Source: UniProtKB-KW nuclear envelope organizationInferred from sequence or structural similarity. Source: UniProtKB |
| Cellular component | endoplasmic reticulum membrane Inferred from sequence or structural similarity. Source: UniProtKB integral to membraneInferred from electronic annotation. Source: UniProtKB-KW nuclear envelopeInferred from sequence or structural similarity. Source: UniProtKB perinuclear region of cytoplasmInferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | protein serine/threonine phosphatase activity Inferred from sequence or structural similarity. Source: UniProtKB |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
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References
| [1] | Sanger Xenopus tropicalis EST/cDNA project Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Egg. |
Cross-references
Sequence databases | |
|---|---|
| CR760700 mRNA. Translation: CAJ82232.1. | |
| RefSeq | NP_001017177.1. |
| UniGene | Str.45358 |
3D structure databases | |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 549931. |
| KEGG | xtr:549931. |
Organism-specific databases | |
| Xenbase | XB-FEAT-5939295. dullard. |
Phylogenomic databases | |
| HOVERGEN | Q28HW9. |
Enzyme and pathway databases | |
| BRENDA | 3.1.3.16. 279072. |
Family and domain databases | |
| InterPro | IPR011948. Dullard. IPR004274. NIF. [Graphical view] |
| Pfam | PF03031. NIF. 1 hit. [Graphical view] |
| SMART | SM00577. CPDc. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR02251. HIF-SF_euk. 1 hit. |
| PROSITE | PS50969. FCP1. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | DULRD_XENTR | ||||||||
| Accession | Primary (citable) accession number: Q28HW9 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | Xenopus annotation project | ||||||||

Clusters with


