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Q28HW9 (CNEP1_XENTR) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 41. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
CTD nuclear envelope phosphatase 1

EC=3.1.3.16
Alternative name(s):
Serine/threonine-protein phosphatase dullard
Gene names
Name:ctdnep1
Synonyms:dullard
ORF Names:TEgg035l07.1
OrganismXenopus tropicalis (Western clawed frog) (Silurana tropicalis) [Reference proteome]
Taxonomic identifier8364 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana

Protein attributes

Sequence length244 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Serine/threonine protein phosphatase that may dephosphorylate and activate lipins. Lipins are phosphatidate phosphatases that catalyze the conversion of phosphatidic acid to diacylglycerol and control the metabolism of fatty acids at differents levels. May indirectly modulate the lipid composition of nuclear and/or endoplasmic reticulum membranes and be required for proper nuclear membrane morphology and/or dynamics. May also indirectly regulate the production of lipid droplets and triacylglycerol. Induces neuronal differentiation by antagonizing BMP signaling. Acts both by dephosphorylating BMPR1A and by promoting BMPR2 proteasomal degradation By similarity.

Catalytic activity

A phosphoprotein + H2O = a protein + phosphate.

Subunit structure

Interacts with bmpr1a, bmpr1b and bmpr2 By similarity.

Subcellular location

Membrane; Single-pass membrane protein Potential. Cytoplasmperinuclear region By similarity.

Sequence similarities

Belongs to the dullard family.

Contains 1 FCP1 homology domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 244244CTD nuclear envelope phosphatase 1
PRO_0000297973

Regions

Transmembrane7 – 2923Helical; Potential
Domain57 – 224168FCP1 homology

Sequences

Sequence LengthMass (Da)Tools
Q28HW9 [UniParc].

Last modified April 4, 2006. Version 1.
Checksum: 92C5AD45DEB2BD73

FASTA24428,149
        10         20         30         40         50         60 
MMRTPGLLGL RGFVAFAAKL WSFVLYLLRR QVRTIIQYQT VRYDVLPLSP ASRNRLSQVK 

        70         80         90        100        110        120 
RKVLVLDLDE TLIHSHHDGV LRPTVRPGTP PDFILKVVID KHPVRFFVHK RPHVDFFLEV 

       130        140        150        160        170        180 
VSQWYELVVF TASMEIYGSA VADKLDNNRG VLRRRFYRQH CTLELGSYIK DLSVVHSDLS 

       190        200        210        220        230        240 
SVVILDNSPG AYRSHPDNAI PIKSWFSDPS DTALLNLLPM LDALRFTADV RSVLSRNLHQ 


HRLW 

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References

[1]Sanger Xenopus tropicalis EST/cDNA project
Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Egg.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR760700 mRNA. Translation: CAJ82232.1.
RefSeqNP_001017177.1. NM_001017177.2.
UniGeneStr.45358.

3D structure databases

ProteinModelPortalQ28HW9.
ModBaseSearch...

Protein-protein interaction databases

STRING8364.ENSXETP00000014538.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID549931.
KEGGxtr:549931.

Organism-specific databases

CTD23399.
XenbaseXB-GENE-5939296. ctdnep1.

Phylogenomic databases

eggNOGCOG5190.
HOVERGENHBG098153.

Gene expression databases

BgeeQ28HW9.

Family and domain databases

Gene3D3.40.50.1000. 1 hit.
InterProIPR011948. Dullard_phosphatase.
IPR023214. HAD-like_dom.
IPR004274. NIF.
[Graphical view]
PfamPF03031. NIF. 1 hit.
[Graphical view]
SMARTSM00577. CPDc. 1 hit.
[Graphical view]
SUPFAMSSF56784. HAD-like_dom. 1 hit.
TIGRFAMsTIGR02251. HIF-SF_euk. 1 hit.
PROSITEPS50969. FCP1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCNEP1_XENTR
AccessionPrimary (citable) accession number: Q28HW9
Entry history
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: April 4, 2006
Last modified: April 3, 2013
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families