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Q28H76

- TRMBA_XENTR

UniProt

Q28H76 - TRMBA_XENTR

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Protein

tRNA (guanine-N(7)-)-methyltransferase A

Gene

mettl1-A

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei86 – 861S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation
Binding sitei162 – 1621S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation
Active sitei165 – 1651UniRule annotation

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB
  2. tRNA binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. RNA (guanine-N7)-methylation Source: GOC
  2. tRNA modification Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

RNA-binding, S-adenosyl-L-methionine, tRNA-binding

Enzyme and pathway databases

UniPathwayiUPA00989.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferase AUniRule annotation (EC:2.1.1.33UniRule annotation)
Alternative name(s):
Methyltransferase-like protein 1-AUniRule annotation
tRNA (guanine(46)-N(7))-methyltransferase AUniRule annotation
tRNA(m7G46)-methyltransferase AUniRule annotation
Gene namesi
Name:mettl1-A
ORF Names:TEgg045g13.1
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
ProteomesiUP000008143: Unplaced

Organism-specific databases

XenbaseiXB-GENE-1000662. mettl1.

Subcellular locationi

Nucleus UniRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 273273tRNA (guanine-N(7)-)-methyltransferase APRO_0000370560Add
BLAST

Proteomic databases

PRIDEiQ28H76.

Expressioni

Gene expression databases

BgeeiQ28H76.

Interactioni

Subunit structurei

Forms a complex with wdr4.UniRule annotation

Protein-protein interaction databases

STRINGi8364.ENSXETP00000021255.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni109 – 1102S-adenosyl-L-methionine bindingUniRule annotation
Regioni142 – 1432S-adenosyl-L-methionine bindingUniRule annotation
Regioni240 – 2423S-adenosyl-L-methionine bindingUniRule annotation

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0220.
GeneTreeiENSGT00390000017840.
HOGENOMiHOG000260965.
InParanoidiQ28H76.
KOiK03439.
OrthoDBiEOG7PS1GC.
TreeFamiTF314083.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_03055. tRNA_methyltr_TrmB_euk.
InterProiIPR029063. SAM-dependent_MTases-like.
IPR025763. Trm8_euk.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view]
PfamiPF02390. Methyltransf_4. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q28H76-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MCNTQATPSD PGITVAHPKK RYYRQRAHSN PMADHTFQYP VKPEIMDWSE
60 70 80 90 100
YYPDYFKPLV PDSAHDDAKD LQERKEQHQV EFADIGCGYG GLLVELSPLF
110 120 130 140 150
PNTLMLGLEI RVKVSDYVQD RIKSLRASHL GQYQNIACIR SNAMKYIPNF
160 170 180 190 200
FKKGQLSKMF FLFPDPHFKK TKHKWRIISP TLLAEYAYVL RIGGMVYTIT
210 220 230 240 250
DVEEVHTWMV KHFTEHPLFE RVAKEELVND IVVGKLGTST EEGKKVQRNK
260 270
GLNLLAVFRR IENSTFIQRD SQQ
Length:273
Mass (Da):31,697
Last modified:May 5, 2009 - v2
Checksum:i79E31E012996D8D5
GO

Sequence cautioni

The sequence AAH76665.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence CAJ83619.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti149 – 1491N → S in AAH76665. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR761007 mRNA. Translation: CAJ83619.1. Different initiation.
BC076665 mRNA. Translation: AAH76665.1. Different initiation.
RefSeqiNP_001006798.2. NM_001006797.2.
UniGeneiStr.11051.

Genome annotation databases

EnsembliENSXETT00000021255; ENSXETP00000021255; ENSXETG00000009655.
GeneIDi448504.
KEGGixtr:448504.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR761007 mRNA. Translation: CAJ83619.1 . Different initiation.
BC076665 mRNA. Translation: AAH76665.1 . Different initiation.
RefSeqi NP_001006798.2. NM_001006797.2.
UniGenei Str.11051.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 8364.ENSXETP00000021255.

Proteomic databases

PRIDEi Q28H76.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSXETT00000021255 ; ENSXETP00000021255 ; ENSXETG00000009655 .
GeneIDi 448504.
KEGGi xtr:448504.

Organism-specific databases

CTDi 4234.
Xenbasei XB-GENE-1000662. mettl1.

Phylogenomic databases

eggNOGi COG0220.
GeneTreei ENSGT00390000017840.
HOGENOMi HOG000260965.
InParanoidi Q28H76.
KOi K03439.
OrthoDBi EOG7PS1GC.
TreeFami TF314083.

Enzyme and pathway databases

UniPathwayi UPA00989 .

Gene expression databases

Bgeei Q28H76.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
HAMAPi MF_03055. tRNA_methyltr_TrmB_euk.
InterProi IPR029063. SAM-dependent_MTases-like.
IPR025763. Trm8_euk.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view ]
Pfami PF02390. Methyltransf_4. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Sanger Xenopus tropicalis EST/cDNA project
    Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Egg.
  2. NIH - Xenopus Gene Collection (XGC) project
    Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.

Entry informationi

Entry nameiTRMBA_XENTR
AccessioniPrimary (citable) accession number: Q28H76
Secondary accession number(s): Q6DFR8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: May 5, 2009
Last modified: October 29, 2014
This is version 61 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3